PubMed

Interleukin-1 beta targeted therapy for type 2 diabetes.

Maedler K, Dharmadhikari G, Schumann DM, Størling J.

Expert Opin Biol Ther. 2009 Sep;9(9):1177-88.PMID: 19604125 [PubMed - in process]Related articles

Pancreatic beta cells and islets take up thiamin by a regulated carrier-mediated process: studies using mice and human pancreatic preparations.

Mee L, Nabokina SM, Sekar VT, Subramanian VS, Maedler K, Said HM.

Am J Physiol Gastrointest Liver Physiol. 2009 Jul;297(1):G197-206. Epub 2009 May 7.PMID: 19423748 [PubMed - indexed for MEDLINE]Related articles

Purinergic P2X7 receptors regulate secretion of interleukin-1 receptor antagonist and beta cell function and survival.

Glas R, Sauter NS, Schulthess FT, Shu L, Oberholzer J, Maedler K.

Diabetologia. 2009 Aug;52(8):1579-88. Epub 2009 Apr 25.PMID: 19396427 [PubMed - indexed for MEDLINE]Related articlesFree article

Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function.

Shu L, Matveyenko AV, Kerr-Conte J, Cho JH, McIntosh CH, Maedler K.

Hum Mol Genet. 2009 Jul 1;18(13):2388-99. Epub 2009 Apr 21.PMID: 19386626 [PubMed - indexed for MEDLINE]Related articles

Deletion of the mitochondrial flavoprotein apoptosis inducing factor (AIF) induces beta-cell apoptosis and impairs beta-cell mass.

Schulthess FT, Katz S, Ardestani A, Kawahira H, Georgia S, Bosco D, Bhushan A, Maedler K.

PLoS One. 2009;4(2):e4394. Epub 2009 Feb 6.PMID: 19197367 [PubMed - indexed for MEDLINE]Related articlesFree article

CXCL10 impairs beta cell function and viability in diabetes through TLR4 signaling.

Schulthess FT, Paroni F, Sauter NS, Shu L, Ribaux P, Haataja L, Strieter RM, Oberholzer J, King CC, Maedler K.

Cell Metab. 2009 Feb;9(2):125-39.PMID: 19187771 [PubMed - indexed for MEDLINE]Related articles

Identification of ALOX5 as a gene regulating adiposity and pancreatic function.

Mehrabian M, Schulthess FT, Nebohacova M, Castellani LW, Zhou Z, Hartiala J, Oberholzer J, Lusis AJ, Maedler K, Allayee H.

Diabetologia. 2008 Jun;51(6):978-88. Epub 2008 Apr 18.PMID: 18421434 [PubMed - indexed for MEDLINE]Related articles

Glucose and leptin induce apoptosis in human beta-cells and impair glucose-stimulated insulin secretion through activation of c-Jun N-terminal kinases.

Maedler K, Schulthess FT, Bielman C, Berney T, Bonny C, Prentki M, Donath MY, Roduit R.

FASEB J. 2008 Jun;22(6):1905-13. Epub 2008 Feb 8.PMID: 18263705 [PubMed - indexed for MEDLINE]Related articlesFree article

The antiinflammatory cytokine interleukin-1 receptor antagonist protects from high-fat diet-induced hyperglycemia.

Sauter NS, Schulthess FT, Galasso R, Castellani LW, Maedler K.

Endocrinology. 2008 May;149(5):2208-18. Epub 2008 Jan 31.PMID: 18239070 [PubMed - indexed for MEDLINE]Related articlesFree article

UCP-2 and UCP-3 proteins are differentially regulated in pancreatic beta-cells.

Li Y, Maedler K, Shu L, Haataja L.

PLoS One. 2008 Jan 2;3(1):e1397.PMID: 18167556 [PubMed - indexed for MEDLINE]Related articlesFree article

Transcription factor 7-like 2 regulates beta-cell survival and function in human pancreatic islets.

Shu L, Sauter NS, Schulthess FT, Matveyenko AV, Oberholzer J, Maedler K.

Diabetes. 2008 Mar;57(3):645-53. Epub 2007 Dec 10.PMID: 18071026 [PubMed - indexed for MEDLINE]Related articlesFree article

The diabetes-linked transcription factor Pax4 is expressed in human pancreatic islets and is activated by mitogens and GLP-1.

