PubMed

Goals of treatment for type 2 diabetes: beta-cell preservation for glycemic control.

Marchetti P, Lupi R, Del Guerra S, Bugliani M, D'Aleo V, Occhipinti M, Boggi U, Marselli L, Masini M.

Diabetes Care. 2009 Nov;32 Suppl 2:S178-83. No abstract available. PMID: 19875548 [PubMed - in process]Related articles

G-protein-coupled receptor 40 (GPR40) expression and its regulation in human pancreatic islets: The role of type 2 diabetes and fatty acids.

Del Guerra S, Bugliani M, D'Aleo V, Del Prato S, Boggi U, Mosca F, Filipponi F, Lupi R.

Nutr Metab Cardiovasc Dis. 2009 Sep 14. [Epub ahead of print]PMID: 19758793 [PubMed - as supplied by publisher]Related articles

Glucagon-Like Peptide-1 Agonists Protect Pancreatic {beta}-Cells From Lipotoxic Endoplasmic Reticulum Stress Through Upregulation of BiP and JunB.

Cunha DA, Ladrière L, Ortis F, Igoillo-Esteve M, Gurzov EN, Lupi R, Marchetti P, Eizirik DL, Cnop M.

Diabetes. 2009 Dec;58(12):2851-2862. Epub 2009 Aug 31.PMID: 19720788 [PubMed - as supplied by publisher]Related articles

Calpain-10 expression is elevated in pancreatic islets from patients with type 2 diabetes.

Ling C, Groop L, Guerra SD, Lupi R.

PLoS One. 2009 Aug 18;4(8):e6558.PMID: 19688040 [PubMed - in process]Related articlesFree article

Effects of exposure of human islet beta-cells to normal and high glucose levels with or without gliclazide or glibenclamide.

Del Guerra S, D'Aleo V, Lupi R, Masini M, Bugliani M, Boggi U, Filipponi F, Marchetti P.

Diabetes Metab. 2009 Sep;35(4):293-8. Epub 2009 Jun 6.PMID: 19502091 [PubMed - in process]Related articles

The non-peptidyl low molecular weight radical scavenger IAC protects human pancreatic islets from lipotoxicity.

D'Aleo V, Del Guerra S, Martano M, Bonamassa B, Canistro D, Soleti A, Valgimigli L, Paolini M, Filipponi F, Boggi U, Del Prato S, Lupi R.

Mol Cell Endocrinol. 2009 Oct 15;309(1-2):63-6. Epub 2009 May 27.PMID: 19481137 [PubMed - indexed for MEDLINE]Related articles

Autophagy in human type 2 diabetes pancreatic beta cells.

Masini M, Bugliani M, Lupi R, del Guerra S, Boggi U, Filipponi F, Marselli L, Masiello P, Marchetti P.

Diabetologia. 2009 Jun;52(6):1083-6. Epub 2009 Apr 15.PMID: 19367387 [PubMed - indexed for MEDLINE]Related articles

Perilipin is present in islets of Langerhans and protects against lipotoxicity when overexpressed in the beta-cell line INS-1.

Borg J, Klint C, Wierup N, Ström K, Larsson S, Sundler F, Lupi R, Marchetti P, Xu G, Kimmel A, Londos C, Holm C.

Endocrinology. 2009 Jul;150(7):3049-57. Epub 2009 Mar 19.PMID: 19299455 [PubMed - indexed for MEDLINE]Related articles

Glucose transporter 2 gene polymorphisms and beta-cell function in isolated human pancreatic islets.

Del Guerra S, Lupi R, D'Aleo V, Filipponi F, Boggi U, Marchetti P.

Diabetes Metab. 2009 Apr;35(2):155-6. Epub 2009 Mar 9. No abstract available. PMID: 19269875 [PubMed - indexed for MEDLINE]Related articles

Beneficial effect of the nonpeptidyl low molecular weight radical scavenger IAC on cultured human islet function.

Mancarella R, Del Guerra S, Masini M, Bugliani M, Valgimigli L, Pedulli GF, Paolini M, Canistro D, Armando A, Soleti A, Filipponi F, Mosca F, Boggi U, Del Prato S, Marchetti P, Lupi R.

