PubMed

Future of Osteoporosis Genetics: Enhancing Genome-Wide Association Studies.

Farber CR, Lusis AJ.

J Bone Miner Res. 2009 Nov 5. [Epub ahead of print] No abstract available. PMID: 19888896 [PubMed - as supplied by publisher]Related articles

A common mutation in paraoxonase-2 results in impaired lactonase activity.

Stoltz DA, Ozer EA, Recker TJ, Estin M, Yang X, Shih DM, Lusis AJ, Zabner J.

J Biol Chem. 2009 Oct 19. [Epub ahead of print]PMID: 19840942 [PubMed - as supplied by publisher]Related articlesFree article

Chylomicronemia Elicits Atherosclerosis in Mice.

Weinstein MM, Yin L, Tu Y, Wang X, Wu X, Castellani LW, Walzem RL, Lusis AJ, Fong LG, Beigneux AP, Young SG.

Arterioscler Thromb Vasc Biol. 2009 Oct 8. [Epub ahead of print]PMID: 19815815 [PubMed - as supplied by publisher]Related articles

Systems biology asks new questions about sex differences.

Arnold AP, van Nas A, Lusis AJ.

Trends Endocrinol Metab. 2009 Dec;20(10):471-6. Epub 2009 Sep 23.PMID: 19783453 [PubMed - in process]Related articles

Copy number variation influences gene expression and metabolic traits in mice.

Orozco LD, Cokus SJ, Ghazalpour A, Ingram-Drake L, Wang S, van Nas A, Che N, Araujo JA, Pellegrini M, Lusis AJ.

Hum Mol Genet. 2009 Nov 1;18(21):4118-29. Epub 2009 Jul 31.PMID: 19648292 [PubMed - in process]Related articles

The roles of PON1 and PON2 in cardiovascular disease and innate immunity.

Shih DM, Lusis AJ.

Curr Opin Lipidol. 2009 Aug;20(4):288-92. Review.PMID: 19474728 [PubMed - indexed for MEDLINE]Related articles

Genome-wide screening for genetic loci associated with noise-induced hearing loss.

White CH, Ohmen JD, Sheth S, Zebboudj AF, McHugh RK, Hoffman LF, Lusis AJ, Davis RC, Friedman RA.

Mamm Genome. 2009 Apr;20(4):207-13. Epub 2009 Apr 1.PMID: 19337678 [PubMed - indexed for MEDLINE]Related articles

Genetic dissection of a major mouse obesity QTL (Carfhg2): integration of gene expression and causality modeling.

Farber CR, Aten JE, Farber EA, de Vera V, Gularte R, Islas-Trejo A, Wen P, Horvath S, Lucero M, Lusis AJ, Medrano JF.

Physiol Genomics. 2009 May 13;37(3):294-302. Epub 2009 Mar 31.PMID: 19336533 [PubMed - indexed for MEDLINE]Related articles

Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks.

Yang X, Deignan JL, Qi H, Zhu J, Qian S, Zhong J, Torosyan G, Majid S, Falkard B, Kleinhanz RR, Karlsson J, Castellani LW, Mumick S, Wang K, Xie T, Coon M, Zhang C, Estrada-Smith D, Farber CR, Wang SS, van Nas A, Ghazalpour A, Zhang B, Macneil DJ, Lamb JR, Dipple KM, Reitman ML, Mehrabian M, Lum PY, Schadt EE, Lusis AJ, Drake TA.

Nat Genet. 2009 Apr;41(4):415-23. Epub 2009 Mar 8.PMID: 19270708 [PubMed - indexed for MEDLINE]Related articles

Genetic regulation of atherosclerotic plaque size and morphology in the innominate artery of hyperlipidemic mice.

Bennett BJ, Wang SS, Wang X, Wu X, Lusis AJ.

Arterioscler Thromb Vasc Biol. 2009 Mar;29(3):348-55. Epub 2009 Jan 2.PMID: 19122174 [PubMed - indexed for MEDLINE]Related articles

CHAC1/MGC4504 is a novel proapoptotic component of the unfolded protein response, downstream of the ATF4-ATF3-CHOP cascade.

Mungrue IN, Pagnon J, Kohannim O, Gargalovic PS, Lusis AJ.