Brun T, He KH, Lupi R, Boehm B, Wojtusciszyn A, Sauter N, Donath M, Marchetti P, Maedler K, Gauthier BR.

Hum Mol Genet. 2008 Feb 15;17(4):478-89. Epub 2007 Nov 7.PMID: 17989064 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta cells in type 2 diabetes - a crucial contribution to pathogenesis.

Maedler K.

Diabetes Obes Metab. 2008 May;10(5):408-20. Epub 2007 Apr 19. Review.PMID: 17451426 [PubMed - indexed for MEDLINE]Related articles

The Fas pathway is involved in pancreatic beta cell secretory function.

Schumann DM, Maedler K, Franklin I, Konrad D, Størling J, Böni-Schnetzler M, Gjinovci A, Kurrer MO, Gauthier BR, Bosco D, Andres A, Berney T, Greter M, Becher B, Chervonsky AV, Halban PA, Mandrup-Poulsen T, Wollheim CB, Donath MY.

Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2861-6. Epub 2007 Feb 13.PMID: 17299038 [PubMed - indexed for MEDLINE]Related articlesFree article

Low concentration of interleukin-1beta induces FLICE-inhibitory protein-mediated beta-cell proliferation in human pancreatic islets.

Maedler K, Schumann DM, Sauter N, Ellingsgaard H, Bosco D, Baertschiger R, Iwakura Y, Oberholzer J, Wollheim CB, Gauthier BR, Donath MY.

Diabetes. 2006 Oct;55(10):2713-22.PMID: 17003335 [PubMed - indexed for MEDLINE]Related articlesFree article

Aging correlates with decreased beta-cell proliferative capacity and enhanced sensitivity to apoptosis: a potential role for Fas and pancreatic duodenal homeobox-1.

Maedler K, Schumann DM, Schulthess F, Oberholzer J, Bosco D, Berney T, Donath MY.

Diabetes. 2006 Sep;55(9):2455-62.PMID: 16936193 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased vulnerability of newly forming beta cells to cytokine-induced cell death.

Meier JJ, Ritzel RA, Maedler K, Gurlo T, Butler PC.

Diabetologia. 2006 Jan;49(1):83-9. Epub 2005 Dec 2.PMID: 16323002 [PubMed - indexed for MEDLINE]Related articles

Mechanisms of beta-cell death in type 2 diabetes.

Donath MY, Ehses JA, Maedler K, Schumann DM, Ellingsgaard H, Eppler E, Reinecke M.

Diabetes. 2005 Dec;54 Suppl 2:S108-13. Review.PMID: 16306327 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of IRS2 in isolated pancreatic islets causes proliferation and protects human beta-cells from hyperglycemia-induced apoptosis.

Mohanty S, Spinas GA, Maedler K, Zuellig RA, Lehmann R, Donath MY, Trüb T, Niessen M.

Exp Cell Res. 2005 Feb 1;303(1):68-78.PMID: 15572028 [PubMed - indexed for MEDLINE]Related articles

Beta-cells in type 2 diabetes: a loss of function and mass.

Maedler K, Donath MY.

Horm Res. 2004;62 Suppl 3:67-73. Review.PMID: 15539803 [PubMed - indexed for MEDLINE]Related articles

Sulfonylurea induced beta-cell apoptosis in cultured human islets.

Maedler K, Carr RD, Bosco D, Zuellig RA, Berney T, Donath MY.

J Clin Endocrinol Metab. 2005 Jan;90(1):501-6. Epub 2004 Oct 13.PMID: 15483097 [PubMed - indexed for MEDLINE]Related articlesFree article

Pioglitazone and sodium salicylate protect human beta-cells against apoptosis and impaired function induced by glucose and interleukin-1beta.

Zeender E, Maedler K, Bosco D, Berney T, Donath MY, Halban PA.

J Clin Endocrinol Metab. 2004 Oct;89(10):5059-66.PMID: 15472206 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of Fas but not Fas ligand on fetal pig beta cells.

Bai L, Maedler K, Donath M, Tuch BE.

Xenotransplantation. 2004 Sep;11(5):426-35.PMID: 15303979 [PubMed - indexed for MEDLINE]Related articles

Extracellular matrix protects pancreatic beta-cells against apoptosis: role of short- and long-term signaling pathways.

