PubMed

Critical roles for the TSC-mTOR pathway in {beta}-cell function.

Mori H, Inoki K, Opland D, Muenzberg H, Villanueva EC, Faouzi M, Ikenoue T, Kwiatkowski D, Macdougald OA, Myers Jr MG, Guan KL.

Am J Physiol Endocrinol Metab. 2009 Aug 18. [Epub ahead of print]PMID: 19690069 [PubMed - as supplied by publisher]Related articles

Critical role for hypothalamic mTOR activity in energy balance.

Mori H, Inoki K, Münzberg H, Opland D, Faouzi M, Villanueva EC, Ikenoue T, Kwiatkowski D, MacDougald OA, Myers MG Jr, Guan KL.

Cell Metab. 2009 Apr;9(4):362-74.PMID: 19356717 [PubMed - indexed for MEDLINE]Related articles

On the role of FOX transcription factors in adipocyte differentiation and insulin-stimulated glucose uptake.

Gerin I, Bommer GT, Lidell ME, Cederberg A, Enerback S, Macdougald OA.

J Biol Chem. 2009 Apr 17;284(16):10755-63. Epub 2009 Feb 24.PMID: 19244248 [PubMed - indexed for MEDLINE]Related articles

Continuous-flow enzyme assay on a microfluidic chip for monitoring glycerol secretion from cultured adipocytes.

Clark AM, Sousa KM, Jennings C, Macdougald OA, Kennedy RT.

Anal Chem. 2009 Mar 15;81(6):2350-6.PMID: 19231843 [PubMed - in process]Related articles

Hyperphagia and obesity in female mice lacking tissue inhibitor of metalloproteinase-1.

Gerin I, Louis GW, Zhang X, Prestwich TC, Kumar TR, Myers MG Jr, Macdougald OA, Nothnick WB.

Endocrinology. 2009 Apr;150(4):1697-704. Epub 2008 Nov 26.PMID: 19036876 [PubMed - indexed for MEDLINE]Related articles

Regulation of cyclin D1 and Wnt10b gene expression by cAMP-responsive element-binding protein during early adipogenesis involves differential promoter methylation.

Fox KE, Colton LA, Erickson PF, Friedman JE, Cha HC, Keller P, MacDougald OA, Klemm DJ.

J Biol Chem. 2008 Dec 12;283(50):35096-105. Epub 2008 Oct 27.PMID: 18957421 [PubMed - indexed for MEDLINE]Related articles

The microRNA miR-8 is a conserved negative regulator of Wnt signaling.

Kennell JA, Gerin I, MacDougald OA, Cadigan KM.

Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15417-22. Epub 2008 Sep 29.PMID: 18824696 [PubMed - indexed for MEDLINE]Related articlesFree article

Disruption of cell-matrix interactions by heparin enhances mesenchymal progenitor adipocyte differentiation.

Luo W, Shitaye H, Friedman M, Bennett CN, Miller J, Macdougald OA, Hankenson KD.

Exp Cell Res. 2008 Nov 1;314(18):3382-91. Epub 2008 Jul 12.PMID: 18674534 [PubMed - indexed for MEDLINE]Related articles

Inhibitor of DNA binding 2 is a small molecule-inducible modulator of peroxisome proliferator-activated receptor-gamma expression and adipocyte differentiation.

Park KW, Waki H, Villanueva CJ, Monticelli LA, Hong C, Kang S, MacDougald OA, Goldrath AW, Tontonoz P.

Mol Endocrinol. 2008 Sep;22(9):2038-48. Epub 2008 Jun 18.PMID: 18562627 [PubMed - indexed for MEDLINE]Related articlesFree article

Phosphorylation of CCAAT/enhancer-binding protein alpha regulates GLUT4 expression and glucose transport in adipocytes.

Cha HC, Oak NR, Kang S, Tran TA, Kobayashi S, Chiang SH, Tenen DG, MacDougald OA.

J Biol Chem. 2008 Jun 27;283(26):18002-11. Epub 2008 Apr 11.PMID: 18408001 [PubMed - indexed for MEDLINE]Related articlesFree article

Fat-specific protein 27 regulates storage of triacylglycerol.

Keller P, Petrie JT, De Rose P, Gerin I, Wright WS, Chiang SH, Nielsen AR, Fischer CP, Pedersen BK, MacDougald OA.

J Biol Chem. 2008 May 23;283(21):14355-65. Epub 2008 Mar 11.PMID: 18334488 [PubMed - indexed for MEDLINE]Related articlesFree article

Wnt/beta-catenin signaling in adipogenesis and metabolism.

Prestwich TC, Macdougald OA.