J Immunol. 2009 Jan 1;182(1):466-76.PMID: 19109178 [PubMed - indexed for MEDLINE]Related articles

Maternal low-protein diet or hypercholesterolemia reduces circulating essential amino acids and leads to intrauterine growth restriction.

Bhasin KK, van Nas A, Martin LJ, Davis RC, Devaskar SU, Lusis AJ.

Diabetes. 2009 Mar;58(3):559-66. Epub 2008 Dec 10.PMID: 19073773 [PubMed - indexed for MEDLINE]Related articlesFree article

A systems-based framework for understanding complex metabolic and cardiovascular disorders.

Wu S, Lusis AJ, Drake TA.

J Lipid Res. 2009 Apr;50 Suppl:S358-63. Epub 2008 Nov 24. Review.PMID: 19033210 [PubMed - indexed for MEDLINE]Related articles

The synergistic inhibition of atherogenesis in apoE-/- mice between pravastatin and the sPLA2 inhibitor varespladib (A-002).

Shaposhnik Z, Wang X, Trias J, Fraser H, Lusis AJ.

J Lipid Res. 2009 Apr;50(4):623-9. Epub 2008 Nov 21.PMID: 19029066 [PubMed - indexed for MEDLINE]Related articles

Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies.

Keating BJ, Tischfield S, Murray SS, Bhangale T, Price TS, Glessner JT, Galver L, Barrett JC, Grant SF, Farlow DN, Chandrupatla HR, Hansen M, Ajmal S, Papanicolaou GJ, Guo Y, Li M, Derohannessian S, de Bakker PI, Bailey SD, Montpetit A, Edmondson AC, Taylor K, Gai X, Wang SS, Fornage M, Shaikh T, Groop L, Boehnke M, Hall AS, Hattersley AT, Frackelton E, Patterson N, Chiang CW, Kim CE, Fabsitz RR, Ouwehand W, Price AL, Munroe P, Caulfield M, Drake T, Boerwinkle E, Reich D, Whitehead AS, Cappola TP, Samani NJ, Lusis AJ, Schadt E, Wilson JG, Koenig W, McCarthy MI, Kathiresan S, Gabriel SB, Hakonarson H, Anand SS, Reilly M, Engert JC, Nickerson DA, Rader DJ, Hirschhorn JN, Fitzgerald GA.

PLoS One. 2008;3(10):e3583. Epub 2008 Oct 31.PMID: 18974833 [PubMed - indexed for MEDLINE]Related articlesFree article

Elucidating the role of gonadal hormones in sexually dimorphic gene coexpression networks.

van Nas A, Guhathakurta D, Wang SS, Yehya N, Horvath S, Zhang B, Ingram-Drake L, Chaudhuri G, Schadt EE, Drake TA, Arnold AP, Lusis AJ.

Endocrinology. 2009 Mar;150(3):1235-49. Epub 2008 Oct 30.PMID: 18974276 [PubMed - indexed for MEDLINE]Related articles

Metabolic syndrome: from epidemiology to systems biology.

Lusis AJ, Attie AD, Reue K.

Nat Rev Genet. 2008 Nov;9(11):819-30. Review.PMID: 18852695 [PubMed - indexed for MEDLINE]Related articles

Nutrigenetic association of the 5-lipoxygenase gene with myocardial infarction.

Allayee H, Baylin A, Hartiala J, Wijesuriya H, Mehrabian M, Lusis AJ, Campos H.

Am J Clin Nutr. 2008 Oct;88(4):934-40.PMID: 18842779 [PubMed - indexed for MEDLINE]Related articlesFree article

An integrative genetics approach to identify candidate genes regulating BMD: combining linkage, gene expression, and association.

Farber CR, van Nas A, Ghazalpour A, Aten JE, Doss S, Sos B, Schadt EE, Ingram-Drake L, Davis RC, Horvath S, Smith DJ, Drake TA, Lusis AJ.

J Bone Miner Res. 2009 Jan;24(1):105-16.PMID: 18767929 [PubMed - indexed for MEDLINE]Related articles

In Memoriam: Roger A. Davis (1945-2008).

Attie AD, Witztum JL, Edwards PA, Lusis AJ.