Cell Transplant. 2008;17(10-11):1271-6.PMID: 19181220 [PubMed - indexed for MEDLINE]Related articles

Cx36 makes channels coupling human pancreatic beta-cells, and correlates with insulin expression.

Serre-Beinier V, Bosco D, Zulianello L, Charollais A, Caille D, Charpantier E, Gauthier BR, Diaferia GR, Giepmans BN, Lupi R, Marchetti P, Deng S, Buhler L, Berney T, Cirulli V, Meda P.

Hum Mol Genet. 2009 Feb 1;18(3):428-39. Epub 2008 Nov 10.PMID: 19000992 [PubMed - indexed for MEDLINE]Related articles

The origin of clonal diversity and structure of Populus alba in Sardinia: evidence from nuclear and plastid microsatellite markers.

Brundu G, Lupi R, Zapelli I, Fossati T, Patrignani G, Camarda I, Sala F, Castiglione S.

Ann Bot. 2008 Dec;102(6):997-1006. Epub 2008 Oct 9.PMID: 18845663 [PubMed - indexed for MEDLINE]Related articles

Effects of different LDL particles on inflammatory molecules in human mesangial cells.

Santini E, Lupi R, Baldi S, Madec S, Chimenti D, Ferrannini E, Solini A.

Diabetologia. 2008 Nov;51(11):2117-25. Epub 2008 Aug 28.PMID: 18751966 [PubMed - indexed for MEDLINE]Related articles

Beta-cell apoptosis in type 2 diabetes: quantitative and functional consequences.

Lupi R, Del Prato S.

Diabetes Metab. 2008 Feb;34 Suppl 2:S56-64. Review.PMID: 18640587 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta-cell failure in type 2 diabetes mellitus.

Lencioni C, Lupi R, Del Prato S.

Curr Diab Rep. 2008 Jun;8(3):179-84. Review.PMID: 18625113 [PubMed - indexed for MEDLINE]Related articles

Initiation and execution of lipotoxic ER stress in pancreatic beta-cells.

Cunha DA, Hekerman P, Ladrière L, Bazarra-Castro A, Ortis F, Wakeham MC, Moore F, Rasschaert J, Cardozo AK, Bellomo E, Overbergh L, Mathieu C, Lupi R, Hai T, Herchuelz A, Marchetti P, Rutter GA, Eizirik DL, Cnop M.

J Cell Sci. 2008 Jul 15;121(Pt 14):2308-18. Epub 2008 Jun 17.PMID: 18559892 [PubMed - indexed for MEDLINE]Related articlesFree article

[From cellular biology to molecular biology: Golgi apparatus from the discovery to nowadays]

Falchetti M, Lupi R, Ottini L.

Med Secoli. 2007;19(1):119-44. Italian. PMID: 18447171 [PubMed - indexed for MEDLINE]Related articles

Gastric cancer with high-level microsatellite instability: target gene mutations, clinicopathologic features, and long-term survival.

Falchetti M, Saieva C, Lupi R, Masala G, Rizzolo P, Zanna I, Ceccarelli K, Sera F, Mariani-Costantini R, Nesi G, Palli D, Ottini L.

Hum Pathol. 2008 Jun;39(6):925-32. Epub 2008 Apr 28.PMID: 18440592 [PubMed - indexed for MEDLINE]Related articles

Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion.

Ling C, Del Guerra S, Lupi R, Rönn T, Granhall C, Luthman H, Masiello P, Marchetti P, Groop L, Del Prato S.

Diabetologia. 2008 Apr;51(4):615-22. Epub 2008 Feb 13.PMID: 18270681 [PubMed - indexed for MEDLINE]Related articlesFree article

Protective effects of St. John's wort extract and its component hyperforin against cytokine-induced cytotoxicity in a pancreatic beta-cell line.

Menegazzi M, Novelli M, Beffy P, D'Aleo V, Tedeschi E, Lupi R, Zoratti E, Marchetti P, Suzuki H, Masiello P.

Int J Biochem Cell Biol. 2008;40(8):1509-21. Epub 2007 Dec 8.PMID: 18226577 [PubMed - indexed for MEDLINE]Related articles

Effects of exendin-4 on islets from type 2 diabetes patients.

