PubMed

BCL9 promotes tumor progression by conferring enhanced proliferative, metastatic, and angiogenic properties to cancer cells.

Mani M, Carrasco DE, Zhang Y, Takada K, Gatt ME, Dutta-Simmons J, Ikeda H, Diaz-Griffero F, Pena-Cruz V, Bertagnolli M, Myeroff LL, Markowitz SD, Anderson KC, Carrasco DR.

Cancer Res. 2009 Oct 1;69(19):7577-86. Epub 2009 Sep 8.PMID: 19738061 [PubMed - in process]Related articles

Sensitive digital quantification of DNA methylation in clinical samples.

Li M, Chen WD, Papadopoulos N, Goodman SN, Bjerregaard NC, Laurberg S, Levin B, Juhl H, Arber N, Moinova H, Durkee K, Schmidt K, He Y, Diehl F, Velculescu VE, Zhou S, Diaz LA Jr, Kinzler KW, Markowitz SD, Vogelstein B.

Nat Biotechnol. 2009 Sep;27(9):858-63. Epub 2009 Aug 16.PMID: 19684580 [PubMed - in process]Related articles

Inactivating germ-line and somatic mutations in polypeptide N-acetylgalactosaminyltransferase 12 in human colon cancers.

Guda K, Moinova H, He J, Jamison O, Ravi L, Natale L, Lutterbaugh J, Lawrence E, Lewis S, Willson JK, Lowe JB, Wiesner GL, Parmigiani G, Barnholtz-Sloan J, Dawson DW, Velculescu VE, Kinzler KW, Papadopoulos N, Vogelstein B, Willis J, Gerken TA, Markowitz SD.

Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12921-5. Epub 2009 Jul 17.PMID: 19617566 [PubMed - indexed for MEDLINE]Related articles

Infrequent detection of germline allele-specific expression of TGFBR1 in lymphoblasts and tissues of colon cancer patients.

Guda K, Natale L, Lutterbaugh J, Wiesner GL, Lewis S, Tanner SM, Tomsic J, Valle L, de la Chapelle A, Elston RC, Willis J, Markowitz SD.

Cancer Res. 2009 Jun 15;69(12):4959-61. Epub 2009 Jun 9.PMID: 19509225 [PubMed - indexed for MEDLINE]Related articles

The effectiveness of colonoscopy in reducing mortality from colorectal cancer.

Markowitz SD, Itzkowitz SH, Berger BM.

Ann Intern Med. 2009 Jun 2;150(11):816-7; author reply 819-20. No abstract available. PMID: 19487718 [PubMed - indexed for MEDLINE]Related articlesFree article

15-Hydroxyprostaglandin dehydrogenase inactivation as a mechanism of resistance to celecoxib chemoprevention of colon tumors.

Yan M, Myung SJ, Fink SP, Lawrence E, Lutterbaugh J, Yang P, Zhou X, Liu D, Rerko RM, Willis J, Dawson D, Tai HH, Barnholtz-Sloan JS, Newman RA, Bertagnolli MM, Markowitz SD.

Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9409-13. Epub 2009 May 22.PMID: 19470469 [PubMed - indexed for MEDLINE]Related articles

NAD+-dependent 15-hydroxyprostaglandin dehydrogenase regulates levels of bioactive lipids in non-small cell lung cancer.

Hughes D, Otani T, Yang P, Newman RA, Yantiss RK, Altorki NK, Port JL, Yan M, Markowitz SD, Mazumdar M, Tai HH, Subbaramaiah K, Dannenberg AJ.

Cancer Prev Res (Phila Pa). 2008 Sep;1(4):241-9.PMID: 19138967 [PubMed - indexed for MEDLINE]Related articlesFree article

Colorectal neoplasia goes with the flow: prostaglandin transport and termination.

Markowitz SD.

Cancer Prev Res (Phila Pa). 2008 Jul;1(2):77-9. Epub 2008 Mar 19. No abstract available. PMID: 19138938 [PubMed - indexed for MEDLINE]Related articlesFree article

An improved method for staining cell colonies in clonogenic assays.

Guda K, Natale L, Markowitz SD.

Cytotechnology. 2007 Jun;54(2):85-8. Epub 2007 Jun 12.PMID: 19003022 [PubMed - in process]Related articlesFree article

Integrated analysis of homozygous deletions, focal amplifications, and sequence alterations in breast and colorectal cancers.