J Lipid Res. 2008 Aug 19. [Epub ahead of print]PMID: 18714092 [PubMed - as supplied by publisher]Related articlesFree article

High-resolution mapping of gene expression using association in an outbred mouse stock.

Ghazalpour A, Doss S, Kang H, Farber C, Wen PZ, Brozell A, Castellanos R, Eskin E, Smith DJ, Drake TA, Lusis AJ.

PLoS Genet. 2008 Aug 8;4(8):e1000149.PMID: 18688273 [PubMed - indexed for MEDLINE]Related articlesFree article

Thioredoxin-interacting protein deficiency induces Akt/Bcl-xL signaling and pancreatic beta-cell mass and protects against diabetes.

Chen J, Hui ST, Couto FM, Mungrue IN, Davis DB, Attie AD, Lusis AJ, Davis RA, Shalev A.

FASEB J. 2008 Oct;22(10):3581-94. Epub 2008 Jun 13.PMID: 18552236 [PubMed - indexed for MEDLINE]Related articlesFree article

Mapping the genetic architecture of gene expression in human liver.

Schadt EE, Molony C, Chudin E, Hao K, Yang X, Lum PY, Kasarskis A, Zhang B, Wang S, Suver C, Zhu J, Millstein J, Sieberts S, Lamb J, GuhaThakurta D, Derry J, Storey JD, Avila-Campillo I, Kruger MJ, Johnson JM, Rohl CA, van Nas A, Mehrabian M, Drake TA, Lusis AJ, Smith RC, Guengerich FP, Strom SC, Schuetz E, Rushmore TH, Ulrich R.

PLoS Biol. 2008 May 6;6(5):e107.PMID: 18462017 [PubMed - indexed for MEDLINE]Related articlesFree article

ATF4-dependent transcription is a key mechanism in VEGF up-regulation by oxidized phospholipids: critical role of oxidized sn-2 residues in activation of unfolded protein response.

Oskolkova OV, Afonyushkin T, Leitner A, von Schlieffen E, Gargalovic PS, Lusis AJ, Binder BR, Bochkov VN.

Blood. 2008 Jul 15;112(2):330-9. Epub 2008 May 1.PMID: 18451308 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of ALOX5 as a gene regulating adiposity and pancreatic function.

Mehrabian M, Schulthess FT, Nebohacova M, Castellani LW, Zhou Z, Hartiala J, Oberholzer J, Lusis AJ, Maedler K, Allayee H.

Diabetologia. 2008 Jun;51(6):978-88. Epub 2008 Apr 18.PMID: 18421434 [PubMed - indexed for MEDLINE]Related articles

Using genetic markers to orient the edges in quantitative trait networks: the NEO software.

Aten JE, Fuller TF, Lusis AJ, Horvath S.

BMC Syst Biol. 2008 Apr 15;2:34.PMID: 18412962 [PubMed - indexed for MEDLINE]Related articlesFree article

A genome-wide panel of congenic mice reveals widespread epistasis of behavior quantitative trait loci.

Gale GD, Yazdi RD, Khan AH, Lusis AJ, Davis RC, Smith DJ.

Mol Psychiatry. 2009 Jun;14(6):631-45. Epub 2008 Apr 1.PMID: 18379576 [PubMed - indexed for MEDLINE]Related articles

Fine mapping of regulatory loci for mammalian gene expression using radiation hybrids.

Park CC, Ahn S, Bloom JS, Lin A, Wang RT, Wu T, Sekar A, Khan AH, Farr CJ, Lusis AJ, Leahy RM, Lange K, Smith DJ.

Nat Genet. 2008 Apr;40(4):421-9. Epub 2008 Mar 23. Erratum in: Nat Genet. 2008 May;40(5):682. PMID: 18362883 [PubMed - indexed for MEDLINE]Related articles

Integrating global gene expression analysis and genetics.

Farber CR, Lusis AJ.

Adv Genet. 2008;60:571-601. Review.PMID: 18358333 [PubMed - indexed for MEDLINE]Related articles

Relationship of paraoxonase 1 (PON1) gene polymorphisms and functional activity with systemic oxidative stress and cardiovascular risk.

Bhattacharyya T, Nicholls SJ, Topol EJ, Zhang R, Yang X, Schmitt D, Fu X, Shao M, Brennan DM, Ellis SG, Brennan ML, Allayee H, Lusis AJ, Hazen SL.

