PubMed

Finding the missing heritability of complex diseases.

Manolio TA, Collins FS, Cox NJ, Goldstein DB, Hindorff LA, Hunter DJ, McCarthy MI, Ramos EM, Cardon LR, Chakravarti A, Cho JH, Guttmacher AE, Kong A, Kruglyak L, Mardis E, Rotimi CN, Slatkin M, Valle D, Whittemore AS, Boehnke M, Clark AG, Eichler EE, Gibson G, Haines JL, Mackay TF, McCarroll SA, Visscher PM.

Nature. 2009 Oct 8;461(7265):747-53. Review.PMID: 19812666 [PubMed - indexed for MEDLINE]Related articles

A new statistic and its power to infer membership in a genome-wide association study using genotype frequencies.

Jacobs KB, Yeager M, Wacholder S, Craig D, Kraft P, Hunter DJ, Paschal J, Manolio TA, Tucker M, Hoover RN, Thomas GD, Chanock SJ, Chatterjee N.

Nat Genet. 2009 Nov;41(11):1253-7. Epub 2009 Oct 4.PMID: 19801980 [PubMed - in process]Related articles

The HapMap and genome-wide association studies in diagnosis and therapy.

Manolio TA, Collins FS.

Annu Rev Med. 2009;60:443-56. Review.PMID: 19630580 [PubMed - indexed for MEDLINE]Related articlesFree article

The ClinSeq Project: piloting large-scale genome sequencing for research in genomic medicine.

Biesecker LG, Mullikin JC, Facio FM, Turner C, Cherukuri PF, Blakesley RW, Bouffard GG, Chines PS, Cruz P, Hansen NF, Teer JK, Maskeri B, Young AC; NISC Comparative Sequencing Program, Manolio TA, Wilson AF, Finkel T, Hwang P, Arai A, Remaley AT, Sachdev V, Shamburek R, Cannon RO, Green ED.

Genome Res. 2009 Sep;19(9):1665-74. Epub 2009 Jul 14.PMID: 19602640 [PubMed - in process]Related articles

External validity of the cardiovascular health study: a comparison with the Medicare population.

DiMartino LD, Hammill BG, Curtis LH, Gottdiener JS, Manolio TA, Powe NR, Schulman KA.

Med Care. 2009 Aug;47(8):916-23.PMID: 19597373 [PubMed - indexed for MEDLINE]Related articlesFree article

Potential etiologic and functional implications of genome-wide association loci for human diseases and traits.

Hindorff LA, Sethupathy P, Junkins HA, Ramos EM, Mehta JP, Collins FS, Manolio TA.

Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9362-7. Epub 2009 May 27.PMID: 19474294 [PubMed - indexed for MEDLINE]Related articlesFree article

Collaborative genome-wide association studies of diverse diseases: programs of the NHGRI's office of population genomics.

Manolio TA.

Pharmacogenomics. 2009 Feb;10(2):235-41. Review.PMID: 19207024 [PubMed - indexed for MEDLINE]Related articles

Cohort studies and the genetics of complex disease.

Manolio TA.

Nat Genet. 2009 Jan;41(1):5-6. No abstract available. PMID: 19112455 [PubMed - indexed for MEDLINE]Related articles

Size matters: just how big is BIG?: Quantifying realistic sample size requirements for human genome epidemiology.

Burton PR, Hansell AL, Fortier I, Manolio TA, Khoury MJ, Little J, Elliott P.

Int J Epidemiol. 2009 Feb;38(1):263-73. Epub 2008 Aug 1.PMID: 18676414 [PubMed - indexed for MEDLINE]Related articlesFree article

A HapMap harvest of insights into the genetics of common disease.

Manolio TA, Brooks LD, Collins FS.

J Clin Invest. 2008 May;118(5):1590-605. Review.PMID: 18451988 [PubMed - indexed for MEDLINE]Related articlesFree article

Variation and temporal trends in the use of diagnostic testing during hospitalization for acute myocardial infarction by age, gender, race, and geography (the Atherosclerosis Risk In Communities Study).

