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Proteomics Analysis of Human Skeletal Muscle Reveals Novel Abnormalities in Obesity and Type 2 Diabetes Mellitus.

Hwang H, Bowen BP, Lefort N, Flynn CR, De Filippis EA, Roberts C, Smoke CC, Meyer C, Højlund K, Yi Z, Mandarino LJ.

Diabetes. 2009 Oct 15. [Epub ahead of print]PMID: 19833877 [PubMed - as supplied by publisher]Related articles

In vivo phosphoproteome of human skeletal muscle revealed by phosphopeptide enrichment and HPLC-ESI-MS/MS.

Højlund K, Bowen BP, Hwang H, Flynn CR, Madireddy L, Geetha T, Langlais P, Meyer C, Mandarino LJ, Yi Z.

J Proteome Res. 2009 Nov;8(11):4954-65.PMID: 19764811 [PubMed - in process]Related articles

Proteome profile of functional mitochondria from human skeletal muscle using one-dimensional gel electrophoresis and HPLC-ESI-MS/MS.

Lefort N, Yi Z, Bowen B, Glancy B, De Filippis EA, Mapes R, Hwang H, Flynn CR, Willis WT, Civitarese A, Højlund K, Mandarino LJ.

J Proteomics. 2009 Aug 20;72(6):1046-60. Epub 2009 Jun 28.PMID: 19567276 [PubMed - indexed for MEDLINE]Related articles

Global relationship between the proteome and transcriptome of human skeletal muscle.

Yi Z, Bowen BP, Hwang H, Jenkinson CP, Coletta DK, Lefort N, Bajaj M, Kashyap S, Berria R, De Filippis EA, Mandarino LJ.

J Proteome Res. 2008 Aug;7(8):3230-41. Epub 2008 Jul 10.PMID: 18613714 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of acute physiological hyperinsulinemia on gene expression in human skeletal muscle in vivo.

Coletta DK, Balas B, Chavez AO, Baig M, Abdul-Ghani M, Kashyap SR, Folli F, Tripathy D, Mandarino LJ, Cornell JE, Defronzo RA, Jenkinson CP.

Am J Physiol Endocrinol Metab. 2008 May;294(5):E910-7. Epub 2008 Mar 11.PMID: 18334611 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-resistant muscle is exercise resistant: evidence for reduced response of nuclear-encoded mitochondrial genes to exercise.

De Filippis E, Alvarez G, Berria R, Cusi K, Everman S, Meyer C, Mandarino LJ.

Am J Physiol Endocrinol Metab. 2008 Mar;294(3):E607-14. Epub 2008 Jan 8.PMID: 18182465 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of the human skeletal muscle proteome by one-dimensional gel electrophoresis and HPLC-ESI-MS/MS.

Højlund K, Yi Z, Hwang H, Bowen B, Lefort N, Flynn CR, Langlais P, Weintraub ST, Mandarino LJ.

Mol Cell Proteomics. 2008 Feb;7(2):257-67. Epub 2007 Oct 1.PMID: 17911086 [PubMed - indexed for MEDLINE]Related articlesFree article

Phosphorylation of human insulin receptor substrate-1 at Serine 629 plays a positive role in insulin signaling.

Luo M, Langlais P, Yi Z, Lefort N, De Filippis EA, Hwang H, Christ-Roberts CY, Mandarino LJ.

Endocrinology. 2007 Oct;148(10):4895-905. Epub 2007 Jul 19.PMID: 17640984 [PubMed - indexed for MEDLINE]Related articlesFree article

The effect of exercise, training, and inactivity on insulin sensitivity in diabetics and their relatives: what is new?

Østergård T, Jessen N, Schmitz O, Mandarino LJ.

Appl Physiol Nutr Metab. 2007 Jun;32(3):541-8. Review.PMID: 17510695 [PubMed - indexed for MEDLINE]Related articles

Global assessment of regulation of phosphorylation of insulin receptor substrate-1 by insulin in vivo in human muscle.