JAMA. 2008 Mar 19;299(11):1265-76.PMID: 18349088 [PubMed - indexed for MEDLINE]Related articlesFree article

Variations in DNA elucidate molecular networks that cause disease.

Chen Y, Zhu J, Lum PY, Yang X, Pinto S, MacNeil DJ, Zhang C, Lamb J, Edwards S, Sieberts SK, Leonardson A, Castellini LW, Wang S, Champy MF, Zhang B, Emilsson V, Doss S, Ghazalpour A, Horvath S, Drake TA, Lusis AJ, Schadt EE.

Nature. 2008 Mar 27;452(7186):429-35. Epub 2008 Mar 16.PMID: 18344982 [PubMed - indexed for MEDLINE]Related articles

Association of stearoyl-CoA desaturase 1 activity with familial combined hyperlipidemia.

Mar-Heyming R, Miyazaki M, Weissglas-Volkov D, Kolaitis NA, Sadaat N, Plaisier C, Pajukanta P, Cantor RM, de Bruin TW, Ntambi JM, Lusis AJ.

Arterioscler Thromb Vasc Biol. 2008 Jun;28(6):1193-9. Epub 2008 Mar 13.PMID: 18340007 [PubMed - indexed for MEDLINE]Related articlesFree article

A treasure trove for lipoprotein biology.

Lusis AJ, Pajukanta P.

Nat Genet. 2008 Feb;40(2):129-30. No abstract available. PMID: 18227868 [PubMed - indexed for MEDLINE]Related articles

Ambient particulate pollutants in the ultrafine range promote early atherosclerosis and systemic oxidative stress.

Araujo JA, Barajas B, Kleinman M, Wang X, Bennett BJ, Gong KW, Navab M, Harkema J, Sioutas C, Lusis AJ, Nel AE.

Circ Res. 2008 Mar 14;102(5):589-96. Epub 2008 Jan 17.PMID: 18202315 [PubMed - indexed for MEDLINE]Related articlesFree article

Thioredoxin-interacting protein: a critical link between glucose toxicity and beta-cell apoptosis.

Chen J, Saxena G, Mungrue IN, Lusis AJ, Shalev A.

Diabetes. 2008 Apr;57(4):938-44. Epub 2008 Jan 2.PMID: 18171713 [PubMed - indexed for MEDLINE]Related articlesFree article

Apolipoprotein AII is a regulator of very low density lipoprotein metabolism and insulin resistance.

Castellani LW, Nguyen CN, Charugundla S, Weinstein MM, Doan CX, Blaner WS, Wongsiriroj N, Lusis AJ.

J Biol Chem. 2008 Apr 25;283(17):11633-44. Epub 2007 Dec 26.PMID: 18160395 [PubMed - indexed for MEDLINE]Related articlesFree article

Metabolic syndrome as a modifier of atherosclerosis in murine models.

Péterfy M, Davis RC, Lusis AJ.

Curr Drug Targets. 2007 Nov;8(11):1215-20. Review.PMID: 18045100 [PubMed - indexed for MEDLINE]Related articles

Network-centered view of coronary artery disease.

Bennett BJ, Romanoski CE, Lusis AJ.

Expert Rev Cardiovasc Ther. 2007 Nov;5(6):1095-103. Review.PMID: 18035925 [PubMed - indexed for MEDLINE]Related articles

Genes on distal chromosome 18 determine vulnerability to excitotoxic neurodegeneration following status epilepticus, but not striatal neurodegeneration induced by quinolinic acid.

McLin JP, Thompson LM, Lusis AJ, Davis RC, Steward O.

Neurobiol Dis. 2008 Mar;29(3):391-9. Epub 2007 Oct 11.PMID: 17996456 [PubMed - indexed for MEDLINE]Related articles

Mapping, genetic isolation, and characterization of genetic loci that determine resistance to atherosclerosis in C3H mice.

Wang SS, Shi W, Wang X, Velky L, Greenlee S, Wang MT, Drake TA, Lusis AJ.

Arterioscler Thromb Vasc Biol. 2007 Dec;27(12):2671-6. Epub 2007 Oct 4.PMID: 17916774 [PubMed - indexed for MEDLINE]Related articlesFree article

FK506, a calcineurin inhibitor, prevents cadmium-induced testicular toxicity in mice.

