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    Results: 1 to 50 of 527

    1.

    Oncogene mutations, copy number gains and mutant allele specific imbalance (MASI) frequently occur together in tumor cells.

    Soh J, Okumura N, Lockwood WW, Yamamoto H, Shigematsu H, Zhang W, Chari R, Shames DS, Tang X, MacAulay C, Varella-Garcia M, Vooder T, Wistuba II, Lam S, Brekken R, Toyooka S, Minna JD, Lam WL, Gazdar AF.

    PLoS One. 2009 Oct 14;4(10):e7464.PMID: 19826477 [PubMed - in process]Related articlesFree article

    2.

    SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas.

    Bass AJ, Watanabe H, Mermel CH, Yu S, Perner S, Verhaak RG, Kim SY, Wardwell L, Tamayo P, Gat-Viks I, Ramos AH, Woo MS, Weir BA, Getz G, Beroukhim R, O'Kelly M, Dutt A, Rozenblatt-Rosen O, Dziunycz P, Komisarof J, Chirieac LR, Lafargue CJ, Scheble V, Wilbertz T, Ma C, Rao S, Nakagawa H, Stairs DB, Lin L, Giordano TJ, Wagner P, Minna JD, Gazdar AF, Zhu CQ, Brose MS, Cecconello I, Jr UR, Marie SK, Dahl O, Shivdasani RA, Tsao MS, Rubin MA, Wong KK, Regev A, Hahn WC, Beer DG, Rustgi AK, Meyerson M.

    Nat Genet. 2009 Nov;41(11):1238-42. Epub 2009 Oct 4.PMID: 19801978 [PubMed - in process]Related articles

    3.

    High level of AKT activity is associated with resistance to MEK inhibitor AZD6244 (ARRY-142886).

    Meng J, Peng H, Dai B, Guo W, Wang L, Ji L, Minna JD, Chresta CM, Smith PD, Fang B, Roth JA.

    Cancer Biol Ther. 2009 Nov 18;8(21). [Epub ahead of print]PMID: 19783898 [PubMed - as supplied by publisher]Related articles

    4.

    Amplification of chromosomal segment 4q12 in non-small cell lung cancer.

    Ramos AH, Dutt A, Mermel C, Perner S, Cho J, Lafargue CJ, Johnson LA, Stiedl AC, Tanaka KE, Bass AJ, Barretina J, Weir BA, Beroukhim R, Thomas RK, Minna JD, Chirieac LR, Lindeman NI, Giordano T, Beer DG, Wagner P, Wistuba II, Rubin MA, Meyerson M.

    Cancer Biol Ther. 2009 Nov 7;8(21). [Epub ahead of print]PMID: 19755855 [PubMed - as supplied by publisher]Related articles

    5.

    miR-93, miR-98, and miR-197 regulate expression of tumor suppressor gene FUS1.

    Du L, Schageman JJ, Subauste MC, Saber B, Hammond SM, Prudkin L, Wistuba II, Ji L, Roth JA, Minna JD, Pertsemlidis A.

    Mol Cancer Res. 2009 Aug;7(8):1234-43. Epub 2009 Aug 11.PMID: 19671678 [PubMed - in process]Related articles

    6.

    Molecular profiling of breast cancer cell lines defines relevant tumor models and provides a resource for cancer gene discovery.

    Kao J, Salari K, Bocanegra M, Choi YL, Girard L, Gandhi J, Kwei KA, Hernandez-Boussard T, Wang P, Gazdar AF, Minna JD, Pollack JR.

    PLoS One. 2009 Jul 3;4(7):e6146.PMID: 19582160 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    A gene-alteration profile of human lung cancer cell lines.

    Blanco R, Iwakawa R, Tang M, Kohno T, Angulo B, Pio R, Montuenga LM, Minna JD, Yokota J, Sanchez-Cespedes M.

    Hum Mutat. 2009 Aug;30(8):1199-206.PMID: 19472407 [PubMed - indexed for MEDLINE]Related articles

    8.