Yi Z, Langlais P, De Filippis EA, Luo M, Flynn CR, Schroeder S, Weintraub ST, Mapes R, Mandarino LJ.

Diabetes. 2007 Jun;56(6):1508-16. Epub 2007 Mar 14.PMID: 17360977 [PubMed - indexed for MEDLINE]Related articlesFree article

Paradoxical changes in muscle gene expression in insulin-resistant subjects after sustained reduction in plasma free fatty acid concentration.

Bajaj M, Medina-Navarro R, Suraamornkul S, Meyer C, DeFronzo RA, Mandarino LJ.

Diabetes. 2007 Mar;56(3):743-52.PMID: 17327445 [PubMed - indexed for MEDLINE]Related articlesFree article

Phosphorylation and activation of a transducible recombinant form of human HSP20 in Escherichia coli.

Flynn CR, Smoke CC, Furnish E, Komalavilas P, Thresher J, Yi Z, Mandarino LJ, Brophy CM.

Protein Expr Purif. 2007 Mar;52(1):50-8. Epub 2006 Sep 12.PMID: 17084643 [PubMed - indexed for MEDLINE]Related articlesFree article

Exercise-induced improvement in vasodilatory function accompanies increased insulin sensitivity in obesity and type 2 diabetes mellitus.

De Filippis E, Cusi K, Ocampo G, Berria R, Buck S, Consoli A, Mandarino LJ.

J Clin Endocrinol Metab. 2006 Dec;91(12):4903-10. Epub 2006 Oct 3.PMID: 17018657 [PubMed - indexed for MEDLINE]Related articlesFree article

IGF-binding protein-1 levels are related to insulin-mediated glucose disposal and are a potential serum marker of insulin resistance.

Maddux BA, Chan A, De Filippis EA, Mandarino LJ, Goldfine ID.

Diabetes Care. 2006 Jul;29(7):1535-7. Erratum in: Diabetes Care. 2006 Nov;29(11):2571. De Filippis, Elena A [added]. PMID: 16801575 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduced skeletal muscle inhibitor of kappaB beta content is associated with insulin resistance in subjects with type 2 diabetes: reversal by exercise training.

Sriwijitkamol A, Christ-Roberts C, Berria R, Eagan P, Pratipanawatr T, DeFronzo RA, Mandarino LJ, Musi N.

Diabetes. 2006 Mar;55(3):760-7.PMID: 16505240 [PubMed - indexed for MEDLINE]Related articlesFree article

Quantification of phosphorylation of insulin receptor substrate-1 by HPLC-ESI-MS/MS.

Yi Z, Luo M, Mandarino LJ, Reyna SM, Carroll CA, Weintraub ST.

J Am Soc Mass Spectrom. 2006 Apr;17(4):562-7. Epub 2006 Feb 28.PMID: 16503154 [PubMed - indexed for MEDLINE]Related articles

LKB1-AMPK signaling in muscle from obese insulin-resistant Zucker rats and effects of training.

Sriwijitkamol A, Ivy JL, Christ-Roberts C, DeFronzo RA, Mandarino LJ, Musi N.

Am J Physiol Endocrinol Metab. 2006 May;290(5):E925-32. Epub 2005 Dec 13.PMID: 16352671 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of a sustained reduction in plasma free fatty acid concentration on intramuscular long-chain fatty Acyl-CoAs and insulin action in type 2 diabetic patients.

Bajaj M, Suraamornkul S, Romanelli A, Cline GW, Mandarino LJ, Shulman GI, DeFronzo RA.

Diabetes. 2005 Nov;54(11):3148-53.PMID: 16249438 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased collagen content in insulin-resistant skeletal muscle.

Berria R, Wang L, Richardson DK, Finlayson J, Belfort R, Pratipanawatr T, De Filippis EA, Kashyap S, Mandarino LJ.

