PubMed

Genetic association analysis of LARS2 with type 2 diabetes.

Reiling E, Jafar-Mohammadi B, van 't Riet E, Weedon MN, van Vliet-Ostaptchouk JV, Hansen T, Saxena R, van Haeften TW, Arp PA, Das S, Nijpels G, Groenewoud MJ, van Hove EC, Uitterlinden AG, Smit JW, Morris AD, Doney AS, Palmer CN, Guiducci C, Hattersley AT, Frayling TM, Pedersen O, Slagboom PE, Altshuler DM, Groop L, Romijn JA, Maassen JA, Hofker MH, Dekker JM, McCarthy MI, 't Hart LM.

Diabetologia. 2009 Oct 22. [Epub ahead of print]PMID: 19847392 [PubMed - as supplied by publisher]Related articles

Gene variants in the novel type 2 diabetes loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A and MTNR1B affect different aspects of pancreatic beta cell function.

Simonis-Bik AM, Nijpels G, van Haeften TW, Houwing-Duistermaat JJ, Boomsma DI, Reiling E, van Hove EC, Diamant M, Kramer MH, Heine RJ, Maassen JA, Slagboom PE, Willemsen G, Dekker JM, Eekhoff EM, de Geus EJ, 't Hart LM.

Diabetes. 2009 Oct 15. [Epub ahead of print]PMID: 19833888 [PubMed - as supplied by publisher]Related articles

A Combined Risk Allele Score of Eight Type 2 Diabetes Genes Is Associated With Reduced First Phase Glucose Stimulated Insulin Secretion During Hyperglycemic Clamps.

't Hart LM, Simonis-Bik AM, Nijpels G, van Haeften TW, Schäfer SA, Houwing-Duistermaat JJ, Boomsma DI, Groenewoud MJ, Reiling E, van Hove EC, Diamant M, Kramer MH, Heine RJ, Maassen JA, Kirchhoff K, Machicao F, Häring HU, Slagboom PE, Willemsen G, Eekhoff EM, de Geus EJ, Dekker JM, Fritsche A.

Diabetes. 2009 Oct 6. [Epub ahead of print]PMID: 19808892 [PubMed - as supplied by publisher]Related articles

Genetic influences on the insulin response of the beta cell to different secretagogues.

Simonis-Bik AM, Eekhoff EM, de Moor MH, Kramer MH, Boomsma DI, Heine RJ, Dekker JM, Maassen JA, 't Hart LM, Diamant M, de Geus EJ.

Diabetologia. 2009 Oct 3. [Epub ahead of print]PMID: 19802603 [PubMed - as supplied by publisher]Related articles

The nuclear appearance of ERK1/2 and p38 determines the sequential induction of ATF2-Thr71 and ATF2-Thr69 phosphorylation by serum in JNK-deficient cells.

Baan B, van der Zon GC, Maassen JA, Ouwens DM.

Mol Cell Endocrinol. 2009 Nov 13;311(1-2):94-100. Epub 2009 Jul 30.PMID: 19647037 [PubMed - in process]Related articles

Combined effects of single-nucleotide polymorphisms in GCK, GCKR, G6PC2 and MTNR1B on fasting plasma glucose and type 2 diabetes risk.

Reiling E, van 't Riet E, Groenewoud MJ, Welschen LM, van Hove EC, Nijpels G, Maassen JA, Dekker JM, 't Hart LM.

Diabetologia. 2009 Sep;52(9):1866-70. Epub 2009 Jun 17.PMID: 19533084 [PubMed - in process]Related articlesFree article

Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE study.

Reiling E, van Vliet-Ostaptchouk JV, van 't Riet E, van Haeften TW, Arp PA, Hansen T, Kremer D, Groenewoud MJ, van Hove EC, Romijn JA, Smit JW, Nijpels G, Heine RJ, Uitterlinden AG, Pedersen O, Slagboom PE, Maassen JA, Hofker MH, 't Hart LM, Dekker JM.

Eur J Hum Genet. 2009 Aug;17(8):1056-62. Epub 2009 Feb 11.PMID: 19209188 [PubMed - indexed for MEDLINE]Related articles

Phosphorus-31 magnetic resonance spectroscopy of skeletal muscle in maternally inherited diabetes and deafness A3243G mitochondrial mutation carriers.

van Elderen SG, Doornbos J, van Essen EH, Lemkes HH, Maassen JA, Smit JW, de Roos A.