    Predicting drug susceptibility of non-small cell lung cancers based on genetic lesions.

    Sos ML, Michel K, Zander T, Weiss J, Frommolt P, Peifer M, Li D, Ullrich R, Koker M, Fischer F, Shimamura T, Rauh D, Mermel C, Fischer S, Stückrath I, Heynck S, Beroukhim R, Lin W, Winckler W, Shah K, LaFramboise T, Moriarty WF, Hanna M, Tolosi L, Rahnenführer J, Verhaak R, Chiang D, Getz G, Hellmich M, Wolf J, Girard L, Peyton M, Weir BA, Chen TH, Greulich H, Barretina J, Shapiro GI, Garraway LA, Gazdar AF, Minna JD, Meyerson M, Wong KK, Thomas RK.

    J Clin Invest. 2009 Jun;119(6):1727-40. doi: 10.1172/JCI37127. Epub 2009 May 18.PMID: 19451690 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Activity and intracellular location of estrogen receptors alpha and beta in human bronchial epithelial cells.

    Ivanova MM, Mazhawidza W, Dougherty SM, Minna JD, Klinge CM.

    Mol Cell Endocrinol. 2009 Jun 16;305(1-2):12-21. Epub 2009 Feb 7.PMID: 19433257 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    Distinct biological roles for the notch ligands Jagged-1 and Jagged-2.

    Choi K, Ahn YH, Gibbons DL, Tran HT, Creighton CJ, Girard L, Minna JD, Qin FX, Kurie JM.

    J Biol Chem. 2009 Jun 26;284(26):17766-74. Epub 2009 Apr 27.PMID: 19398556 [PubMed - indexed for MEDLINE]Related articles

    11.

    Multifocal lung cancers--clonality vs field cancerization and does it matter?

    Gazdar AF, Minna JD.

    J Natl Cancer Inst. 2009 Apr 15;101(8):541-3. Epub 2009 Apr 7. No abstract available. PMID: 19351914 [PubMed - indexed for MEDLINE]Related articles

    12.

    PTEN loss contributes to erlotinib resistance in EGFR-mutant lung cancer by activation of Akt and EGFR.

    Sos ML, Koker M, Weir BA, Heynck S, Rabinovsky R, Zander T, Seeger JM, Weiss J, Fischer F, Frommolt P, Michel K, Peifer M, Mermel C, Girard L, Peyton M, Gazdar AF, Minna JD, Garraway LA, Kashkar H, Pao W, Meyerson M, Thomas RK.

    Cancer Res. 2009 Apr 15;69(8):3256-61. Epub 2009 Apr 7.PMID: 19351834 [PubMed - indexed for MEDLINE]Related articles

    13.

    SRBC/cavin-3 is a caveolin adapter protein that regulates caveolae function.

    McMahon KA, Zajicek H, Li WP, Peyton MJ, Minna JD, Hernandez VJ, Luby-Phelps K, Anderson RG.

    EMBO J. 2009 Apr 22;28(8):1001-15. Epub 2009 Mar 5.PMID: 19262564 [PubMed - indexed for MEDLINE]Related articles

    14.

    Alterations in genes of the EGFR signaling pathway and their relationship to EGFR tyrosine kinase inhibitor sensitivity in lung cancer cell lines.

    Gandhi J, Zhang J, Xie Y, Soh J, Shigematsu H, Zhang W, Yamamoto H, Peyton M, Girard L, Lockwood WW, Lam WL, Varella-Garcia M, Minna JD, Gazdar AF.

    PLoS One. 2009;4(2):e4576. Epub 2009 Feb 24.PMID: 19238210 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Small-cell lung cancer: translational research enroute to therapeutic advances.

    Dowell J, Minna JD.

    Oncology (Williston Park). 2008 Nov 30;22(13):1493, 1495. No abstract available. PMID: 19227570 [PubMed - indexed for MEDLINE]Related articles

    16.

    Histone deacetylase inhibitor romidepsin enhances anti-tumor effect of erlotinib in non-small cell lung cancer (NSCLC) cell lines.

