PubMed

Estrogens Attenuate Oxidative Stress and the Differentiation and Apoptosis of Osteoblasts by DNA Binding-Independent Actions of the ERalpha.

Almeida M, Martin-Millan M, Ambrogini E, Bradsher R, Han L, Chen XD, Roberson PK, Weinstein RS, O'Brien CA, Jilka RL, Manolagas SC.

J Bone Miner Res. 2009 Oct 12. [Epub ahead of print]PMID: 19821774 [PubMed - as supplied by publisher]Related articles

Increased lipid oxidation causes oxidative stress, increased peroxisome proliferator-activated receptor-gamma expression, and diminished pro-osteogenic Wnt signaling in the skeleton.

Almeida M, Ambrogini E, Han L, Manolagas SC, Jilka RL.

J Biol Chem. 2009 Oct 2;284(40):27438-48. Epub 2009 Aug 5.PMID: 19657144 [PubMed - indexed for MEDLINE]Related articles

Commitment to the osteoblast lineage is not required for RANKL gene expression.

Galli C, Fu Q, Wang W, Olsen BR, Manolagas SC, Jilka RL, O'Brien CA.

J Biol Chem. 2009 May 8;284(19):12654-62. Epub 2009 Mar 11.PMID: 19279010 [PubMed - indexed for MEDLINE]Related articles

Giant osteoclast formation and long-term oral bisphosphonate therapy.

Weinstein RS, Roberson PK, Manolagas SC.

N Engl J Med. 2009 Jan 1;360(1):53-62.PMID: 19118304 [PubMed - indexed for MEDLINE]Related articlesFree article

Intermittent PTH stimulates periosteal bone formation by actions on post-mitotic preosteoblasts.

Jilka RL, O'Brien CA, Ali AA, Roberson PK, Weinstein RS, Manolagas SC.

Bone. 2009 Feb;44(2):275-86. Epub 2008 Oct 22.PMID: 19010455 [PubMed - indexed for MEDLINE]Related articles

Control of bone mass and remodeling by PTH receptor signaling in osteocytes.

O'Brien CA, Plotkin LI, Galli C, Goellner JJ, Gortazar AR, Allen MR, Robling AG, Bouxsein M, Schipani E, Turner CH, Jilka RL, Weinstein RS, Manolagas SC, Bellido T.

PLoS One. 2008 Aug 13;3(8):e2942.PMID: 18698360 [PubMed - indexed for MEDLINE]Related articlesFree article

Connexin 43 is required for the anti-apoptotic effect of bisphosphonates on osteocytes and osteoblasts in vivo.

Plotkin LI, Lezcano V, Thostenson J, Weinstein RS, Manolagas SC, Bellido T.

J Bone Miner Res. 2008 Nov;23(11):1712-21.PMID: 18597631 [PubMed - indexed for MEDLINE]Related articlesFree article

De-fense! De-fense! De-fense: scavenging H2O2 while making cholesterol.

Manolagas SC.

Endocrinology. 2008 Jul;149(7):3264-6. Epub 2008 May 15. No abstract available. PMID: 18483146 [PubMed - indexed for MEDLINE]Related articlesFree article

Targeted deletion of a distant transcriptional enhancer of the receptor activator of nuclear factor-kappaB ligand gene reduces bone remodeling and increases bone mass.

Galli C, Zella LA, Fretz JA, Fu Q, Pike JW, Weinstein RS, Manolagas SC, O'Brien CA.

Endocrinology. 2008 Jan;149(1):146-53. Epub 2007 Oct 11.PMID: 17932217 [PubMed - indexed for MEDLINE]Related articlesFree article

Extracellular matrix made by bone marrow cells facilitates expansion of marrow-derived mesenchymal progenitor cells and prevents their differentiation into osteoblasts.

Chen XD, Dusevich V, Feng JQ, Manolagas SC, Jilka RL.

