PubMed

Interferon autoantibodies associated with AIRE deficiency decrease the expression of IFN-stimulated genes.

Kisand K, Link M, Wolff AS, Meager A, Tserel L, Org T, Murumägi A, Uibo R, Willcox N, Trebusak Podkrajsek K, Battelino T, Lobell A, Kämpe O, Lima K, Meloni A, Ergun-Longmire B, Maclaren NK, Perheentupa J, Krohn KJ, Scott HS, Husebye ES, Peterson P.

Blood. 2008 Oct 1;112(7):2657-66. Epub 2008 Jul 7.PMID: 18606876 [PubMed - indexed for MEDLINE]Related articlesFree article

Childhood obesity and insulin resistance.

Maclaren NK, Gujral S, Ten S, Motagheti R.

Cell Biochem Biophys. 2007;48(2-3):73-8.PMID: 17709876 [PubMed - indexed for MEDLINE]Related articles

Insulin-like growth factor binding protein-1 to screen for insulin resistance in children.

Motaghedi R, Gujral S, Sinha S, Sison C, Ten S, Maclaren NK.

Diabetes Technol Ther. 2007 Feb;9(1):43-51.PMID: 17316097 [PubMed - indexed for MEDLINE]Related articles

Insulin pump therapy from the time of diagnosis of type 1 diabetes.

Ramchandani N, Ten S, Anhalt H, Sinha S, Ching J, Finkelstein A, Maclaren NK.

Diabetes Technol Ther. 2006 Dec;8(6):663-70.PMID: 17109598 [PubMed - indexed for MEDLINE]Related articles

Oral insulin therapy to prevent progression of immune-mediated (type 1) diabetes.

Ergun-Longmire B, Marker J, Zeidler A, Rapaport R, Raskin P, Bode B, Schatz D, Vargas A, Rogers D, Schwartz S, Malone J, Krischer J, Maclaren NK.

Ann N Y Acad Sci. 2004 Dec;1029:260-77.PMID: 15681764 [PubMed - indexed for MEDLINE]Related articles

Multiple autoantibodies as predictors of Type 1 diabetes in a general population.

Maclaren NK, Lan MS, Schatz D, Malone J, Notkins AL, Krischer J.

Diabetologia. 2003 Jun;46(6):873-4. Epub 2003 Jun 11. No abstract available. PMID: 12802500 [PubMed - indexed for MEDLINE]Related articles

NKT cells and type-1 diabetes and the "hygiene hypothesis" to explain the rising incidence rates.

Kukreja A, Maclaren NK.

Diabetes Technol Ther. 2002;4(3):323-33. Review.PMID: 12165171 [PubMed - indexed for MEDLINE]Related articles

Guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus.

Sacks DB, Bruns DE, Goldstein DE, Maclaren NK, McDonald JM, Parrott M.

Clin Chem. 2002 Mar;48(3):436-72.PMID: 11861436 [PubMed - indexed for MEDLINE]Related articlesFree article

HLA-DR3 and DR4 and their relation to the incidence and progression of diabetic retinopathy.

Wong TY, Cruickshank KJ, Klein R, Klein BE, Moss SE, Palta M, Riley WJ, Maclaren NK, Vadheim CM, Rotter JI.

Ophthalmology. 2002 Feb;109(2):275-81.PMID: 11825808 [PubMed - indexed for MEDLINE]Related articles

Diabetes vaccines: a future to be realized.

Lin-Su K, Kukreja A, Maclaren NK.

Diabetes Technol Ther. 2001 Fall;3(3):451-61. Review.PMID: 11762523 [PubMed - indexed for MEDLINE]Related articles

Medical care from childhood to adulthood in type 1 and type 2 diabetes.

Costi G, Ten S, Maclaren NK.

J Endocrinol Invest. 2001 Oct;24(9):692-707. Review.PMID: 11716156 [PubMed - indexed for MEDLINE]Related articles

Autoantibodies and human leucocyte antigen class II in first-degree family members of Mexican-American type 1 diabetic patients.

Zeidler A, Raffel LJ, Costin G, Shaw SJ, Buchanan TA, Noble J, Rotter JI, Palmer J, Krischer JP, Wait C, Maclaren NK.

J Clin Endocrinol Metab. 2001 Oct;86(10):4957-62.PMID: 11600569 [PubMed - indexed for MEDLINE]Related articlesFree article

Islet cell autoimmunity in youth onset diabetes mellitus in Northern India.

Goswami R, Kochupillai N, Gupta N, Kukreja A, Lan M, Maclaren NK.

