PubMed

The global diabetes epidemic as a consequence of lifestyle-induced low-grade inflammation.

Kolb H, Mandrup-Poulsen T.

Diabetologia. 2009 Nov 5. [Epub ahead of print]PMID: 19890624 [PubMed - as supplied by publisher]Related articles

Suppressor of cytokine signalling-3 inhibits tumor necrosis factor-alpha induced apoptosis and signalling in beta cells.

Bruun C, Heding PE, Rønn SG, Frobøse H, Rhodes CJ, Mandrup-Poulsen T, Billestrup N.

Mol Cell Endocrinol. 2009 Nov 13;311(1-2):32-8. Epub 2009 Jul 28.PMID: 19643162 [PubMed - in process]Related articles

Inhibition of nuclear factor-kappaB or Bax prevents endoplasmic reticulum stress- but not nitric oxide-mediated apoptosis in INS-1E cells.

Tonnesen MF, Grunnet LG, Friberg J, Cardozo AK, Billestrup N, Eizirik DL, Størling J, Mandrup-Poulsen T.

Endocrinology. 2009 Sep;150(9):4094-103. Epub 2009 Jun 25.PMID: 19556421 [PubMed - indexed for MEDLINE]Related articles

Sustained effects of interleukin-1 receptor antagonist treatment in type 2 diabetes.

Larsen CM, Faulenbach M, Vaag A, Ehses JA, Donath MY, Mandrup-Poulsen T.

Diabetes Care. 2009 Sep;32(9):1663-8. Epub 2009 Jun 19.PMID: 19542207 [PubMed - indexed for MEDLINE]Related articlesFree article

IL-1 receptor antagonism and muscle gene expression in patients with type 2 diabetes.

Berchtold LA, Larsen CM, Vaag A, Faulenbach M, Workman CT, Kruhøffer M, Donath M, Mandrup-Poulsen T.

Eur Cytokine Netw. 2009 Jun 1;20(2):81-87.PMID: 19541594 [PubMed - as supplied by publisher]Related articles

Proinflammatory cytokines activate the intrinsic apoptotic pathway in beta-cells.

Grunnet LG, Aikin R, Tonnesen MF, Paraskevas S, Blaabjerg L, Størling J, Rosenberg L, Billestrup N, Maysinger D, Mandrup-Poulsen T.

Diabetes. 2009 Aug;58(8):1807-15. Epub 2009 May 26.PMID: 19470609 [PubMed - indexed for MEDLINE]Related articlesFree article

The anti-interleukin-1 in type 1 diabetes action trial--background and rationale.

Pickersgill LM, Mandrup-Poulsen TR.

Diabetes Metab Res Rev. 2009 May;25(4):321-4. Review.PMID: 19405081 [PubMed - indexed for MEDLINE]Related articles

Functional SOCS1 polymorphisms are associated with variation in obesity in whites.

Gylvin T, Ek J, Nolsøe R, Albrechtsen A, Andersen G, Bergholdt R, Brorsson C, Bang-Berthelsen CH, Hansen T, Karlsen AE, Billestrup N, Borch-Johnsen K, Jørgensen T, Pedersen O, Mandrup-Poulsen T, Nerup J, Pociot F.

Diabetes Obes Metab. 2009 Mar;11(3):196-203.PMID: 19215277 [PubMed - indexed for MEDLINE]Related articles

G protein-coupled receptor 39 deficiency is associated with pancreatic islet dysfunction.

Holst B, Egerod KL, Jin C, Petersen PS, Østergaard MV, Hald J, Sprinkel AM, Størling J, Mandrup-Poulsen T, Holst JJ, Thams P, Orskov C, Wierup N, Sundler F, Madsen OD, Schwartz TW.

Endocrinology. 2009 Jun;150(6):2577-85. Epub 2009 Feb 12.PMID: 19213833 [PubMed - indexed for MEDLINE]Related articles

IL-1beta-induced chemokine and Fas expression are inhibited by suppressor of cytokine signalling-3 in insulin-producing cells.

Jacobsen ML, Rønn SG, Bruun C, Larsen CM, Eizirik DL, Mandrup-Poulsen T, Billestrup N.