    Zhang W, Peyton M, Xie Y, Soh J, Minna JD, Gazdar AF, Frenkel EP.

    J Thorac Oncol. 2009 Feb;4(2):161-6.PMID: 19179890 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Deregulated EGFR signaling during lung cancer progression: mutations, amplicons, and autocrine loops.

    Gazdar AF, Minna JD.

    Cancer Prev Res (Phila Pa). 2008 Aug;1(3):156-60. No abstract available. PMID: 19138950 [PubMed - indexed for MEDLINE]Related articles

    18.

    MET gene amplification or EGFR mutation activate MET in lung cancers untreated with EGFR tyrosine kinase inhibitors.

    Kubo T, Yamamoto H, Lockwood WW, Valencia I, Soh J, Peyton M, Jida M, Otani H, Fujii T, Ouchida M, Takigawa N, Kiura K, Shimizu K, Date H, Minna JD, Varella-Garcia M, Lam WL, Gazdar AF, Toyooka S.

    Int J Cancer. 2009 Apr 15;124(8):1778-84.PMID: 19117057 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Data driven semantic integration of translational lung cancer research at MDAnderson Cancer Center.

    Deus HF, Stanislaus R, Behrens C, Wistuba II, Minna JD, Garner HR, Swisher SG, Roth JA, Correa AM, Broom B, Coombes K, Almeida JS.

    AMIA Annu Symp Proc. 2008 Nov 6:927.PMID: 18999102 [PubMed - in process]Related articles

    20.

    Semaphorin 3B inhibits the phosphatidylinositol 3-kinase/Akt pathway through neuropilin-1 in lung and breast cancer cells.

    Castro-Rivera E, Ran S, Brekken RA, Minna JD.

    Cancer Res. 2008 Oct 15;68(20):8295-303.PMID: 18922901 [PubMed - indexed for MEDLINE]Related articlesFree article

    21.

    Cytoglobin, the newest member of the globin family, functions as a tumor suppressor gene.

    Shivapurkar N, Stastny V, Okumura N, Girard L, Xie Y, Prinsen C, Thunnissen FB, Wistuba II, Czerniak B, Frenkel E, Roth JA, Liloglou T, Xinarianos G, Field JK, Minna JD, Gazdar AF.

    Cancer Res. 2008 Sep 15;68(18):7448-56.PMID: 18794132 [PubMed - indexed for MEDLINE]Related articlesFree article

    22.

    Comparisons of tyrosine phosphorylated proteins in cells expressing lung cancer-specific alleles of EGFR and KRAS.

    Guha U, Chaerkady R, Marimuthu A, Patterson AS, Kashyap MK, Harsha HC, Sato M, Bader JS, Lash AE, Minna JD, Pandey A, Varmus HE.

    Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):14112-7. Epub 2008 Sep 5.PMID: 18776048 [PubMed - indexed for MEDLINE]Related articlesFree article

    23.

    PIK3CA mutations and copy number gains in human lung cancers.

    Yamamoto H, Shigematsu H, Nomura M, Lockwood WW, Sato M, Okumura N, Soh J, Suzuki M, Wistuba II, Fong KM, Lee H, Toyooka S, Date H, Lam WL, Minna JD, Gazdar AF.

    Cancer Res. 2008 Sep 1;68(17):6913-21.PMID: 18757405 [PubMed - indexed for MEDLINE]Related articlesFree article

    24.

    A Semantic Web management model for integrative biomedical informatics.

    Deus HF, Stanislaus R, Veiga DF, Behrens C, Wistuba II, Minna JD, Garner HR, Swisher SG, Roth JA, Correa AM, Broom B, Coombes K, Chang A, Vogel LH, Almeida JS.

    PLoS One. 2008 Aug 13;3(8):e2946.PMID: 18698353 [PubMed - indexed for MEDLINE]Related articlesFree article

    25.

    Predicting the future for people with lung cancer.

    Xie Y, Minna JD.

    Nat Med. 2008 Aug;14(8):812-3. No abstract available. PMID: 18685594 [PubMed - indexed for MEDLINE]Related articles

    26.

