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Inhibitory effects of nordihydroguaiaretic acid (NDGA) on the IGF-1 receptor and androgen dependent growth of LAPC-4 prostate cancer cells.

Ryan CJ, Zavodovskaya M, Youngren JF, Campbell M, Diamond M, Jones J, Shiry L, Allan G, Maddux BA, Goldfine ID.

Prostate. 2008 Aug 1;68(11):1232-40.PMID: 18491370 [PubMed - indexed for MEDLINE]Related articles

The role of membrane glycoprotein plasma cell antigen 1/ectonucleotide pyrophosphatase phosphodiesterase 1 in the pathogenesis of insulin resistance and related abnormalities.

Goldfine ID, Maddux BA, Youngren JF, Reaven G, Accili D, Trischitta V, Vigneri R, Frittitta L.

Endocr Rev. 2008 Feb;29(1):62-75. Epub 2008 Jan 16. Review. Erratum in: Endocr Rev. 2009 Feb;30(1):117. PMID: 18199690 [PubMed - indexed for MEDLINE]Related articlesFree article

Nordihydroguaiaretic acid (NDGA), an inhibitor of the HER2 and IGF-1 receptor tyrosine kinases, blocks the growth of HER2-overexpressing human breast cancer cells.

Zavodovskaya M, Campbell MJ, Maddux BA, Shiry L, Allan G, Hodges L, Kushner P, Kerner JA, Youngren JF, Goldfine ID.

J Cell Biochem. 2008 Feb 1;103(2):624-35.PMID: 17562544 [PubMed - indexed for MEDLINE]Related articles

Nordihydroguaiaretic acid inhibits insulin-like growth factor signaling, growth, and survival in human neuroblastoma cells.

Meyer GE, Chesler L, Liu D, Gable K, Maddux BA, Goldenberg DD, Youngren JF, Goldfine ID, Weiss WA, Matthay KK, Rosenthal SM.

J Cell Biochem. 2007 Dec 15;102(6):1529-41.PMID: 17486636 [PubMed - indexed for MEDLINE]Related articles

Parallel synthesis of diarylureas and their evaluation as inhibitors of insulin-like growth factor receptor.

Anderson MO, Yu H, Penaranda C, Maddux BA, Goldfine ID, Youngren JF, Guy RK.

J Comb Chem. 2006 Sep-Oct;8(5):784-90.PMID: 16961415 [PubMed - indexed for MEDLINE]Related articles

IGF-binding protein-1 levels are related to insulin-mediated glucose disposal and are a potential serum marker of insulin resistance.

Maddux BA, Chan A, De Filippis EA, Mandarino LJ, Goldfine ID.

Diabetes Care. 2006 Jul;29(7):1535-7. Erratum in: Diabetes Care. 2006 Nov;29(11):2571. De Filippis, Elena A [added]. PMID: 16801575 [PubMed - indexed for MEDLINE]Related articlesFree article

Diarylureas are small-molecule inhibitors of insulin-like growth factor I receptor signaling and breast cancer cell growth.

Gable KL, Maddux BA, Penaranda C, Zavodovskaya M, Campbell MJ, Lobo M, Robinson L, Schow S, Kerner JA, Goldfine ID, Youngren JF.

Mol Cancer Ther. 2006 Apr;5(4):1079-86.PMID: 16648580 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of the insulin receptor inhibitor PC-1/ENPP1 induces insulin resistance and hyperglycemia.

Maddux BA, Chang YN, Accili D, McGuinness OP, Youngren JF, Goldfine ID.

Am J Physiol Endocrinol Metab. 2006 Apr;290(4):E746-9. Epub 2005 Nov 8.PMID: 16278247 [PubMed - indexed for MEDLINE]Related articlesFree article

Nordihydroguaiaretic acid (NDGA) inhibits the IGF-1 and c-erbB2/HER2/neu receptors and suppresses growth in breast cancer cells.

Youngren JF, Gable K, Penaranda C, Maddux BA, Zavodovskaya M, Lobo M, Campbell M, Kerner J, Goldfine ID.

Breast Cancer Res Treat. 2005 Nov;94(1):37-46.PMID: 16142439 [PubMed - indexed for MEDLINE]Related articles

Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes.

Meyre D, Bouatia-Naji N, Tounian A, Samson C, Lecoeur C, Vatin V, Ghoussaini M, Wachter C, Hercberg S, Charpentier G, Patsch W, Pattou F, Charles MA, Tounian P, Clément K, Jouret B, Weill J, Maddux BA, Goldfine ID, Walley A, Boutin P, Dina C, Froguel P.

Nat Genet. 2005 Aug;37(8):863-7. Epub 2005 Jul 17.PMID: 16025115 [PubMed - indexed for MEDLINE]Related articlesFree article

The molecular basis for oxidative stress-induced insulin resistance.

