PubMed

The HIV-1 integrase genotype strongly predicts raltegravir susceptibility but not viral fitness of primary virus isolates.

Buzón MJ, Dalmau J, Puertas MC, Puig J, Clotet B, Martinez-Picado J.

AIDS. 2009 Sep 16. [Epub ahead of print]PMID: 19770695 [PubMed - as supplied by publisher]Related articles

Rate of accumulation of thymidine analogue mutations in patients continuing to receive virologically failing regimens containing zidovudine or stavudine: implications for antiretroviral therapy programs in resource-limited settings.

Cozzi-Lepri A, Phillips AN, Martinez-Picado J, Monforte A, Katlama C, Eg Hansen AB, Horban A, Bruun J, Clotet B, Lundgren JD; EuroSIDA Study Group.

J Infect Dis. 2009 Sep 1;200(5):687-97.PMID: 19604043 [PubMed - indexed for MEDLINE]Related articles

[Potential of integrase inhibitors to deplete HIV reservoirs or prevent their replenishment]

Llibre JM, Martínez-Picado J.

Enferm Infecc Microbiol Clin. 2008 Nov;26 Suppl 12:17-22. Review. Spanish. PMID: 19572421 [PubMed - indexed for MEDLINE]Related articlesFree article

New macrocyclic amines showing activity as HIV entry inhibitors against wild type and multi-drug resistant viruses.

Rusconi S, Lo Cicero M, Viganò O, Sirianni F, Bulgheroni E, Ferramosca S, Bencini A, Bianchi A, Ruiz L, Cabrera C, Martinez-Picado J, Supuran CT, Galli M.

Molecules. 2009 May 22;14(5):1927-37.PMID: 19471212 [PubMed - indexed for MEDLINE]Related articles

Effect of the human immunodeficiency virus type 1 reverse transcriptase polymorphism Leu-214 on replication capacity and drug susceptibility.

Puertas MC, Buzón MJ, Artese A, Alcaro S, Menendez-Arias L, Perno CF, Clotet B, Ceccherini-Silberstein F, Martinez-Picado J.

J Virol. 2009 Aug;83(15):7434-9. Epub 2009 May 20.PMID: 19457988 [PubMed - indexed for MEDLINE]Related articles

Transient treatment exclusively containing nucleoside analogue reverse transcriptase inhibitors in highly antiretroviral-experienced patients preserves viral benefit when a fully active therapy was initiated.

Bonjoch A, Buzon MJ, Llibre JM, Negredo E, Puig J, Pérez-Alvarez N, Videla S, Martinez-Picado J, Clotet B.

HIV Clin Trials. 2008 Nov-Dec;9(6):387-98.PMID: 19203904 [PubMed - indexed for MEDLINE]Related articles

Transport of lamivudine [(-)-beta-L-2',3'-dideoxy-3'-thiacytidine] and high-affinity interaction of nucleoside reverse transcriptase inhibitors with human organic cation transporters 1, 2, and 3.

Minuesa G, Volk C, Molina-Arcas M, Gorboulev V, Erkizia I, Arndt P, Clotet B, Pastor-Anglada M, Koepsell H, Martinez-Picado J.

J Pharmacol Exp Ther. 2009 Apr;329(1):252-61. Epub 2009 Jan 13. Erratum in: J Pharmacol Exp Ther. 2009 Jun;329(3):1187. PMID: 19141712 [PubMed - indexed for MEDLINE]Related articles

Contribution of immunological and virological factors to extremely severe primary HIV type 1 infection.

Dalmau J, Puertas MC, Azuara M, Mariño A, Frahm N, Mothe B, Izquierdo-Useros N, Buzón MJ, Paredes R, Matas L, Allen TM, Brander C, Rodrigo C, Clotet B, Martinez-Picado J.

Clin Infect Dis. 2009 Jan 15;48(2):229-38.PMID: 19093810 [PubMed - indexed for MEDLINE]Related articles

Variability in the plasma concentration of efavirenz and nevirapine is associated with genotypic resistance after treatment interruption.

