PubMed

Characterization of Erg K+ channels in alpha- and beta-cells of mouse and human islets.

Hardy AB, Fox JE, Giglou PR, Wijesekara N, Bhattacharjee A, Sultan S, Gyulkhandanyan AV, Gaisano HY, MacDonald PE, Wheeler MB.

J Biol Chem. 2009 Oct 30;284(44):30441-52. Epub 2009 Aug 18.PMID: 19690348 [PubMed - in process]Related articles

Insulin granule recruitment and exocytosis is dependent on p110gamma in insulinoma and human beta-cells.

Pigeau GM, Kolic J, Ball BJ, Hoppa MB, Wang YW, Rückle T, Woo M, Manning Fox JE, MacDonald PE.

Diabetes. 2009 Sep;58(9):2084-92. Epub 2009 Jun 23.PMID: 19549714 [PubMed - indexed for MEDLINE]Related articles

SUMOylation regulates Kv2.1 and modulates pancreatic beta-cell excitability.

Dai XQ, Kolic J, Marchi P, Sipione S, Macdonald PE.

J Cell Sci. 2009 Mar 15;122(Pt 6):775-9. Epub 2009 Feb 17.PMID: 19223394 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of kinin B2 receptor signaling in the recruitment of circulating progenitor cells with neovascularization potential.

Kränkel N, Katare RG, Siragusa M, Barcelos LS, Campagnolo P, Mangialardi G, Fortunato O, Spinetti G, Tran N, Zacharowski K, Wojakowski W, Mroz I, Herman A, Manning Fox JE, MacDonald PE, Schanstra JP, Bascands JL, Ascione R, Angelini G, Emanueli C, Madeddu P.

Circ Res. 2008 Nov 21;103(11):1335-43. Epub 2008 Oct 16.PMID: 18927465 [PubMed - indexed for MEDLINE]Related articles

Kiss-and-run exocytosis and fusion pores of secretory vesicles in human beta-cells.

Hanna ST, Pigeau GM, Galvanovskis J, Clark A, Rorsman P, MacDonald PE.

Pflugers Arch. 2009 Apr;457(6):1343-50. Epub 2008 Sep 16.PMID: 18795319 [PubMed - indexed for MEDLINE]Related articles

K(ATP)-channels and glucose-regulated glucagon secretion.

Rorsman P, Salehi SA, Abdulkader F, Braun M, MacDonald PE.

Trends Endocrinol Metab. 2008 Oct;19(8):277-84. Epub 2008 Sep 2. Review.PMID: 18771934 [PubMed - indexed for MEDLINE]Related articles

Splice variant-dependent regulation of beta-cell sodium-calcium exchange by acyl-coenzyme As.

Hamming KS, Riedel MJ, Soliman D, Matemisz LC, Webster NJ, Searle GJ, MacDonald PE, Light PE.

Mol Endocrinol. 2008 Oct;22(10):2293-306. Epub 2008 Jul 17.PMID: 18635667 [PubMed - indexed for MEDLINE]Related articlesFree article

Investigation of transport mechanisms and regulation of intracellular Zn2+ in pancreatic alpha-cells.

Gyulkhandanyan AV, Lu H, Lee SC, Bhattacharjee A, Wijesekara N, Fox JE, MacDonald PE, Chimienti F, Dai FF, Wheeler MB.

J Biol Chem. 2008 Apr 11;283(15):10184-97. Epub 2008 Feb 4.PMID: 18250168 [PubMed - indexed for MEDLINE]Related articlesFree article

A K ATP channel-dependent pathway within alpha cells regulates glucagon release from both rodent and human islets of Langerhans.

MacDonald PE, De Marinis YZ, Ramracheya R, Salehi A, Ma X, Johnson PR, Cox R, Eliasson L, Rorsman P.

PLoS Biol. 2007 Jun;5(6):e143.PMID: 17503968 [PubMed - indexed for MEDLINE]Related articlesFree article

The ins and outs of secretion from pancreatic beta-cells: control of single-vesicle exo- and endocytosis.

MacDonald PE, Rorsman P.

Physiology (Bethesda). 2007 Apr;22:113-21. Review.PMID: 17420302 [PubMed - indexed for MEDLINE]Related articlesFree article

Corelease and differential exit via the fusion pore of GABA, serotonin, and ATP from LDCV in rat pancreatic beta cells.

Braun M, Wendt A, Karanauskaite J, Galvanovskis J, Clark A, MacDonald PE, Rorsman P.