Diabetes Res Clin Pract. 2001 Jul;53(1):47-54.PMID: 11378213 [PubMed - indexed for MEDLINE]Related articles

Current cases in which epitope mimicry is considered as a component cause of autoimmune disease: immune-mediated (type 1) diabetes.

Kukreja A, Maclaren NK.

Cell Mol Life Sci. 2000 Apr;57(4):534-41. Review.PMID: 11130453 [PubMed - indexed for MEDLINE]Related articles

The human leukocyte antigen HLA DRB3*020/DQA1*0501 haplotype is associated with Graves' disease in African Americans.

Chen QY, Nadell D, Zhang XY, Kukreja A, Huang YJ, Wise J, Svec F, Richards R, Friday KE, Vargas A, Gomez R, Chalew S, Lan MS, Tomer Y, Maclaren NK.

J Clin Endocrinol Metab. 2000 Apr;85(4):1545-9.PMID: 10770195 [PubMed - indexed for MEDLINE]Related articlesFree article

Autoimmunity and diabetes.

Kukreja A, Maclaren NK.

J Clin Endocrinol Metab. 1999 Dec;84(12):4371-8. Review.PMID: 10599690 [PubMed - indexed for MEDLINE]Related articlesFree article

HLA-DRB1*08, DRB1*03/DRB3*0101, and DRB3*0202 are susceptibility genes for Graves' disease in North American Caucasians, whereas DRB1*07 is protective.

Chen QY, Huang W, She JX, Baxter F, Volpe R, Maclaren NK.

J Clin Endocrinol Metab. 1999 Sep;84(9):3182-6.PMID: 10487684 [PubMed - indexed for MEDLINE]Related articlesFree article

Retroviruses and autoimmune endocrine diseases.

Coutant R, MacLaren NK.

Ann Med Interne (Paris). 1999 Apr;150(3):235-44. Review. No abstract available. PMID: 10445095 [PubMed - indexed for MEDLINE]Related articles

Cryptic epitope and autoimmunity.

Lan MS, Maclaren NK.

Diabetes Metab Rev. 1998 Dec;14(4):333-4. No abstract available. PMID: 10096004 [PubMed - indexed for MEDLINE]Related articles

Association of diabetes mellitus and chronic hepatitis C virus infection.

Mason AL, Lau JY, Hoang N, Qian K, Alexander GJ, Xu L, Guo L, Jacob S, Regenstein FG, Zimmerman R, Everhart JE, Wasserfall C, Maclaren NK, Perrillo RP.

Hepatology. 1999 Feb;29(2):328-33.PMID: 9918906 [PubMed - indexed for MEDLINE]Related articles

HERV-K10s and immune-mediated (type 1) diabetes.

Lan MS, Mason A, Coutant R, Chen QY, Vargas A, Rao J, Gomez R, Chalew S, Garry R, Maclaren NK.

Cell. 1998 Oct 2;95(1):14-6; discussion 16. No abstract available. PMID: 9778243 [PubMed - indexed for MEDLINE]Related articles

The gene responsible for autoimmune polyglandular syndrome type 1 maps to chromosome 21q22.3 in US patients.

Chen QY, Lan MS, She JX, Maclaren NK.

J Autoimmun. 1998 Apr;11(2):177-83.PMID: 9650097 [PubMed - indexed for MEDLINE]Related articles

The relationship between humoral and cellular immunity to IA-2 in IDDM.

Ellis TM, Schatz DA, Ottendorfer EW, Lan MS, Wasserfall C, Salisbury PJ, She JX, Notkins AL, Maclaren NK, Atkinson MA.

Diabetes. 1998 Apr;47(4):566-9.PMID: 9568688 [PubMed - indexed for MEDLINE]Related articlesFree article

Family cell lines available for research--an endangered resource?

Lernmark A, Eisenbarth G, Ducat L, Erlich HA, Faustman D, Maclaren NK, Ott J, Permutt MA, She JX, Todd J.

Am J Hum Genet. 1997 Sep;61(3):778-9. No abstract available. PMID: 9326346 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-dependent diabetes mellitus (IDDM) is associated with CTLA4 polymorphisms in multiple ethnic groups.

Marron MP, Raffel LJ, Garchon HJ, Jacob CO, Serrano-Rios M, Martinez Larrad MT, Teng WP, Park Y, Zhang ZX, Goldstein DR, Tao YW, Beaurain G, Bach JF, Huang HS, Luo DF, Zeidler A, Rotter JI, Yang MC, Modilevsky T, Maclaren NK, She JX.