Lupi R, Mancarella R, Del Guerra S, Bugliani M, Del Prato S, Boggi U, Mosca F, Filipponi F, Marchetti P.

Diabetes Obes Metab. 2008 Jun;10(6):515-9. Epub 2008 Jan 14.PMID: 18201204 [PubMed - indexed for MEDLINE]Related articles

Molecular analysis of a colorectal carcinoma from a mummy of the XVth century.

Falchetti M, Lupi R, Ottini L.

Med Secoli. 2006;18(3):943-51. No abstract available. PMID: 18175630 [PubMed - indexed for MEDLINE]Related articles

Reduction of oxidative stress by a new low-molecular-weight antioxidant improves metabolic alterations in a nonobese mouse diabetes model.

Novelli M, D'Aleo V, Lupi R, Paolini M, Soleti A, Marchetti P, Masiello P.

Pancreas. 2007 Nov;35(4):e10-7.PMID: 18090226 [PubMed - indexed for MEDLINE]Related articles

The diabetes-linked transcription factor Pax4 is expressed in human pancreatic islets and is activated by mitogens and GLP-1.

Brun T, He KH, Lupi R, Boehm B, Wojtusciszyn A, Sauter N, Donath M, Marchetti P, Maedler K, Gauthier BR.

Hum Mol Genet. 2008 Feb 15;17(4):478-89. Epub 2007 Nov 7.PMID: 17989064 [PubMed - indexed for MEDLINE]Related articlesFree article

The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients.

Marchetti P, Bugliani M, Lupi R, Marselli L, Masini M, Boggi U, Filipponi F, Weir GC, Eizirik DL, Cnop M.

Diabetologia. 2007 Dec;50(12):2486-94. Epub 2007 Sep 30.PMID: 17906960 [PubMed - indexed for MEDLINE]Related articles

Crystal structure of the T315I Abl mutant in complex with the aurora kinases inhibitor PHA-739358.

Modugno M, Casale E, Soncini C, Rosettani P, Colombo R, Lupi R, Rusconi L, Fancelli D, Carpinelli P, Cameron AD, Isacchi A, Moll J.

Cancer Res. 2007 Sep 1;67(17):7987-90.PMID: 17804707 [PubMed - indexed for MEDLINE]Related articlesFree article

Association between the BRCA2 N372H variant and male breast cancer risk: a population-based case-control study in Tuscany, Central Italy.

Palli D, Falchetti M, Masala G, Lupi R, Sera F, Saieva C, D'Amico C, Ceroti M, Rizzolo P, Caligo MA, Zanna I, Ottini L.

BMC Cancer. 2007 Sep 3;7:170.PMID: 17767707 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes.

Lyssenko V, Lupi R, Marchetti P, Del Guerra S, Orho-Melander M, Almgren P, Sjögren M, Ling C, Eriksson KF, Lethagen AL, Mancarella R, Berglund G, Tuomi T, Nilsson P, Del Prato S, Groop L.

J Clin Invest. 2007 Aug;117(8):2155-63.PMID: 17671651 [PubMed - indexed for MEDLINE]Related articlesFree article

BRCA1/BRCA2 rearrangements and CHEK2 common mutations are infrequent in Italian male breast cancer cases.

Falchetti M, Lupi R, Rizzolo P, Ceccarelli K, Zanna I, Calò V, Tommasi S, Masala G, Paradiso A, Gulino A, Giannini G, Russo A, Palli D, Ottini L.

Breast Cancer Res Treat. 2008 Jul;110(1):161-7. Epub 2007 Jul 28.PMID: 17661168 [PubMed - indexed for MEDLINE]Related articles

Insulin secretion defects of human type 2 diabetic islets are corrected in vitro by a new reactive oxygen species scavenger.

Lupi R, Del Guerra S, Mancarella R, Novelli M, Valgimigli L, Pedulli GF, Paolini M, Soleti A, Filipponi F, Mosca F, Boggi U, Del Prato S, Masiello P, Marchetti P.

Diabetes Metab. 2007 Nov;33(5):340-5. Epub 2007 Jul 9.PMID: 17616474 [PubMed - indexed for MEDLINE]Related articlesFree article

[Prevention of mediterranean anemia in Latium: Ida Bianco archives]

Falchetti M, Lupi R, Ottini L.