J Magn Reson Imaging. 2009 Jan;29(1):127-31.PMID: 19097109 [PubMed - indexed for MEDLINE]Related articles

Variants of CDKAL1 and IGF2BP2 affect first-phase insulin secretion during hyperglycaemic clamps.

Groenewoud MJ, Dekker JM, Fritsche A, Reiling E, Nijpels G, Heine RJ, Maassen JA, Machicao F, Schäfer SA, Häring HU, 't Hart LM, van Haeften TW.

Diabetologia. 2008 Sep;51(9):1659-63. Epub 2008 Jul 11.PMID: 18618095 [PubMed - indexed for MEDLINE]Related articles

Fatty acid-induced mitochondrial uncoupling in adipocytes as a key protective factor against insulin resistance and beta cell dysfunction: do adipocytes consume sufficient amounts of oxygen to oxidise fatty acids?

Maassen JA, Romijn JA, Heine RJ.

Diabetologia. 2008 May;51(5):907-8. Epub 2008 Mar 4. No abstract available. PMID: 18317722 [PubMed - indexed for MEDLINE]Related articlesFree article

Dynamics of insulin signalling in liver during hyperinsulinemic euglycaemic clamp conditions in vivo and the effects of high-fat feeding in male mice.

Korsheninnikova E, Voshol PJ, Baan B, van der Zon GC, Havekes LM, Romijn JA, Maassen JA, Ouwens DM.

Arch Physiol Biochem. 2007 Oct-Dec;113(4-5):173-85.PMID: 18158643 [PubMed - indexed for MEDLINE]Related articles

Lessons that can be learned from patients with diabetogenic mutations in mitochondrial DNA: implications for common type 2 diabetes.

Maassen JA, 't Hart LM, Ouwens DM.

Curr Opin Clin Nutr Metab Care. 2007 Nov;10(6):693-7. Review.PMID: 18089949 [PubMed - indexed for MEDLINE]Related articles

Loss of 50% of excess weight using a very low energy diet improves insulin-stimulated glucose disposal and skeletal muscle insulin signalling in obese insulin-treated type 2 diabetic patients.

Jazet IM, Schaart G, Gastaldelli A, Ferrannini E, Hesselink MK, Schrauwen P, Romijn JA, Maassen JA, Pijl H, Ouwens DM, Meinders AE.

Diabetologia. 2008 Feb;51(2):309-19. Epub 2007 Dec 14.PMID: 18080107 [PubMed - indexed for MEDLINE]Related articles

Neuropeptide Y polymorphism significantly magnifies diabetes and cardiovascular disease risk in obesity: the Hoorn Study.

Jaakkola U, Kallio J, Heine RJ, Nijpels G, T' Hart LM, Maassen JA, Bouter LM, Stehouwer CD, Dekker JM.

Eur J Clin Nutr. 2009 Jan;63(1):150-2. Epub 2007 Nov 28.PMID: 18043699 [PubMed - indexed for MEDLINE]Related articles

Fatty acid-induced mitochondrial uncoupling in adipocytes as a key protective factor against insulin resistance and beta cell dysfunction: a new concept in the pathogenesis of obesity-associated type 2 diabetes mellitus.

Maassen JA, Romijn JA, Heine RJ.

Diabetologia. 2007 Oct;50(10):2036-41. Epub 2007 Aug 22.PMID: 17712547 [PubMed - indexed for MEDLINE]Related articlesFree article

The A3243G tRNALeu(UUR) mutation induces mitochondrial dysfunction and variable disease expression without dominant negative acting translational defects in complex IV subunits at UUR codons.

Janssen GM, Hensbergen PJ, van Bussel FJ, Balog CI, Maassen JA, Deelder AM, Raap AK.

Hum Mol Genet. 2007 Oct 15;16(20):2472-81. Epub 2007 Jul 25.PMID: 17656376 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-mediated phosphorylation of the proline-rich Akt substrate PRAS40 is impaired in insulin target tissues of high-fat diet-fed rats.

Nascimento EB, Fodor M, van der Zon GC, Jazet IM, Meinders AE, Voshol PJ, Vlasblom R, Baan B, Eckel J, Maassen JA, Diamant M, Ouwens DM.

Diabetes. 2006 Dec;55(12):3221-8.PMID: 17130464 [PubMed - indexed for MEDLINE]Related articlesFree article

The HADHSC gene encoding short-chain L-3-hydroxyacyl-CoA dehydrogenase (SCHAD) and type 2 diabetes susceptibility: the DAMAGE study.

van Hove EC, Hansen T, Dekker JM, Reiling E, Nijpels G, Jørgensen T, Borch-Johnsen K, Hamid YH, Heine RJ, Pedersen O, Maassen JA, 't Hart LM.

