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Peroxisome proliferator-activated receptor alpha (PPARalpha) protects against oleate-induced INS-1E beta cell dysfunction by preserving carbohydrate metabolism.

Frigerio F, Brun T, Bartley C, Usardi A, Bosco D, Ravnskjær K, Mandrup S, Maechler P.

Diabetologia. 2009 Nov 12. [Epub ahead of print]PMID: 19908022 [PubMed - as supplied by publisher]Related articles

Saturated fatty acid-induced insulin resistance is associated with mitochondrial dysfunction in skeletal muscle cells.

Hirabara SM, Curi R, Maechler P.

J Cell Physiol. 2010 Jan;222(1):187-94.PMID: 19780047 [PubMed - in process]Related articles

Silencing of the mitochondrial NADH shuttle component aspartate-glutamate carrier AGC1/Aralar1 in INS-1E cells and rat islets.

Casimir M, Rubi B, Frigerio F, Chaffard G, Maechler P.

Biochem J. 2009 Dec 10;424(3):459-66.PMID: 19764902 [PubMed - in process]Related articlesFree article

Adenovector GAD65 gene delivery into the rat trigeminal ganglion produces orofacial analgesia.

Vit JP, Ohara PT, Sundberg C, Rubi B, Maechler P, Liu C, Puntel M, Lowenstein P, Castro M, Jasmin L.

Mol Pain. 2009 Aug 5;5:42.PMID: 19656360 [PubMed - indexed for MEDLINE]Related articlesFree article

Mitochondrial glutamate carrier GC1 as a newly identified player in the control of glucose-stimulated insulin secretion.

Casimir M, Lasorsa FM, Rubi B, Caille D, Palmieri F, Meda P, Maechler P.

J Biol Chem. 2009 Sep 11;284(37):25004-14. Epub 2009 Jul 7.PMID: 19584051 [PubMed - indexed for MEDLINE]Related articles

Transient oxidative stress damages mitochondrial machinery inducing persistent beta-cell dysfunction.

Li N, Brun T, Cnop M, Cunha DA, Eizirik DL, Maechler P.

J Biol Chem. 2009 Aug 28;284(35):23602-12. Epub 2009 Jun 22.PMID: 19546218 [PubMed - indexed for MEDLINE]Related articles

Overexpression of the malate-aspartate NADH shuttle member Aralar1 in the clonal beta-cell line BRIN-BD11 enhances amino-acid-stimulated insulin secretion and cell metabolism.

Bender K, Maechler P, McClenaghan NH, Flatt PR, Newsholme P.

Clin Sci (Lond). 2009 Sep 1;117(9):321-30.PMID: 19344310 [PubMed - indexed for MEDLINE]Related articles

Deletion of glutamate dehydrogenase in beta-cells abolishes part of the insulin secretory response not required for glucose homeostasis.

Carobbio S, Frigerio F, Rubi B, Vetterli L, Bloksgaard M, Gjinovci A, Pournourmohammadi S, Herrera PL, Reith W, Mandrup S, Maechler P.

J Biol Chem. 2009 Jan 9;284(2):921-9. Epub 2008 Nov 17.PMID: 19015267 [PubMed - indexed for MEDLINE]Related articles

Preventing mitochondrial fission impairs mitochondrial function and leads to loss of mitochondrial DNA.

Parone PA, Da Cruz S, Tondera D, Mattenberger Y, James DI, Maechler P, Barja F, Martinou JC.

PLoS One. 2008 Sep 22;3(9):e3257.PMID: 18806874 [PubMed - indexed for MEDLINE]Related articlesFree article

The sensitivity of pancreatic beta-cells to mitochondrial injuries triggered by lipotoxicity and oxidative stress.

Li N, Frigerio F, Maechler P.

Biochem Soc Trans. 2008 Oct;36(Pt 5):930-4. Review.PMID: 18793163 [PubMed - indexed for MEDLINE]Related articles

Tissue specificity of mitochondrial glutamate pathways and the control of metabolic homeostasis.

Frigerio F, Casimir M, Carobbio S, Maechler P.

Biochim Biophys Acta. 2008 Jul-Aug;1777(7-8):965-72. Epub 2008 Apr 30. Review.PMID: 18486589 [PubMed - indexed for MEDLINE]Related articles

Functional significance of repressor element 1 silencing transcription factor (REST) target genes in pancreatic beta cells.

Martin D, Allagnat F, Chaffard G, Caille D, Fukuda M, Regazzi R, Abderrahmani A, Waeber G, Meda P, Maechler P, Haefliger JA.