Med Secoli. 2006;18(1):241-61. Italian. PMID: 17526287 [PubMed - indexed for MEDLINE]Related articles

Multiple P2X receptors are involved in the modulation of apoptosis in human mesangial cells: evidence for a role of P2X4.

Solini A, Santini E, Chimenti D, Chiozzi P, Pratesi F, Cuccato S, Falzoni S, Lupi R, Ferrannini E, Pugliese G, Di Virgilio F.

Am J Physiol Renal Physiol. 2007 May;292(5):F1537-47. Epub 2007 Jan 30.PMID: 17264311 [PubMed - indexed for MEDLINE]Related articlesFree article

Gliclazide protects human islet beta-cells from apoptosis induced by intermittent high glucose.

Del Guerra S, Grupillo M, Masini M, Lupi R, Bugliani M, Torri S, Boggi U, Del Chiaro M, Vistoli F, Mosca F, Del Prato S, Marchetti P.

Diabetes Metab Res Rev. 2007 Mar;23(3):234-8.PMID: 16952202 [PubMed - indexed for MEDLINE]Related articles

Transcription factors of beta-cell differentiation and maturation in isolated human islets: effects of high glucose, high free fatty acids and type 2 diabetes.

Lupi R, Bugliani M, Del Guerra S, Del Prato S, Marchetti P, Boggi U, Filipponi F, Mosca F.

Nutr Metab Cardiovasc Dis. 2006 Sep;16(6):e7-8. Epub 2006 Mar 31. No abstract available. PMID: 16935697 [PubMed - indexed for MEDLINE]Related articles

Effects of C-peptide on isolated human pancreatic islet cells.

Bugliani M, Torri S, Lupi R, Del Guerra S, Grupillo M, Del Chiaro M, Mosca F, Boggi U, Del Prato S, Marchetti P.

Diabetes Metab Res Rev. 2007 Mar;23(3):215-9.PMID: 16874846 [PubMed - indexed for MEDLINE]Related articles

Patterns of genomic instability in gastric cancer: clinical implications and perspectives.

Ottini L, Falchetti M, Lupi R, Rizzolo P, Agnese V, Colucci G, Bazan V, Russo A.

Ann Oncol. 2006 Jun;17 Suppl 7:vii97-102.PMID: 16760303 [PubMed - indexed for MEDLINE]Related articlesFree article

The pancreatic beta-cell in human Type 2 diabetes.

Marchetti P, Del Prato S, Lupi R, Del Guerra S.

Nutr Metab Cardiovasc Dis. 2006 Mar;16 Suppl 1:S3-6. Epub 2006 Feb 9. Review.PMID: 16530127 [PubMed - indexed for MEDLINE]Related articles

The direct effects of the angiotensin-converting enzyme inhibitors, zofenoprilat and enalaprilat, on isolated human pancreatic islets.

Lupi R, Del Guerra S, Bugliani M, Boggi U, Mosca F, Torri S, Del Prato S, Marchetti P.

Eur J Endocrinol. 2006 Feb;154(2):355-61.PMID: 16452552 [PubMed - indexed for MEDLINE]Related articlesFree article

[Molecular paleopathology: a novel perspective for biomedical history]

Ottini L, Lupi R, Falchetti M, Fornaciari G, Mariani-Costantini R, Angeletti LR.

Med Secoli. 2005;17(1):181-91. Italian. PMID: 16285089 [PubMed - indexed for MEDLINE]Related articles

Is there a role for locally produced interleukin-1 in the deleterious effects of high glucose or the type 2 diabetes milieu to human pancreatic islets?

Welsh N, Cnop M, Kharroubi I, Bugliani M, Lupi R, Marchetti P, Eizirik DL.

Diabetes. 2005 Nov;54(11):3238-44.PMID: 16249450 [PubMed - indexed for MEDLINE]Related articlesFree article

ErbB-receptors expression and survival in breast carcinoma: a 15-year follow-up study.

Bianchi S, Palli D, Falchetti M, Saieva C, Masala G, Mancini B, Lupi R, Noviello C, Omerovic J, Paglierani M, Vezzosi V, Alimandi M, Mariani-Costantini R, Ottini L.