Diabetologia. 2009 Feb;52(2):281-8. Epub 2008 Nov 11.PMID: 19002429 [PubMed - indexed for MEDLINE]Related articles

Suppressor of cytokine signalling-3 expression inhibits cytokine-mediated destruction of primary mouse and rat pancreatic islets and delays allograft rejection.

Rønn SG, Börjesson A, Bruun C, Heding PE, Frobøse H, Mandrup-Poulsen T, Karlsen AE, Rasschaert J, Sandler S, Billestrup N.

Diabetologia. 2008 Oct;51(10):1873-82. Epub 2008 Jul 22.PMID: 18648765 [PubMed - indexed for MEDLINE]Related articles

Mixed-meal tolerance test versus glucagon stimulation test for the assessment of beta-cell function in therapeutic trials in type 1 diabetes.

Greenbaum CJ, Mandrup-Poulsen T, McGee PF, Battelino T, Haastert B, Ludvigsson J, Pozzilli P, Lachin JM, Kolb H; Type 1 Diabetes Trial Net Research Group; European C-Peptide Trial Study Group.

Diabetes Care. 2008 Oct;31(10):1966-71. Epub 2008 Jul 15.PMID: 18628574 [PubMed - indexed for MEDLINE]Related articlesFree article

[Treatment of diabetes mellitus with biologic therapeutics]

Larsen CM, Mandrup-Poulsen T.

Ugeskr Laeger. 2008 Jun 9;170(24):2134-7. Danish. PMID: 18565296 [PubMed - indexed for MEDLINE]Related articles

The use of interleukin-1-receptor antagonists in the treatment of diabetes mellitus.

Donath MY, Mandrup-Poulsen T.

Nat Clin Pract Endocrinol Metab. 2008 May;4(5):240-1. Epub 2008 Mar 4. No abstract available. PMID: 18317479 [PubMed - indexed for MEDLINE]Related articles

The imidazoline RX871024 induces death of proliferating insulin-secreting cells by activation of c-jun N-terminal kinase.

Zaitseva II, Størling J, Mandrup-Poulsen T, Berggren PO, Zaitsev SV.

Cell Mol Life Sci. 2008 Apr;65(7-8):1248-55.PMID: 18278435 [PubMed - indexed for MEDLINE]Related articles

Cytokines and beta-cell biology: from concept to clinical translation.

Donath MY, Størling J, Berchtold LA, Billestrup N, Mandrup-Poulsen T.

Endocr Rev. 2008 May;29(3):334-50. Epub 2007 Nov 29. Review.PMID: 18048762 [PubMed - indexed for MEDLINE]Related articlesFree article

[Interleukin-1 receptor antagonist-treatment of patients with type 2 diabetes]

Larsen CM, Faulenbach M, Vaag A, Vølund A, Ehses J, Seifert B, Mandrup-Poulsen T, Donath M.

Ugeskr Laeger. 2007 Nov 5;169(45):3868-71. Danish. PMID: 18031661 [PubMed]Related articles

Proliferation of sorted human and rat beta cells.

Parnaud G, Bosco D, Berney T, Pattou F, Kerr-Conte J, Donath MY, Bruun C, Mandrup-Poulsen T, Billestrup N, Halban PA.

Diabetologia. 2008 Jan;51(1):91-100. Epub 2007 Nov 10.PMID: 17994216 [PubMed - indexed for MEDLINE]Related articles

Interleukin-1-receptor antagonist in type 2 diabetes mellitus.

Larsen CM, Faulenbach M, Vaag A, Vølund A, Ehses JA, Seifert B, Mandrup-Poulsen T, Donath MY.

N Engl J Med. 2007 Apr 12;356(15):1517-26.PMID: 17429083 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of immune mediators at diagnosis of Type 1 diabetes with later clinical remission.

Schloot NC, Hanifi-Moghaddam P, Aabenhus-Andersen N, Alizadeh BZ, Saha MT, Knip M, Devendra D, Wilkin T, Bonifacio E, Roep BO, Kolb H, Mandrup-Poulsen T.

Diabet Med. 2007 May;24(5):512-20. Epub 2007 Mar 22.PMID: 17381505 [PubMed - indexed for MEDLINE]Related articles

The Fas pathway is involved in pancreatic beta cell secretory function.

