PubMed

Rictor is a novel target of p70 S6 kinase-1.

Treins C, Warne PH, Magnuson MA, Pende M, Downward J.

Oncogene. 2009 Nov 23. [Epub ahead of print]PMID: 19935711 [PubMed - as supplied by publisher]

Disruption of PPARgamma signaling results in mouse prostatic intraepithelial neoplasia involving active autophagy.

Jiang M, Fernandez S, Jerome WG, He Y, Yu X, Cai H, Boone B, Yi Y, Magnuson MA, Roy-Burman P, Matusik RJ, Shappell SB, Hayward SW.

Cell Death Differ. 2009 Oct 16. [Epub ahead of print]PMID: 19834493 [PubMed - as supplied by publisher]Related articles

Multiple, temporal-specific roles for HNF6 in pancreatic endocrine and ductal differentiation.

Zhang H, Ables ET, Pope CF, Washington MK, Hipkens S, Means AL, Path G, Seufert J, Costa RH, Leiter AB, Magnuson MA, Gannon M.

Mech Dev. 2009 Dec;126(11-12):958-73. Epub 2009 Sep 18.PMID: 19766716 [PubMed - in process]Related articles

New complexity in differentiating stem cells toward hepatic and pancreatic fates.

Huppert SS, Magnuson MA.

Sci Signal. 2009 Aug 11;2(83):pe50.PMID: 19671927 [PubMed - in process]Related articles

Hepatic energy state is regulated by glucagon receptor signaling in mice.

Berglund ED, Lee-Young RS, Lustig DG, Lynes SE, Donahue EP, Camacho RC, Meredith ME, Magnuson MA, Charron MJ, Wasserman DH.

J Clin Invest. 2009 Aug;119(8):2412-22.PMID: 19662685 [PubMed - indexed for MEDLINE]Related articlesFree article

Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function.

Wang S, Jensen JN, Seymour PA, Hsu W, Dor Y, Sander M, Magnuson MA, Serup P, Gu G.

Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9715-20. Epub 2009 Jun 1.PMID: 19487660 [PubMed - indexed for MEDLINE]Related articles

mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice.

Guertin DA, Stevens DM, Saitoh M, Kinkel S, Crosby K, Sheen JH, Mullholland DJ, Magnuson MA, Wu H, Sabatini DM.

Cancer Cell. 2009 Feb 3;15(2):148-59.PMID: 19185849 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential structure of atrial and ventricular KATP: atrial KATP channels require SUR1.

Flagg TP, Kurata HT, Masia R, Caputa G, Magnuson MA, Lefer DJ, Coetzee WA, Nichols CG.

Circ Res. 2008 Dec 5;103(12):1458-65. Epub 2008 Oct 30.PMID: 18974387 [PubMed - indexed for MEDLINE]Related articles

A Rictor-Myo1c complex participates in dynamic cortical actin events in 3T3-L1 adipocytes.

Hagan GN, Lin Y, Magnuson MA, Avruch J, Czech MP.

Mol Cell Biol. 2008 Jul;28(13):4215-26. Epub 2008 Apr 21.PMID: 18426911 [PubMed - indexed for MEDLINE]Related articlesFree article

Sugar binding to recombinant wild-type and mutant glucokinase monitored by kinetic measurement and tryptophan fluorescence.

Zelent B, Odili S, Buettger C, Shiota C, Grimsby J, Taub R, Magnuson MA, Vanderkooi JM, Matschinsky FM.

Biochem J. 2008 Jul 15;413(2):269-80.PMID: 18370929 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of sulfonylurea receptor type 1 subunits of ATP-sensitive potassium channels in myocardial ischemia/reperfusion injury.

Elrod JW, Harrell M, Flagg TP, Gundewar S, Magnuson MA, Nichols CG, Coetzee WA, Lefer DJ.