J Gen Physiol. 2007 Mar;129(3):221-31. Epub 2007 Feb 12.PMID: 17296927 [PubMed - indexed for MEDLINE]Related articlesFree article

Hyperpolarization-activated cyclic nucleotide-gated channels in pancreatic beta-cells.

El-Kholy W, MacDonald PE, Fox JM, Bhattacharjee A, Xue T, Gao X, Zhang Y, Stieber J, Li RA, Tsushima RG, Wheeler MB.

Mol Endocrinol. 2007 Mar;21(3):753-64. Epub 2006 Dec 7.PMID: 17158221 [PubMed - indexed for MEDLINE]Related articlesFree article

Release of small transmitters through kiss-and-run fusion pores in rat pancreatic beta cells.

MacDonald PE, Braun M, Galvanovskis J, Rorsman P.

Cell Metab. 2006 Oct;4(4):283-90.PMID: 17011501 [PubMed - indexed for MEDLINE]Related articles

Role of phosphatidylinositol 3-kinasegamma in the beta-cell: interactions with glucagon-like peptide-1.

Li LX, MacDonald PE, Ahn DS, Oudit GY, Backx PH, Brubaker PL.

Endocrinology. 2006 Jul;147(7):3318-25. Epub 2006 Mar 30.PMID: 16574789 [PubMed - indexed for MEDLINE]Related articlesFree article

Oscillations, intercellular coupling, and insulin secretion in pancreatic beta cells.

MacDonald PE, Rorsman P.

PLoS Biol. 2006 Feb;4(2):e49. Epub 2006 Feb 14. No abstract available. PMID: 16464129 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose-sensing mechanisms in pancreatic beta-cells.

MacDonald PE, Joseph JW, Rorsman P.

Philos Trans R Soc Lond B Biol Sci. 2005 Dec 29;360(1464):2211-25. Review.PMID: 16321791 [PubMed - indexed for MEDLINE]Related articlesFree article

Calcium increases endocytotic vesicle size and accelerates membrane fission in insulin-secreting INS-1 cells.

MacDonald PE, Eliasson L, Rorsman P.

J Cell Sci. 2005 Dec 15;118(Pt 24):5911-20. Epub 2005 Nov 29.PMID: 16317049 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulated exocytosis and kiss-and-run of synaptic-like microvesicles in INS-1 and primary rat beta-cells.

MacDonald PE, Obermüller S, Vikman J, Galvanovskis J, Rorsman P, Eliasson L.

Diabetes. 2005 Mar;54(3):736-43.PMID: 15734850 [PubMed - indexed for MEDLINE]Related articlesFree article

A pancreatic islet-specific microRNA regulates insulin secretion.

Poy MN, Eliasson L, Krutzfeldt J, Kuwajima S, Ma X, Macdonald PE, Pfeffer S, Tuschl T, Rajewsky N, Rorsman P, Stoffel M.

Nature. 2004 Nov 11;432(7014):226-30.PMID: 15538371 [PubMed - indexed for MEDLINE]Related articles

Impaired glucose-stimulated insulin secretion, enhanced intraperitoneal insulin tolerance, and increased beta-cell mass in mice lacking the p110gamma isoform of phosphoinositide 3-kinase.

MacDonald PE, Joseph JW, Yau D, Diao J, Asghar Z, Dai F, Oudit GY, Patel MM, Backx PH, Wheeler MB.

Endocrinology. 2004 Sep;145(9):4078-83. Epub 2004 Jul 1.PMID: 15231713 [PubMed - indexed for MEDLINE]Related articlesFree article

Antagonism of rat beta-cell voltage-dependent K+ currents by exendin 4 requires dual activation of the cAMP/protein kinase A and phosphatidylinositol 3-kinase signaling pathways.

MacDonald PE, Wang X, Xia F, El-kholy W, Targonsky ED, Tsushima RG, Wheeler MB.

J Biol Chem. 2003 Dec 26;278(52):52446-53. Epub 2003 Oct 16.PMID: 14565957 [PubMed - indexed for MEDLINE]Related articlesFree article

Voltage-dependent K(+) channels in pancreatic beta cells: role, regulation and potential as therapeutic targets.

MacDonald PE, Wheeler MB.

Diabetologia. 2003 Aug;46(8):1046-62. Epub 2003 Jun 27. Review.PMID: 12830383 [PubMed - indexed for MEDLINE]Related articles

The phosphatidylinositol 3-kinase inhibitor LY294002 potently blocks K(V) currents via a direct mechanism.