Am J Physiol Endocrinol Metab. 2006 Mar;290(3):E560-5. Epub 2005 Oct 25.PMID: 16249255 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of phosphorylation sites in insulin receptor substrate-1 by hypothesis-driven high-performance liquid chromatography-electrospray ionization tandem mass spectrometry.

Yi Z, Luo M, Carroll CA, Weintraub ST, Mandarino LJ.

Anal Chem. 2005 Sep 1;77(17):5693-9.PMID: 16131083 [PubMed - indexed for MEDLINE]Related articles

Identification of insulin receptor substrate 1 serine/threonine phosphorylation sites using mass spectrometry analysis: regulatory role of serine 1223.

Luo M, Reyna S, Wang L, Yi Z, Carroll C, Dong LQ, Langlais P, Weintraub ST, Mandarino LJ.

Endocrinology. 2005 Oct;146(10):4410-6. Epub 2005 Jul 14.PMID: 16020478 [PubMed - indexed for MEDLINE]Related articlesFree article

Lipid infusion decreases the expression of nuclear encoded mitochondrial genes and increases the expression of extracellular matrix genes in human skeletal muscle.

Richardson DK, Kashyap S, Bajaj M, Cusi K, Mandarino SJ, Finlayson J, DeFronzo RA, Jenkinson CP, Mandarino LJ.

J Biol Chem. 2005 Mar 18;280(11):10290-7. Epub 2004 Dec 14.PMID: 15598661 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of pioglitazone on circulating adipocytokine levels and insulin sensitivity in type 2 diabetic patients.

Miyazaki Y, Mahankali A, Wajcberg E, Bajaj M, Mandarino LJ, DeFronzo RA.

J Clin Endocrinol Metab. 2004 Sep;89(9):4312-9.PMID: 15356026 [PubMed - indexed for MEDLINE]Related articlesFree article

Exercise training increases glycogen synthase activity and GLUT4 expression but not insulin signaling in overweight nondiabetic and type 2 diabetic subjects.

Christ-Roberts CY, Pratipanawatr T, Pratipanawatr W, Berria R, Belfort R, Kashyap S, Mandarino LJ.

Metabolism. 2004 Sep;53(9):1233-42.PMID: 15334390 [PubMed - indexed for MEDLINE]Related articles

Glycogen synthase: key effect of exercise on insulin action.

Christ-Roberts CY, Mandarino LJ.

Exerc Sport Sci Rev. 2004 Jul;32(3):90-4. Review.PMID: 15243203 [PubMed - indexed for MEDLINE]Related articles

Impaired mitochondrial activity and insulin-resistant offspring of patients with type 2 diabetes.

Bajaj M, Mandarino LJ.

N Engl J Med. 2004 Jun 3;350(23):2419-21; author reply 2419-21. No abstract available. PMID: 15179700 [PubMed - indexed for MEDLINE]Related articles

Adiponectin receptors gene expression and insulin sensitivity in non-diabetic Mexican Americans with or without a family history of Type 2 diabetes.

Civitarese AE, Jenkinson CP, Richardson D, Bajaj M, Cusi K, Kashyap S, Berria R, Belfort R, DeFronzo RA, Mandarino LJ, Ravussin E.

Diabetologia. 2004 May;47(5):816-20. Epub 2004 Apr 23.PMID: 15105989 [PubMed - indexed for MEDLINE]Related articles

Ceramide content is increased in skeletal muscle from obese insulin-resistant humans.

Adams JM 2nd, Pratipanawatr T, Berria R, Wang E, DeFronzo RA, Sullards MC, Mandarino LJ.

Diabetes. 2004 Jan;53(1):25-31.PMID: 14693694 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased insulin receptor signaling and glycogen synthase activity contribute to the synergistic effect of exercise on insulin action.

Christ-Roberts CY, Pratipanawatr T, Pratipanawatr W, Berria R, Belfort R, Mandarino LJ.