Darwich L, Esteve A, Ruiz L, Bellido R, Clotet B, Martinez-Picado J.

Antivir Ther. 2008;13(7):945-51.PMID: 19043929 [PubMed - indexed for MEDLINE]Related articles

Raltegravir susceptibility and fitness progression of HIV type-1 integrase in patients on long-term antiretroviral therapy.

Buzón MJ, Marfil S, Puertas MC, Garcia E, Clotet B, Ruiz L, Blanco J, Martinez-Picado J, Cabrera C.

Antivir Ther. 2008;13(7):881-93.PMID: 19043922 [PubMed - indexed for MEDLINE]Related articles

The magnitude of interferon-gamma responses to human cytomegalovirus is predictive for HIV-1 disease progression.

Darwich L, Cabrera C, Romeu J, Martinez-Picado J, Esté JA, Tural C, Bellido R, Clotet B, Angulo A, Ruiz L, Bofill M.

J Acquir Immune Defic Syndr. 2008 Dec 15;49(5):507-12.PMID: 18989229 [PubMed - indexed for MEDLINE]Related articles

Capture and transfer of HIV-1 particles by mature dendritic cells converges with the exosome-dissemination pathway.

Izquierdo-Useros N, Naranjo-Gómez M, Archer J, Hatch SC, Erkizia I, Blanco J, Borràs FE, Puertas MC, Connor JH, Fernández-Figueras MT, Moore L, Clotet B, Gummuluru S, Martinez-Picado J.

Blood. 2009 Mar 19;113(12):2732-41. Epub 2008 Oct 22.PMID: 18945959 [PubMed - indexed for MEDLINE]Related articles

Functional consequences of human immunodeficiency virus escape from an HLA-B*13-restricted CD8+ T-cell epitope in p1 Gag protein.

Prado JG, Honeyborne I, Brierley I, Puertas MC, Martinez-Picado J, Goulder PJ.

J Virol. 2009 Jan;83(2):1018-25. Epub 2008 Oct 22.PMID: 18945768 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanistic basis of zidovudine hypersusceptibility and lamivudine resistance conferred by the deletion of codon 69 in the HIV-1 reverse transcriptase coding region.

Kisic M, Mendieta J, Puertas MC, Parera M, Martínez MA, Martinez-Picado J, Menéndez-Arias L.

J Mol Biol. 2008 Oct 3;382(2):327-41. Epub 2008 Jul 17.PMID: 18662701 [PubMed - indexed for MEDLINE]Related articles

Targeting only reverse transcriptase with zidovudine/lamivudine/abacavir plus tenofovir in HIV-1-infected patients with multidrug-resistant virus: a multicentre pilot study.

Llibre JM, Bonjoch A, Iribarren J, Galindo MJ, Negredo E, Domingo P, Pérez-Alvarez N, Martinez-Picado J, Schapiro J, Clotet B; HIV Conference Call Study Group.

HIV Med. 2008 Aug;9(7):508-13. Epub 2008 May 15.PMID: 18484978 [PubMed - indexed for MEDLINE]Related articles

Drug-resistance mutations number and K70R or T215Y/F substitutions predict treatment resumption during guided treatment interruptions.

Darwich L, Esteve A, Ruiz L, Paredes R, Bellido R, Cabrera C, Romeu J, Bofill M, Clotet B, Martinez-Picado J.

AIDS Res Hum Retroviruses. 2008 May;24(5):725-32.PMID: 18462084 [PubMed - indexed for MEDLINE]Related articles

HIV transfer between CD4 T cells does not require LFA-1 binding to ICAM-1 and is governed by the interaction of HIV envelope glycoprotein with CD4.

Puigdomènech I, Massanella M, Izquierdo-Useros N, Ruiz-Hernandez R, Curriu M, Bofill M, Martinez-Picado J, Juan M, Clotet B, Blanco J.