J Cell Physiol. 2006 Mar;206(3):702-8.PMID: 16245316 [PubMed - indexed for MEDLINE]Related articles

Hepatitis C virus infection and human pancreatic beta-cell dysfunction.

Masini M, Campani D, Boggi U, Menicagli M, Funel N, Pollera M, Lupi R, Del Guerra S, Bugliani M, Torri S, Del Prato S, Mosca F, Filipponi F, Marchetti P.

Diabetes Care. 2005 Apr;28(4):940-1. No abstract available. PMID: 15793203 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional and molecular defects of pancreatic islets in human type 2 diabetes.

Del Guerra S, Lupi R, Marselli L, Masini M, Bugliani M, Sbrana S, Torri S, Pollera M, Boggi U, Mosca F, Del Prato S, Marchetti P.

Diabetes. 2005 Mar;54(3):727-35.PMID: 15734849 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional and morphological alterations of mitochondria in pancreatic beta cells from type 2 diabetic patients.

Anello M, Lupi R, Spampinato D, Piro S, Masini M, Boggi U, Del Prato S, Rabuazzo AM, Purrello F, Marchetti P.

Diabetologia. 2005 Feb;48(2):282-9. Epub 2005 Jan 15.PMID: 15654602 [PubMed - indexed for MEDLINE]Related articles

Effects of prolonged in vitro exposure to sulphonylureas on the function and survival of human islets.

Del Guerra S, Marselli L, Lupi R, Boggi U, Mosca F, Benzi L, Del Prato S, Marchetti P.

J Diabetes Complications. 2005 Jan-Feb;19(1):60-4.PMID: 15642492 [PubMed - indexed for MEDLINE]Related articles

Pancreatic islets from type 2 diabetic patients have functional defects and increased apoptosis that are ameliorated by metformin.

Marchetti P, Del Guerra S, Marselli L, Lupi R, Masini M, Pollera M, Bugliani M, Boggi U, Vistoli F, Mosca F, Del Prato S.

J Clin Endocrinol Metab. 2004 Nov;89(11):5535-41.PMID: 15531508 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of peripheral benzodiazepine receptors on the function and survival of isolated human pancreatic islets.

Marselli L, Trincavelli L, Santangelo C, Lupi R, Del Guerra S, Boggi U, Falleni A, Gremigni V, Mosca F, Martini C, Dotta F, Di Mario U, Del Prato S, Marchetti P.

Eur J Endocrinol. 2004 Aug;151(2):207-14.PMID: 15296476 [PubMed - indexed for MEDLINE]Related articlesFree article

TP53 in gastric cancer: mutations in the l3 loop and LSH motif DNA-binding domains of TP53 predict poor outcome.

Migliavacca M, Ottini L, Bazan V, Agnese V, Corsale S, Macaluso M, Lupi R, Dardanoni G, Valerio MR, Pantuso G, Di Fede G, Tomasino RM, Gebbia N, Mariani-Costantini R, Russo A.

J Cell Physiol. 2004 Sep;200(3):476-85.PMID: 15254976 [PubMed - indexed for MEDLINE]Related articles

Improved insulin secretory function and reduced chemotactic properties after tissue culture of islets from type 1 diabetic patients.

Lupi R, Marselli L, Dionisi S, Del Guerra S, Boggi U, Del Chiaro M, Lencioni C, Bugliani M, Mosca F, Di Mario U, Del Prato S, Dotta F, Marchetti P.

Diabetes Metab Res Rev. 2004 May-Jun;20(3):246-51.PMID: 15133757 [PubMed - indexed for MEDLINE]Related articles

An alternative and simple method to consistently prepare viable isolated human islets for clinical transplantation.

Bugliani M, Lupi R, Del Guerra S, Boggi U, Marselli L, Sbrana S, Vistoli F, Torri S, Del Chiaro M, Signori S, Filipponi F, Del Prato S, Campa M, Corsini V, Campatelli A, Di Candio F, Mosca F, Marchetti P.

Transplant Proc. 2004 Apr;36(3):605-6.PMID: 15110608 [PubMed - indexed for MEDLINE]Related articles