PubMed

Acromegaly pathogenesis and treatment.

Melmed S.

J Clin Invest. 2009 Nov;119(11):3189-202. doi: 10.1172/JCI39375. Epub 2009 Nov 2. Review.PMID: 19884662 [PubMed - indexed for MEDLINE]Related articles

E2F1 induces pituitary tumor transforming gene (PTTG1) expression in human pituitary tumors.

Zhou C, Wawrowsky K, Bannykh S, Gutman S, Melmed S.

Mol Endocrinol. 2009 Dec;23(12):2000-12. Epub 2009 Oct 16.PMID: 19837943 [PubMed - in process]Related articles

Differential ligand-mediated pituitary somatostatin receptor subtype signaling: implications for corticotroph tumor therapy.

Ben-Shlomo A, Schmid H, Wawrowsky K, Pichurin O, Hubina E, Chesnokova V, Liu NA, Culler M, Melmed S.

J Clin Endocrinol Metab. 2009 Nov;94(11):4342-50. Epub 2009 Oct 9.PMID: 19820006 [PubMed - in process]Related articles

Rapid and sustained reduction of serum growth hormone and insulin-like growth factor-1 in patients with acromegaly receiving lanreotide Autogel((R)) therapy: a randomized, placebo-controlled, multicenter study with a 52 week open extension.

Melmed S, Cook D, Schopohl J, Goth MI, Lam KS, Marek J.

Pituitary. 2009 Jul 29. [Epub ahead of print]PMID: 19639415 [PubMed - as supplied by publisher]Related articles

Pituitary tumour-transforming gene (PTTG) and pituitary senescence.

Chesnokova V, Melmed S.

Horm Res. 2009 Apr;71 Suppl 2:82-7. Epub 2009 Apr 29. Review.PMID: 19407503 [PubMed - indexed for MEDLINE]Related articles

Heregulin regulates prolactinoma gene expression.

Vlotides G, Cooper O, Chen YH, Ren SG, Greenman Y, Melmed S.

Cancer Res. 2009 May 15;69(10):4209-16. Epub 2009 Apr 28.PMID: 19401448 [PubMed - indexed for MEDLINE]Related articles

Fibroblast growth factor-2 autofeedback regulation in pituitary folliculostellate TtT/GF cells.

Vlotides G, Chen YH, Eigler T, Ren SG, Melmed S.

Endocrinology. 2009 Jul;150(7):3252-8. Epub 2009 Apr 9.PMID: 19359387 [PubMed - indexed for MEDLINE]Related articles

Pituitary adenoma growth: a model for cellular senescence and cytokine action.

Arzt E, Chesnokova V, Stalla GK, Melmed S.

Cell Cycle. 2009 Mar 1;8(5):677-8. Epub 2009 Mar 12. No abstract available. PMID: 19223763 [PubMed - indexed for MEDLINE]Related articles

Guidelines for acromegaly management: an update.

Melmed S, Colao A, Barkan A, Molitch M, Grossman AB, Kleinberg D, Clemmons D, Chanson P, Laws E, Schlechte J, Vance ML, Ho K, Giustina A; Acromegaly Consensus Group.

J Clin Endocrinol Metab. 2009 May;94(5):1509-17. Epub 2009 Feb 10. Review.PMID: 19208732 [PubMed - indexed for MEDLINE]Related articles

Constitutive somatostatin receptor activity determines tonic pituitary cell response.

Ben-Shlomo A, Zhou C, Pichurin O, Chesnokova V, Liu NA, Culler MD, Melmed S.

Mol Endocrinol. 2009 Mar;23(3):337-48. Epub 2009 Jan 8.PMID: 19131507 [PubMed - indexed for MEDLINE]Related articles

The utility of oral glucose tolerance testing for diagnosis and assessment of treatment outcomes in 166 patients with acromegaly.

Carmichael JD, Bonert VS, Mirocha JM, Melmed S.

J Clin Endocrinol Metab. 2009 Feb;94(2):523-7. Epub 2008 Nov 25.PMID: 19033371 [PubMed - indexed for MEDLINE]Related articles

Changing patterns of the adult growth hormone deficiency diagnosis documented in a decade-long global surveillance database.

Webb SM, Strasburger CJ, Mo D, Hartman ML, Melmed S, Jung H, Blum WF, Attanasio AF; HypoCCS International Advisory Board.