Retrovirology. 2008 Mar 31;5:32.PMID: 18377648 [PubMed - indexed for MEDLINE]Related articlesFree article

HIV-1 reverse transcriptase inhibitor resistance mutations and fitness: a view from the clinic and ex vivo.

Martinez-Picado J, Martínez MA.

Virus Res. 2008 Jun;134(1-2):104-23. Epub 2008 Mar 4. Review.PMID: 18289713 [PubMed - indexed for MEDLINE]Related articles

Expression and functionality of anti-human immunodeficiency virus and anticancer drug uptake transporters in immune cells.

Minuesa G, Purcet S, Erkizia I, Molina-Arcas M, Bofill M, Izquierdo-Useros N, Casado FJ, Clotet B, Pastor-Anglada M, Martinez-Picado J.

J Pharmacol Exp Ther. 2008 Feb;324(2):558-67. Epub 2007 Nov 27.PMID: 18042828 [PubMed - indexed for MEDLINE]Related articlesFree article

Random T-cell receptor recruitment in human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T cells from genetically identical twins infected with the same HIV-1 strain.

Yu XG, Lichterfeld M, Williams KL, Martinez-Picado J, Walker BD.

J Virol. 2007 Nov;81(22):12666-9. Epub 2007 Sep 5.PMID: 17804503 [PubMed - indexed for MEDLINE]Related articlesFree article

A whole-genome association study of major determinants for host control of HIV-1.

Fellay J, Shianna KV, Ge D, Colombo S, Ledergerber B, Weale M, Zhang K, Gumbs C, Castagna A, Cossarizza A, Cozzi-Lepri A, De Luca A, Easterbrook P, Francioli P, Mallal S, Martinez-Picado J, Miro JM, Obel N, Smith JP, Wyniger J, Descombes P, Antonarakis SE, Letvin NL, McMichael AJ, Haynes BF, Telenti A, Goldstein DB.

Science. 2007 Aug 17;317(5840):944-7. Epub 2007 Jul 19.PMID: 17641165 [PubMed - indexed for MEDLINE]Related articlesFree article

Maturation of blood-derived dendritic cells enhances human immunodeficiency virus type 1 capture and transmission.

Izquierdo-Useros N, Blanco J, Erkizia I, Fernández-Figueras MT, Borràs FE, Naranjo-Gómez M, Bofill M, Ruiz L, Clotet B, Martinez-Picado J.

J Virol. 2007 Jul;81(14):7559-70. Epub 2007 May 2.PMID: 17475656 [PubMed - indexed for MEDLINE]Related articlesFree article

AM3 modulates dendritic cell pathogen recognition capabilities by targeting DC-SIGN.

Serrano-Gómez D, Martínez-Nuñez RT, Sierra-Filardi E, Izquierdo N, Colmenares M, Pla J, Rivas L, Martinez-Picado J, Jimenez-Barbero J, Alonso-Lebrero JL, González S, Corbí AL.

Antimicrob Agents Chemother. 2007 Jul;51(7):2313-23. Epub 2007 Apr 23.PMID: 17452477 [PubMed - indexed for MEDLINE]Related articlesFree article

Relative fitness and replication capacity of a multinucleoside analogue-resistant clinical human immunodeficiency virus type 1 isolate with a deletion of codon 69 in the reverse transcriptase coding region.

Villena C, Prado JG, Puertas MC, Martínez MA, Clotet B, Ruiz L, Parkin NT, Menéndez-Arias L, Martinez-Picado J.

J Virol. 2007 May;81(9):4713-21. Epub 2007 Feb 21.PMID: 17314158 [PubMed - indexed for MEDLINE]Related articlesFree article

3'-Azido-2',3'-dideoxythymidine (zidovudine) uptake mechanisms in T lymphocytes.

Purcet S, Minuesa G, Molina-Arcas M, Erkizia I, Casado FJ, Clotet B, Martinez-Picado J, Pastor-Anglada M.

Antivir Ther. 2006;11(6):803-11.PMID: 17310825 [PubMed - indexed for MEDLINE]Related articles

Antiretroviral therapy interruption guided by CD4 cell counts and plasma HIV-1 RNA levels in chronically HIV-1-infected patients.