Evans JL, Maddux BA, Goldfine ID.

Antioxid Redox Signal. 2005 Jul-Aug;7(7-8):1040-52. Review.PMID: 15998259 [PubMed - indexed for MEDLINE]Related articles

Analysis of insulin-stimulated insulin receptor activation and glucose transport in cultured skeletal muscle cells from obese subjects.

Pender C, Goldfine ID, Kulp JL, Tanner CJ, Maddux BA, MacDonald KG, Houmard JA, Youngren JF.

Metabolism. 2005 May;54(5):598-603.PMID: 15877289 [PubMed - indexed for MEDLINE]Related articles

Increased hepatic levels of the insulin receptor inhibitor, PC-1/NPP1, induce insulin resistance and glucose intolerance.

Dong H, Maddux BA, Altomonte J, Meseck M, Accili D, Terkeltaub R, Johnson K, Youngren JF, Goldfine ID.

Diabetes. 2005 Feb;54(2):367-72.PMID: 15677494 [PubMed - indexed for MEDLINE]Related articlesFree article

Structure-based de novo design of ligands using a three-dimensional model of the insulin receptor.

Tan C, Wei L, Ottensmeyer FP, Goldfine I, Maddux BA, Yip CC, Batey RA, Kotra LP.

Bioorg Med Chem Lett. 2004 Mar 22;14(6):1407-10.PMID: 15006372 [PubMed - indexed for MEDLINE]Related articles

Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction?

Evans JL, Goldfine ID, Maddux BA, Grodsky GM.

Diabetes. 2003 Jan;52(1):1-8. Review.PMID: 12502486 [PubMed - indexed for MEDLINE]Related articlesFree article

Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes.

Evans JL, Goldfine ID, Maddux BA, Grodsky GM.

Endocr Rev. 2002 Oct;23(5):599-622. Review.PMID: 12372842 [PubMed - indexed for MEDLINE]Related articlesFree article

Decreased insulin receptor (IR) autophosphorylation in fibroblasts from patients with PCOS: effects of serine kinase inhibitors and IR activators.

Li M, Youngren JF, Dunaif A, Goldfine ID, Maddux BA, Zhang BB, Evans JL.

J Clin Endocrinol Metab. 2002 Sep;87(9):4088-93.PMID: 12213853 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of insulin receptor function by a small molecule insulin receptor activator.

Pender C, Goldfine ID, Manchem VP, Evans JL, Spevak WR, Shi S, Rao S, Bajjalieh S, Maddux BA, Youngren JF.

J Biol Chem. 2002 Nov 15;277(46):43565-71. Epub 2002 Sep 3.PMID: 12213804 [PubMed - indexed for MEDLINE]Related articlesFree article

Small molecule insulin receptor activators potentiate insulin action in insulin-resistant cells.

Li M, Youngren JF, Manchem VP, Kozlowski M, Zhang BB, Maddux BA, Goldfine ID.

Diabetes. 2001 Oct;50(10):2323-8.PMID: 11574415 [PubMed - indexed for MEDLINE]Related articlesFree article

Protection against oxidative stress-induced insulin resistance in rat L6 muscle cells by mircomolar concentrations of alpha-lipoic acid.

Maddux BA, See W, Lawrence JC Jr, Goldfine AL, Goldfine ID, Evans JL.

Diabetes. 2001 Feb;50(2):404-10.PMID: 11272154 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of PC-1 in the etiology of insulin resistance.

Goldfine ID, Maddux BA, Youngren JF, Trischitta V, Frittitta L.

Ann N Y Acad Sci. 1999 Nov 18;892:204-22. Review.PMID: 10842664 [PubMed - indexed for MEDLINE]Related articles

Membrane glycoprotein PC-1 inhibition of insulin receptor function occurs via direct interaction with the receptor alpha-subunit.

Maddux BA, Goldfine ID.

Diabetes. 2000 Jan;49(1):13-9.PMID: 10615944 [PubMed - indexed for MEDLINE]Related articlesFree article

A soluble PC-1 circulates in human plasma: relationship with insulin resistance and associated abnormalities.

Frittitta L, Camastra S, Baratta R, Costanzo BV, D'Adamo M, Graci S, Spampinato D, Maddux BA, Vigneri R, Ferrannini E, Trischitta V.

J Clin Endocrinol Metab. 1999 Oct;84(10):3620-5.PMID: 10523005 [PubMed - indexed for MEDLINE]Related articlesFree article

Membrane glycoprotein PC-1 and insulin resistance.

Goldfine ID, Maddux BA, Youngren JF, Frittitta L, Trischitta V, Dohm GL.