J Bone Miner Res. 2007 Dec;22(12):1943-56.PMID: 17680726 [PubMed - indexed for MEDLINE]Related articles

Skeletal involution by age-associated oxidative stress and its acceleration by loss of sex steroids.

Almeida M, Han L, Martin-Millan M, Plotkin LI, Stewart SA, Roberson PK, Kousteni S, O'Brien CA, Bellido T, Parfitt AM, Weinstein RS, Jilka RL, Manolagas SC.

J Biol Chem. 2007 Sep 14;282(37):27285-97. Epub 2007 Jul 10.PMID: 17623659 [PubMed - indexed for MEDLINE]Related articlesFree article

Oxidative stress antagonizes Wnt signaling in osteoblast precursors by diverting beta-catenin from T cell factor- to forkhead box O-mediated transcription.

Almeida M, Han L, Martin-Millan M, O'Brien CA, Manolagas SC.

J Biol Chem. 2007 Sep 14;282(37):27298-305. Epub 2007 Jul 10.PMID: 17623658 [PubMed - indexed for MEDLINE]Related articlesFree article

Gone with the Wnts: beta-catenin, T-cell factor, forkhead box O, and oxidative stress in age-dependent diseases of bone, lipid, and glucose metabolism.

Manolagas SC, Almeida M.

Mol Endocrinol. 2007 Nov;21(11):2605-14. Epub 2007 Jul 10. Review.PMID: 17622581 [PubMed - indexed for MEDLINE]Related articlesFree article

A novel ligand-independent function of the estrogen receptor is essential for osteocyte and osteoblast mechanotransduction.

Aguirre JI, Plotkin LI, Gortazar AR, Millan MM, O'Brien CA, Manolagas SC, Bellido T.

J Biol Chem. 2007 Aug 31;282(35):25501-8. Epub 2007 Jul 3.PMID: 17609204 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucocorticoids induce osteocyte apoptosis by blocking focal adhesion kinase-mediated survival. Evidence for inside-out signaling leading to anoikis.

Plotkin LI, Manolagas SC, Bellido T.

J Biol Chem. 2007 Aug 17;282(33):24120-30. Epub 2007 Jun 20.PMID: 17581824 [PubMed - indexed for MEDLINE]Related articlesFree article

Quantifying osteoblast and osteocyte apoptosis: challenges and rewards.

Jilka RL, Weinstein RS, Parfitt AM, Manolagas SC.

J Bone Miner Res. 2007 Oct;22(10):1492-501. Review.PMID: 17542686 [PubMed - indexed for MEDLINE]Related articles

A novel locus on the X chromosome regulates post-maturity bone density changes in mice.

Szumska D, Benes H, Kang P, Weinstein RS, Jilka RL, Manolagas SC, Shmookler Reis RJ.

Bone. 2007 Mar;40(3):758-66. Epub 2006 Dec 19.PMID: 17185055 [PubMed - indexed for MEDLINE]Related articlesFree article

Induction of osteoblast differentiation by selective activation of kinase-mediated actions of the estrogen receptor.

Kousteni S, Almeida M, Han L, Bellido T, Jilka RL, Manolagas SC.

Mol Cell Biol. 2007 Feb;27(4):1516-30. Epub 2006 Dec 11.PMID: 17158928 [PubMed - indexed for MEDLINE]Related articlesFree article

Response to Windahl et al.

Manolagas SC, Jilka RL, Kousteni S, Bellido T, Weinstein RS, O'Brien CA, Plotkin L, Han L.

J Clin Invest. 2006 Nov;116(11):2834. No abstract available. PMID: 17080186 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucocorticoids act directly on osteoclasts to increase their life span and reduce bone density.

Jia D, O'Brien CA, Stewart SA, Manolagas SC, Weinstein RS.

Endocrinology. 2006 Dec;147(12):5592-9. Epub 2006 Aug 24.PMID: 16935844 [PubMed - indexed for MEDLINE]Related articlesFree article

Parathyroid hormone controls receptor activator of NF-kappaB ligand gene expression via a distant transcriptional enhancer.