Ruiz L, Paredes R, Gómez G, Romeu J, Domingo P, Pérez-Alvarez N, Tambussi G, Llibre JM, Martínez-Picado J, Vidal F, Fumaz CR, Clotet B; TIBET Study Group.

AIDS. 2007 Jan 11;21(2):169-78.PMID: 17197807 [PubMed - indexed for MEDLINE]Related articles

Risk of selecting resistance mutations during treatment interruption.

Martinez-Picado J, Wai Yan Tam L.

Curr Opin HIV AIDS. 2007 Jan;2(1):6-13.PMID: 19372859 [PubMed - in process]Related articles

Genetic evolution of gp41 reveals a highly exclusive relationship between codons 36, 38 and 43 in gp41 under long-term enfuvirtide-containing salvage regimen.

Cabrera C, Marfil S, García E, Martinez-Picado J, Bonjoch A, Bofill M, Moreno S, Ribera E, Domingo P, Clotet B, Ruiz L.

AIDS. 2006 Oct 24;20(16):2075-80.PMID: 17053353 [PubMed - indexed for MEDLINE]Related articles

Naive CD4(+) T cells and recent thymic emigrant levels in treated individuals with HIV: clinical relevance.

Bofill M, Martinez-Picado J, Ruiz-Hernandez R, Cabrera C, Marfil S, Erkizia I, Bellido R, Romeu J, Clotet B, Ruiz L.

AIDS Res Hum Retroviruses. 2006 Sep;22(9):893-6.PMID: 16989615 [PubMed - indexed for MEDLINE]Related articles

Use of a novel assay based on intact recombinant viruses expressing green (EGFP) or red (DsRed2) fluorescent proteins to examine the contribution of pol and env genes to overall HIV-1 replicative fitness.

Weber J, Weberova J, Carobene M, Mirza M, Martinez-Picado J, Kazanjian P, Quiñones-Mateu ME.

J Virol Methods. 2006 Sep;136(1-2):102-17. Epub 2006 May 11.PMID: 16690137 [PubMed - indexed for MEDLINE]Related articles

Fitness cost of escape mutations in p24 Gag in association with control of human immunodeficiency virus type 1.

Martinez-Picado J, Prado JG, Fry EE, Pfafferott K, Leslie A, Chetty S, Thobakgale C, Honeyborne I, Crawford H, Matthews P, Pillay T, Rousseau C, Mullins JI, Brander C, Walker BD, Stuart DI, Kiepiela P, Goulder P.

J Virol. 2006 Apr;80(7):3617-23.PMID: 16537629 [PubMed - indexed for MEDLINE]Related articlesFree article

Constraints on HIV-1 evolution and immunodominance revealed in monozygotic adult twins infected with the same virus.

Draenert R, Allen TM, Liu Y, Wrin T, Chappey C, Verrill CL, Sirera G, Eldridge RL, Lahaie MP, Ruiz L, Clotet B, Petropoulos CJ, Walker BD, Martinez-Picado J.

J Exp Med. 2006 Mar 20;203(3):529-39. Epub 2006 Mar 13.PMID: 16533886 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased antiretroviral potency by the addition of enfuvirtide to a four-drug regimen in antiretroviral-naive, HIV-infected patients.

Moltó J, Ruiz L, Valle M, Martinez-Picado J, Bonjoch A, Bravo I, Negredo E, Heilek-Sneider GM, Clotet B.

Antivir Ther. 2006;11(1):47-51.PMID: 16518959 [PubMed - indexed for MEDLINE]Related articles

HIV type 1 fitness evolution in antiretroviral-experienced patients with sustained CD4+ T cell counts but persistent virologic failure.

Prado JG, Parkin NT, Clotet B, Ruiz L, Martinez-Picado J.