Martin LJ, Chen H, Liao X, Allayee H, Shih DM, Lee GS, Hovland DN Jr, Robbins WA, Carnes K, Hess RA, Lusis AJ, Collins MD.

Toxicol Sci. 2007 Dec;100(2):474-85. Epub 2007 Sep 4.PMID: 17785681 [PubMed - indexed for MEDLINE]Related articlesFree article

The problem of passenger genes in transgenic mice.

Lusis AJ, Yu J, Wang SS.

Arterioscler Thromb Vasc Biol. 2007 Oct;27(10):2100-3. Epub 2007 Aug 9. Review. No abstract available. PMID: 17690316 [PubMed - indexed for MEDLINE]Related articlesFree article

USF1 contributes to high serum lipid levels in Dutch FCHL families and U.S. whites with coronary artery disease.

Lee JC, Weissglas-Volkov D, Kyttälä M, Sinsheimer JS, Jokiaho A, de Bruin TW, Lusis AJ, Brennan ML, van Greevenbroek MM, van der Kallen CJ, Hazen SL, Pajukanta P.

Arterioscler Thromb Vasc Biol. 2007 Oct;27(10):2222-7. Epub 2007 Aug 2.PMID: 17673701 [PubMed - indexed for MEDLINE]Related articlesFree article

Weighted gene coexpression network analysis strategies applied to mouse weight.

Fuller TF, Ghazalpour A, Aten JE, Drake TA, Lusis AJ, Horvath S.

Mamm Genome. 2007 Jul;18(6-7):463-72. Epub 2007 Aug 1.PMID: 17668265 [PubMed - indexed for MEDLINE]Related articlesFree article

Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE.

Bradley MN, Hong C, Chen M, Joseph SB, Wilpitz DC, Wang X, Lusis AJ, Collins A, Hseuh WA, Collins JL, Tangirala RK, Tontonoz P.

J Clin Invest. 2007 Aug;117(8):2337-46.PMID: 17657314 [PubMed - indexed for MEDLINE]Related articlesFree article

Air-pollutant chemicals and oxidized lipids exhibit genome-wide synergistic effects on endothelial cells.

Gong KW, Zhao W, Li N, Barajas B, Kleinman M, Sioutas C, Horvath S, Lusis AJ, Nel A, Araujo JA.

Genome Biol. 2007;8(7):R149.PMID: 17655762 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of pathways for atherosclerosis in mice: integration of quantitative trait locus analysis and global gene expression data.

Wang SS, Schadt EE, Wang H, Wang X, Ingram-Drake L, Shi W, Drake TA, Lusis AJ.

Circ Res. 2007 Aug 3;101(3):e11-30. Epub 2007 Jul 19.PMID: 17641228 [PubMed - indexed for MEDLINE]Related articlesFree article

The Hyplip2 locus causes hypertriglyceridemia by decreased clearance of triglycerides.

Moen CJ, Tholens AP, Voshol PJ, de Haan W, Havekes LM, Gargalovic P, Lusis AJ, van Dyk KW, Frants RR, Hofker MH, Rensen PC.

J Lipid Res. 2007 Oct;48(10):2182-92. Epub 2007 Jul 3.PMID: 17609525 [PubMed - indexed for MEDLINE]Related articlesFree article

A genome-wide set of congenic mouse strains derived from CAST/Ei on a C57BL/6 background.

Davis RC, Jin A, Rosales M, Yu S, Xia X, Ranola K, Schadt EE, Lusis AJ.

Genomics. 2007 Sep;90(3):306-13. Epub 2007 Jun 27.PMID: 17600671 [PubMed - indexed for MEDLINE]Related articles

Heme oxygenase-1 expression in macrophages plays a beneficial role in atherosclerosis.

Orozco LD, Kapturczak MH, Barajas B, Wang X, Weinstein MM, Wong J, Deshane J, Bolisetty S, Shaposhnik Z, Shih DM, Agarwal A, Lusis AJ, Araujo JA.

Circ Res. 2007 Jun 22;100(12):1703-11. Epub 2007 May 10.PMID: 17495224 [PubMed - indexed for MEDLINE]Related articlesFree article