Pearte CA, Myerson M, Coresh J, McNamara RL, Rosamond W, Taylor H, Manolio TA; Atherosclerosis Risk In Communities Study.

Am J Cardiol. 2008 May 1;101(9):1219-25. Epub 2008 Mar 17.PMID: 18435947 [PubMed - indexed for MEDLINE]Related articles

Biorepositories--at the bleeding edge.

Manolio TA.

Int J Epidemiol. 2008 Apr;37(2):231-3. No abstract available. PMID: 18381397 [PubMed - indexed for MEDLINE]Related articlesFree article

How to interpret a genome-wide association study.

Pearson TA, Manolio TA.

JAMA. 2008 Mar 19;299(11):1335-44. Erratum in: JAMA. 2008 May 14;299(18):2150. PMID: 18349094 [PubMed - indexed for MEDLINE]Related articlesFree article

Study designs to enhance identification of genetic factors in healthy aging.

Manolio TA.

Nutr Rev. 2007 Dec;65(12 Pt 2):S228-33. Review.PMID: 18240554 [PubMed - indexed for MEDLINE]Related articles

Validity of reported genetic risk factors for acute coronary syndrome.

Feero WG, Manolio TA, Guttmacher AE, Collins FS.

JAMA. 2007 Oct 17;298(15):1757; author reply 1759. No abstract available. PMID: 17940226 [PubMed - indexed for MEDLINE]Related articles

Turning the pump handle: evolving methods for integrating the evidence on gene-disease association.

Higgins JP, Little J, Ioannidis JP, Bray MS, Manolio TA, Smeeth L, Sterne JA, Anagnostelis B, Butterworth AS, Danesh J, Dezateux C, Gallacher JE, Gwinn M, Lewis SJ, Minelli C, Pharoah PD, Salanti G, Sanderson S, Smith LA, Taioli E, Thompson JR, Thompson SG, Walker N, Zimmern RL, Khoury MJ.

Am J Epidemiol. 2007 Oct 15;166(8):863-6. Epub 2007 Sep 5. No abstract available. PMID: 17804859 [PubMed - indexed for MEDLINE]Related articlesFree article

New models of collaboration in genome-wide association studies: the Genetic Association Information Network.

GAIN Collaborative Research Group, Manolio TA, Rodriguez LL, Brooks L, Abecasis G; Collaborative Association Study of Psoriasis, Ballinger D, Daly M, Donnelly P, Faraone SV; International Multi-Center ADHD Genetics Project, Frazer K, Gabriel S, Gejman P; Molecular Genetics of Schizophrenia Collaboration, Guttmacher A, Harris EL, Insel T, Kelsoe JR; Bipolar Genome Study, Lander E, McCowin N, Mailman MD, Nabel E, Ostell J, Pugh E, Sherry S, Sullivan PF; Major Depression Stage 1 Genomewide Association in Population-Based Samples Study, Thompson JF, Warram J; Genetics of Kidneys in Diabetes (GoKinD) Study, Wholley D, Milos PM, Collins FS.

Nat Genet. 2007 Sep;39(9):1045-51.PMID: 17728769 [PubMed - indexed for MEDLINE]Related articles

Association of carotid artery intima-media thickness, plaques, and C-reactive protein with future cardiovascular disease and all-cause mortality: the Cardiovascular Health Study.

Cao JJ, Arnold AM, Manolio TA, Polak JF, Psaty BM, Hirsch CH, Kuller LH, Cushman M.

Circulation. 2007 Jul 3;116(1):32-8. Epub 2007 Jun 18.PMID: 17576871 [PubMed - indexed for MEDLINE]Related articlesFree article

Retinal microvascular signs, cognitive function, and dementia in older persons: the Cardiovascular Health Study.

Baker ML, Marino Larsen EK, Kuller LH, Klein R, Klein BE, Siscovick DS, Bernick C, Manolio TA, Wong TY.

Stroke. 2007 Jul;38(7):2041-7. Epub 2007 May 24.PMID: 17525385 [PubMed - indexed for MEDLINE]Related articlesFree article

Ethnic differences in the relationship of carotid atherosclerosis to coronary calcification: the Multi-Ethnic Study of Atherosclerosis.