Mol Cell Biochem. 1998 May;182(1-2):177-84. Review.PMID: 9609127 [PubMed - indexed for MEDLINE]Related articles

Overexpression of membrane glycoprotein PC-1 can influence insulin action at a post-receptor site.

Kumakura S, Maddux BA, Sung CK.

J Cell Biochem. 1998 Mar 1;68(3):366-77.PMID: 9518262 [PubMed - indexed for MEDLINE]Related articles

PC-1 content in skeletal muscle of non-obese, non-diabetic subjects: relationship to insulin receptor tyrosine kinase and whole body insulin sensitivity.

Frittitta L, Youngren J, Vigneri R, Maddux BA, Trischitta V, Goldfine ID.

Diabetologia. 1996 Oct;39(10):1190-5.PMID: 8897006 [PubMed - indexed for MEDLINE]Related articles

Skeletal muscle content of membrane glycoprotein PC-1 in obesity. Relationship to muscle glucose transport.

Youngren JF, Maddux BA, Sasson S, Sbraccia P, Tapscott EB, Swanson MS, Dohm GL, Goldfine ID.

Diabetes. 1996 Oct;45(10):1324-8.PMID: 8826966 [PubMed - indexed for MEDLINE]Related articles

Membrane glycoprotein PC-1 and insulin resistance in non-insulin-dependent diabetes mellitus.

Maddux BA, Sbraccia P, Kumakura S, Sasson S, Youngren J, Fisher A, Spencer S, Grupe A, Henzel W, Stewart TA, et al.

Nature. 1995 Feb 2;373(6513):448-51.PMID: 7830796 [PubMed - indexed for MEDLINE]Related articles

Characterization of human placental insulin-like growth factor-I/insulin hybrid receptors by protein microsequencing and purification.

Kasuya J, Paz IB, Maddux BA, Goldfine ID, Hefta SA, Fujita-Yamaguchi Y.

Biochemistry. 1993 Dec 14;32(49):13531-6.PMID: 8257688 [PubMed - indexed for MEDLINE]Related articles

Inhibitors of insulin receptor tyrosine kinase in fibroblasts from diverse patients with impaired insulin action: evidence for a novel mechanism of postreceptor insulin resistance.

Maddux BA, Sbraccia P, Reaven GM, Moller DE, Goldfine ID.

J Clin Endocrinol Metab. 1993 Jul;77(1):73-9.PMID: 7686917 [PubMed - indexed for MEDLINE]Related articles

High-affinity insulin binding to an atypical insulin-like growth factor-I receptor in human breast cancer cells.

Milazzo G, Yip CC, Maddux BA, Vigneri R, Goldfine ID.

J Clin Invest. 1992 Mar;89(3):899-908.PMID: 1311720 [PubMed - indexed for MEDLINE]Related articlesFree article

Transmembrane signalling by insulin via an insulin receptor mutated at tyrosines 1158, 1162, and 1163.

Rafaeloff R, Maddux BA, Brunetti A, Sbraccia P, Sung CK, Patel R, Hawley DM, Goldfine ID.

Biochem Biophys Res Commun. 1991 Sep 16;179(2):912-8.PMID: 1898412 [PubMed - indexed for MEDLINE]Related articles

Progestins induce down-regulation of insulin-like growth factor-I (IGF-I) receptors in human breast cancer cells: potential autocrine role of IGF-II.

Papa V, Hartmann KK, Rosenthal SM, Maddux BA, Siiteri PK, Goldfine ID.

Mol Endocrinol. 1991 May;5(5):709-17.PMID: 1649393 [PubMed - indexed for MEDLINE]Related articles

Evidence that insulin plus ATP may induce a conformational change in the beta subunit of the insulin receptor without inducing receptor autophosphorylation.

Maddux BA, Goldfine ID.

J Biol Chem. 1991 Apr 15;266(11):6731-6.PMID: 1849890 [PubMed - indexed for MEDLINE]Related articlesFree article

Production of inhibitor of insulin-receptor tyrosine kinase in fibroblasts from patient with insulin resistance and NIDDM.

Sbraccia P, Goodman PA, Maddux BA, Wong KY, Chen YD, Reaven GM, Goldfine ID.

Diabetes. 1991 Feb;40(2):295-9.PMID: 1846830 [PubMed - indexed for MEDLINE]Related articles

Regulating insulin-receptor-gene expression by differentiation and hormones.

Mamula PW, McDonald AR, Brunetti A, Okabayashi Y, Wong KY, Maddux BA, Logsdon C, Goldfine ID.

Diabetes Care. 1990 Mar;13(3):288-301. Review.PMID: 2407479 [PubMed - indexed for MEDLINE]Related articles

Monoclonal antibodies to the human insulin receptor mimic a spectrum of biological effects in transfected 3T3/HIR fibroblasts without activating receptor kinase.