Curr Opin Cell Biol. 2007 Dec;19(6):612-7. Epub 2007 Nov 9. Review.PMID: 17997088 [PubMed - indexed for MEDLINE]Related articlesFree article

Resistance to diet-induced obesity and improved insulin sensitivity in mice with a regulator of G protein signaling-insensitive G184S Gnai2 allele.

Huang X, Charbeneau RA, Fu Y, Kaur K, Gerin I, MacDougald OA, Neubig RR.

Diabetes. 2008 Jan;57(1):77-85. Epub 2007 Oct 10.PMID: 17928396 [PubMed - indexed for MEDLINE]Related articlesFree article

The rapidly expanding family of adipokines.

MacDougald OA, Burant CF.

Cell Metab. 2007 Sep;6(3):159-61.PMID: 17767903 [PubMed - indexed for MEDLINE]Related articles

Wnt10b increases postnatal bone formation by enhancing osteoblast differentiation.

Bennett CN, Ouyang H, Ma YL, Zeng Q, Gerin I, Sousa KM, Lane TF, Krishnan V, Hankenson KD, MacDougald OA.

J Bone Miner Res. 2007 Dec;22(12):1924-32.PMID: 17708715 [PubMed - indexed for MEDLINE]Related articles

p53-mediated activation of miRNA34 candidate tumor-suppressor genes.

Bommer GT, Gerin I, Feng Y, Kaczorowski AJ, Kuick R, Love RE, Zhai Y, Giordano TJ, Qin ZS, Moore BB, MacDougald OA, Cho KR, Fearon ER.

Curr Biol. 2007 Aug 7;17(15):1298-307. Epub 2007 Jul 26.PMID: 17656095 [PubMed - indexed for MEDLINE]Related articles

Ectopic expression of Wnt10b decreases adiposity and improves glucose homeostasis in obese rats.

Aslanidi G, Kroutov V, Philipsberg G, Lamb K, Campbell-Thompson M, Walter GA, Kurenov S, Ignacio Aguirre J, Keller P, Hankenson K, Macdougald OA, Zolotukhin S.

Am J Physiol Endocrinol Metab. 2007 Sep;293(3):E726-36. Epub 2007 Jun 19.PMID: 17578883 [PubMed - indexed for MEDLINE]Related articlesFree article

Metallothionein expression is suppressed in primary human hepatocellular carcinomas and is mediated through inactivation of CCAAT/enhancer binding protein alpha by phosphatidylinositol 3-kinase signaling cascade.

Datta J, Majumder S, Kutay H, Motiwala T, Frankel W, Costa R, Cha HC, MacDougald OA, Jacob ST, Ghoshal K.

Cancer Res. 2007 Mar 15;67(6):2736-46.PMID: 17363595 [PubMed - indexed for MEDLINE]Related articlesFree article

Wnt signaling stimulates osteoblastogenesis of mesenchymal precursors by suppressing CCAAT/enhancer-binding protein alpha and peroxisome proliferator-activated receptor gamma.

Kang S, Bennett CN, Gerin I, Rapp LA, Hankenson KD, Macdougald OA.

J Biol Chem. 2007 May 11;282(19):14515-24. Epub 2007 Mar 10.PMID: 17351296 [PubMed - indexed for MEDLINE]Related articlesFree article

Wnt10b inhibits obesity in ob/ob and agouti mice.

Wright WS, Longo KA, Dolinsky VW, Gerin I, Kang S, Bennett CN, Chiang SH, Prestwich TC, Gress C, Burant CF, Susulic VS, MacDougald OA.

Diabetes. 2007 Feb;56(2):295-303.PMID: 17259372 [PubMed - indexed for MEDLINE]Related articlesFree article

Physical dissection of the CCAAT/enhancer-binding protein alpha in regulating the mouse amelogenin gene.

Xu Y, Zhou YL, Erickson RL, Macdougald OA, Snead ML.

Biochem Biophys Res Commun. 2007 Mar 2;354(1):56-61. Epub 2007 Jan 2.PMID: 17210130 [PubMed - indexed for MEDLINE]Related articlesFree article

Adipocyte differentiation from the inside out.

Rosen ED, MacDougald OA.

Nat Rev Mol Cell Biol. 2006 Dec;7(12):885-96. Review.PMID: 17139329 [PubMed - indexed for MEDLINE]Related articles

TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth.

Inoki K, Ouyang H, Zhu T, Lindvall C, Wang Y, Zhang X, Yang Q, Bennett C, Harada Y, Stankunas K, Wang CY, He X, MacDougald OA, You M, Williams BO, Guan KL.

Cell. 2006 Sep 8;126(5):955-68.PMID: 16959574 [PubMed - indexed for MEDLINE]Related articles

CCAAT/enhancer-binding protein alpha mediates induction of hepatic phosphoenolpyruvate carboxykinase by p38 mitogen-activated protein kinase.