Clin Infect Dis. 2005 Sep 1;41(5):729-37. Epub 2005 Jul 22.PMID: 16080097 [PubMed - indexed for MEDLINE]Related articles

Impact of drug resistance genotypes on CD4+ counts and plasma viremia in heavily antiretroviral-experienced HIV-infected patients.

Rodes B, García F, Gutierrez C, Martinez-Picado J, Aguilera A, Saumoy M, Vallejo A, Domingo P, Dalmau D, Ribas MA, Blanco JL, Pedreira J, Perez-Elias MJ, Leal M, de Mendoza C, Soriano V; Red de Investigación en SIDA.

J Med Virol. 2005 Sep;77(1):23-8.PMID: 16032728 [PubMed - indexed for MEDLINE]Related articles

Phenotypic hypersusceptibility to multiple protease inhibitors and low replicative capacity in patients who are chronically infected with human immunodeficiency virus type 1.

Martinez-Picado J, Wrin T, Frost SD, Clotet B, Ruiz L, Brown AJ, Petropoulos CJ, Parkin NT.

J Virol. 2005 May;79(10):5907-13.PMID: 15857976 [PubMed - indexed for MEDLINE]Related articlesFree article

Interaction of nucleoside inhibitors of HIV-1 reverse transcriptase with the concentrative nucleoside transporter-1 (SLC28A1).

Cano-Soldado P, Lorráyoz IM, Molina-Arcas M, Casado FJ, Martinez-Picado J, Lostao MP, Pastor-Anglada M.

Antivir Ther. 2004 Dec;9(6):993-1002.PMID: 15651758 [PubMed - indexed for MEDLINE]Related articles

Alternation of antiretroviral drug regimens for HIV infection. Efficacy, safety and tolerability at week 96 of the Swatch Study.

Negredo E, Paredes R, Peraire J, Pedrol E, Côté H, Gel S, Fumoz CR, Ruiz L, Abril V, Rodriguez de Castro E, Ochoa C, Martinez-Picado J, Montaner J, Rey-Joly C, Clotet B; Swatch Study Team.

Antivir Ther. 2004 Dec;9(6):889-93.PMID: 15651747 [PubMed - indexed for MEDLINE]Related articles

Influence of prior structured treatment interruptions on the length of time without antiretroviral treatment in chronically HIV-infected subjects.

Moltó J, Ruiz L, Romeu J, Martínez-Picado J, Negredo E, Tural C, Sirera G, Clotet B.

AIDS Res Hum Retroviruses. 2004 Dec;20(12):1283-8.PMID: 15650419 [PubMed - indexed for MEDLINE]Related articles

Cell entry and export of nucleoside analogues.

Pastor-Anglada M, Cano-Soldado P, Molina-Arcas M, Lostao MP, Larráyoz I, Martínez-Picado J, Casado FJ.

Virus Res. 2005 Feb;107(2):151-64. Review.PMID: 15649561 [PubMed - indexed for MEDLINE]Related articles

Evidence for preferential genotyping of a minority human immunodeficiency virus population due to primer-template mismatching during PCR-based amplification.

Martinez-Picado J, Morales-Lopetegi K, Villena C, Gutiérrez C, Izquierdo N, Marfil S, Clotet B, Ruiz L.

J Clin Microbiol. 2005 Jan;43(1):436-8.PMID: 15635008 [PubMed - indexed for MEDLINE]Related articlesFree article

Relative replication fitness of multi-nucleoside analogue-resistant HIV-1 strains bearing a dipeptide insertion in the fingers subdomain of the reverse transcriptase and mutations at codons 67 and 215.

Prado JG, Franco S, Matamoros T, Ruiz L, Clotet B, Menéndez-Arias L, Martínez MA, Martinez-Picado J.

Virology. 2004 Aug 15;326(1):103-12.PMID: 15262499 [PubMed - indexed for MEDLINE]Related articles

Lack of longitudinal intrapatient correlation between p24 antigenemia and levels of human immunodeficiency virus (HIV) type 1 RNA in patients with chronic hiv infection during structured treatment interruptions.