J Clin Endocrinol Metab. 2009 Feb;94(2):392-9. Epub 2008 Nov 11.PMID: 19001512 [PubMed - indexed for MEDLINE]Related articles

Guidelines for the treatment of growth hormone excess and growth hormone deficiency in adults.

Giustina A, Barkan A, Chanson P, Grossman A, Hoffman A, Ghigo E, Casanueva F, Colao A, Lamberts S, Sheppard M, Melmed S; Pituitary Society; European Neuroendocrine Association.

J Endocrinol Invest. 2008 Sep;31(9):820-38. Review.PMID: 18997495 [PubMed - indexed for MEDLINE]Related articles

p21(Cip1) restrains pituitary tumor growth.

Chesnokova V, Zonis S, Kovacs K, Ben-Shlomo A, Wawrowsky K, Bannykh S, Melmed S.

Proc Natl Acad Sci U S A. 2008 Nov 11;105(45):17498-503. Epub 2008 Nov 3.PMID: 18981426 [PubMed - indexed for MEDLINE]Related articlesFree article

Treatment of pituitary-dependent Cushing's disease with the multireceptor ligand somatostatin analog pasireotide (SOM230): a multicenter, phase II trial.

Boscaro M, Ludlam WH, Atkinson B, Glusman JE, Petersenn S, Reincke M, Snyder P, Tabarin A, Biller BM, Findling J, Melmed S, Darby CH, Hu K, Wang Y, Freda PU, Grossman AB, Frohman LA, Bertherat J.

J Clin Endocrinol Metab. 2009 Jan;94(1):115-22. Epub 2008 Oct 28.PMID: 18957506 [PubMed - indexed for MEDLINE]Related articles

Rat prolactinoma cell growth regulation by epidermal growth factor receptor ligands.

Vlotides G, Siegel E, Donangelo I, Gutman S, Ren SG, Melmed S.

Cancer Res. 2008 Aug 1;68(15):6377-86.PMID: 18676863 [PubMed - indexed for MEDLINE]Related articlesFree article

Pituitary tumor transforming gene 1 regulates Aurora kinase A activity.

Tong Y, Ben-Shlomo A, Zhou C, Wawrowsky K, Melmed S.

Oncogene. 2008 Oct 23;27(49):6385-95. Epub 2008 Jul 28.PMID: 18663361 [PubMed - indexed for MEDLINE]Related articles

Lipodystrophy in patients with acromegaly receiving pegvisomant.

Bonert VS, Kennedy L, Petersenn S, Barkan A, Carmichael J, Melmed S.

J Clin Endocrinol Metab. 2008 Sep;93(9):3515-8. Epub 2008 Jul 8.PMID: 18611977 [PubMed - indexed for MEDLINE]Related articlesFree article

Oct-1 induces pituitary tumor transforming gene expression in endocrine tumors.

Zhou C, Tong Y, Wawrowsky K, Bannykh S, Donangelo I, Melmed S.

Endocr Relat Cancer. 2008 Sep;15(3):817-31. Epub 2008 Jun 11.PMID: 18550719 [PubMed - indexed for MEDLINE]Related articlesFree article

In vivo time-lapse imaging delineates the zebrafish pituitary proopiomelanocortin lineage boundary regulated by FGF3 signal.

Liu NA, Ren M, Song J, Ríos Y, Wawrowsky K, Ben-Shlomo A, Lin S, Melmed S.

Dev Biol. 2008 Jul 15;319(2):192-200. Epub 2008 Apr 9.PMID: 18514643 [PubMed - indexed for MEDLINE]Related articlesFree article

A critical analysis of clinically available somatostatin analog formulations for therapy of acromegaly.

Murray RD, Melmed S.

J Clin Endocrinol Metab. 2008 Aug;93(8):2957-68. Epub 2008 May 13. Review.PMID: 18477663 [PubMed - indexed for MEDLINE]Related articlesFree article

Treatment of adrenocorticotropin-dependent Cushing's syndrome: a consensus statement.

Biller BM, Grossman AB, Stewart PM, Melmed S, Bertagna X, Bertherat J, Buchfelder M, Colao A, Hermus AR, Hofland LJ, Klibanski A, Lacroix A, Lindsay JR, Newell-Price J, Nieman LK, Petersenn S, Sonino N, Stalla GK, Swearingen B, Vance ML, Wass JA, Boscaro M.

J Clin Endocrinol Metab. 2008 Jul;93(7):2454-62. Epub 2008 Apr 15. Review.PMID: 18413427 [PubMed - indexed for MEDLINE]Related articlesFree article

gp130-Related Cytokines and Their Receptors in the Pituitary.