Hum Mol Genet. 1997 Aug;6(8):1275-82.PMID: 9259273 [PubMed - indexed for MEDLINE]Related articlesFree article

Autoantigens in insulin-dependent diabetes mellitus: molecular cloning and characterization of human IA-2 beta.

Li Q, Borovitskaya AE, DeSilva MG, Wasserfall C, Maclaren NK, Notkins AL, Lan MS.

Proc Assoc Am Physicians. 1997 Jul;109(4):429-39.PMID: 9220540 [PubMed - indexed for MEDLINE]Related articles

Immunization therapies in the prevention of diabetes.

Ramiya VK, Lan MS, Wasserfall CH, Notkins AL, Maclaren NK.

J Autoimmun. 1997 Jun;10(3):287-92.PMID: 9218756 [PubMed - indexed for MEDLINE]Related articles

Insulin-dependent diabetes mellitus: the hypothesis of molecular mimicry between islet cell antigens and microorganisms.

Maclaren NK, Alkinson MA.

Mol Med Today. 1997 Feb;3(2):76-83. Review.PMID: 9060005 [PubMed - indexed for MEDLINE]Related articles

Effect of oral and intravenous insulin and glutamic acid decarboxylase in NOD mice.

Ramiya VK, Shang XZ, Wasserfall CH, Maclaren NK.

Autoimmunity. 1997;26(3):139-51.PMID: 9550282 [PubMed - indexed for MEDLINE]Related articles

Insulin in diabetes prevention.

Ramiya VK, Maclaren NK.

Horm Res. 1997;48 Suppl 4:67-70.PMID: 9350452 [PubMed - indexed for MEDLINE]Related articles

Pharmacokinetics of aminoguanidine administration and effects on the diabetes frequency in nonobese diabetic mice.

Bowman MA, Simell OG, Peck AB, Cornelius J, Luchetta R, Look Z, Maclaren NK, Atkinson MA.

J Pharmacol Exp Ther. 1996 Nov;279(2):790-4.PMID: 8930185 [PubMed - indexed for MEDLINE]Related articles

IA-2 and IA-2 beta are major autoantigens in IDDM and the precursors of the 40 kDa and 37 kDa tryptic fragments.

Notkins AL, Lu J, Li Q, VanderVegt FP, Wasserfall C, Maclaren NK, Lan MS.

J Autoimmun. 1996 Oct;9(5):677-82.PMID: 8933284 [PubMed - indexed for MEDLINE]Related articles

No linkage or association of telomeric and centromeric T-cell receptor beta-chain markers with susceptibility to type 1 insulin-dependent diabetes in HLA-DR4 multiplex families.

McDermott MF, Schmidt-Wolf G, Sinha AA, Koo M, Porter MA, Briant L, Cambon-Thomsen A, Maclaren NK, Fiske D, Bertera S, Trucco M, Amos CI, McDevitt HO, Kastner DL.

Eur J Immunogenet. 1996 Oct;23(5):361-70.PMID: 8909943 [PubMed - indexed for MEDLINE]Related articles

Immunotherapies in diabetes.

Ramiya VK, Maclaren NK.

Trends Endocrinol Metab. 1996 Sep;7(7):252-7.PMID: 18406756 [PubMed - in process]Related articles

Prediabetic markers in children with stress hyperglycemia.

Bhisitkul DM, Vinik AI, Morrow AL, She JX, Shults J, Powers AC, Maclaren NK.

Arch Pediatr Adolesc Med. 1996 Sep;150(9):936-41.PMID: 8790124 [PubMed - indexed for MEDLINE]Related articles

Cow's milk and insulin-dependent diabetes mellitus. Innocent until proven guilty.

Schatz DA, Maclaren NK.

JAMA. 1996 Aug 28;276(8):647-8. No abstract available. PMID: 8773639 [PubMed - indexed for MEDLINE]Related articles

Quantitative thresholds of MHC class II I-E expressed on hemopoietically derived antigen-presenting cells in transgenic NOD/Lt mice determine level of diabetes resistance and indicate mechanism of protection.

Hanson MS, Cetkovic-Cvrlje M, Ramiya VK, Atkinson MA, Maclaren NK, Singh B, Elliott JF, Serreze DV, Leiter EH.

J Immunol. 1996 Aug 1;157(3):1279-87.PMID: 8757636 [PubMed - indexed for MEDLINE]Related articles

Although DR3-DQB1*0201 may be associated with multiple component diseases of the autoimmune polyglandular syndromes, the human leukocyte antigen DR4-DQB1*0302 haplotype is implicated only in beta-cell autoimmunity.