    Summary report 7th Annual Targeted Therapies of the Treatment of Lung Cancer.

    Einhorn LH, Bonomi P, Bunn PA Jr, Camidge DR, Carbone DP, Choy H, Dubinett SM, Gandara DR, Gaspar LE, Govindan R, Johnson DH, Minna JD, Scagliotti G, West HJ, Herbst RS.

    J Thorac Oncol. 2008 May;3(5):545-55. No abstract available. PMID: 18449013 [PubMed - indexed for MEDLINE]Related articles

    27.

    Differential methylation of a short CpG-rich sequence within exon 1 of TCF21 gene: a promising cancer biomarker assay.

    Shivapurkar N, Stastny V, Xie Y, Prinsen C, Frenkel E, Czerniak B, Thunnissen FB, Minna JD, Gazdar AF.

    Cancer Epidemiol Biomarkers Prev. 2008 Apr;17(4):995-1000.PMID: 18398044 [PubMed - indexed for MEDLINE]Related articlesFree article

    28.

    DNA amplification is a ubiquitous mechanism of oncogene activation in lung and other cancers.

    Lockwood WW, Chari R, Coe BP, Girard L, Macaulay C, Lam S, Gazdar AF, Minna JD, Lam WL.

    Oncogene. 2008 Jul 31;27(33):4615-24. Epub 2008 Apr 7.PMID: 18391978 [PubMed - indexed for MEDLINE]Related articles

    29.

    The RASSF1A tumor suppressor restrains anaphase-promoting complex/cyclosome activity during the G1/S phase transition to promote cell cycle progression in human epithelial cells.

    Whitehurst AW, Ram R, Shivakumar L, Gao B, Minna JD, White MA.

    Mol Cell Biol. 2008 May;28(10):3190-7. Epub 2008 Mar 17.PMID: 18347058 [PubMed - indexed for MEDLINE]Related articlesFree article

    30.

    Pten inactivation accelerates oncogenic K-ras-initiated tumorigenesis in a mouse model of lung cancer.

    Iwanaga K, Yang Y, Raso MG, Ma L, Hanna AE, Thilaganathan N, Moghaddam S, Evans CM, Li H, Cai WW, Sato M, Minna JD, Wu H, Creighton CJ, Demayo FJ, Wistuba II, Kurie JM.

    Cancer Res. 2008 Feb 15;68(4):1119-27.PMID: 18281487 [PubMed - indexed for MEDLINE]Related articlesFree article

    31.

    IP6K2 is a client for HSP90 and a target for cancer therapeutics development.

    Shames DS, Minna JD.

    Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1389-90. Epub 2008 Jan 29. No abstract available. PMID: 18230718 [PubMed - indexed for MEDLINE]Related articlesFree article

    32.

    Genomic profiling identifies TITF1 as a lineage-specific oncogene amplified in lung cancer.

    Kwei KA, Kim YH, Girard L, Kao J, Pacyna-Gengelbach M, Salari K, Lee J, Choi YL, Sato M, Wang P, Hernandez-Boussard T, Gazdar AF, Petersen I, Minna JD, Pollack JR.

    Oncogene. 2008 Jun 5;27(25):3635-40. Epub 2008 Jan 21.PMID: 18212743 [PubMed - indexed for MEDLINE]Related articles

    33.

    RASSF1A polymorphism A133S is associated with early onset breast cancer in BRCA1/2 mutation carriers.

    Gao B, Xie XJ, Huang C, Shames DS, Chen TT, Lewis CM, Bian A, Zhang B, Olopade OI, Garber JE, Euhus DM, Tomlinson GE, Minna JD.

    Cancer Res. 2008 Jan 1;68(1):22-5.PMID: 18172292 [PubMed - indexed for MEDLINE]Related articlesFree article

    34.

    Loss and reduction of FUS1 protein expression is a frequent phenomenon in the pathogenesis of lung cancer.

    Prudkin L, Behrens C, Liu DD, Zhou X, Ozburn NC, Bekele BN, Minna JD, Moran C, Roth JA, Ji L, Wistuba II.