Manolio TA, Arnold AM, Post W, Bertoni AG, Schreiner PJ, Sacco RL, Saad MF, Detrano RL, Szklo M.

Atherosclerosis. 2008 Mar;197(1):132-8. Epub 2007 Apr 6.PMID: 17412347 [PubMed - indexed for MEDLINE]Related articlesFree article

Acculturation is associated with hypertension in a multiethnic sample.

Moran A, Roux AV, Jackson SA, Kramer H, Manolio TA, Shrager S, Shea S.

Am J Hypertens. 2007 Apr;20(4):354-63.PMID: 17386340 [PubMed - indexed for MEDLINE]Related articles

Genes, environment, health, and disease: facing up to complexity.

Manolio TA, Collins FS.

Hum Hered. 2007;63(2):63-6. Epub 2007 Feb 2. No abstract available. PMID: 17283435 [PubMed - indexed for MEDLINE]Related articlesFree article

Intrinsic contribution of gender and ethnicity to normal ankle-brachial index values: the Multi-Ethnic Study of Atherosclerosis (MESA).

Aboyans V, Criqui MH, McClelland RL, Allison MA, McDermott MM, Goff DC Jr, Manolio TA.

J Vasc Surg. 2007 Feb;45(2):319-27.PMID: 17264011 [PubMed - indexed for MEDLINE]Related articles

Merging and emerging cohorts: necessary but not sufficient.

Collins FS, Manolio TA.

Nature. 2007 Jan 18;445(7125):259. No abstract available. PMID: 17230172 [PubMed - indexed for MEDLINE]Related articles

Diabetes, gender, and left ventricular structure in African-Americans: the atherosclerosis risk in communities study.

Foppa M, Duncan BB, Arnett DK, Benjamin EJ, Liebson PR, Manolio TA, Skelton TN.

Cardiovasc Ultrasound. 2006 Nov 8;4:43.PMID: 17092348 [PubMed - indexed for MEDLINE]Related articlesFree article

Taking our obligations to research participants seriously: disclosing individual results of genetic research.

Manolio TA.

Am J Bioeth. 2006 Nov-Dec;6(6):32-4; author reply W10-2. No abstract available. PMID: 17085403 [PubMed - indexed for MEDLINE]Related articles

Associations between findings on cranial magnetic resonance imaging and retinal photography in the elderly: the Cardiovascular Health Study.

Longstreth W Jr, Larsen EK, Klein R, Wong TY, Sharrett AR, Lefkowitz D, Manolio TA.

Am J Epidemiol. 2007 Jan 1;165(1):78-84. Epub 2006 Oct 13.PMID: 17041135 [PubMed - indexed for MEDLINE]Related articlesFree article

Genes, environment and the value of prospective cohort studies.

Manolio TA, Bailey-Wilson JE, Collins FS.

Nat Rev Genet. 2006 Oct;7(10):812-20. Review.PMID: 16983377 [PubMed - indexed for MEDLINE]Related articles

Blood pressure level and outcomes in adults aged 65 and older with prior ischemic stroke.

Kaplan RC, Tirschwell DL, Longstreth WT Jr, Manolio TA, Heckbert SR, LeValley AJ, Lefkowitz D, El-Saed A, Psaty BM.

J Am Geriatr Soc. 2006 Sep;54(9):1309-16.PMID: 16970636 [PubMed - indexed for MEDLINE]Related articles

Obtaining informed consent for genetic studies: The multiethnic study of atherosclerosis.

Green D, Cushman M, Dermond N, Johnson EA, Castro C, Arnett D, Hill J, Manolio TA.

Am J Epidemiol. 2006 Nov 1;164(9):845-51. Epub 2006 Aug 23.PMID: 16928727 [PubMed - indexed for MEDLINE]Related articlesFree article

Education and the cognitive decline associated with MRI-defined brain infarct.