Schumann DM, Maedler K, Franklin I, Konrad D, Størling J, Böni-Schnetzler M, Gjinovci A, Kurrer MO, Gauthier BR, Bosco D, Andres A, Berney T, Greter M, Becher B, Chervonsky AV, Halban PA, Mandrup-Poulsen T, Wollheim CB, Donath MY.

Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2861-6. Epub 2007 Feb 13.PMID: 17299038 [PubMed - indexed for MEDLINE]Related articlesFree article

[Auto-antibodies against glutamic acid decarboxylase and diabetes]

Mandrup-Poulsen TR.

Ugeskr Laeger. 2007 Jan 22;169(4):300-4. Review. Danish. PMID: 17274923 [PubMed - indexed for MEDLINE]Related articles

Inhibition of histone deacetylases prevents cytokine-induced toxicity in beta cells.

Larsen L, Tonnesen M, Ronn SG, Størling J, Jørgensen S, Mascagni P, Dinarello CA, Billestrup N, Mandrup-Poulsen T.

Diabetologia. 2007 Apr;50(4):779-89. Epub 2007 Jan 31.PMID: 17265033 [PubMed - indexed for MEDLINE]Related articles

Diabetes and suppressors of cytokine signaling proteins.

Rønn SG, Billestrup N, Mandrup-Poulsen T.

Diabetes. 2007 Feb;56(2):541-8. Review. No abstract available. PMID: 17259405 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of interferon-gamma and interleukin 10 genotypes and serum levels with partial clinical remission in type 1 diabetes.

Alizadeh BZ, Hanifi-Moghaddam P, Eerligh P, van der Slik AR, Kolb H, Kharagjitsingh AV, Pereira Arias AM, Ronkainen M, Knip M, Bonfanti R, Bonifacio E, Devendra D, Wilkin T, Giphart MJ, Koeleman BP, Nolsøe R, Mandrup Poulsen T, Schloot NC, Roep BO; DIABMARKER Study Group.

Clin Exp Immunol. 2006 Sep;145(3):480-4.PMID: 16907917 [PubMed - indexed for MEDLINE]Related articlesFree article

RX871024 reduces NO production but does not protect against pancreatic beta-cell death induced by proinflammatory cytokines.

Zaitseva II, Sharoyko V, Størling J, Efendic S, Guerin C, Mandrup-Poulsen T, Nicotera P, Berggren PO, Zaitsev SV.

Biochem Biophys Res Commun. 2006 Sep 8;347(4):1121-8. Epub 2006 Jul 14.PMID: 16870144 [PubMed - indexed for MEDLINE]Related articles

IL-1beta-induced pro-apoptotic signalling is facilitated by NCAM/FGF receptor signalling and inhibited by the C3d ligand in the INS-1E rat beta cell line.

Petersen LG, Størling J, Heding P, Li S, Berezin V, Saldeen J, Billestrup N, Bock E, Mandrup-Poulsen T.

Diabetologia. 2006 Aug;49(8):1864-75. Epub 2006 May 23.PMID: 16718462 [PubMed - indexed for MEDLINE]Related articles

Association of a microsatellite in FASL to type II diabetes and of the FAS-670G>A genotype to insulin resistance.

Nolsøe RL, Hamid YH, Pociot F, Paulsen S, Andersen KM, Borch-Johnsen K, Drivsholm T, Hansen T, Pedersen O, Mandrup-Poulsen T.

Genes Immun. 2006 Jun;7(4):316-21. Epub 2006 May 4.PMID: 16691186 [PubMed - indexed for MEDLINE]Related articles

Cytokine-induced proapoptotic gene expression in insulin-producing cells is related to rapid, sustained, and nonoscillatory nuclear factor-kappaB activation.

Ortis F, Cardozo AK, Crispim D, Störling J, Mandrup-Poulsen T, Eizirik DL.

Mol Endocrinol. 2006 Aug;20(8):1867-79. Epub 2006 Mar 23.PMID: 16556731 [PubMed - indexed for MEDLINE]Related articlesFree article

Suppressor of cytokine Signaling-3 inhibits interleukin-1 signaling by targeting the TRAF-6/TAK1 complex.

Frobøse H, Rønn SG, Heding PE, Mendoza H, Cohen P, Mandrup-Poulsen T, Billestrup N.