Leary RJ, Lin JC, Cummins J, Boca S, Wood LD, Parsons DW, Jones S, Sjöblom T, Park BH, Parsons R, Willis J, Dawson D, Willson JK, Nikolskaya T, Nikolsky Y, Kopelovich L, Papadopoulos N, Pennacchio LA, Wang TL, Markowitz SD, Parmigiani G, Kinzler KW, Vogelstein B, Velculescu VE.

Proc Natl Acad Sci U S A. 2008 Oct 21;105(42):16224-9. Epub 2008 Oct 13.PMID: 18852474 [PubMed - indexed for MEDLINE]Related articlesFree article

Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks.

Motegi A, Liaw HJ, Lee KY, Roest HP, Maas A, Wu X, Moinova H, Markowitz SD, Ding H, Hoeijmakers JH, Myung K.

Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12411-6. Epub 2008 Aug 21.PMID: 18719106 [PubMed - indexed for MEDLINE]Related articlesFree article

Ugene, a newly identified protein that is commonly overexpressed in cancer and binds uracil DNA glycosylase.

Guo C, Zhang X, Fink SP, Platzer P, Wilson K, Willson JK, Wang Z, Markowitz SD.

Cancer Res. 2008 Aug 1;68(15):6118-26.PMID: 18676834 [PubMed - indexed for MEDLINE]Related articlesFree article

The noncoding RNA, miR-126, suppresses the growth of neoplastic cells by targeting phosphatidylinositol 3-kinase signaling and is frequently lost in colon cancers.

Guo C, Sah JF, Beard L, Willson JK, Markowitz SD, Guda K.

Genes Chromosomes Cancer. 2008 Nov;47(11):939-46.PMID: 18663744 [PubMed - indexed for MEDLINE]Related articlesFree article

15-Hydroxyprostaglandin dehydrogenase is a target of hepatocyte nuclear factor 3beta and a tumor suppressor in lung cancer.

Huang G, Eisenberg R, Yan M, Monti S, Lawrence E, Fu P, Walbroehl J, Löwenberg E, Golub T, Merchan J, Tenen DG, Markowitz SD, Halmos B.

Cancer Res. 2008 Jul 1;68(13):5040-8.PMID: 18593902 [PubMed - indexed for MEDLINE]Related articlesFree article

The aberrant methylation of TSP1 suppresses TGF-beta1 activation in colorectal cancer.

Rojas A, Meherem S, Kim YH, Washington MK, Willis JE, Markowitz SD, Grady WM.

Int J Cancer. 2008 Jul 1;123(1):14-21.PMID: 18425817 [PubMed - indexed for MEDLINE]Related articlesFree article

Comparative lesion sequencing provides insights into tumor evolution.

Jones S, Chen WD, Parmigiani G, Diehl F, Beerenwinkel N, Antal T, Traulsen A, Nowak MA, Siegel C, Velculescu VE, Kinzler KW, Vogelstein B, Willis J, Markowitz SD.

Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4283-8. Epub 2008 Mar 12.PMID: 18337506 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of susceptibility genes for cancer in a genome-wide scan: results from the colon neoplasia sibling study.

Daley D, Lewis S, Platzer P, MacMillen M, Willis J, Elston RC, Markowitz SD, Wiesner GL.

Am J Hum Genet. 2008 Mar;82(3):723-36. Epub 2008 Feb 28.PMID: 18313025 [PubMed - indexed for MEDLINE]Related articlesFree article

Epigenetic silencing of the intronic microRNA hsa-miR-342 and its host gene EVL in colorectal cancer.

Grady WM, Parkin RK, Mitchell PS, Lee JH, Kim YH, Tsuchiya KD, Washington MK, Paraskeva C, Willson JK, Kaz AM, Kroh EM, Allen A, Fritz BR, Markowitz SD, Tewari M.

Oncogene. 2008 Jun 19;27(27):3880-8. Epub 2008 Feb 11.PMID: 18264139 [PubMed - indexed for MEDLINE]Related articles

Mutational inactivation of TGFBR2 in microsatellite unstable colon cancer arises from the cooperation of genomic instability and the clonal outgrowth of transforming growth factor beta resistant cells.

Biswas S, Trobridge P, Romero-Gallo J, Billheimer D, Myeroff LL, Willson JK, Markowitz SD, Grady WM.

Genes Chromosomes Cancer. 2008 Feb;47(2):95-106.PMID: 17985359 [PubMed - indexed for MEDLINE]Related articles

The genomic landscapes of human breast and colorectal cancers.

