PubMed

PolyI:C induction of diabetes is controlled by Iddm4 in rats with a full regulatory T cell pool.

Hornum L, Lundsgaard D, Markholst H.

Ann N Y Acad Sci. 2007 Sep;1110:65-72.PMID: 17911421 [PubMed - indexed for MEDLINE]Related articles

CD40 is required for development of islet inflammation in the RIP-CD154 transgenic mouse model of type 1 diabetes.

Haase C, Markholst H.

Ann N Y Acad Sci. 2007 Jun;1107:373-9.PMID: 17804565 [PubMed - indexed for MEDLINE]Related articles

Inhibition of NKG2D receptor function by antibody therapy attenuates transfer-induced colitis in SCID mice.

Kjellev S, Haase C, Lundsgaard D, Ursø B, Tornehave D, Markholst H.

Eur J Immunol. 2007 May;37(5):1397-406.PMID: 17407193 [PubMed - indexed for MEDLINE]Related articles

Both Gimap5 and the diabetogenic BBDP allele of Gimap5 induce apoptosis in T cells.

Dalberg U, Markholst H, Hornum L.

Int Immunol. 2007 Apr;19(4):447-53. Epub 2007 Mar 15.PMID: 17369194 [PubMed - indexed for MEDLINE]Related articlesFree article

Characteristics of rat CD4(+)CD25(+) T cells and their ability to prevent not only diabetes but also insulitis in an adoptive transfer model in BB rats.

Holm TL, Lundsgaard D, Markholst H.

Scand J Immunol. 2006 Jul;64(1):17-29.PMID: 16784487 [PubMed - indexed for MEDLINE]Related articles

Reconstitution of Scid mice with CD4+CD25- T cells leads to rapid colitis: an improved model for pharmacologic testing.

Kjellev S, Lundsgaard D, Poulsen SS, Markholst H.

Int Immunopharmacol. 2006 Aug;6(8):1341-54. Epub 2006 May 23.PMID: 16782548 [PubMed - indexed for MEDLINE]Related articles

Immunomodulatory dendritic cells require autologous serum to circumvent nonspecific immunosuppressive activity in vivo.

Haase C, Ejrnaes M, Juedes AE, Wolfe T, Markholst H, von Herrath MG.

Blood. 2005 Dec 15;106(13):4225-33. Epub 2005 Aug 23.PMID: 16118326 [PubMed - indexed for MEDLINE]Related articlesFree article

In vivo control of diabetogenic T-cells by regulatory CD4+CD25+ T-cells expressing Foxp3.

Lundsgaard D, Holm TL, Hornum L, Markholst H.

Diabetes. 2005 Apr;54(4):1040-7.PMID: 15793242 [PubMed - indexed for MEDLINE]Related articlesFree article

The antiapoptotic gene Ian4l1 in the rat: genomic organization and promoter characterization.

Andersen UN, Markholst H, Hornum L.

Gene. 2004 Oct 27;341:141-8.PMID: 15474297 [PubMed - indexed for MEDLINE]Related articles

Local activation of dendritic cells leads to insulitis and development of insulin-dependent diabetes in transgenic mice expressing CD154 on the pancreatic beta-cells.

Haase C, Skak K, Michelsen BK, Markholst H.

Diabetes. 2004 Oct;53(10):2588-95.PMID: 15448088 [PubMed - indexed for MEDLINE]Related articlesFree article

Improved beta-cell survival and reduced insulitis in a type 1 diabetic rat model after treatment with a beta-cell-selective K(ATP) channel opener.

Skak K, Gotfredsen CF, Lundsgaard D, Hansen JB, Sturis J, Markholst H.

Diabetes. 2004 Apr;53(4):1089-95.PMID: 15047626 [PubMed - indexed for MEDLINE]Related articlesFree article

New autoimmune genes and the pathogenesis of type 1 diabetes.

Hornum L, Markholst H.

Curr Diab Rep. 2004 Apr;4(2):135-42.PMID: 15035974 [PubMed - indexed for MEDLINE]Related articles

Comparative mapping of rat Iddm4 to segments on HSA7 and MMU6.

Hornum L, DeScipio C, Markholst H, Troutman SA, Novak S, Leif J, Greiner D, Mordes JP, Blankenhorn EP.

Mamm Genome. 2004 Jan;15(1):53-61.PMID: 14727142 [PubMed - indexed for MEDLINE]Related articles

A co-transfer system in young prediabetic BB rats: reactivated autoreactive T cells can be partly controlled.

Lundsgaard D, Markholst H.

J Autoimmun. 2003 Dec;21(4):325-38.PMID: 14624756 [PubMed - indexed for MEDLINE]Related articles

Ian4 is required for mitochondrial integrity and T cell survival.