Elkins JS, Longstreth WT Jr, Manolio TA, Newman AB, Bhadelia RA, Johnston SC.

Neurology. 2006 Aug 8;67(3):435-40.PMID: 16894104 [PubMed - indexed for MEDLINE]Related articles

White matter grade and ventricular volume on brain MRI as markers of longevity in the cardiovascular health study.

Kuller LH, Arnold AM, Longstreth WT Jr, Manolio TA, O'Leary DH, Burke GL, Fried LP, Newman AB.

Neurobiol Aging. 2007 Sep;28(9):1307-15. Epub 2006 Jul 20.PMID: 16857296 [PubMed - indexed for MEDLINE]Related articles

High rates of obesity and cardiovascular disease risk factors in lower middle class community in Pakistan: the Metroville Health Study.

Dennis B, Aziz K, She L, Faruqui AM, Davis CE, Manolio TA, Burke GL, Aziz S.

J Pak Med Assoc. 2006 Jun;56(6):267-72.PMID: 16827250 [PubMed - indexed for MEDLINE]Related articles

Reporting genetic results in research studies: summary and recommendations of an NHLBI working group.

Bookman EB, Langehorne AA, Eckfeldt JH, Glass KC, Jarvik GP, Klag M, Koski G, Motulsky A, Wilfond B, Manolio TA, Fabsitz RR, Luepker RV; NHLBI Working Group.

Am J Med Genet A. 2006 May 15;140(10):1033-40.PMID: 16575896 [PubMed - indexed for MEDLINE]Related articlesFree article

Familial aggregation of atrial fibrillation in Iceland.

Arnar DO, Thorvaldsson S, Manolio TA, Thorgeirsson G, Kristjansson K, Hakonarson H, Stefansson K.

Eur Heart J. 2006 Mar;27(6):708-12. Epub 2006 Jan 20.PMID: 16428254 [PubMed - indexed for MEDLINE]Related articlesFree article

10-year follow-up of subclinical cardiovascular disease and risk of coronary heart disease in the Cardiovascular Health Study.

Kuller LH, Arnold AM, Psaty BM, Robbins JA, O'Leary DH, Tracy RP, Burke GL, Manolio TA, Chaves PH.

Arch Intern Med. 2006 Jan 9;166(1):71-8.PMID: 16401813 [PubMed - indexed for MEDLINE]Related articlesFree article

Left atrial volume, geometry, and function in systolic and diastolic heart failure of persons > or =65 years of age (the cardiovascular health study).

Gottdiener JS, Kitzman DW, Aurigemma GP, Arnold AM, Manolio TA.

Am J Cardiol. 2006 Jan 1;97(1):83-9. Epub 2005 Nov 15.PMID: 16377289 [PubMed - indexed for MEDLINE]Related articles

Clinical significance of calcification of the fibrous skeleton of the heart and aortosclerosis in community dwelling elderly. The Cardiovascular Health Study (CHS).

Barasch E, Gottdiener JS, Larsen EK, Chaves PH, Newman AB, Manolio TA.

Am Heart J. 2006 Jan;151(1):39-47.PMID: 16368289 [PubMed - indexed for MEDLINE]Related articles

The association of microalbuminuria with clinical cardiovascular disease and subclinical atherosclerosis in the elderly: the Cardiovascular Health Study.

Cao JJ, Barzilay JI, Peterson D, Manolio TA, Psaty BM, Kuller L, Wexler J, Bleyer AJ, Cushman M.

Atherosclerosis. 2006 Aug;187(2):372-7. Epub 2005 Oct 20.PMID: 16242696 [PubMed - indexed for MEDLINE]Related articles

Vascular events, mortality, and preventive therapy following ischemic stroke in the elderly.

Kaplan RC, Tirschwell DL, Longstreth WT Jr, Manolio TA, Heckbert SR, Lefkowitz D, El-Saed A, Psaty BM.

Neurology. 2005 Sep 27;65(6):835-42. Erratum in: Neurology. 2006 Feb 28;66(4):493. PMID: 16186519 [PubMed - indexed for MEDLINE]Related articles

Risk factors for declining ankle-brachial index in men and women 65 years or older: the Cardiovascular Health Study.