Huang W, Connor E, Rosa TD, Muir A, Schatz D, Silverstein J, Crockett S, She JX, Maclaren NK.

J Clin Endocrinol Metab. 1996 Jul;81(7):2559-63.PMID: 8675578 [PubMed - indexed for MEDLINE]Related articles

IA-2, a transmembrane protein of the protein tyrosine phosphatase family, is a major autoantigen in insulin-dependent diabetes mellitus.

Lan MS, Wasserfall C, Maclaren NK, Notkins AL.

Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6367-70.PMID: 8692821 [PubMed - indexed for MEDLINE]Related articlesFree article

Antigen based therapies to prevent diabetes in NOD mice.

Ramiya VK, Shang XZ, Pharis PG, Wasserfall CH, Stabler TV, Muir AB, Schatz DA, Maclaren NK.

J Autoimmun. 1996 Jun;9(3):349-56.PMID: 8816970 [PubMed - indexed for MEDLINE]Related articles

The nature of autoantigens targeted in autoimmune endocrine diseases.

Song YH, Li Y, Maclaren NK.

Immunol Today. 1996 May;17(5):232-38. Review.PMID: 8991385 [PubMed - indexed for MEDLINE]Related articles

Confirmation of three susceptibility genes to insulin-dependent diabetes mellitus: IDDM4, IDDM5 and IDDM8.

Luo DF, Buzzetti R, Rotter JI, Maclaren NK, Raffel LJ, Nisticò L, Giovannini C, Pozzilli P, Thomson G, She JX.

Hum Mol Genet. 1996 May;5(5):693-8.PMID: 8733139 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of a second transmembrane protein tyrosine phosphatase, IA-2beta, as an autoantigen in insulin-dependent diabetes mellitus: precursor of the 37-kDa tryptic fragment.

Lu J, Li Q, Xie H, Chen ZJ, Borovitskaya AE, Maclaren NK, Notkins AL, Lan MS.

Proc Natl Acad Sci U S A. 1996 Mar 19;93(6):2307-11.PMID: 8637868 [PubMed - indexed for MEDLINE]Related articlesFree article

No primary association between the 308 polymorphism in the tumor necrosis factor alpha promoter region and insulin-dependent diabetes mellitus.

Deng GY, Maclaren NK, Huang HS, Zhang LP, She JX.

Hum Immunol. 1996 Feb;45(2):137-42.PMID: 8882412 [PubMed - indexed for MEDLINE]Related articles

Paternally transmitted IDDM2 influences diabetes susceptibility despite biallelic expression of the insulin gene in human pancreas.

Bui MM, Luo DF, She JY, Maclaren NK, Muir A, Thomson G, She JX.

J Autoimmun. 1996 Feb;9(1):97-103.PMID: 8845059 [PubMed - indexed for MEDLINE]Related articles

Age and family relationship accentuate the risk of insulin-dependent diabetes mellitus (IDDM) in relatives of patients with IDDM.

Cantor AB, Krischer JP, Cuthbertson DD, Schatz DA, Riley WJ, Malone J, Schwartz S, Quattrin T, Maclaren NK.

J Clin Endocrinol Metab. 1995 Dec;80(12):3739-43.PMID: 8530627 [PubMed - indexed for MEDLINE]Related articles

Affected-sib-pair mapping of a novel susceptibility gene to insulin-dependent diabetes mellitus (IDDM8) on chromosome 6q25-q27.

Luo DF, Bui MM, Muir A, Maclaren NK, Thomson G, She JX.

Am J Hum Genet. 1995 Oct;57(4):911-9.PMID: 7573053 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of LMP2 and LMP7 genes within the major histocompatibility complex with insulin-dependent diabetes mellitus: population and family studies.

Deng GY, Muir A, Maclaren NK, She JX.

Am J Hum Genet. 1995 Feb;56(2):528-34.PMID: 7847389 [PubMed - indexed for MEDLINE]Related articlesFree article

Intrafamilial and case-control association analysis of D2S152 in insulin-dependent diabetes.

Luo DF, Maclaren NK, Huang HS, Muir A, She JX.

Autoimmunity. 1995;21(2):143-7.PMID: 8679904 [PubMed - indexed for MEDLINE]Related articles

High risk HLA-DR/DQ genotypes for IDD confer susceptibility to autoantibodies but DQB1*0602 does not prevent them.

Huang W, She JX, Muir A, Laskowska D, Zorovich B, Schatz D, Maclaren NK.

J Autoimmun. 1994 Dec;7(6):889-97.PMID: 7888045 [PubMed - indexed for MEDLINE]Related articles