J Appl Physiol. 2003 Dec;95(6):2519-29. Epub 2003 Aug 8.PMID: 12909611 [PubMed - indexed for MEDLINE]Related articlesFree article

Rosiglitazone improves downstream insulin receptor signaling in type 2 diabetic patients.

Miyazaki Y, He H, Mandarino LJ, DeFronzo RA.

Diabetes. 2003 Aug;52(8):1943-50.PMID: 12882909 [PubMed - indexed for MEDLINE]Related articlesFree article

Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1.

Patti ME, Butte AJ, Crunkhorn S, Cusi K, Berria R, Kashyap S, Miyazaki Y, Kohane I, Costello M, Saccone R, Landaker EJ, Goldfine AB, Mun E, DeFronzo R, Finlayson J, Kahn CR, Mandarino LJ.

Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8466-71. Epub 2003 Jun 27.PMID: 12832613 [PubMed - indexed for MEDLINE]Related articlesFree article

Tumor necrosis factor alpha and insulin resistance in obese type 2 diabetic patients.

Miyazaki Y, Pipek R, Mandarino LJ, DeFronzo RA.

Int J Obes Relat Metab Disord. 2003 Jan;27(1):88-94.PMID: 12532159 [PubMed - indexed for MEDLINE]Related articles

Abdominal fat distribution and peripheral and hepatic insulin resistance in type 2 diabetes mellitus.

Miyazaki Y, Glass L, Triplitt C, Wajcberg E, Mandarino LJ, DeFronzo RA.

Am J Physiol Endocrinol Metab. 2002 Dec;283(6):E1135-43.PMID: 12424102 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of pioglitazone on abdominal fat distribution and insulin sensitivity in type 2 diabetic patients.

Miyazaki Y, Mahankali A, Matsuda M, Mahankali S, Hardies J, Cusi K, Mandarino LJ, DeFronzo RA.

J Clin Endocrinol Metab. 2002 Jun;87(6):2784-91.PMID: 12050251 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of misoprostol (PGE1) on glucose metabolism in type-2-diabetic and control subjects.

Lee NA, Matsuda M, Bressler P, Pratipanawatr T, Glass L, Mandarino LJ, DeFronzo RA.

Diabetes Obes Metab. 2002 May;4(3):195-200.PMID: 12047398 [PubMed - indexed for MEDLINE]Related articles

Normalization of plasma glucose concentration by insulin therapy improves insulin-stimulated glycogen synthesis in type 2 diabetes.

Pratipanawatr T, Cusi K, Ngo P, Pratipanawatr W, Mandarino LJ, DeFronzo RA.

Diabetes. 2002 Feb;51(2):462-8.PMID: 11812756 [PubMed - indexed for MEDLINE]Related articlesFree article

Exercise training improves muscle insulin resistance but not insulin receptor signaling in obese Zucker rats.

Christ CY, Hunt D, Hancock J, Garcia-Macedo R, Mandarino LJ, Ivy JL.

J Appl Physiol. 2002 Feb;92(2):736-44.PMID: 11796688 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of rosiglitazone on glucose and non-esterified fatty acid metabolism in Type II diabetic patients.

Miyazaki Y, Glass L, Triplitt C, Matsuda M, Cusi K, Mahankali A, Mahankali S, Mandarino LJ, DeFronzo RA.

Diabetologia. 2001 Dec;44(12):2210-9.PMID: 11793023 [PubMed - indexed for MEDLINE]Related articles

Skeletal muscle insulin resistance in normoglycemic subjects with a strong family history of type 2 diabetes is associated with decreased insulin-stimulated insulin receptor substrate-1 tyrosine phosphorylation.

Pratipanawatr W, Pratipanawatr T, Cusi K, Berria R, Adams JM, Jenkinson CP, Maezono K, DeFronzo RA, Mandarino LJ.

Diabetes. 2001 Nov;50(11):2572-8.PMID: 11679436 [PubMed - indexed for MEDLINE]Related articlesFree article

Exercise increases hexokinase II mRNA, but not activity in obesity and type 2 diabetes.