Prado JG, Shintani A, Bofill M, Clotet B, Ruiz L, Martinez-Picado J.

J Clin Microbiol. 2004 Apr;42(4):1620-5.PMID: 15071015 [PubMed - indexed for MEDLINE]Related articlesFree article

Immune selection for altered antigen processing leads to cytotoxic T lymphocyte escape in chronic HIV-1 infection.

Draenert R, Le Gall S, Pfafferott KJ, Leslie AJ, Chetty P, Brander C, Holmes EC, Chang SC, Feeney ME, Addo MM, Ruiz L, Ramduth D, Jeena P, Altfeld M, Thomas S, Tang Y, Verrill CL, Dixon C, Prado JG, Kiepiela P, Martinez-Picado J, Walker BD, Goulder PJ.

J Exp Med. 2004 Apr 5;199(7):905-15.PMID: 15067030 [PubMed - indexed for MEDLINE]Related articlesFree article

HIV evolution: CTL escape mutation and reversion after transmission.

Leslie AJ, Pfafferott KJ, Chetty P, Draenert R, Addo MM, Feeney M, Tang Y, Holmes EC, Allen T, Prado JG, Altfeld M, Brander C, Dixon C, Ramduth D, Jeena P, Thomas SA, St John A, Roach TA, Kupfer B, Luzzi G, Edwards A, Taylor G, Lyall H, Tudor-Williams G, Novelli V, Martinez-Picado J, Kiepiela P, Walker BD, Goulder PJ.

Nat Med. 2004 Mar;10(3):282-9. Epub 2004 Feb 8.PMID: 14770175 [PubMed - indexed for MEDLINE]Related articles

Fitness variations and their impact on the evolution of antiretroviral drug resistance.

Menéndez-Arias L, Martínez MA, Quiñones-Mateu ME, Martinez-Picado J.

Curr Drug Targets Infect Disord. 2003 Dec;3(4):355-71. Review.PMID: 14754435 [PubMed - indexed for MEDLINE]Related articles

Role of structured treatment interruption before a 5-drug salvage antiretroviral regimen: the Retrogene Study.

Ruiz L, Ribera E, Bonjoch A, Romeu J, Martinez-Picado J, Paredes R, Díaz M, Marfil S, Negredo E, García-Prado J, Tural C, Sirera G, Clotet B.

J Infect Dis. 2003 Oct 1;188(7):977-85. Epub 2003 Sep 23.PMID: 14513417 [PubMed - indexed for MEDLINE]Related articles

A novel TaqMan real-time PCR assay to estimate ex vivo human immunodeficiency virus type 1 fitness in the era of multi-target (pol and env) antiretroviral therapy.

Weber J, Rangel HR, Chakraborty B, Tadele M, Martinez MA, Martinez-Picado J, Marotta ML, Mirza M, Ruiz L, Clotet B, Wrin T, Petropoulos CJ, Quiñones-Mateu ME.

J Gen Virol. 2003 Aug;84(Pt 8):2217-28.PMID: 12867654 [PubMed - indexed for MEDLINE]Related articlesFree article

Alternation of antiretroviral drug regimens for HIV infection. A randomized, controlled trial.

Martinez-Picado J, Negredo E, Ruiz L, Shintani A, Fumaz CR, Zala C, Domingo P, Vilaró J, Llibre JM, Viciana P, Hertogs K, Boucher C, D'Aquila RT, Clotet B; SWATCH Study Team.

Ann Intern Med. 2003 Jul 15;139(2):81-9.PMID: 12859157 [PubMed - indexed for MEDLINE]Related articlesFree article

Viral evolution during structured treatment interruptions in chronically human immunodeficiency virus-infected individuals.

Martinez-Picado J, Frost SD, Izquierdo N, Morales-Lopetegi K, Marfil S, Puig T, Cabrera C, Clotet B, Ruiz L.

J Virol. 2002 Dec;76(23):12344-8.PMID: 12414975 [PubMed - indexed for MEDLINE]Related articlesFree article