Melmed S.

Trends Endocrinol Metab. 1997 Dec;8(10):391-7.PMID: 18406828 [PubMed - in process]Related articles

gp130-Related Cytokines and Their Receptors in the Pituitary.

Melmed S.

Trends Endocrinol Metab. 1998 May-Jun;9(4):155-61.PMID: 18406260 [PubMed - in process]Related articles

Ovarian hyperstimulation syndrome caused by an FSH-secreting pituitary adenoma.

Cooper O, Geller JL, Melmed S.

Nat Clin Pract Endocrinol Metab. 2008 Apr;4(4):234-8. Epub 2008 Feb 12.PMID: 18268519 [PubMed - indexed for MEDLINE]Related articlesFree article

Update in pituitary disease.

Melmed S.

J Clin Endocrinol Metab. 2008 Feb;93(2):331-8. Review.PMID: 18258780 [PubMed - indexed for MEDLINE]Related articlesFree article

Anti-aging therapy with human growth hormone associated with metastatic colon cancer in a patient with Crohn's colitis.

Melmed GY, Devlin SM, Vlotides G, Dhall D, Ross S, Yu R, Melmed S.

Clin Gastroenterol Hepatol. 2008 Mar;6(3):360-3. Epub 2008 Feb 6.PMID: 18255351 [PubMed - indexed for MEDLINE]Related articlesFree article

Acromegaly.

Ben-Shlomo A, Melmed S.

Endocrinol Metab Clin North Am. 2008 Mar;37(1):101-22, viii. Review.PMID: 18226732 [PubMed - indexed for MEDLINE]Related articlesFree article

Somatostatin agonists for treatment of acromegaly.

Ben-Shlomo A, Melmed S.

Mol Cell Endocrinol. 2008 May 14;286(1-2):192-8. Epub 2007 Nov 29. Review.PMID: 18191325 [PubMed - indexed for MEDLINE]Related articlesFree article

Pasireotide--a somatostatin analog for the potential treatment of acromegaly, neuroendocrine tumors and Cushing's disease.

Ben-Shlomo A, Melmed S.

IDrugs. 2007 Dec;10(12):885-95.PMID: 18041687 [PubMed - indexed for MEDLINE]Related articles

Senescence mediates pituitary hypoplasia and restrains pituitary tumor growth.

Chesnokova V, Zonis S, Rubinek T, Yu R, Ben-Shlomo A, Kovacs K, Wawrowsky K, Melmed S.

Cancer Res. 2007 Nov 1;67(21):10564-72.PMID: 17975001 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of growth hormone and prolactin gene expression and secretion by chimeric somatostatin-dopamine molecules.

Gruszka A, Ren SG, Dong J, Culler MD, Melmed S.

Endocrinology. 2007 Dec;148(12):6107-14. Epub 2007 Jul 26.PMID: 17656461 [PubMed - indexed for MEDLINE]Related articlesFree article

Discordant proliferation and differentiation in pituitary tumor-transforming gene-null bone marrow stem cells.

Rubinek T, Chesnokova V, Wolf I, Wawrowsky K, Vlotides G, Melmed S.

Am J Physiol Cell Physiol. 2007 Sep;293(3):C1082-92. Epub 2007 Jul 11.PMID: 17626243 [PubMed - indexed for MEDLINE]Related articlesFree article

Selective regulation of somatostatin receptor subtype signaling: evidence for constitutive receptor activation.

Ben-Shlomo A, Pichurin O, Barshop NJ, Wawrowsky KA, Taylor J, Culler MD, Chesnokova V, Liu NA, Melmed S.

Mol Endocrinol. 2007 Oct;21(10):2565-78. Epub 2007 Jul 3.PMID: 17609435 [PubMed - indexed for MEDLINE]Related articlesFree article

Aryl hydrocarbon receptor interacting protein and pituitary tumorigenesis: another interesting protein.

Melmed S.

J Clin Endocrinol Metab. 2007 May;92(5):1617-9. No abstract available. PMID: 17483376 [PubMed - indexed for MEDLINE]Related articlesFree article

Pituitary tumor transforming gene interacts with Sp1 to modulate G1/S cell phase transition.

Tong Y, Tan Y, Zhou C, Melmed S.