Diabetes. 2006 Nov;55(11):3193-6.PMID: 17065362 [PubMed - indexed for MEDLINE]Related articlesFree article

Mitochondrial diabetes and its lessons for common Type 2 diabetes.

Maassen JA, 't Hart LM, Janssen GM, Reiling E, Romijn JA, Lemkes HH.

Biochem Soc Trans. 2006 Nov;34(Pt 5):819-23.PMID: 17052206 [PubMed - indexed for MEDLINE]Related articles

Sustained activation of the mammalian target of rapamycin nutrient sensing pathway is associated with hepatic insulin resistance, but not with steatosis, in mice.

Korsheninnikova E, van der Zon GC, Voshol PJ, Janssen GM, Havekes LM, Grefhorst A, Kuipers F, Reijngoud DJ, Romijn JA, Ouwens DM, Maassen JA.

Diabetologia. 2006 Dec;49(12):3049-57. Epub 2006 Sep 28.PMID: 17006666 [PubMed - indexed for MEDLINE]Related articles

Diabetes-associated mitochondrial DNA mutation A3243G impairs cellular metabolic pathways necessary for beta cell function.

de Andrade PB, Rubi B, Frigerio F, van den Ouweland JM, Maassen JA, Maechler P.

Diabetologia. 2006 Aug;49(8):1816-26. Epub 2006 May 31.PMID: 16736129 [PubMed - indexed for MEDLINE]Related articles

New insights in the molecular pathogenesis of the maternally inherited diabetes and deafness syndrome.

Maassen JA, Jahangir Tafrechi RS, Janssen GM, Raap AK, Lemkes HH, 't Hart LM.

Endocrinol Metab Clin North Am. 2006 Jun;35(2):385-96, x-xi. Review.PMID: 16632100 [PubMed - indexed for MEDLINE]Related articles

The role of c-Jun N-terminal kinase, p38, and extracellular signal-regulated kinase in insulin-induced Thr69 and Thr71 phosphorylation of activating transcription factor 2.

Baan B, van Dam H, van der Zon GC, Maassen JA, Ouwens DM.

Mol Endocrinol. 2006 Aug;20(8):1786-95. Epub 2006 Apr 6.PMID: 16601071 [PubMed - indexed for MEDLINE]Related articlesFree article

Mitochondrial dysfunction in adipocytes: the culprit in type 2 diabetes?

Maassen JA.

Diabetologia. 2006 Apr;49(4):619-20. No abstract available. PMID: 16491392 [PubMed - indexed for MEDLINE]Related articles

Effect of a 2-day very low-energy diet on skeletal muscle insulin sensitivity in obese type 2 diabetic patients on insulin therapy.

Jazet IM, Ouwens DM, Schaart G, Pijl H, Keizer H, Maassen JA, Meinders AE.

Metabolism. 2005 Dec;54(12):1669-78.PMID: 16311102 [PubMed - indexed for MEDLINE]Related articles

Distinct nuclear gene expression profiles in cells with mtDNA depletion and homoplasmic A3243G mutation.

Jahangir Tafrechi RS, Svensson PJ, Janssen GM, Szuhai K, Maassen JA, Raap AK.

Mutat Res. 2005 Oct 15;578(1-2):43-52.PMID: 16202796 [PubMed - indexed for MEDLINE]Related articles

Molecular mechanisms of mitochondrial diabetes (MIDD).

Maassen JA, Janssen GM, 't Hart LM.

Ann Med. 2005;37(3):213-21. Review.PMID: 16019720 [PubMed - indexed for MEDLINE]Related articles

Evidence that the mitochondrial leucyl tRNA synthetase (LARS2) gene represents a novel type 2 diabetes susceptibility gene.

't Hart LM, Hansen T, Rietveld I, Dekker JM, Nijpels G, Janssen GM, Arp PA, Uitterlinden AG, Jørgensen T, Borch-Johnsen K, Pols HA, Pedersen O, van Duijn CM, Heine RJ, Maassen JA.

Diabetes. 2005 Jun;54(6):1892-5.PMID: 15919814 [PubMed - indexed for MEDLINE]Related articlesFree article

Cardiac dysfunction induced by high-fat diet is associated with altered myocardial insulin signalling in rats.