Qiao L, MacDougald OA, Shao J.

J Biol Chem. 2006 Aug 25;281(34):24390-7. Epub 2006 Jun 27.PMID: 16807249 [PubMed - indexed for MEDLINE]Related articlesFree article

Transcription factor sumoylation and factor YY1 serve to modulate mouse amelogenin gene expression.

Xu Y, Zhou YL, Ann DK, MacDougald OA, Shum L, Snead ML.

Eur J Oral Sci. 2006 May;114 Suppl 1:169-77; discussion 201-2, 381.PMID: 16674681 [PubMed - indexed for MEDLINE]Related articles

Regulation of bone mass by Wnt signaling.

Krishnan V, Bryant HU, Macdougald OA.

J Clin Invest. 2006 May;116(5):1202-9. Review.PMID: 16670761 [PubMed - indexed for MEDLINE]Related articlesFree article

NF-Y and CCAAT/enhancer-binding protein alpha synergistically activate the mouse amelogenin gene.

Xu Y, Zhou YL, Luo W, Zhu QS, Levy D, MacDougald OA, Snead ML.

J Biol Chem. 2006 Jun 9;281(23):16090-8. Epub 2006 Apr 4.PMID: 16595692 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of Wnts in prostate cancer bone metastases.

Hall CL, Kang S, MacDougald OA, Keller ET.

J Cell Biochem. 2006 Mar 1;97(4):661-72. Review.PMID: 16447163 [PubMed - indexed for MEDLINE]Related articles

Obesity and metabolic perturbations after loss of aquaporin 7, the adipose glycerol transporter.

MacDougald OA, Burant CF.

Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):10759-60. Epub 2005 Jul 26. No abstract available. PMID: 16046537 [PubMed - indexed for MEDLINE]Related articlesFree article

Fickle factor foils fat fate.

MacDougald OA, Burant CF.

Nat Cell Biol. 2005 Jun;7(6):543-5. No abstract available. PMID: 15928698 [PubMed - indexed for MEDLINE]Related articles

Wnt signaling inhibits adipogenesis through beta-catenin-dependent and -independent mechanisms.

Kennell JA, MacDougald OA.

J Biol Chem. 2005 Jun 24;280(25):24004-10. Epub 2005 Apr 22.PMID: 15849360 [PubMed - indexed for MEDLINE]Related articlesFree article

LXRbeta is required for adipocyte growth, glucose homeostasis, and beta cell function.

Gerin I, Dolinsky VW, Shackman JG, Kennedy RT, Chiang SH, Burant CF, Steffensen KR, Gustafsson JA, MacDougald OA.

J Biol Chem. 2005 Jun 17;280(24):23024-31. Epub 2005 Apr 13.PMID: 15831500 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of osteoblastogenesis and bone mass by Wnt10b.

Bennett CN, Longo KA, Wright WS, Suva LJ, Lane TF, Hankenson KD, MacDougald OA.

Proc Natl Acad Sci U S A. 2005 Mar 1;102(9):3324-9. Epub 2005 Feb 22.PMID: 15728361 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of Wnt signaling on brown adipocyte differentiation and metabolism mediated by PGC-1alpha.

Kang S, Bajnok L, Longo KA, Petersen RK, Hansen JB, Kristiansen K, MacDougald OA.

Mol Cell Biol. 2005 Feb;25(4):1272-82.PMID: 15684380 [PubMed - indexed for MEDLINE]Related articlesFree article

Wnt10b deficiency promotes coexpression of myogenic and adipogenic programs in myoblasts.

Vertino AM, Taylor-Jones JM, Longo KA, Bearden ED, Lane TF, McGehee RE Jr, MacDougald OA, Peterson CA.

Mol Biol Cell. 2005 Apr;16(4):2039-48. Epub 2005 Jan 26.PMID: 15673614 [PubMed - indexed for MEDLINE]Related articlesFree article

Wnt10b inhibits development of white and brown adipose tissues.

Longo KA, Wright WS, Kang S, Gerin I, Chiang SH, Lucas PC, Opp MR, MacDougald OA.

J Biol Chem. 2004 Aug 20;279(34):35503-9. Epub 2004 Jun 9.PMID: 15190075 [PubMed - indexed for MEDLINE]Related articlesFree article

Phosphorylation of C/EBPalpha inhibits granulopoiesis.

Ross SE, Radomska HS, Wu B, Zhang P, Winnay JN, Bajnok L, Wright WS, Schaufele F, Tenen DG, MacDougald OA.

Mol Cell Biol. 2004 Jan;24(2):675-86.PMID: 14701740 [PubMed - indexed for MEDLINE]Related articlesFree article

Will fatty worms help cure human obesity?