Oncogene. 2007 Aug 16;26(38):5596-605. Epub 2007 Mar 12.PMID: 17353909 [PubMed - indexed for MEDLINE]Related articlesFree article

Pituitary tumor-transforming gene: physiology and implications for tumorigenesis.

Vlotides G, Eigler T, Melmed S.

Endocr Rev. 2007 Apr;28(2):165-86. Epub 2007 Feb 26. Review.PMID: 17325339 [PubMed - indexed for MEDLINE]Related articlesFree article

Medical progress: Acromegaly.

Melmed S.

N Engl J Med. 2006 Dec 14;355(24):2558-73. Review. No abstract available. Erratum in: N Engl J Med. 2007 Feb 22;356(8):879. PMID: 17167139 [PubMed - indexed for MEDLINE]Related articles

Murine pituitary tumor-transforming gene functions as a securin protein in insulin-secreting cells.

Yu R, Cruz-Soto M, Li Calzi S, Hui H, Melmed S.

J Endocrinol. 2006 Oct;191(1):45-53.PMID: 17065388 [PubMed - indexed for MEDLINE]Related articlesFree article

Aryl hydrocarbon receptor interacting protein variants in sporadic pituitary adenomas.

Yu R, Bonert V, Saporta I, Raffel LJ, Melmed S.

J Clin Endocrinol Metab. 2006 Dec;91(12):5126-9. Epub 2006 Oct 3.PMID: 17018653 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanisms for growth factor-induced pituitary tumor transforming gene-1 expression in pituitary folliculostellate TtT/GF cells.

Vlotides G, Cruz-Soto M, Rubinek T, Eigler T, Auernhammer CJ, Melmed S.

Mol Endocrinol. 2006 Dec;20(12):3321-35. Epub 2006 Sep 7.PMID: 16959877 [PubMed - indexed for MEDLINE]Related articlesFree article

Acromegaly with moderate hyperprolactinemia caused by an intrasellar macroadenoma.

Bonert VS, Melmed S.

Nat Clin Pract Endocrinol Metab. 2006 Jul;2(7):408-12; quiz following 412.PMID: 16932323 [PubMed - indexed for MEDLINE]Related articles

Supplemental growth hormone in healthy adults: the endocrinologist's responsibility.

Melmed S.

Nat Clin Pract Endocrinol Metab. 2006 Mar;2(3):119. No abstract available. PMID: 16932266 [PubMed - indexed for MEDLINE]Related articles

Skin manifestations in acromegaly.

Ben-Shlomo A, Melmed S.

Clin Dermatol. 2006 Jul-Aug;24(4):256-9. Review.PMID: 16828406 [PubMed - indexed for MEDLINE]Related articles

Implication of pituitary tropic status on tumor development.

Donangelo I, Melmed S.

Front Horm Res. 2006;35:1-8. Review.PMID: 16809918 [PubMed - indexed for MEDLINE]Related articles

Pituitary tumor transforming gene overexpression facilitates pituitary tumor development.

Donangelo I, Gutman S, Horvath E, Kovacs K, Wawrowsky K, Mount M, Melmed S.

Endocrinology. 2006 Oct;147(10):4781-91. Epub 2006 Jun 29.PMID: 16809444 [PubMed - indexed for MEDLINE]Related articlesFree article

Sex-steroid milieu determines diabetes rescue in pttg-null mice.

Fraenkel M, Caloyeras J, Ren SG, Melmed S.

J Endocrinol. 2006 Jun;189(3):519-28.PMID: 16731783 [PubMed - indexed for MEDLINE]Related articlesFree article

Pyridoxal phosphate inhibits pituitary cell proliferation and hormone secretion.

Ren SG, Melmed S.

Endocrinology. 2006 Aug;147(8):3936-42. Epub 2006 May 11.PMID: 16690808 [PubMed - indexed for MEDLINE]Related articlesFree article

Elucidating the murine brain transcriptional network in a segregating mouse population to identify core functional modules for obesity and diabetes.

Lum PY, Chen Y, Zhu J, Lamb J, Melmed S, Wang S, Drake TA, Lusis AJ, Schadt EE.

J Neurochem. 2006 Apr;97 Suppl 1:50-62.PMID: 16635250 [PubMed - indexed for MEDLINE]Related articles

Pathophysiology of pituitary adenomas.

Donangelo I, Melmed S.

J Endocrinol Invest. 2005;28(11 Suppl International):100-5. Review.PMID: 16625857 [PubMed - indexed for MEDLINE]Related articles