Wood LD, Parsons DW, Jones S, Lin J, Sjöblom T, Leary RJ, Shen D, Boca SM, Barber T, Ptak J, Silliman N, Szabo S, Dezso Z, Ustyanksky V, Nikolskaya T, Nikolsky Y, Karchin R, Wilson PA, Kaminker JS, Zhang Z, Croshaw R, Willis J, Dawson D, Shipitsin M, Willson JK, Sukumar S, Polyak K, Park BH, Pethiyagoda CL, Pant PV, Ballinger DG, Sparks AB, Hartigan J, Smith DR, Suh E, Papadopoulos N, Buckhaults P, Markowitz SD, Parmigiani G, Kinzler KW, Velculescu VE, Vogelstein B.

Science. 2007 Nov 16;318(5853):1108-13. Epub 2007 Oct 11.PMID: 17932254 [PubMed - indexed for MEDLINE]Related articlesFree article

Resuscitation with 100%, compared with 21%, oxygen following brief, repeated periods of apnea can protect vulnerable neonatal brain regions from apoptotic injury.

Mendoza-Paredes A, Liu H, Schears G, Yu Z, Markowitz SD, Schultz S, Pastuszko P, Greeley WJ, Nadkarni V, Kubin J, Wilson DF, Pastuszko A.

Resuscitation. 2008 Feb;76(2):261-70. Epub 2007 Aug 31.PMID: 17765386 [PubMed - indexed for MEDLINE]Related articlesFree article

Response of brain oxygenation and metabolism to deep hypothermic circulatory arrest in newborn piglets: comparison of pH-stat and alpha-stat strategies.

Markowitz SD, Mendoza-Paredes A, Liu H, Pastuszko P, Schultz SP, Schears GJ, Greeley WJ, Wilson DF, Pastuszko A.

Ann Thorac Surg. 2007 Jul;84(1):170-6.PMID: 17588406 [PubMed - indexed for MEDLINE]Related articlesFree article

Aspirin and colon cancer--targeting prevention?

Markowitz SD.

N Engl J Med. 2007 May 24;356(21):2195-8. No abstract available. PMID: 17522404 [PubMed - indexed for MEDLINE]Related articles

Is TGFBR1*6A a susceptibility allele for nonsyndromic familial colorectal neoplasia?

Daley D, Morgan W, Lewis S, Willis J, Elston RC, Markowitz SD, Wiesner GL.

Cancer Epidemiol Biomarkers Prev. 2007 May;16(5):892-4.PMID: 17507611 [PubMed - indexed for MEDLINE]Related articlesFree article

Surrogate markers for neurological outcome in children after deep hypothermic circulatory arrest.

Markowitz SD, Ichord RN, Wernovsky G, Gaynor JW, Nicolson SC.

Semin Cardiothorac Vasc Anesth. 2007 Mar;11(1):59-65. Review.PMID: 17484174 [PubMed - indexed for MEDLINE]Related articles

Brain oxygen and metabolism is dependent on the rate of low-flow cardiopulmonary bypass following circulatory arrest in newborn piglets.

Pastuszko P, Liu H, Mendoza-Paredes A, Schultz SE, Markowitz SD, Greeley WJ, Wilson DF, Pastuszko A.

Eur J Cardiothorac Surg. 2007 May;31(5):899-905. Epub 2007 Mar 1.PMID: 17336082 [PubMed - indexed for MEDLINE]Related articlesFree article

Clinical trial resources on the internet must be designed to reach underrepresented minorities.

Wilson JJ, Mick R, Wei SJ, Rustgi AK, Markowitz SD, Hampshire M, Metz JM.

Cancer J. 2006 Nov-Dec;12(6):475-81.PMID: 17207317 [PubMed - indexed for MEDLINE]Related articles

Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination.

Motegi A, Sood R, Moinova H, Markowitz SD, Liu PP, Myung K.

J Cell Biol. 2006 Dec 4;175(5):703-8. Epub 2006 Nov 27.PMID: 17130289 [PubMed - indexed for MEDLINE]Related articlesFree article

The consensus coding sequences of human breast and colorectal cancers.

Sjöblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE.

Science. 2006 Oct 13;314(5797):268-74. Epub 2006 Sep 7.PMID: 16959974 [PubMed - indexed for MEDLINE]Related articlesFree article

15-Hydroxyprostaglandin dehydrogenase is an in vivo suppressor of colon tumorigenesis.