Fu Q, Manolagas SC, O'Brien CA.

Mol Cell Biol. 2006 Sep;26(17):6453-68.PMID: 16914731 [PubMed - indexed for MEDLINE]Related articlesFree article

Dissociation of the pro-apoptotic effects of bisphosphonates on osteoclasts from their anti-apoptotic effects on osteoblasts/osteocytes with novel analogs.

Plotkin LI, Manolagas SC, Bellido T.

Bone. 2006 Sep;39(3):443-52. Epub 2006 Apr 19.PMID: 16627025 [PubMed - indexed for MEDLINE]Related articles

Osteocyte apoptosis is induced by weightlessness in mice and precedes osteoclast recruitment and bone loss.

Aguirre JI, Plotkin LI, Stewart SA, Weinstein RS, Parfitt AM, Manolagas SC, Bellido T.

J Bone Miner Res. 2006 Apr;21(4):605-15. Epub 2006 Apr 5.PMID: 16598381 [PubMed - indexed for MEDLINE]Related articles

Classical genotropic versus kinase-initiated regulation of gene transcription by the estrogen receptor alpha.

Almeida M, Han L, O'brien CA, Kousteni S, Manolagas SC.

Endocrinology. 2006 Apr;147(4):1986-96. Epub 2005 Dec 29.PMID: 16384865 [PubMed - indexed for MEDLINE]Related articlesFree article

Wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by beta-catenin-dependent and -independent signaling cascades involving Src/ERK and phosphatidylinositol 3-kinase/AKT.

Almeida M, Han L, Bellido T, Manolagas SC, Kousteni S.

J Biol Chem. 2005 Dec 16;280(50):41342-51. Epub 2005 Oct 25.PMID: 16251184 [PubMed - indexed for MEDLINE]Related articlesFree article

Chronic elevation of parathyroid hormone in mice reduces expression of sclerostin by osteocytes: a novel mechanism for hormonal control of osteoblastogenesis.

Bellido T, Ali AA, Gubrij I, Plotkin LI, Fu Q, O'Brien CA, Manolagas SC, Jilka RL.

Endocrinology. 2005 Nov;146(11):4577-83. Epub 2005 Aug 4.PMID: 16081646 [PubMed - indexed for MEDLINE]Related articlesFree article

IL-6 is not required for parathyroid hormone stimulation of RANKL expression, osteoclast formation, and bone loss in mice.

O'Brien CA, Jilka RL, Fu Q, Stewart S, Weinstein RS, Manolagas SC.

Am J Physiol Endocrinol Metab. 2005 Nov;289(5):E784-93. Epub 2005 Jun 14.PMID: 15956054 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanical stimulation prevents osteocyte apoptosis: requirement of integrins, Src kinases, and ERKs.

Plotkin LI, Mathov I, Aguirre JI, Parfitt AM, Manolagas SC, Bellido T.

Am J Physiol Cell Physiol. 2005 Sep;289(3):C633-43. Epub 2005 May 4.PMID: 15872009 [PubMed - indexed for MEDLINE]Related articlesFree article

Nongenotropic, anti-apoptotic signaling of 1alpha,25(OH)2-vitamin D3 and analogs through the ligand binding domain of the vitamin D receptor in osteoblasts and osteocytes. Mediation by Src, phosphatidylinositol 3-, and JNK kinases.

Vertino AM, Bula CM, Chen JR, Almeida M, Han L, Bellido T, Kousteni S, Norman AW, Manolagas SC.

J Biol Chem. 2005 Apr 8;280(14):14130-7. Epub 2005 Jan 25.PMID: 15671029 [PubMed - indexed for MEDLINE]Related articlesFree article

Rosiglitazone causes bone loss in mice by suppressing osteoblast differentiation and bone formation.

Ali AA, Weinstein RS, Stewart SA, Parfitt AM, Manolagas SC, Jilka RL.