Circulation. 2008 Mar 18;117(11):1405-13. Epub 2008 Mar 3. Erratum in: Circulation.2008 May 6;117(18):e332. PMID: 18316485 [PubMed - indexed for MEDLINE]Related articlesFree article

Pdx-1 and Ptf1a concurrently determine fate specification of pancreatic multipotent progenitor cells.

Burlison JS, Long Q, Fujitani Y, Wright CV, Magnuson MA.

Dev Biol. 2008 Apr 1;316(1):74-86. Epub 2008 Jan 26.PMID: 18294628 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatic glucose sensing: does flux matter?

Shiota M, Magnuson MA.

J Clin Invest. 2008 Mar;118(3):841-4.PMID: 18292804 [PubMed - indexed for MEDLINE]Related articlesFree article

A nonclassical bHLH Rbpj transcription factor complex is required for specification of GABAergic neurons independent of Notch signaling.

Hori K, Cholewa-Waclaw J, Nakada Y, Glasgow SM, Masui T, Henke RM, Wildner H, Martarelli B, Beres TM, Epstein JA, Magnuson MA, Macdonald RJ, Birchmeier C, Johnson JE.

Genes Dev. 2008 Jan 15;22(2):166-78.PMID: 18198335 [PubMed - indexed for MEDLINE]Related articlesFree article

pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis.

Gannon M, Ables ET, Crawford L, Lowe D, Offield MF, Magnuson MA, Wright CV.

Dev Biol. 2008 Feb 15;314(2):406-17. Epub 2007 Nov 4.PMID: 18155690 [PubMed - indexed for MEDLINE]Related articlesFree article

Muscle-specific deletion of rictor impairs insulin-stimulated glucose transport and enhances Basal glycogen synthase activity.

Kumar A, Harris TE, Keller SR, Choi KM, Magnuson MA, Lawrence JC Jr.

Mol Cell Biol. 2008 Jan;28(1):61-70. Epub 2007 Oct 29.PMID: 17967879 [PubMed - indexed for MEDLINE]Related articlesFree article

Early pancreatic development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complex.

Masui T, Long Q, Beres TM, Magnuson MA, MacDonald RJ.

Genes Dev. 2007 Oct 15;21(20):2629-43.PMID: 17938243 [PubMed - indexed for MEDLINE]Related articlesFree article

Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse.

Wang S, Zhang J, Zhao A, Hipkens S, Magnuson MA, Gu G.

Mech Dev. 2007 Nov-Dec;124(11-12):898-910. Epub 2007 Sep 4.PMID: 17928203 [PubMed - indexed for MEDLINE]Related articlesFree article

Caveats and considerations for performing pancreas-specific gene manipulations in the mouse.

Magnuson MA, Burlison JS.

Diabetes Obes Metab. 2007 Nov;9 Suppl 2:5-13.PMID: 17919173 [PubMed - indexed for MEDLINE]Related articles

Obesity and the beta cell: lessons from leptin.

Niswender KD, Magnuson MA.

J Clin Invest. 2007 Oct;117(10):2753-6.PMID: 17909621 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of Protor as a novel Rictor-binding component of mTOR complex-2.

Pearce LR, Huang X, Boudeau J, Pawłowski R, Wullschleger S, Deak M, Ibrahim AF, Gourlay R, Magnuson MA, Alessi DR.

Biochem J. 2007 Aug 1;405(3):513-22.PMID: 17461779 [PubMed - indexed for MEDLINE]Related articlesFree article

Cytosolic phosphoenolpyruvate carboxykinase does not solely control the rate of hepatic gluconeogenesis in the intact mouse liver.

Burgess SC, He T, Yan Z, Lindner J, Sherry AD, Malloy CR, Browning JD, Magnuson MA.

Cell Metab. 2007 Apr;5(4):313-20.PMID: 17403375 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucokinase thermolability and hepatic regulatory protein binding are essential factors for predicting the blood glucose phenotype of missense mutations.