Hammar E, Parnaud G, Bosco D, Perriraz N, Maedler K, Donath M, Rouiller DG, Halban PA.

Diabetes. 2004 Aug;53(8):2034-41.PMID: 15277383 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose- and interleukin-1beta-induced beta-cell apoptosis requires Ca2+ influx and extracellular signal-regulated kinase (ERK) 1/2 activation and is prevented by a sulfonylurea receptor 1/inwardly rectifying K+ channel 6.2 (SUR/Kir6.2) selective potassium channel opener in human islets.

Maedler K, Størling J, Sturis J, Zuellig RA, Spinas GA, Arkhammar PO, Mandrup-Poulsen T, Donath MY.

Diabetes. 2004 Jul;53(7):1706-13.PMID: 15220194 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin modulates beta cell expression of IL-1 receptor antagonist and release of IL-1beta in human islets.

Maedler K, Sergeev P, Ehses JA, Mathe Z, Bosco D, Berney T, Dayer JM, Reinecke M, Halban PA, Donath MY.

Proc Natl Acad Sci U S A. 2004 May 25;101(21):8138-43. Epub 2004 May 12.PMID: 15141093 [PubMed - indexed for MEDLINE]Related articlesFree article

Inflammatory mediators and islet beta-cell failure: a link between type 1 and type 2 diabetes.

Donath MY, Størling J, Maedler K, Mandrup-Poulsen T.

J Mol Med. 2003 Aug;81(8):455-70. Epub 2003 Jul 18. Review.PMID: 12879149 [PubMed - indexed for MEDLINE]Related articles

Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function.

Maedler K, Oberholzer J, Bucher P, Spinas GA, Donath MY.

Diabetes. 2003 Mar;52(3):726-33.PMID: 12606514 [PubMed - indexed for MEDLINE]Related articlesFree article

[The pathogenesis of type 2 diabetes--new aspects and clinical consequences]

Donath MY, Maedler K, Sergeev P, Dyntar D, Thomas D, Spinas GA.

Ther Umsch. 2002 Aug;59(8):381-5. German. PMID: 12235729 [PubMed - indexed for MEDLINE]Related articles

Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets.

Maedler K, Sergeev P, Ris F, Oberholzer J, Joller-Jemelka HI, Spinas GA, Kaiser N, Halban PA, Donath MY.

J Clin Invest. 2002 Sep;110(6):851-60.PMID: 12235117 [PubMed - indexed for MEDLINE]Related articlesFree article

Impact of integrin-matrix matching and inhibition of apoptosis on the survival of purified human beta-cells in vitro.

Ris F, Hammar E, Bosco D, Pilloud C, Maedler K, Donath MY, Oberholzer J, Zeender E, Morel P, Rouiller D, Halban PA.

Diabetologia. 2002 Jun;45(6):841-50. Epub 2002 May 8.PMID: 12107728 [PubMed - indexed for MEDLINE]Related articles

FLIP switches Fas-mediated glucose signaling in human pancreatic beta cells from apoptosis to cell replication.

Maedler K, Fontana A, Ris F, Sergeev P, Toso C, Oberholzer J, Lehmann R, Bachmann F, Tasinato A, Spinas GA, Halban PA, Donath MY.

Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8236-41.PMID: 12060768 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose and palmitic acid induce degeneration of myofibrils and modulate apoptosis in rat adult cardiomyocytes.

Dyntar D, Eppenberger-Eberhardt M, Maedler K, Pruschy M, Eppenberger HM, Spinas GA, Donath MY.

Diabetes. 2001 Sep;50(9):2105-13.PMID: 11522678 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose induces beta-cell apoptosis via upregulation of the Fas receptor in human islets.

Maedler K, Spinas GA, Lehmann R, Sergeev P, Weber M, Fontana A, Kaiser N, Donath MY.

Diabetes. 2001 Aug;50(8):1683-90.PMID: 11473025 [PubMed - indexed for MEDLINE]Related articlesFree article

Distinct effects of saturated and monounsaturated fatty acids on beta-cell turnover and function.

Maedler K, Spinas GA, Dyntar D, Moritz W, Kaiser N, Donath MY.

Diabetes. 2001 Jan;50(1):69-76.PMID: 11147797 [PubMed - indexed for MEDLINE]Related articlesFree article