Myung SJ, Rerko RM, Yan M, Platzer P, Guda K, Dotson A, Lawrence E, Dannenberg AJ, Lovgren AK, Luo G, Pretlow TP, Newman RA, Willis J, Dawson D, Markowitz SD.

Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):12098-102. Epub 2006 Jul 31.PMID: 16880406 [PubMed - indexed for MEDLINE]Related articlesFree article

CpG island methylation of genes accumulates during the adenoma progression step of the multistep pathogenesis of colorectal cancer.

Kim YH, Petko Z, Dzieciatkowski S, Lin L, Ghiassi M, Stain S, Chapman WC, Washington MK, Willis J, Markowitz SD, Grady WM.

Genes Chromosomes Cancer. 2006 Aug;45(8):781-9.PMID: 16708352 [PubMed - indexed for MEDLINE]Related articles

Detection of mononucleotide repeat sequence alterations in a large background of normal DNA for screening high-frequency microsatellite instability cancers.

Sun X, Liu Y, Lutterbaugh J, Chen WD, Markowitz SD, Guo B.

Clin Cancer Res. 2006 Jan 15;12(2):454-9.PMID: 16428486 [PubMed - indexed for MEDLINE]Related articlesFree article

Proliferation and Cdk4 expression in microsatellite unstable colon cancers with TGFBR2 mutations.

Grady WM, Willis JE, Trobridge P, Romero-Gallo J, Munoz N, Olechnowicz J, Ferguson K, Gautam S, Markowitz SD.

Int J Cancer. 2006 Feb 1;118(3):600-8.PMID: 16108056 [PubMed - indexed for MEDLINE]Related articles

Detection in fecal DNA of colon cancer-specific methylation of the nonexpressed vimentin gene.

Chen WD, Han ZJ, Skoletsky J, Olson J, Sah J, Myeroff L, Platzer P, Lu S, Dawson D, Willis J, Pretlow TP, Lutterbaugh J, Kasturi L, Willson JK, Rao JS, Shuber A, Markowitz SD.

J Natl Cancer Inst. 2005 Aug 3;97(15):1124-32.PMID: 16077070 [PubMed - indexed for MEDLINE]Related articlesFree article

Aberrantly methylated CDKN2A, MGMT, and MLH1 in colon polyps and in fecal DNA from patients with colorectal polyps.

Petko Z, Ghiassi M, Shuber A, Gorham J, Smalley W, Washington MK, Schultenover S, Gautam S, Markowitz SD, Grady WM.

Clin Cancer Res. 2005 Feb 1;11(3):1203-9.PMID: 15709190 [PubMed - indexed for MEDLINE]Related articlesFree article

Inadvertent extra-epidural catheter placement in an infant.

Berkowitz D, Kaye RD, Markowitz SD, Cook-Sather SD.

Anesth Analg. 2005 Feb;100(2):365-6.PMID: 15673858 [PubMed - indexed for MEDLINE]Related articlesFree article

15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGF-beta-induced suppressor of human gastrointestinal cancers.

Yan M, Rerko RM, Platzer P, Dawson D, Willis J, Tong M, Lawrence E, Lutterbaugh J, Lu S, Willson JK, Luo G, Hensold J, Tai HH, Wilson K, Markowitz SD.

Proc Natl Acad Sci U S A. 2004 Dec 14;101(50):17468-73. Epub 2004 Dec 1.PMID: 15574495 [PubMed - indexed for MEDLINE]Related articlesFree article

Blood glucose control during selective arterial stimulation and venous sampling for localization of focal hyperinsulinism lesions in anesthetized children.

Cucchiaro G, Markowitz SD, Kaye R, Adzick NS, Litman RS, Stanley CA, Watcha MF.

Anesth Analg. 2004 Oct;99(4):1044-8, table of contents.PMID: 15385347 [PubMed - indexed for MEDLINE]Related articlesFree article

C8orf4 is a transforming growth factor B induced transcript downregulated in metastatic colon cancer.

Friedman JB, Brunschwig EB, Platzer P, Wilson K, Markowitz SD.

Int J Cancer. 2004 Aug 10;111(1):72-5.PMID: 15185345 [PubMed - indexed for MEDLINE]Related articles

Three classes of genes mutated in colorectal cancers with chromosomal instability.