Endocrinology. 2005 Mar;146(3):1226-35. Epub 2004 Dec 9.PMID: 15591153 [PubMed - indexed for MEDLINE]Related articlesFree article

Bisphosphonates and estrogens inhibit osteocyte apoptosis via distinct molecular mechanisms downstream of extracellular signal-regulated kinase activation.

Plotkin LI, Aguirre JI, Kousteni S, Manolagas SC, Bellido T.

J Biol Chem. 2005 Feb 25;280(8):7317-25. Epub 2004 Dec 6.PMID: 15590626 [PubMed - indexed for MEDLINE]Related articlesFree article

Transient versus sustained phosphorylation and nuclear accumulation of ERKs underlie anti-versus pro-apoptotic effects of estrogens.

Chen JR, Plotkin LI, Aguirre JI, Han L, Jilka RL, Kousteni S, Bellido T, Manolagas SC.

J Biol Chem. 2005 Feb 11;280(6):4632-8. Epub 2004 Nov 22.PMID: 15557324 [PubMed - indexed for MEDLINE]Related articlesFree article

Kinase-mediated transcription, activators of nongenotropic estrogen-like signaling (ANGELS), and osteoporosis: a different perspective on the HRT dilemma.

Manolagas SC, Kousteni S, Chen JR, Schuller M, Plotkin L, Bellido T.

Kidney Int Suppl. 2004 Oct;(91):S41-9. Review.PMID: 15461702 [PubMed - indexed for MEDLINE]Related articles

In vivo visualization of aging-associated gene transcription: evidence for free radical theory of aging.

Zhang J, Dai J, Lu Y, Yao Z, O'Brien CA, Murtha JM, Qi W, Hall DE, Manolagas SC, Ershler WB, Keller ET.

Exp Gerontol. 2004 Feb;39(2):239-47. Erratum in: Exp Gerontol. 2004 Jul;39(7):1115. PMID: 15036418 [PubMed - indexed for MEDLINE]Related articles

The skeletal effects of glucocorticoid excess override those of orchidectomy in mice.

Weinstein RS, Jia D, Powers CC, Stewart SA, Jilka RL, Parfitt AM, Manolagas SC.

Endocrinology. 2004 Apr;145(4):1980-7. Epub 2004 Jan 8.PMID: 14715712 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucocorticoids act directly on osteoblasts and osteocytes to induce their apoptosis and reduce bone formation and strength.

O'Brien CA, Jia D, Plotkin LI, Bellido T, Powers CC, Stewart SA, Manolagas SC, Weinstein RS.

Endocrinology. 2004 Apr;145(4):1835-41. Epub 2003 Dec 22.PMID: 14691012 [PubMed - indexed for MEDLINE]Related articlesFree article

A patient with pseudohypoparathyroidism.

Ijaz MT, Manolagas SC.

J Ark Med Soc. 2003 Nov;100(5):164-6. No abstract available. PMID: 14606225 [PubMed - indexed for MEDLINE]Related articles

Proteasomal degradation of Runx2 shortens parathyroid hormone-induced anti-apoptotic signaling in osteoblasts. A putative explanation for why intermittent administration is needed for bone anabolism.

Bellido T, Ali AA, Plotkin LI, Fu Q, Gubrij I, Roberson PK, Weinstein RS, O'Brien CA, Manolagas SC, Jilka RL.

J Biol Chem. 2003 Dec 12;278(50):50259-72. Epub 2003 Oct 1.PMID: 14523023 [PubMed - indexed for MEDLINE]Related articlesFree article

Kinase-mediated regulation of common transcription factors accounts for the bone-protective effects of sex steroids.

Kousteni S, Han L, Chen JR, Almeida M, Plotkin LI, Bellido T, Manolagas SC.

J Clin Invest. 2003 Jun;111(11):1651-64.PMID: 12782668 [PubMed - indexed for MEDLINE]Related articlesFree article

Reversal of bone loss in mice by nongenotropic signaling of sex steroids.