Brunetti A, Maddux BA, Wong KY, Hofmann C, Whittaker J, Sung C, Goldfine ID.

Biochem Biophys Res Commun. 1989 Nov 30;165(1):212-8.PMID: 2556135 [PubMed - indexed for MEDLINE]Related articles

Monoclonal antibodies mimic insulin activation of ribosomal protein S6 kinase without activation of insulin receptor tyrosine kinase. Studies in cells transfected with normal and mutant human insulin receptors.

Sung CK, Maddux BA, Hawley DM, Goldfine ID.

J Biol Chem. 1989 Nov 15;264(32):18951-9.PMID: 2553727 [PubMed - indexed for MEDLINE]Related articlesFree article

Human insulin receptor radioimmunoassay: applicability to insulin-resistant states.

Pezzino V, Papa V, Trischitta V, Brunetti A, Goodman PA, Treutelaar MK, Williams JA, Maddux BA, Vigneri R, Goldfine ID.

Am J Physiol. 1989 Sep;257(3 Pt 1):E451-7.PMID: 2782405 [PubMed - indexed for MEDLINE]Related articles

Insulin receptor monoclonal antibodies that mimic insulin action without activating tyrosine kinase.

Hawley DM, Maddux BA, Patel RG, Wong KY, Mamula PW, Firestone GL, Brunetti A, Verspohl E, Goldfine ID.

J Biol Chem. 1989 Feb 15;264(5):2438-44.PMID: 2536710 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanisms of insulin-induced insulin-receptor downregulation. Decrease of receptor biosynthesis and mRNA levels.

Okabayashi Y, Maddux BA, McDonald AR, Logsdon CD, Williams JA, Goldfine ID.

Diabetes. 1989 Feb;38(2):182-7.PMID: 2644141 [PubMed - indexed for MEDLINE]Related articles

Muscle cell differentiation is associated with increased insulin receptor biosynthesis and messenger RNA levels.

Brunetti A, Maddux BA, Wong KY, Goldfine ID.

J Clin Invest. 1989 Jan;83(1):192-8.PMID: 2910907 [PubMed - indexed for MEDLINE]Related articlesFree article

Localization of the insulin-binding site to the cysteine-rich region of the insulin receptor alpha-subunit.

Yip CC, Hsu H, Patel RG, Hawley DM, Maddux BA, Goldfine ID.

Biochem Biophys Res Commun. 1988 Nov 30;157(1):321-9.PMID: 3058126 [PubMed - indexed for MEDLINE]Related articles

Sequence and analysis of promoter region of human insulin-receptor gene.

Mamula PW, Wong KY, Maddux BA, McDonald AR, Goldfine ID.

Diabetes. 1988 Sep;37(9):1241-6.PMID: 3410165 [PubMed - indexed for MEDLINE]Related articles

Insulin and insulin-like growth factor I regulate the same biological functions in HEP-G2 cells via their own specific receptors.

Verspohl EJ, Maddux BA, Goldfine ID.

J Clin Endocrinol Metab. 1988 Jul;67(1):169-74.PMID: 2837499 [PubMed - indexed for MEDLINE]Related articles

Mechanism of glucocorticoid receptor down-regulation by glucocorticoids.

Rosewicz S, McDonald AR, Maddux BA, Goldfine ID, Miesfeld RL, Logsdon CD.

J Biol Chem. 1988 Feb 25;263(6):2581-4.PMID: 3343225 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of insulin-receptor mRNA levels by glucocorticoids.

McDonald AR, Maddux BA, Okabayashi Y, Wong KY, Hawley DM, Logsdon CD, Goldfine ID.

Diabetes. 1987 Jun;36(6):779-81.PMID: 3569675 [PubMed - indexed for MEDLINE]Related articles

Monoclonal antibodies to the human insulin receptor that activate glucose transport but not insulin receptor kinase activity.

Forsayeth JR, Caro JF, Sinha MK, Maddux BA, Goldfine ID.

Proc Natl Acad Sci U S A. 1987 May;84(10):3448-51.PMID: 3033648 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of monoclonal antibodies on human insulin receptor autophosphorylation, negative cooperativity, and down-regulation.

Forsayeth JR, Montemurro A, Maddux BA, DePirro R, Goldfine ID.

J Biol Chem. 1987 Mar 25;262(9):4134-40.PMID: 2435731 [PubMed - indexed for MEDLINE]Related articlesFree article

Human autoantibodies directed against the human, but not the rat, insulin receptor.

De Pirro R, Rossetti L, Montemurro A, Lauro R, Gammeltoft S, Maddux BA, Goldfine ID.

J Clin Endocrinol Metab. 1985 Nov;61(5):986-9.PMID: 4044783 [PubMed - indexed for MEDLINE]Related articles