Pandarpurkar M, Wilson-Fritch L, Corvera S, Markholst H, Hornum L, Greiner DL, Mordes JP, Rossini AA, Bortell R.

Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10382-7. Epub 2003 Aug 20.PMID: 12930893 [PubMed - indexed for MEDLINE]Related articlesFree article

The diabetes-prone BB rat carries a frameshift mutation in Ian4, a positional candidate of Iddm1.

Hornum L, Rømer J, Markholst H.

Diabetes. 2002 Jun;51(6):1972-9.PMID: 12031988 [PubMed - indexed for MEDLINE]Related articlesFree article

An F344 rat congenic for BB/DP rat-derived diabetes susceptibility loci Iddm1 and Iddm2.

Hornum L, Lundsgaard D, Markholst H.

Mamm Genome. 2001 Nov;12(11):867-8. No abstract available. PMID: 11845290 [PubMed - indexed for MEDLINE]Related articles

A sequence-ready PAC contig of a 550-kb region on rat chromosome 4 including the diabetes susceptibility gene Lyp.

Hornum L, Markholst H.

Genomics. 2000 Nov 1;69(3):305-13.PMID: 11056048 [PubMed - indexed for MEDLINE]Related articles

Functional rest through intensive treatment with insulin and potassium channel openers preserves residual beta-cell function and mass in acutely diabetic BB rats.

Rasmussen SB, Sørensen TS, Hansen JB, Mandrup-Poulsen T, Hornum L, Markholst H.

Horm Metab Res. 2000 Jul;32(7):294-300.PMID: 10965937 [PubMed - indexed for MEDLINE]Related articles

Mapping of Zyx coding for zyxin in the rat and its exclusion as a candidate gene for lymphopenia.

Hornum L, Markholst H.

Cytogenet Cell Genet. 2000;88(3-4):310-1. No abstract available. PMID: 10828616 [PubMed - indexed for MEDLINE]Related articles

Comparative mapping of the human homologue of the rat diabetes susceptibility gene lyp to a 1.3-Mb segment on HSA7.

Hornum L, Markholst H.

Genomics. 2000 Apr 1;65(1):81-3.PMID: 10777670 [PubMed - indexed for MEDLINE]Related articles

Genetic map of the lymphopenia region on rat chromosome 4.

Hornum L, Markholst H.

Transplant Proc. 1999 May;31(3):1615-7. No abstract available. PMID: 10331022 [PubMed - indexed for MEDLINE]Related articles

Mapping of caspase-2 in the rat and its exclusion as a candidate gene for lymphopenia.

Hornum L, Rasmussen SB, Markholst H.

Mamm Genome. 1999 Mar;10(3):244-8.PMID: 10051319 [PubMed - indexed for MEDLINE]Related articles

A pronounced thymic B cell deficiency in the spontaneously diabetic BB rat.

Tullin S, Farris P, Petersen JS, Hornum L, Jackerott M, Markholst H.

J Immunol. 1997 Jun 1;158(11):5554-9.PMID: 9164980 [PubMed - indexed for MEDLINE]Related articles

Segregation of autoimmune type 1 diabetes in a cross between diabetic BB and brown Norway rats.

Jackerott M, Hornum L, Andreasen BE, Markholst H.

J Autoimmun. 1997 Feb;10(1):35-41.PMID: 9080298 [PubMed - indexed for MEDLINE]Related articles

Mapping of the rat Ptn gene to chromosome 4.

Hornum L, Markholst H.

Mamm Genome. 1996 Dec;7(12):923-4. No abstract available. PMID: 8995771 [PubMed - indexed for MEDLINE]Related articles

Mapping of the rat Hoxa11 homeobox gene to chromosome 4.

Hornum L, Markholst H.

Mamm Genome. 1995 Aug;6(8):559-60. No abstract available. PMID: 8589533 [PubMed - indexed for MEDLINE]Related articles

The rat T-cell lymphopenia resistance gene (Lyp) maps between D4Mit6 and Npy on RN04.

Hornum L, Jackerott M, Markholst H.

Mamm Genome. 1995 May;6(5):371-2. No abstract available. PMID: 7626892 [PubMed - indexed for MEDLINE]Related articles

Neonatal tolerization with glutamic acid decarboxylase but not with bovine serum albumin delays the onset of diabetes in NOD mice.

Petersen JS, Karlsen AE, Markholst H, Worsaae A, Dyrberg T, Michelsen B.

Diabetes. 1994 Dec;43(12):1478-84.PMID: 7958502 [PubMed - indexed for MEDLINE]Related articles

Interleukin-1 beta (IL-1) does not reduce the diabetes incidence in diabetes-prone BB rats.