Diabetologia. 2008 Aug;51(8):1429-39. Epub 2008 Apr 3.PMID: 18385973 [PubMed - indexed for MEDLINE]Related articles

Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase.

Ahuja N, Schwer B, Carobbio S, Waltregny D, North BJ, Castronovo V, Maechler P, Verdin E.

J Biol Chem. 2007 Nov 16;282(46):33583-92. Epub 2007 Aug 22.PMID: 17715127 [PubMed - indexed for MEDLINE]Related articlesFree article

Mitochondrial damages and the regulation of insulin secretion.

Maechler P, de Andrade PB.

Biochem Soc Trans. 2006 Nov;34(Pt 5):824-7.PMID: 17052207 [PubMed - indexed for MEDLINE]Related articles

The importance of redox shuttles to pancreatic beta-cell energy metabolism and function.

Bender K, Newsholme P, Brennan L, Maechler P.

Biochem Soc Trans. 2006 Nov;34(Pt 5):811-4.PMID: 17052204 [PubMed - indexed for MEDLINE]Related articles

The antiepileptic drug topiramate preserves metabolism-secretion coupling in insulin secreting cells chronically exposed to the fatty acid oleate.

Frigerio F, Chaffard G, Berwaer M, Maechler P.

Biochem Pharmacol. 2006 Oct 16;72(8):965-73. Epub 2006 Aug 28.PMID: 16934763 [PubMed - indexed for MEDLINE]Related articles

Dopamine modulates von Willebrand factor secretion in endothelial cells via D2-D4 receptors.

Zarei S, Frieden M, Rubi B, Villemin P, Gauthier BR, Maechler P, Vischer UM.

J Thromb Haemost. 2006 Jul;4(7):1588-95.PMID: 16839358 [PubMed - indexed for MEDLINE]Related articles

Diabetes-associated mitochondrial DNA mutation A3243G impairs cellular metabolic pathways necessary for beta cell function.

de Andrade PB, Rubi B, Frigerio F, van den Ouweland JM, Maassen JA, Maechler P.

Diabetologia. 2006 Aug;49(8):1816-26. Epub 2006 May 31.PMID: 16736129 [PubMed - indexed for MEDLINE]Related articles

In beta-cells, mitochondria integrate and generate metabolic signals controlling insulin secretion.

Maechler P, Carobbio S, Rubi B.

Int J Biochem Cell Biol. 2006;38(5-6):696-709. Epub 2006 Jan 6. Review.PMID: 16443386 [PubMed - indexed for MEDLINE]Related articles

Vesicular storage and secretion of L-glutamate from glucagon-like peptide 1-secreting clonal intestinal L cells.

Uehara S, Jung SK, Morimoto R, Arioka S, Miyaji T, Juge N, Hiasa M, Shimizu K, Ishimura A, Otsuka M, Yamamoto A, Maechler P, Moriyama Y.

J Neurochem. 2006 Jan;96(2):550-60. Epub 2005 Dec 8.PMID: 16336630 [PubMed - indexed for MEDLINE]Related articles

Dopamine D2-like receptors are expressed in pancreatic beta cells and mediate inhibition of insulin secretion.

Rubí B, Ljubicic S, Pournourmohammadi S, Carobbio S, Armanet M, Bartley C, Maechler P.

J Biol Chem. 2005 Nov 4;280(44):36824-32. Epub 2005 Aug 29.PMID: 16129680 [PubMed - indexed for MEDLINE]Related articlesFree article

Peroxisome proliferator-activated receptor alpha (PPARalpha) potentiates, whereas PPARgamma attenuates, glucose-stimulated insulin secretion in pancreatic beta-cells.

Ravnskjaer K, Boergesen M, Rubi B, Larsen JK, Nielsen T, Fridriksson J, Maechler P, Mandrup S.

Endocrinology. 2005 Aug;146(8):3266-76. Epub 2005 May 5.PMID: 15878969 [PubMed - indexed for MEDLINE]Related articlesFree article

Alteration of the malonyl-CoA/carnitine palmitoyltransferase I interaction in the beta-cell impairs glucose-induced insulin secretion.

Herrero L, Rubí B, Sebastián D, Serra D, Asins G, Maechler P, Prentki M, Hegardt FG.

Diabetes. 2005 Feb;54(2):462-71.PMID: 15677504 [PubMed - indexed for MEDLINE]Related articlesFree article

Mitochondrial activation and the pyruvate paradox in a human cell line.

de Andrade PB, Casimir M, Maechler P.