    Clin Cancer Res. 2008 Jan 1;14(1):41-7.PMID: 18172250 [PubMed - indexed for MEDLINE]Related articlesFree article

    35.

    Characterizing the cancer genome in lung adenocarcinoma.

    Weir BA, Woo MS, Getz G, Perner S, Ding L, Beroukhim R, Lin WM, Province MA, Kraja A, Johnson LA, Shah K, Sato M, Thomas RK, Barletta JA, Borecki IB, Broderick S, Chang AC, Chiang DY, Chirieac LR, Cho J, Fujii Y, Gazdar AF, Giordano T, Greulich H, Hanna M, Johnson BE, Kris MG, Lash A, Lin L, Lindeman N, Mardis ER, McPherson JD, Minna JD, Morgan MB, Nadel M, Orringer MB, Osborne JR, Ozenberger B, Ramos AH, Robinson J, Roth JA, Rusch V, Sasaki H, Shepherd F, Sougnez C, Spitz MR, Tsao MS, Twomey D, Verhaak RG, Weinstock GM, Wheeler DA, Winckler W, Yoshizawa A, Yu S, Zakowski MF, Zhang Q, Beer DG, Wistuba II, Watson MA, Garraway LA, Ladanyi M, Travis WD, Pao W, Rubin MA, Gabriel SB, Gibbs RA, Varmus HE, Wilson RK, Lander ES, Meyerson M.

    Nature. 2007 Dec 6;450(7171):893-8. Epub 2007 Nov 4.PMID: 17982442 [PubMed - indexed for MEDLINE]Related articlesFree article

    36.

    Fragile histidine triad-mediated tumor suppression of lung cancer by targeting multiple components of the Ras/Rho GTPase molecular switch.

    Jayachandran G, Sazaki J, Nishizaki M, Xu K, Girard L, Minna JD, Roth JA, Ji L.

    Cancer Res. 2007 Nov 1;67(21):10379-88.PMID: 17974981 [PubMed - indexed for MEDLINE]Related articlesFree article

    37.

    Epidermal growth factor receptor pathway analysis identifies amphiregulin as a key factor for cisplatin resistance of human breast cancer cells.

    Eckstein N, Servan K, Girard L, Cai D, von Jonquieres G, Jaehde U, Kassack MU, Gazdar AF, Minna JD, Royer HD.

    J Biol Chem. 2008 Jan 11;283(2):739-50. Epub 2007 Oct 17.PMID: 17942395 [PubMed - indexed for MEDLINE]Related articlesFree article

    38.

    New molecularly targeted therapies for lung cancer.

    Sun S, Schiller JH, Spinola M, Minna JD.

    J Clin Invest. 2007 Oct;117(10):2740-50. Review.PMID: 17909619 [PubMed - indexed for MEDLINE]Related articlesFree article

    39.

    Tumor mRNA expression profiles predict responses to chemotherapy.

    Minna JD, Girard L, Xie Y.

    J Clin Oncol. 2007 Oct 1;25(28):4329-36. Review. No abstract available. PMID: 17906194 [PubMed - indexed for MEDLINE]Related articles

    40.

    Seizure 6-like (SEZ6L) gene and risk for lung cancer.

    Gorlov IP, Meyer P, Liloglou T, Myles J, Boettger MB, Cassidy A, Girard L, Minna JD, Fischer R, Duffy S, Spitz MR, Haeussinger K, Kammerer S, Cantor C, Dierkesmann R, Field JK, Amos CI.

    Cancer Res. 2007 Sep 1;67(17):8406-11.PMID: 17804757 [PubMed - indexed for MEDLINE]Related articlesFree article

    41.

    Epidermal growth factor receptors with tyrosine kinase domain mutations exhibit reduced Cbl association, poor ubiquitylation, and down-regulation but are efficiently internalized.

    Padrón D, Sato M, Shay JW, Gazdar AF, Minna JD, Roth MG.