Cusi KJ, Pratipanawatr T, Koval J, Printz R, Ardehali H, Granner DK, Defronzo RA, Mandarino LJ.

Metabolism. 2001 May;50(5):602-6.PMID: 11319725 [PubMed - indexed for MEDLINE]Related articles

Improved glycemic control and enhanced insulin sensitivity in type 2 diabetic subjects treated with pioglitazone.

Miyazaki Y, Mahankali A, Matsuda M, Glass L, Mahankali S, Ferrannini E, Cusi K, Mandarino LJ, DeFronzo RA.

Diabetes Care. 2001 Apr;24(4):710-9.PMID: 11315836 [PubMed - indexed for MEDLINE]Related articlesFree article

Physiological hyperinsulinemia impairs insulin-stimulated glycogen synthase activity and glycogen synthesis.

Iozzo P, Pratipanawatr T, Pijl H, Vogt C, Kumar V, Pipek R, Matsuda M, Mandarino LJ, Cusi KJ, DeFronzo RA.

Am J Physiol Endocrinol Metab. 2001 May;280(5):E712-9.PMID: 11287353 [PubMed - indexed for MEDLINE]Related articlesFree article

Exercise training increases ERK2 activity in skeletal muscle of obese Zucker rats.

Osman AA, Hancock J, Hunt DG, Ivy JL, Mandarino LJ.

J Appl Physiol. 2001 Feb;90(2):454-60.PMID: 11160042 [PubMed - indexed for MEDLINE]Related articlesFree article

Fuel selection in human skeletal muscle in insulin resistance: a reexamination.

Kelley DE, Mandarino LJ.

Diabetes. 2000 May;49(5):677-83. Review.PMID: 10905472 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of MAP kinase pathway activity in vivo in human skeletal muscle.

Osman AA, Pendergrass M, Koval J, Maezono K, Cusi K, Pratipanawatr T, Mandarino LJ.

Am J Physiol Endocrinol Metab. 2000 Jun;278(6):E992-9.PMID: 10827000 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle.

Cusi K, Maezono K, Osman A, Pendergrass M, Patti ME, Pratipanawatr T, DeFronzo RA, Kahn CR, Mandarino LJ.

J Clin Invest. 2000 Feb;105(3):311-20.PMID: 10675357 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of exercise and insulin on insulin signaling proteins in human skeletal muscle.

Koval JA, Maezono K, Patti ME, Pendergrass M, DeFronzo RA, Mandarino LJ.

Med Sci Sports Exerc. 1999 Jul;31(7):998-1004.PMID: 10416561 [PubMed - indexed for MEDLINE]Related articles

Insulin-induced hexokinase II expression is reduced in obesity and NIDDM.

Pendergrass M, Koval J, Vogt C, Yki-Jarvinen H, Iozzo P, Pipek R, Ardehali H, Printz R, Granner D, DeFronzo RA, Mandarino LJ.

Diabetes. 1998 Mar;47(3):387-94.PMID: 9519744 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of hexokinase II activity and expression in human muscle by moderate exercise.

Koval JA, DeFronzo RA, O'Doherty RM, Printz R, Ardehali H, Granner DK, Mandarino LJ.

Am J Physiol. 1998 Feb;274(2 Pt 1):E304-8.PMID: 9486162 [PubMed - indexed for MEDLINE]Related articlesFree article

Cloning, chromosome localization, expression, and characterization of an Src homology 2 and pleckstrin homology domain-containing insulin receptor binding protein hGrb10gamma.

Dong LQ, Du H, Porter SG, Kolakowski LF Jr, Lee AV, Mandarino LJ, Fan J, Yee D, Liu F.

J Biol Chem. 1997 Nov 14;272(46):29104-12. Erratum in: J Biol Chem 1998 Feb 13;273(7):4288. Mandarino J [corrected to Mandarino LJ]. PMID: 9360986 [PubMed - indexed for MEDLINE]Related articlesFree article