Pino MF, Kim KA, Shelton KD, Lindner J, Odili S, Li C, Collins HW, Shiota M, Matschinsky FM, Magnuson MA.

J Biol Chem. 2007 May 4;282(18):13906-16. Epub 2007 Mar 12.PMID: 17353190 [PubMed - indexed for MEDLINE]Related articlesFree article

Pancreatic glucokinase is activated by insulin-like growth factor-I.

Yoshida K, Murao K, Imachi H, Cao WM, Yu X, Li J, Ahmed RA, Kitanaka N, Wong NC, Unterman TG, Magnuson MA, Ishida T.

Endocrinology. 2007 Jun;148(6):2904-13. Epub 2007 Feb 22.PMID: 17317782 [PubMed - indexed for MEDLINE]Related articlesFree article

Recombinase-mediated cassette exchange to rapidly and efficiently generate mice with human cardiac sodium channels.

Liu K, Hipkens S, Yang T, Abraham R, Zhang W, Chopra N, Knollmann B, Magnuson MA, Roden DM.

Genesis. 2006 Nov;44(11):556-64.PMID: 17083109 [PubMed - indexed for MEDLINE]Related articles

Ptf1a determines horizontal and amacrine cell fates during mouse retinal development.

Fujitani Y, Fujitani S, Luo H, Qiu F, Burlison J, Long Q, Kawaguchi Y, Edlund H, MacDonald RJ, Furukawa T, Fujikado T, Magnuson MA, Xiang M, Wright CV.

Development. 2006 Nov;133(22):4439-50.PMID: 17075007 [PubMed - indexed for MEDLINE]Related articlesFree article

Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability.

Shiota C, Woo JT, Lindner J, Shelton KD, Magnuson MA.

Dev Cell. 2006 Oct;11(4):583-9. Epub 2006 Sep 7.PMID: 16962829 [PubMed - indexed for MEDLINE]Related articles

Cholinergic regulation of fuel-induced hormone secretion and respiration of SUR1-/- mouse islets.

Doliba NM, Qin W, Vatamaniuk MZ, Buettger CW, Collins HW, Magnuson MA, Kaestner KH, Wilson DF, Carr RD, Matschinsky FM.

Am J Physiol Endocrinol Metab. 2006 Sep;291(3):E525-35. Epub 2006 Apr 25.PMID: 16638820 [PubMed - indexed for MEDLINE]Related articlesFree article

Selective deletion of Pten in pancreatic beta cells leads to increased islet mass and resistance to STZ-induced diabetes.

Stiles BL, Kuralwalla-Martinez C, Guo W, Gregorian C, Wang Y, Tian J, Magnuson MA, Wu H.

Mol Cell Biol. 2006 Apr;26(7):2772-81.PMID: 16537919 [PubMed - indexed for MEDLINE]Related articlesFree article

Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation.

Fujitani Y, Fujitani S, Boyer DF, Gannon M, Kawaguchi Y, Ray M, Shiota M, Stein RW, Magnuson MA, Wright CV.

Genes Dev. 2006 Jan 15;20(2):253-66.PMID: 16418487 [PubMed - indexed for MEDLINE]Related articlesFree article

The network of glucokinase-expressing cells in glucose homeostasis and the potential of glucokinase activators for diabetes therapy.

Matschinsky FM, Magnuson MA, Zelent D, Jetton TL, Doliba N, Han Y, Taub R, Grimsby J.

Diabetes. 2006 Jan;55(1):1-12. Review.PMID: 16380470 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatocyte nuclear factor-4alpha is essential for glucose-stimulated insulin secretion by pancreatic beta-cells.

Miura A, Yamagata K, Kakei M, Hatakeyama H, Takahashi N, Fukui K, Nammo T, Yoneda K, Inoue Y, Sladek FM, Magnuson MA, Kasai H, Miyagawa J, Gonzalez FJ, Shimomura I.