FEBS Lett. 2004 Dec 17;578(3):224-8.PMID: 15589824 [PubMed - indexed for MEDLINE]Related articles

New insights into amino acid metabolism, beta-cell function and diabetes.

Newsholme P, Brennan L, Rubi B, Maechler P.

Clin Sci (Lond). 2005 Mar;108(3):185-94. Review.PMID: 15544573 [PubMed - indexed for MEDLINE]Related articles

Sustained glucose-stimulated insulin secretion in mouse islets is not culture-dependent.

Carobbio S, Maechler P.

Diabetologia. 2004 Oct;47(10):1856-7. Epub 2004 Oct 22. No abstract available. PMID: 15502918 [PubMed - indexed for MEDLINE]Related articles

The malate-aspartate NADH shuttle member Aralar1 determines glucose metabolic fate, mitochondrial activity, and insulin secretion in beta cells.

Rubi B, del Arco A, Bartley C, Satrustegui J, Maechler P.

J Biol Chem. 2004 Dec 31;279(53):55659-66. Epub 2004 Oct 19.PMID: 15494407 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin secretion profiles are modified by overexpression of glutamate dehydrogenase in pancreatic islets.

Carobbio S, Ishihara H, Fernandez-Pascual S, Bartley C, Martin-Del-Rio R, Maechler P.

Diabetologia. 2004 Feb;47(2):266-76. Epub 2003 Dec 20.PMID: 14689183 [PubMed - indexed for MEDLINE]Related articles

Novel regulation of insulin secretion: the role of mitochondria.

Maechler P.

Curr Opin Investig Drugs. 2003 Oct;4(10):1166-72. Review.PMID: 14649207 [PubMed - indexed for MEDLINE]Related articles

Glucose sensitivity and metabolism-secretion coupling studied during two-year continuous culture in INS-1E insulinoma cells.

Merglen A, Theander S, Rubi B, Chaffard G, Wollheim CB, Maechler P.

Endocrinology. 2004 Feb;145(2):667-78. Epub 2003 Oct 30.PMID: 14592952 [PubMed - indexed for MEDLINE]Related articlesFree article

A high carbohydrate diet does not induce hyperglycaemia in a mitochondrial glycerol-3-phosphate dehydrogenase-deficient mouse.

Barberà A, Gudayol M, Eto K, Corominola H, Maechler P, Miró O, Cardellach F, Gomis R.

Diabetologia. 2003 Oct;46(10):1394-401. Epub 2003 Sep 13.PMID: 13680126 [PubMed - indexed for MEDLINE]Related articles

Mitochondria-derived glutamate at the interplay between branched-chain amino acid and glucose-induced insulin secretion.

Broca C, Brennan L, Petit P, Newsholme P, Maechler P.

FEBS Lett. 2003 Jun 19;545(2-3):167-72.PMID: 12804769 [PubMed - indexed for MEDLINE]Related articles

Connexin-36 contributes to control function of insulin-producing cells.

Le Gurun S, Martin D, Formenton A, Maechler P, Caille D, Waeber G, Meda P, Haefliger JA.

J Biol Chem. 2003 Sep 26;278(39):37690-7. Epub 2003 May 22.PMID: 12766175 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of mitochondrial Na+-Ca2+ exchanger increases mitochondrial metabolism and potentiates glucose-stimulated insulin secretion in rat pancreatic islets.

Lee B, Miles PD, Vargas L, Luan P, Glasco S, Kushnareva Y, Kornbrust ES, Grako KA, Wollheim CB, Maechler P, Olefsky JM, Anderson CM.

Diabetes. 2003 Apr;52(4):965-73.PMID: 12663468 [PubMed - indexed for MEDLINE]Related articlesFree article

Islet beta-cell secretion determines glucagon release from neighbouring alpha-cells.

Ishihara H, Maechler P, Gjinovci A, Herrera PL, Wollheim CB.

Nat Cell Biol. 2003 Apr;5(4):330-5.PMID: 12640462 [PubMed - indexed for MEDLINE]Related articles

The transcription factor SREBP-1c is instrumental in the development of beta-cell dysfunction.

Wang H, Maechler P, Antinozzi PA, Herrero L, Hagenfeldt-Johansson KA, Bjorklund A, Wollheim CB.

J Biol Chem. 2003 May 9;278(19):16622-9. Epub 2003 Feb 24.PMID: 12600983 [PubMed - indexed for MEDLINE]Related articlesFree article

Mitochondria as the conductor of metabolic signals for insulin exocytosis in pancreatic beta-cells.