Chiang SH, MacDougald OA.

Trends Genet. 2003 Oct;19(10):523-5.PMID: 14550624 [PubMed - indexed for MEDLINE]Related articles

T-cell factor 4N (TCF-4N), a novel isoform of mouse TCF-4, synergizes with beta-catenin to coactivate C/EBPalpha and steroidogenic factor 1 transcription factors.

Kennell JA, O'Leary EE, Gummow BM, Hammer GD, MacDougald OA.

Mol Cell Biol. 2003 Aug;23(15):5366-75.PMID: 12861022 [PubMed - indexed for MEDLINE]Related articlesFree article

Signaling pathway puts the break on fat cell formation.

MacDougald OA.

ScientificWorldJournal. 2001 May 1;1:188-9. Review.PMID: 12805664 [PubMed - indexed for MEDLINE]Related articles

Role of Wnt10b and C/EBPalpha in spontaneous adipogenesis of 243 cells.

Bennett CN, Hodge CL, MacDougald OA, Schwartz J.

Biochem Biophys Res Commun. 2003 Feb 28;302(1):12-6.PMID: 12593840 [PubMed - indexed for MEDLINE]Related articles

Wnt signaling protects 3T3-L1 preadipocytes from apoptosis through induction of insulin-like growth factors.

Longo KA, Kennell JA, Ochocinska MJ, Ross SE, Wright WS, MacDougald OA.

J Biol Chem. 2002 Oct 11;277(41):38239-44. Epub 2002 Aug 1.PMID: 12154096 [PubMed - indexed for MEDLINE]Related articlesFree article

Microarray analyses during adipogenesis: understanding the effects of Wnt signaling on adipogenesis and the roles of liver X receptor alpha in adipocyte metabolism.

Ross SE, Erickson RL, Gerin I, DeRose PM, Bajnok L, Longo KA, Misek DE, Kuick R, Hanash SM, Atkins KB, Andresen SM, Nebb HI, Madsen L, Kristiansen K, MacDougald OA.

Mol Cell Biol. 2002 Aug;22(16):5989-99.PMID: 12138207 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of Wnt signaling during adipogenesis.

Bennett CN, Ross SE, Longo KA, Bajnok L, Hemati N, Johnson KW, Harrison SD, MacDougald OA.

J Biol Chem. 2002 Aug 23;277(34):30998-1004. Epub 2002 Jun 7.PMID: 12055200 [PubMed - indexed for MEDLINE]Related articlesFree article

Wnt signaling promotes oncogenic transformation by inhibiting c-Myc-induced apoptosis.

You Z, Saims D, Chen S, Zhang Z, Guttridge DC, Guan KL, MacDougald OA, Brown AM, Evan G, Kitajewski J, Wang CY.

J Cell Biol. 2002 Apr 29;157(3):429-40. Epub 2002 Apr 29.PMID: 11980918 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of members of the Wnt signaling pathway in the embryonic pituitary gland.

Douglas KR, Brinkmeier ML, Kennell JA, Eswara P, Harrison TA, Patrianakos AI, Sprecher BS, Potok MA, Lyons RH Jr, MacDougald OA, Camper SA.

Mamm Genome. 2001 Nov;12(11):843-51.PMID: 11845287 [PubMed - indexed for MEDLINE]Related articles

Adipogenesis: forces that tip the scales.

MacDougald OA, Mandrup S.

Trends Endocrinol Metab. 2002 Jan-Feb;13(1):5-11. Review.PMID: 11750856 [PubMed - indexed for MEDLINE]Related articles

CCAAT/enhancer binding protein alpha assembles essential cooperating factors in common subnuclear domains.

Schaufele F, Enwright JF 3rd, Wang X, Teoh C, Srihari R, Erickson R, MacDougald OA, Day RN.

Mol Endocrinol. 2001 Oct;15(10):1665-76.PMID: 11579200 [PubMed - indexed for MEDLINE]Related articlesFree article

p300 coactivates the adipogenic transcription factor CCAAT/enhancer-binding protein alpha.

Erickson RL, Hemati N, Ross SE, MacDougald OA.

J Biol Chem. 2001 May 11;276(19):16348-55.PMID: 11340085 [PubMed - indexed for MEDLINE]Related articlesFree article

Growth hormone regulates phosphorylation and function of CCAAT/enhancer-binding protein beta by modulating Akt and glycogen synthase kinase-3.

Piwien-Pilipuk G, Van Mater D, Ross SE, MacDougald OA, Schwartz J.

J Biol Chem. 2001 Jun 1;276(22):19664-71. Epub 2001 Mar 13.PMID: 11278638 [PubMed - indexed for MEDLINE]Related articlesFree article