J Biol Chem. 2006 Feb 24;281(8):5246-57. Epub 2005 Dec 23.PMID: 16377800 [PubMed - indexed for MEDLINE]Related articlesFree article

RIP-Cre revisited, evidence for impairments of pancreatic beta-cell function.

Lee JY, Ristow M, Lin X, White MF, Magnuson MA, Hennighausen L.

J Biol Chem. 2006 Feb 3;281(5):2649-53. Epub 2005 Dec 1.PMID: 16326700 [PubMed - indexed for MEDLINE]Related articlesFree article

Targeted disruption of hepatic frataxin expression causes impaired mitochondrial function, decreased life span and tumor growth in mice.

Thierbach R, Schulz TJ, Isken F, Voigt A, Mietzner B, Drewes G, von Kleist-Retzow JC, Wiesner RJ, Magnuson MA, Puccio H, Pfeiffer AF, Steinberg P, Ristow M.

Hum Mol Genet. 2005 Dec 15;14(24):3857-64. Epub 2005 Nov 8. Erratum in: Hum Mol Genet. 2007 Dec 1;16(23):2987. PMID: 16278235 [PubMed - indexed for MEDLINE]Related articlesFree article

Optical imaging of pancreatic beta cells in living mice expressing a mouse insulin I promoter-firefly luciferase transgene.

Park SY, Wang X, Chen Z, Powers AC, Magnuson MA, Head WS, Piston DW, Bell GI.

Genesis. 2005 Oct;43(2):80-6.PMID: 16108006 [PubMed - indexed for MEDLINE]Related articles

Thiazolidinediones expand body fluid volume through PPARgamma stimulation of ENaC-mediated renal salt absorption.

Guan Y, Hao C, Cha DR, Rao R, Lu W, Kohan DE, Magnuson MA, Redha R, Zhang Y, Breyer MD.

Nat Med. 2005 Aug;11(8):861-6. Epub 2005 Jul 10.PMID: 16007095 [PubMed - indexed for MEDLINE]Related articles

Targeted inactivation of hepatocyte growth factor receptor c-met in beta-cells leads to defective insulin secretion and GLUT-2 downregulation without alteration of beta-cell mass.

Roccisana J, Reddy V, Vasavada RC, Gonzalez-Pertusa JA, Magnuson MA, Garcia-Ocaña A.

Diabetes. 2005 Jul;54(7):2090-102.PMID: 15983210 [PubMed - indexed for MEDLINE]Related articlesFree article

Conditional knockout of macrophage PPARgamma increases atherosclerosis in C57BL/6 and low-density lipoprotein receptor-deficient mice.

Babaev VR, Yancey PG, Ryzhov SV, Kon V, Breyer MD, Magnuson MA, Fazio S, Linton MF.

Arterioscler Thromb Vasc Biol. 2005 Aug;25(8):1647-53. Epub 2005 Jun 9.PMID: 15947238 [PubMed - indexed for MEDLINE]Related articlesFree article

Impaired glucagon secretory responses in mice lacking the type 1 sulfonylurea receptor.

Shiota C, Rocheleau JV, Shiota M, Piston DW, Magnuson MA.

Am J Physiol Endocrinol Metab. 2005 Oct;289(4):E570-7. Epub 2005 Jun 7.PMID: 15941784 [PubMed - indexed for MEDLINE]Related articlesFree article

Imaging Beta cell development in real-time using pancreatic explants from mice with green fluorescent protein-labeled pancreatic Beta cells.

Gunawardana SC, Hara M, Bell GI, Head WS, Magnuson MA, Piston DW.

In Vitro Cell Dev Biol Anim. 2005 Jan-Feb;41(1-2):7-11.PMID: 15926862 [PubMed - indexed for MEDLINE]Related articles

Energy homeostasis and gastrointestinal endocrine differentiation do not require the anorectic hormone peptide YY.

Schonhoff S, Baggio L, Ratineau C, Ray SK, Lindner J, Magnuson MA, Drucker DJ, Leiter AB.