Reimers JI, Mørch L, Markholst H, Wogensen LD, Andersen HU, Mandrup-Poulsen T, Nerup J.

Autoimmunity. 1994;17(2):105-18.PMID: 8061161 [PubMed - indexed for MEDLINE]Related articles

Decreased weight gain in BB rats before the clinical onset of insulin-dependent diabetes.

Markholst H, Eastman S, Wilson D, Fisher L, Lernmark A.

Diabetes Res Clin Pract. 1993 Jul;21(1):31-8.PMID: 8253019 [PubMed - indexed for MEDLINE]Related articles

Diabetes segregates as a single locus in crosses between inbred BB rats prone or resistant to diabetes.

Markholst H, Eastman S, Wilson D, Andreasen BE, Lernmark A.

J Exp Med. 1991 Jul 1;174(1):297-300.PMID: 2056281 [PubMed - indexed for MEDLINE]Related articlesFree article

Transplantation of purified islet cells in diabetic BB rats.

Pipeleers D, Pipeleers-Marichal M, Markholst H, Hoorens A, Klöppel G.

Diabetologia. 1991 Jun;34(6):390-6.PMID: 1832111 [PubMed - indexed for MEDLINE]Related articles

Leukocytosis at the onset of diabetes in crosses of inbred BB rats.

Eastman S, Markholst H, Wilson D, Lernmark A.

Diabetes Res Clin Pract. 1991 May;12(2):113-23.PMID: 1879302 [PubMed - indexed for MEDLINE]Related articles

Molecular analysis of the pathogenesis of beta-cell destruction in insulin-dependent diabetes mellitus.

Lernmark A, Bärmeier H, Dube S, Hagopian W, Karlsen AE, Markholst H, Wilson C, Wassmuth R.

West J Med. 1990 Nov;153(5):499-502. Review. No abstract available. PMID: 1979704 [PubMed - indexed for MEDLINE]Related articlesFree article

Lack of systematically found insulin autoantibodies in spontaneously diabetic BB rats.

Markholst H, Klaff LJ, Klöppel G, Lernmark A, Mordes JP, Palmer J.

Diabetes. 1990 Jun;39(6):720-7.PMID: 2189763 [PubMed - indexed for MEDLINE]Related articles

Decreased levels of serum alpha-isoamylase prior to diabetes onset in BB rats.

Markholst H, Laursen HV.

Pancreas. 1990 Mar;5(2):144-50.PMID: 2315291 [PubMed - indexed for MEDLINE]Related articles

Increased levels of circulating immune complexes are not associated with diabetes in BB rats.

Contreas G, Dyrberg T, Madsen OD, Markholst H, Lernmark A.

Diabetes Res. 1989 Mar;10(3):109-13.PMID: 2805585 [PubMed - indexed for MEDLINE]Related articles

Insulitis and diabetes are preceded by a decrease in beta cell volume in diabetes-prone BB rats.

Löhr M, Markholst H, Dyrberg T, Klöppel G, Oberholzer M, Lernmark A.

Pancreas. 1989;4(1):95-100.PMID: 2654931 [PubMed - indexed for MEDLINE]Related articles

Derivation of non-lymphopenic BB rats with an intercross breeding.

Herold KC, Kastern W, Markholst H, Lernmark A.

Autoimmunity. 1989;3(2):83-93.PMID: 2577492 [PubMed - indexed for MEDLINE]Related articles

Interleukin-1 potentiates glucose stimulated insulin release in the isolated perfused pancreas.

Wogensen LD, Mandrup-Poulsen T, Markholst H, Mølvig J, Lernmark A, Holst JJ, Dinarello CA, Nerup J.

Acta Endocrinol (Copenh). 1988 Mar;117(3):302-6.PMID: 3289298 [PubMed - indexed for MEDLINE]Related articles

Reduced pancreatic insulin is associated with retarded growth of the pancreas in young prediabetic BB rats.

Markholst H, Lernmark A.

Pancreas. 1988;3(2):140-4.PMID: 3287368 [PubMed - indexed for MEDLINE]Related articles

[Spontaneous diabetes and diabetes induced by streptozotocin in the rat and mouse]

Lernmark A, Markholst H, Laursen H, Contreas G, Altieri M, Baekkeskov S, Herold R, Kastern W, Madsen OD.

Journ Annu Diabetol Hotel Dieu. 1988:15-31. Review. French. No abstract available. PMID: 2971832 [PubMed - indexed for MEDLINE]Related articles

Insulin release and pancreatic insulin is reduced in young prediabetic BB rats.

Svenningsen A, Dyrberg T, Markholst H, Binder C, Lernmark A.

Acta Endocrinol (Copenh). 1986 Jul;112(3):367-71.PMID: 3529783 [PubMed - indexed for MEDLINE]Related articles