    Cancer Res. 2007 Aug 15;67(16):7695-702.PMID: 17699773 [PubMed - indexed for MEDLINE]Related articlesFree article

    42.

    Homozygous deletion scanning of the lung cancer genome at a 100-kb resolution.

    Nagayama K, Kohno T, Sato M, Arai Y, Minna JD, Yokota J.

    Genes Chromosomes Cancer. 2007 Nov;46(11):1000-10.PMID: 17674361 [PubMed - indexed for MEDLINE]Related articles

    43.

    Silencing of HPV 18 oncoproteins With RNA interference causes growth inhibition of cervical cancer cells.

    Lea JS, Sunaga N, Sato M, Kalahasti G, Miller DS, Minna JD, Muller CY.

    Reprod Sci. 2007 Jan;14(1):20-8.PMID: 17636212 [PubMed - indexed for MEDLINE]Related articles

    44.

    Tumor suppressor 101F6 and ascorbate synergistically and selectively inhibit non-small cell lung cancer growth by caspase-independent apoptosis and autophagy.

    Ohtani S, Iwamaru A, Deng W, Ueda K, Wu G, Jayachandran G, Kondo S, Atkinson EN, Minna JD, Roth JA, Ji L.

    Cancer Res. 2007 Jul 1;67(13):6293-303.PMID: 17616688 [PubMed - indexed for MEDLINE]Related articlesFree article

    45.

    An NQO1- and PARP-1-mediated cell death pathway induced in non-small-cell lung cancer cells by beta-lapachone.

    Bey EA, Bentle MS, Reinicke KE, Dong Y, Yang CR, Girard L, Minna JD, Bornmann WG, Gao J, Boothman DA.

    Proc Natl Acad Sci U S A. 2007 Jul 10;104(28):11832-7. Epub 2007 Jul 3.PMID: 17609380 [PubMed - indexed for MEDLINE]Related articlesFree article

    46.

    EGFR signaling is required for TGF-beta 1 mediated COX-2 induction in human bronchial epithelial cells.

    Liu M, Yang SC, Sharma S, Luo J, Cui X, Peebles KA, Huang M, Sato M, Ramirez RD, Shay JW, Minna JD, Dubinett SM.

    Am J Respir Cell Mol Biol. 2007 Nov;37(5):578-88. Epub 2007 Jun 28.PMID: 17600311 [PubMed - indexed for MEDLINE]Related articlesFree article

    47.

    Genes regulating the sensitivity of solid tumor cell lines to cytotoxic agents: a literature review.

    Sekine I, Minna JD, Nishio K, Saijo N, Tamura T.

    Jpn J Clin Oncol. 2007 May;37(5):329-36. Review.PMID: 17599944 [PubMed - indexed for MEDLINE]Related articlesFree article

    48.

    Somatic mutations in the tyrosine kinase domain of epidermal growth factor receptor (EGFR) abrogate EGFR-mediated radioprotection in non-small cell lung carcinoma.

    Das AK, Chen BP, Story MD, Sato M, Minna JD, Chen DJ, Nirodi CS.

    Cancer Res. 2007 Jun 1;67(11):5267-74.PMID: 17545606 [PubMed - indexed for MEDLINE]Related articlesFree article

    49.

    sIR: siRNA Information Resource, a web-based tool for siRNA sequence design and analysis and an open access siRNA database.

    Shah JK, Garner HR, White MA, Shames DS, Minna JD.

    BMC Bioinformatics. 2007 May 31;8:178.PMID: 17540034 [PubMed - indexed for MEDLINE]Related articlesFree article

    50.

    Expression of nicotinic acetylcholine receptor subunit genes in non-small-cell lung cancer reveals differences between smokers and nonsmokers.

    Lam DC, Girard L, Ramirez R, Chau WS, Suen WS, Sheridan S, Tin VP, Chung LP, Wong MP, Shay JW, Gazdar AF, Lam WK, Minna JD.

    Cancer Res. 2007 May 15;67(10):4638-47.PMID: 17510389 [PubMed - indexed for MEDLINE]Related articlesFree article

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