Mol Endocrinol. 2006 Jul;20(7):1587-96. Epub 2006 Mar 16.PMID: 16543409 [PubMed - indexed for MEDLINE]Related articlesFree article

Growth arrest- and DNA-damage-inducible 45beta gene inhibits c-Jun N-terminal kinase and extracellular signal-regulated kinase and decreases IL-1beta-induced apoptosis in insulin-producing INS-1E cells.

Larsen CM, Døssing MG, Papa S, Franzoso G, Billestrup N, Mandrup-Poulsen T.

Diabetologia. 2006 May;49(5):980-9. Epub 2006 Mar 10.PMID: 16528573 [PubMed - indexed for MEDLINE]Related articles

Plasma cytokine levels in young and elderly twins: genes versus environment and relation to in vivo insulin action.

Grunnet L, Poulsen P, Klarlund Pedersen B, Mandrup-Poulsen T, Vaag A.

Diabetologia. 2006 Feb;49(2):343-50. Epub 2005 Dec 23.PMID: 16374628 [PubMed - indexed for MEDLINE]Related articles

Interleukin-6 and diabetes: the good, the bad, or the indifferent?

Kristiansen OP, Mandrup-Poulsen T.

Diabetes. 2005 Dec;54 Suppl 2:S114-24. Review.PMID: 16306329 [PubMed - indexed for MEDLINE]Related articlesFree article

Extracellular signal-regulated kinase is essential for interleukin-1-induced and nuclear factor kappaB-mediated gene expression in insulin-producing INS-1E cells.

Larsen L, Størling J, Darville M, Eizirik DL, Bonny C, Billestrup N, Mandrup-Poulsen T.

Diabetologia. 2005 Dec;48(12):2582-90. Epub 2005 Nov 11.PMID: 16283237 [PubMed - indexed for MEDLINE]Related articles

Functional promoter haplotypes of the human FAS gene are associated with the phenotype of SLE characterized by thrombocytopenia.

Nolsøe RL, Kelly JA, Pociot F, Moser KL, Kristiansen OP, Mandrup-Poulsen T, Harley JB.

Genes Immun. 2005 Dec;6(8):699-706.PMID: 16163374 [PubMed - indexed for MEDLINE]Related articles

Nitric oxide contributes to cytokine-induced apoptosis in pancreatic beta cells via potentiation of JNK activity and inhibition of Akt.

Størling J, Binzer J, Andersson AK, Züllig RA, Tonnesen M, Lehmann R, Spinas GA, Sandler S, Billestrup N, Mandrup-Poulsen T.

Diabetologia. 2005 Oct;48(10):2039-50. Epub 2005 Aug 25.PMID: 16132952 [PubMed - indexed for MEDLINE]Related articles

[Is there any documentation for Lyrica in the treatment of painful diabetic neuropathy?]

Persson F, Mogensen CE, Mandrup-Poulsen T.

Ugeskr Laeger. 2005 Apr 18;167(16):1768-9; author reply 1769-70. Danish. No abstract available. PMID: 15898613 [PubMed - indexed for MEDLINE]Related articles

An immune origin of type 2 diabetes?

Kolb H, Mandrup-Poulsen T.

Diabetologia. 2005 Jun;48(6):1038-50. Epub 2005 Apr 30. Review. Erratum in: Diabetologia. 2005 Aug;48(8):1677. PMID: 15864529 [PubMed - indexed for MEDLINE]Related articles

Calcium has a permissive role in interleukin-1beta-induced c-jun N-terminal kinase activation in insulin-secreting cells.

Størling J, Zaitsev SV, Kapelioukh IL, Karlsen AE, Billestrup N, Berggren PO, Mandrup-Poulsen T.

Endocrinology. 2005 Jul;146(7):3026-36. Epub 2005 Apr 14.PMID: 15831571 [PubMed - indexed for MEDLINE]Related articlesFree article

Is puberty an accelerator of type 1 diabetes in IL6-174CC females?

Gillespie KM, Nolsøe R, Betin VM, Kristiansen OP, Bingley PJ, Mandrup-Poulsen T, Gale EA.

Diabetes. 2005 Apr;54(4):1245-8.PMID: 15793269 [PubMed - indexed for MEDLINE]Related articlesFree article

[European Nicotinamide Diabetes Intervention Trial (ENDIT)--secondary publication. A randomized, placebo-controlled trial of intervention before the onset of type 1 diabetes]

Reimers JI, Larsen CM, Mandrup-Poulsen TR; European Nicotinamide Diabetes Intervention Trial Group.