Maechler P.

Cell Mol Life Sci. 2002 Nov;59(11):1803-18. Review.PMID: 12530515 [PubMed - indexed for MEDLINE]Related articles

Increase in cellular glutamate levels stimulates exocytosis in pancreatic beta-cells.

Høy M, Maechler P, Efanov AM, Wollheim CB, Berggren PO, Gromada J.

FEBS Lett. 2002 Nov 6;531(2):199-203.PMID: 12417312 [PubMed - indexed for MEDLINE]Related articles

Adenovirus-mediated overexpression of liver carnitine palmitoyltransferase I in INS1E cells: effects on cell metabolism and insulin secretion.

Rubí B, Antinozzi PA, Herrero L, Ishihara H, Asins G, Serra D, Wollheim CB, Maechler P, Hegardt FG.

Biochem J. 2002 May 15;364(Pt 1):219-26.PMID: 11988095 [PubMed - indexed for MEDLINE]Related articlesFree article

Mitochondria respond to Ca2+ already in the submicromolar range: correlation with redox state.

Pitter JG, Maechler P, Wollheim CB, Spät A.

Cell Calcium. 2002 Feb;31(2):97-104.PMID: 11969250 [PubMed - indexed for MEDLINE]Related articles

Implication of glutamate in the kinetics of insulin secretion in rat and mouse perfused pancreas.

Maechler P, Gjinovci A, Wollheim CB.

Diabetes. 2002 Feb;51 Suppl 1:S99-102.PMID: 11815466 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta-cell mitochondria and insulin secretion: messenger role of nucleotides and metabolites.

Wollheim CB, Maechler P.

Diabetes. 2002 Feb;51 Suppl 1:S37-42. Review.PMID: 11815456 [PubMed - indexed for MEDLINE]Related articlesFree article

Mitochondrial function in normal and diabetic beta-cells.

Maechler P, Wollheim CB.

Nature. 2001 Dec 13;414(6865):807-12. Review.PMID: 11742413 [PubMed - indexed for MEDLINE]Related articles

GAD65-mediated glutamate decarboxylation reduces glucose-stimulated insulin secretion in pancreatic beta cells.

Rubi B, Ishihara H, Hegardt FG, Wollheim CB, Maechler P.

J Biol Chem. 2001 Sep 28;276(39):36391-6. Epub 2001 Jul 25.PMID: 11473118 [PubMed - indexed for MEDLINE]Related articlesFree article

Pdx1 level defines pancreatic gene expression pattern and cell lineage differentiation.

Wang H, Maechler P, Ritz-Laser B, Hagenfeldt KA, Ishihara H, Philippe J, Wollheim CB.

J Biol Chem. 2001 Jul 6;276(27):25279-86. Epub 2001 Apr 17.PMID: 11309388 [PubMed - indexed for MEDLINE]Related articles

Modulation of glutamate generation in mitochondria affects hormone secretion in INS-1E beta cells.

Maechler P, Antinozzi PA, Wollheim CB.

IUBMB Life. 2000 Jul;50(1):27-31.PMID: 11087117 [PubMed - indexed for MEDLINE]Related articles

Mitochondrial signals in glucose-stimulated insulin secretion in the beta cell.

Maechler P, Wollheim CB.

J Physiol. 2000 Nov 15;529 Pt 1:49-56. Review.PMID: 11080250 [PubMed - indexed for MEDLINE]Related articlesFree article

Mitochondrial calcium oscillations in C2C12 myotubes.

Challet C, Maechler P, Wollheim CB, Ruegg UT.

J Biol Chem. 2001 Feb 9;276(6):3791-7. Epub 2000 Oct 17.PMID: 11036072 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatocyte nuclear factor 4alpha regulates the expression of pancreatic beta -cell genes implicated in glucose metabolism and nutrient-induced insulin secretion.

Wang H, Maechler P, Antinozzi PA, Hagenfeldt KA, Wollheim CB.

J Biol Chem. 2000 Nov 17;275(46):35953-9.PMID: 10967120 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular targets of a human HNF1 alpha mutation responsible for pancreatic beta-cell dysfunction.

Wang H, Antinozzi PA, Hagenfeldt KA, Maechler P, Wollheim CB.

EMBO J. 2000 Aug 15;19(16):4257-64.PMID: 10944108 [PubMed - indexed for MEDLINE]Related articlesFree article