Kennedy M, Solomon C, Manolio TA, Criqui MH, Newman AB, Polak JF, Burke GL, Enright P, Cushman M.

Arch Intern Med. 2005 Sep 12;165(16):1896-902.PMID: 16157835 [PubMed - indexed for MEDLINE]Related articlesFree article

C-reactive protein and the 10-year incidence of coronary heart disease in older men and women: the cardiovascular health study.

Cushman M, Arnold AM, Psaty BM, Manolio TA, Kuller LH, Burke GL, Polak JF, Tracy RP.

Circulation. 2005 Jul 5;112(1):25-31. Epub 2005 Jun 27.PMID: 15983251 [PubMed - indexed for MEDLINE]Related articlesFree article

Cardiovascular mortality risk in chronic kidney disease: comparison of traditional and novel risk factors.

Shlipak MG, Fried LF, Cushman M, Manolio TA, Peterson D, Stehman-Breen C, Bleyer A, Newman A, Siscovick D, Psaty B.

JAMA. 2005 Apr 13;293(14):1737-45.PMID: 15827312 [PubMed - indexed for MEDLINE]Related articlesFree article

A comparison of death certificate out-of-hospital coronary heart disease death with physician-adjudicated sudden cardiac death.

Fox CS, Evans JC, Larson MG, Lloyd-Jones DM, O'Donnell CJ, Sorlie PD, Manolio TA, Kannel WB, Levy D.

Am J Cardiol. 2005 Apr 1;95(7):856-9.PMID: 15781015 [PubMed - indexed for MEDLINE]Related articles

Incidence of cardiovascular disease in older Americans: the cardiovascular health study.

Arnold AM, Psaty BM, Kuller LH, Burke GL, Manolio TA, Fried LP, Robbins JA, Kronmal RA.

J Am Geriatr Soc. 2005 Feb;53(2):211-8.PMID: 15673343 [PubMed - indexed for MEDLINE]Related articles

Fish consumption and stroke risk in elderly individuals: the cardiovascular health study.

Mozaffarian D, Longstreth WT Jr, Lemaitre RN, Manolio TA, Kuller LH, Burke GL, Siscovick DS.

Arch Intern Med. 2005 Jan 24;165(2):200-6. Erratum in: Arch Intern Med. 2005 Mar 28;165(6):683. PMID: 15668367 [PubMed - indexed for MEDLINE]Related articlesFree article

Incidence, manifestations, and predictors of worsening white matter on serial cranial magnetic resonance imaging in the elderly: the Cardiovascular Health Study.

Longstreth WT Jr, Arnold AM, Beauchamp NJ Jr, Manolio TA, Lefkowitz D, Jungreis C, Hirsch CH, O'Leary DH, Furberg CD.

Stroke. 2005 Jan;36(1):56-61. Epub 2004 Nov 29.PMID: 15569873 [PubMed - indexed for MEDLINE]Related articlesFree article

Respiratory muscle strength and the risk of incident cardiovascular events.

van der Palen J, Rea TD, Manolio TA, Lumley T, Newman AB, Tracy RP, Enright PL, Psaty BM.

Thorax. 2004 Dec;59(12):1063-7.PMID: 15563706 [PubMed - indexed for MEDLINE]Related articlesFree article

Risk of congestive heart failure in an elderly population treated with peripheral alpha-1 antagonists.

Bryson CL, Smith NL, Kuller LH, Chaves PH, Manolio TA, Lewis W, Boyko EJ, Furberg CD, Psaty BM.

J Am Geriatr Soc. 2004 Oct;52(10):1648-54.PMID: 15450040 [PubMed - indexed for MEDLINE]Related articles

Stroke risk factors and loss of high cognitive function.

Elkins JS, O'Meara ES, Longstreth WT Jr, Carlson MC, Manolio TA, Johnston SC.

Neurology. 2004 Sep 14;63(5):793-9.PMID: 15365125 [PubMed - indexed for MEDLINE]Related articles