Kousteni S, Chen JR, Bellido T, Han L, Ali AA, O'Brien CA, Plotkin L, Fu Q, Mancino AT, Wen Y, Vertino AM, Powers CC, Stewart SA, Ebert R, Parfitt AM, Weinstein RS, Jilka RL, Manolagas SC.

Science. 2002 Oct 25;298(5594):843-6. Erratum in: Science. 2003 Feb 21;299(5610):1184. PMID: 12399595 [PubMed - indexed for MEDLINE]Related articlesFree article

Parathyroid hormone stimulates receptor activator of NFkappa B ligand and inhibits osteoprotegerin expression via protein kinase A activation of cAMP-response element-binding protein.

Fu Q, Jilka RL, Manolagas SC, O'Brien CA.

J Biol Chem. 2002 Dec 13;277(50):48868-75. Epub 2002 Oct 2.PMID: 12364326 [PubMed - indexed for MEDLINE]Related articlesFree article

Sex steroids and bone.

Manolagas SC, Kousteni S, Jilka RL.

Recent Prog Horm Res. 2002;57:385-409. Review.PMID: 12017554 [PubMed - indexed for MEDLINE]Related articlesFree article

Divergent effects of selective peroxisome proliferator-activated receptor-gamma 2 ligands on adipocyte versus osteoblast differentiation.

Lecka-Czernik B, Moerman EJ, Grant DF, Lehmann JM, Manolagas SC, Jilka RL.

Endocrinology. 2002 Jun;143(6):2376-84.PMID: 12021203 [PubMed - indexed for MEDLINE]Related articlesFree article

Promotion of osteoclast survival and antagonism of bisphosphonate-induced osteoclast apoptosis by glucocorticoids.

Weinstein RS, Chen JR, Powers CC, Stewart SA, Landes RD, Bellido T, Jilka RL, Parfitt AM, Manolagas SC.

J Clin Invest. 2002 Apr;109(8):1041-8.PMID: 11956241 [PubMed - indexed for MEDLINE]Related articlesFree article

Cbfa1 does not regulate RANKL gene activity in stromal/osteoblastic cells.

O'Brien CA, Kern B, Gubrij I, Karsenty G, Manolagas SC.

Bone. 2002 Mar;30(3):453-62.PMID: 11882458 [PubMed - indexed for MEDLINE]Related articles

Manipulating Programmed Cell Death for Better Living!

Manolagas SC.

Sci STKE. 2001 Jun 19;2001(87):PE1.PMID: 11865191 [PubMed - as supplied by publisher]Related articles

Inhibin suppresses and activin stimulates osteoblastogenesis and osteoclastogenesis in murine bone marrow cultures.

Gaddy-Kurten D, Coker JK, Abe E, Jilka RL, Manolagas SC.

Endocrinology. 2002 Jan;143(1):74-83.PMID: 11751595 [PubMed - indexed for MEDLINE]Related articlesFree article

Transduction of cell survival signals by connexin-43 hemichannels.

Plotkin LI, Manolagas SC, Bellido T.

J Biol Chem. 2002 Mar 8;277(10):8648-57. Epub 2001 Dec 10.PMID: 11741942 [PubMed - indexed for MEDLINE]Related articlesFree article

Breast cancer increases osteoclastogenesis by secreting M-CSF and upregulating RANKL in stromal cells.

Mancino AT, Klimberg VS, Yamamoto M, Manolagas SC, Abe E.

J Surg Res. 2001 Sep;100(1):18-24.PMID: 11516200 [PubMed - indexed for MEDLINE]Related articles

Perspective: nonreproductive sites of action of reproductive hormones.

Manolagas SC, Kousteni S.

Endocrinology. 2001 Jun;142(6):2200-4. Review. No abstract available. PMID: 11356663 [PubMed - indexed for MEDLINE]Related articlesFree article