Mol Cell Biol. 2005 May;25(10):4189-99.PMID: 15870288 [PubMed - indexed for MEDLINE]Related articlesFree article

Deletion of PPARgamma in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance.

Jones JR, Barrick C, Kim KA, Lindner J, Blondeau B, Fujimoto Y, Shiota M, Kesterson RA, Kahn BB, Magnuson MA.

Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):6207-12. Epub 2005 Apr 15.PMID: 15833818 [PubMed - indexed for MEDLINE]Related articlesFree article

5-amino-imidazole carboxamide riboside acutely potentiates glucose-stimulated insulin secretion from mouse pancreatic islets by KATP channel-dependent and -independent pathways.

Wang CZ, Wang Y, Di A, Magnuson MA, Ye H, Roe MW, Nelson DJ, Bell GI, Philipson LH.

Biochem Biophys Res Commun. 2005 May 20;330(4):1073-9.PMID: 15823553 [PubMed - indexed for MEDLINE]Related articles

Insights into the structure and regulation of glucokinase from a novel mutation (V62M), which causes maturity-onset diabetes of the young.

Gloyn AL, Odili S, Zelent D, Buettger C, Castleden HA, Steele AM, Stride A, Shiota C, Magnuson MA, Lorini R, d'Annunzio G, Stanley CA, Kwagh J, van Schaftingen E, Veiga-da-Cunha M, Barbetti F, Dunten P, Han Y, Grimsby J, Taub R, Ellard S, Hattersley AT, Matschinsky FM.

J Biol Chem. 2005 Apr 8;280(14):14105-13. Epub 2005 Jan 25.PMID: 15677479 [PubMed - indexed for MEDLINE]Related articlesFree article

Strategies for the use of site-specific recombinases in genome engineering.

Jones JR, Shelton KD, Magnuson MA.

Methods Mol Med. 2005;103:245-57.PMID: 15542911 [PubMed - indexed for MEDLINE]Related articles

The Pal elements in the upstream glucokinase promoter exhibit dyad symmetry and display cell-specific enhancer activity when multimerised.

Moates JM, Magnuson MA.

Diabetologia. 2004 Sep;47(9):1632-40. Epub 2004 Sep 10.PMID: 15365616 [PubMed - indexed for MEDLINE]Related articles

Generation of a conditional allele of the mouse prostaglandin EP4 receptor.

Schneider A, Guan Y, Zhang Y, Magnuson MA, Pettepher C, Loftin CD, Langenbach R, Breyer RM, Breyer MD.

Genesis. 2004 Sep;40(1):7-14.PMID: 15354288 [PubMed - indexed for MEDLINE]Related articles

Impaired tricarboxylic acid cycle activity in mouse livers lacking cytosolic phosphoenolpyruvate carboxykinase.

Burgess SC, Hausler N, Merritt M, Jeffrey FM, Storey C, Milde A, Koshy S, Lindner J, Magnuson MA, Malloy CR, Sherry AD.

J Biol Chem. 2004 Nov 19;279(47):48941-9. Epub 2004 Sep 3.PMID: 15347677 [PubMed - indexed for MEDLINE]Related articlesFree article

Efficient DNA cassette exchange in mouse embryonic stem cells by staggered positive-negative selection.

Long Q, Shelton KD, Lindner J, Jones JR, Magnuson MA.

Genesis. 2004 Aug;39(4):256-62.PMID: 15286998 [PubMed - indexed for MEDLINE]Related articles

Insulin secretory defects and impaired islet architecture in pancreatic beta-cell-specific STAT3 knockout mice.

Gorogawa S, Fujitani Y, Kaneto H, Hazama Y, Watada H, Miyamoto Y, Takeda K, Akira S, Magnuson MA, Yamasaki Y, Kajimoto Y, Hori M.

Biochem Biophys Res Commun. 2004 Jul 9;319(4):1159-70.PMID: 15194489 [PubMed - indexed for MEDLINE]Related articles