Ugeskr Laeger. 2005 Jan 17;167(3):293-6. Danish. No abstract available. PMID: 15704800 [PubMed - indexed for MEDLINE]Related articles

Poor pregnancy outcome in women with type 2 diabetes.

Clausen TD, Mathiesen E, Ekbom P, Hellmuth E, Mandrup-Poulsen T, Damm P.

Diabetes Care. 2005 Feb;28(2):323-8.PMID: 15677787 [PubMed - indexed for MEDLINE]Related articlesFree article

Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells.

Cardozo AK, Ortis F, Storling J, Feng YM, Rasschaert J, Tonnesen M, Van Eylen F, Mandrup-Poulsen T, Herchuelz A, Eizirik DL.

Diabetes. 2005 Feb;54(2):452-61.PMID: 15677503 [PubMed - indexed for MEDLINE]Related articlesFree article

Variations of the interleukin-6 promoter are associated with features of the metabolic syndrome in Caucasian Danes.

Hamid YH, Rose CS, Urhammer SA, Glümer C, Nolsøe R, Kristiansen OP, Mandrup-Poulsen T, Borch-Johnsen K, Jorgensen T, Hansen T, Pedersen O.

Diabetologia. 2005 Feb;48(2):251-60. Epub 2005 Jan 11.PMID: 15645209 [PubMed - indexed for MEDLINE]Related articles

Type 1 database mellitus: an inflammatory disease of the islet.

Bergholdt R, Heding P, Nielsen K, Nolsøe R, Sparre T, Størling J, Nerup J, Pociot F, Mandrup-Poulsen T.

Adv Exp Med Biol. 2004;552:129-53. Review. No abstract available. PMID: 15622962 [PubMed - indexed for MEDLINE]Related articles

Antitumorigenic effect of proteasome inhibitors on insulinoma cells.

Størling J, Allaman-Pillet N, Karlsen AE, Billestrup N, Bonny C, Mandrup-Poulsen T.

Endocrinology. 2005 Apr;146(4):1718-26. Epub 2004 Dec 23.PMID: 15618349 [PubMed - indexed for MEDLINE]Related articlesFree article

Suppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1beta-mediated toxicity through inhibition of multiple nuclear factor-kappaB-regulated proapoptotic pathways.

Karlsen AE, Heding PE, Frobøse H, Rønn SG, Kruhøffer M, Orntoft TF, Darville M, Eizirik DL, Pociot F, Nerup J, Mandrup-Poulsen T, Billestrup N.

Diabetologia. 2004 Nov;47(11):1998-2011. Epub 2004 Dec 2.PMID: 15578154 [PubMed - indexed for MEDLINE]Related articles

Mutation analysis of suppressor of cytokine signalling 3, a candidate gene in Type 1 diabetes and insulin sensitivity.

Gylvin T, Nolsøe R, Hansen T, Nielsen EM, Bergholdt R, Karlsen AE, Billestrup N, Borch-Johnsen K, Pedersen O, Mandrup-Poulsen T, Nerup J, Pociot F.

Diabetologia. 2004 Jul;47(7):1273-7. Epub 2004 Jul 13.PMID: 15249995 [PubMed - indexed for MEDLINE]Related articles

Glucose- and interleukin-1beta-induced beta-cell apoptosis requires Ca2+ influx and extracellular signal-regulated kinase (ERK) 1/2 activation and is prevented by a sulfonylurea receptor 1/inwardly rectifying K+ channel 6.2 (SUR/Kir6.2) selective potassium channel opener in human islets.

Maedler K, Størling J, Sturis J, Zuellig RA, Spinas GA, Arkhammar PO, Mandrup-Poulsen T, Donath MY.

Diabetes. 2004 Jul;53(7):1706-13.PMID: 15220194 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of a type 1 diabetes-associated CD4 promoter haplotype with high constitutive activity.

Kristiansen OP, Karlsen AE, Larsen ZM, Johannesen J, Pociot F, Mandrup-Poulsen T; Danish IDDM Epidemiology and Genetics Group and Danish Study Group of IDDM in Childhood.

Scand J Immunol. 2004 Jun;59(6):582-91.PMID: 15182254 [PubMed - indexed for MEDLINE]Related articles