Wang Z, Cummins JM, Shen D, Cahill DP, Jallepalli PV, Wang TL, Parsons DW, Traverso G, Awad M, Silliman N, Ptak J, Szabo S, Willson JK, Markowitz SD, Goldberg ML, Karess R, Kinzler KW, Vogelstein B, Velculescu VE, Lengauer C.

Cancer Res. 2004 May 1;64(9):2998-3001.PMID: 15126332 [PubMed - indexed for MEDLINE]Related articlesFree article

Posterior inferior cerebellar artery infarction: an unusual complication of posterior spinal fusion surgery in an adolescent with idiopathic scoliosis.

Rose JB, Markowitz SD, Gundlapalli SP, Fishkin S, Ecker ML.

Anesthesiology. 2004 May;100(5):1308-11. No abstract available. PMID: 15114232 [PubMed - indexed for MEDLINE]Related articlesFree article

The human tumour suppressor gene SLC5A8 expresses a Na+-monocarboxylate cotransporter.

Coady MJ, Chang MH, Charron FM, Plata C, Wallendorff B, Sah JF, Markowitz SD, Romero MF, Lapointe JY.

J Physiol. 2004 Jun 15;557(Pt 3):719-31. Epub 2004 Apr 16.PMID: 15090606 [PubMed - indexed for MEDLINE]Related articlesFree article

Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer.

Suzuki H, Watkins DN, Jair KW, Schuebel KE, Markowitz SD, Chen WD, Pretlow TP, Yang B, Akiyama Y, Van Engeland M, Toyota M, Tokino T, Hinoda Y, Imai K, Herman JG, Baylin SB.

Nat Genet. 2004 Apr;36(4):417-22. Epub 2004 Mar 14.PMID: 15034581 [PubMed - indexed for MEDLINE]Related articles

PRL-3 expression in metastatic cancers.

Bardelli A, Saha S, Sager JA, Romans KE, Xin B, Markowitz SD, Lengauer C, Velculescu VE, Kinzler KW, Vogelstein B.

Clin Cancer Res. 2003 Nov 15;9(15):5607-15.PMID: 14654542 [PubMed - indexed for MEDLINE]Related articlesFree article

A subset of familial colorectal neoplasia kindreds linked to chromosome 9q22.2-31.2.

Wiesner GL, Daley D, Lewis S, Ticknor C, Platzer P, Lutterbaugh J, MacMillen M, Baliner B, Willis J, Elston RC, Markowitz SD.

Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12961-5. Epub 2003 Oct 17.PMID: 14566058 [PubMed - indexed for MEDLINE]Related articlesFree article

SLC5A8, a sodium transporter, is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers.

Li H, Myeroff L, Smiraglia D, Romero MF, Pretlow TP, Kasturi L, Lutterbaugh J, Rerko RM, Casey G, Issa JP, Willis J, Willson JK, Plass C, Markowitz SD.

Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8412-7. Epub 2003 Jun 26.PMID: 12829793 [PubMed - indexed for MEDLINE]Related articlesFree article

Hereditary colon cancer genes.

Grady WM, Markowitz SD.

Methods Mol Biol. 2003;222:59-83. Review. No abstract available. PMID: 12710680 [PubMed - indexed for MEDLINE]Related articles

Evidence of selection for clones having genetic inactivation of the activin A type II receptor (ACVR2) gene in gastrointestinal cancers.

Hempen PM, Zhang L, Bansal RK, Iacobuzio-Donahue CA, Murphy KM, Maitra A, Vogelstein B, Whitehead RH, Markowitz SD, Willson JK, Yeo CJ, Hruban RH, Kern SE.

Cancer Res. 2003 Mar 1;63(5):994-9.PMID: 12615714 [PubMed - indexed for MEDLINE]Related articlesFree article

Initial evaluation of a new optic laryngoscope blade.

Markowitz SD, White PF, Issioui T, Jones SB, Klein KW, Thomason JW, Rajchert DM, Pittoni G, Savarese F.

J Clin Anesth. 2002 Dec;14(8):604-7.PMID: 12565121 [PubMed - indexed for MEDLINE]Related articles

Comparison of acustimulation and ondansetron for the treatment of established postoperative nausea and vomiting.

Coloma M, White PF, Ogunnaike BO, Markowitz SD, Brown PM, Lee AQ, Berrisford SB, Wakefield CA, Issioui T, Jones SB, Jones DB.

Anesthesiology. 2002 Dec;97(6):1387-92.PMID: 12459663 [PubMed - indexed for MEDLINE]Related articlesFree article