El-Kholy W, Macdonald PE, Lin JH, Wang J, Fox JM, Light PE, Wang Q, Tsushima RG, Wheeler MB.

FASEB J. 2003 Apr;17(6):720-2. Epub 2003 Feb 5.PMID: 12586735 [PubMed - indexed for MEDLINE]Related articlesFree article

Temperature and redox state dependence of native Kv2.1 currents in rat pancreatic beta-cells.

MacDonald PE, Salapatek AM, Wheeler MB.

J Physiol. 2003 Feb 1;546(Pt 3):647-53.PMID: 12562993 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucagon-like peptide-1 receptor activation antagonizes voltage-dependent repolarizing K(+) currents in beta-cells: a possible glucose-dependent insulinotropic mechanism.

MacDonald PE, Salapatek AM, Wheeler MB.

Diabetes. 2002 Dec;51 Suppl 3:S443-7.PMID: 12475788 [PubMed - indexed for MEDLINE]Related articlesFree article

The multiple actions of GLP-1 on the process of glucose-stimulated insulin secretion.

MacDonald PE, El-Kholy W, Riedel MJ, Salapatek AM, Light PE, Wheeler MB.

Diabetes. 2002 Dec;51 Suppl 3:S434-42. Review.PMID: 12475787 [PubMed - indexed for MEDLINE]Related articlesFree article

Synaptosome-associated protein of 25 kilodaltons modulates Kv2.1 voltage-dependent K(+) channels in neuroendocrine islet beta-cells through an interaction with the channel N terminus.

MacDonald PE, Wang G, Tsuk S, Dodo C, Kang Y, Tang L, Wheeler MB, Cattral MS, Lakey JR, Salapatek AM, Lotan I, Gaisano HY.

Mol Endocrinol. 2002 Nov;16(11):2452-61.PMID: 12403834 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of Kv2.1 voltage-dependent K+ channels in pancreatic beta-cells enhances glucose-dependent insulin secretion.

MacDonald PE, Sewing S, Wang J, Joseph JW, Smukler SR, Sakellaropoulos G, Wang J, Saleh MC, Chan CB, Tsushima RG, Salapatek AM, Wheeler MB.

J Biol Chem. 2002 Nov 22;277(47):44938-45. Epub 2002 Sep 20.PMID: 12270920 [PubMed - indexed for MEDLINE]Related articlesFree article

Members of the Kv1 and Kv2 voltage-dependent K(+) channel families regulate insulin secretion.

MacDonald PE, Ha XF, Wang J, Smukler SR, Sun AM, Gaisano HY, Salapatek AM, Backx PH, Wheeler MB.

Mol Endocrinol. 2001 Aug;15(8):1423-35.PMID: 11463864 [PubMed - indexed for MEDLINE]Related articlesFree article

Mutations to the third cytoplasmic domain of the glucagon-like peptide 1 (GLP-1) receptor can functionally uncouple GLP-1-stimulated insulin secretion in HIT-T15 cells.

Salapatek AM, MacDonald PE, Gaisano HY, Wheeler MB.

Mol Endocrinol. 1999 Aug;13(8):1305-17.PMID: 10446905 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets.

Chan CB, MacDonald PE, Saleh MC, Johns DC, Marbàn E, Wheeler MB.

Diabetes. 1999 Jul;48(7):1482-6.PMID: 10389858 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucagon-like peptide 1 increases insulin sensitivity in depancreatized dogs.

Sandhu H, Wiesenthal SR, MacDonald PE, McCall RH, Tchipashvili V, Rashid S, Satkunarajah M, Irwin DM, Shi ZQ, Brubaker PL, Wheeler MB, Vranic M, Efendic S, Giacca A.

Diabetes. 1999 May;48(5):1045-53.PMID: 10331409 [PubMed - indexed for MEDLINE]Related articlesFree article

Isolation and characterization of transposon Tn5-induced symbiotic mutants of Rhizobium loti.

Chua KY, Pankhurst CE, Macdonald PE, Hopcroft DH, Jarvis BD, Scott DB.

J Bacteriol. 1985 Apr;162(1):335-43.PMID: 2984178 [PubMed - indexed for MEDLINE]Related articlesFree article

A computerized method of determining the statistical significance of the observed mortality experience.

Book DT, Slattery FM, MacDonald PE.

Trans Assoc Life Insur Med Dir Am. 1971;54:219-57. No abstract available. PMID: 5087500 [PubMed - indexed for MEDLINE]Related articles