Ouwens DM, Boer C, Fodor M, de Galan P, Heine RJ, Maassen JA, Diamant M.

Diabetologia. 2005 Jun;48(6):1229-37. Epub 2005 Apr 30.PMID: 15864533 [PubMed - indexed for MEDLINE]Related articles

[Molecular diagnosis on indication of maturity onset diabetes of the young; results from 184 patients]

Losekoot M, Broekman AJ, Breuning MH, de Koning EJ, Romijn JA, Maassen JA.

Ned Tijdschr Geneeskd. 2005 Jan 15;149(3):139-43. Dutch. PMID: 15693590 [PubMed - indexed for MEDLINE]Related articles

The p38 mitogen-activated protein kinase inhibitor SB203580 reduces glucose turnover by the glucose transporter-4 of 3T3-L1 adipocytes in the insulin-stimulated state.

Bazuine M, Carlotti F, Rabelink MJ, Vellinga J, Hoeben RC, Maassen JA.

Endocrinology. 2005 Apr;146(4):1818-24. Epub 2005 Jan 21.PMID: 15665038 [PubMed - indexed for MEDLINE]Related articlesFree article

Genistein directly inhibits GLUT4-mediated glucose uptake in 3T3-L1 adipocytes.

Bazuine M, van den Broek PJ, Maassen JA.

Biochem Biophys Res Commun. 2005 Jan 14;326(2):511-4.PMID: 15582607 [PubMed - indexed for MEDLINE]Related articles

Mutations in the NSD1 gene in patients with Sotos syndrome associate with endocrine and paracrine alterations in the IGF system.

De Boer L, Van Duyvenvoorde HA, Willemstein-Van Hove EC, Hoogerbrugge CM, Van Doorn J, Maassen JA, Karperien M, Wit JM.

Eur J Endocrinol. 2004 Sep;151(3):333-41.PMID: 15362962 [PubMed - indexed for MEDLINE]Related articlesFree article

A man with diabetes and heart failure.

Nijveldt R, Serné EH, Sepers JM, Maassen JA, Cornel JH, Arnold AE.

Lancet. 2004 Aug 14-20;364(9434):636. No abstract available. PMID: 15313366 [PubMed - indexed for MEDLINE]Related articles

Regulation of GLUT1-mediated glucose uptake by PKClambda-PKCbeta(II) interactions in 3T3-L1 adipocytes.

Bosch RR, Bazuine M, Span PN, Willems PH, Olthaar AJ, van Rennes H, Maassen JA, Tack CJ, Hermus AR, Sweep CG.

Biochem J. 2004 Dec 1;384(Pt 2):349-55.PMID: 15307820 [PubMed - indexed for MEDLINE]Related articlesFree article

Mitogen-activated protein kinase (MAPK) phosphatase-1 and -4 attenuate p38 MAPK during dexamethasone-induced insulin resistance in 3T3-L1 adipocytes.

Bazuine M, Carlotti F, Tafrechi RS, Hoeben RC, Maassen JA.

Mol Endocrinol. 2004 Jul;18(7):1697-707. Epub 2004 Apr 15.PMID: 15184525 [PubMed - indexed for MEDLINE]Related articlesFree article

The Gly482Ser variant in the peroxisome proliferator-activated receptor gamma coactivator-1 is not associated with diabetes-related traits in non-diabetic German and Dutch populations.

Stumvoll M, Fritsche A, t'Hart LM, Machann J, Thamer C, Tschritter O, Van Haeften TW, Jacob S, Dekker JM, Maassen JA, Machicao F, Schick F, Heine RJ, Häring H.

Exp Clin Endocrinol Diabetes. 2004 May;112(5):253-7.PMID: 15146371 [PubMed - indexed for MEDLINE]Related articles

A novel 7301-bp deletion in mitochondrial DNA in a patient with Kearns-Sayre syndrome, diabetes mellitus, and primary amenorrhoea.

De Block CE, De Leeuw IH, Maassen JA, Ballaux D, Martin JJ.

Exp Clin Endocrinol Diabetes. 2004 Feb;112(2):80-3.PMID: 15031771 [PubMed - indexed for MEDLINE]Related articles

Lentiviral vectors efficiently transduce quiescent mature 3T3-L1 adipocytes.

Carlotti F, Bazuine M, Kekarainen T, Seppen J, Pognonec P, Maassen JA, Hoeben RC.

Mol Ther. 2004 Feb;9(2):209-17.PMID: 14759805 [PubMed - indexed for MEDLINE]Related articles

Mitochondrial diabetes: molecular mechanisms and clinical presentation.

Maassen JA, 'T Hart LM, Van Essen E, Heine RJ, Nijpels G, Jahangir Tafrechi RS, Raap AK, Janssen GM, Lemkes HH.

Diabetes. 2004 Feb;53 Suppl 1:S103-9. Review.PMID: 14749274 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic factors and insulin secretion: gene variants in the IGF genes.

't Hart LM, Fritsche A, Rietveld I, Dekker JM, Nijpels G, Machicao F, Stumvoll M, van Duijn CM, Häring HU, Heine RJ, Maassen JA, van Haeften TW.

Diabetes. 2004 Feb;53 Suppl 1:S26-30.PMID: 14749262 [PubMed - indexed for MEDLINE]Related articlesFree article

Arsenite stimulated glucose transport in 3T3-L1 adipocytes involves both Glut4 translocation and p38 MAPK activity.

Bazuine M, Ouwens DM, Gomes de Mesquita DS, Maassen JA.

Eur J Biochem. 2003 Oct;270(19):3891-903.PMID: 14511371 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification and functional assessment of novel and known insulin receptor mutations in five patients with syndromes of severe insulin resistance.

Maassen JA, Tobias ES, Kayserilli H, Tukel T, Yuksel-Apak M, D'Haens E, Kleijer WJ, Féry F, van der Zon GC.

J Clin Endocrinol Metab. 2003 Sep;88(9):4251-7.PMID: 12970295 [PubMed - indexed for MEDLINE]Related articlesFree article

CD36 deficiency increases insulin sensitivity in muscle, but induces insulin resistance in the liver in mice.

Goudriaan JR, Dahlmans VE, Teusink B, Ouwens DM, Febbraio M, Maassen JA, Romijn JA, Havekes LM, Voshol PJ.

J Lipid Res. 2003 Dec;44(12):2270-7. Epub 2003 Aug 16.PMID: 12923231 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased hepatic insulin sensitivity together with decreased hepatic triglyceride stores in hormone-sensitive lipase-deficient mice.

Voshol PJ, Haemmerle G, Ouwens DM, Zimmermann R, Zechner R, Teusink B, Maassen JA, Havekes LM, Romijn JA.

Endocrinology. 2003 Aug;144(8):3456-62.PMID: 12865325 [PubMed - indexed for MEDLINE]Related articlesFree article

Lack of association between gene variants in the ALMS1 gene and Type 2 diabetes mellitus.

't Hart LM, Maassen JA, Dekker JM, Heine RJ, Maassen JA.

Diabetologia. 2003 Jul;46(7):1023-4. Epub 2003 Jun 21. No abstract available. PMID: 12827243 [PubMed - indexed for MEDLINE]Related articles

Prevalence of mutations in AGPAT2 among human lipodystrophies.

Magré J, Delépine M, Van Maldergem L, Robert JJ, Maassen JA, Meier M, Panz VR, Kim CA, Tubiana-Rufi N, Czernichow P, Seemanova E, Buchanan CR, Lacombe D, Vigouroux C, Lascols O, Kahn CR, Capeau J, Lathrop M.

Diabetes. 2003 Jun;52(6):1573-8.PMID: 12765973 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular characterization of WFS1 in patients with Wolfram syndrome.

van ven Ouweland JM, Cryns K, Pennings RJ, Walraven I, Janssen GM, Maassen JA, Veldhuijzen BF, Arntzenius AB, Lindhout D, Cremers CW, Van Camp G, Dikkeschei LD.

J Mol Diagn. 2003 May;5(2):88-95.PMID: 12707373 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of protein kinase CbetaII increases glucose uptake in 3T3-L1 adipocytes through elevated expression of glucose transporter 1 at the plasma membrane.

Bosch RR, Bazuine M, Wake MM, Span PN, Olthaar AJ, Schürmann A, Maassen JA, Hermus AR, Willems PH, Sweep CG.

Mol Endocrinol. 2003 Jul;17(7):1230-9. Epub 2003 Apr 17.PMID: 12702734 [PubMed - indexed for MEDLINE]Related articlesFree article

Mitochondrial diabetes, diabetes and the thiamine-responsive megaloblastic anaemia syndrome and MODY-2. Diseases with common pathophysiology?

Maassen JA.

Panminerva Med. 2002 Dec;44(4):295-300. Review.PMID: 12434122 [PubMed - indexed for MEDLINE]Related articles