PubMed

'Nothing is permanent but change'- antigenic variation in persistent bacterial pathogens.

Palmer GH, Bankhead T, Lukehart SA.

Cell Microbiol. 2009 Dec;11(12):1697-705. Epub 2009 Aug 25.PMID: 19709057 [PubMed - in process]Related articles

Common strategies for antigenic variation by bacterial, fungal and protozoan pathogens.

Deitsch KW, Lukehart SA, Stringer JR.

Nat Rev Microbiol. 2009 Jul;7(7):493-503. Epub 2009 Jun 8. Review.PMID: 19503065 [PubMed - indexed for MEDLINE]Related articles

TP0262 is a modulator of promoter activity of tpr Subfamily II genes of Treponema pallidum ssp. pallidum.

Giacani L, Godornes C, Puray-Chavez M, Guerra-Giraldez C, Tompa M, Lukehart SA, Centurion-Lara A.

Mol Microbiol. 2009 Jun;72(5):1087-99. Epub 2009 Apr 30.PMID: 19432808 [PubMed - indexed for MEDLINE]Related articlesFree article

Treponema denticola does not induce production of common innate immune mediators from primary gingival epithelial cells.

Brissette CA, Pham TT, Coats SR, Darveau RP, Lukehart SA.

Oral Microbiol Immunol. 2008 Dec;23(6):474-81.PMID: 18954353 [PubMed - indexed for MEDLINE]Related articles

Isolation and laboratory maintenance of Treponema pallidum.

Lukehart SA, Marra CM.

Curr Protoc Microbiol. 2007 Nov;Chapter 12:Unit 12A.1.PMID: 18770607 [PubMed - indexed for MEDLINE]Related articles

Normalization of serum rapid plasma reagin titer predicts normalization of cerebrospinal fluid and clinical abnormalities after treatment of neurosyphilis.

Marra CM, Maxwell CL, Tantalo LC, Sahi SK, Lukehart SA.

Clin Infect Dis. 2008 Oct 1;47(7):893-9.PMID: 18715154 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular Studies in Treponema pallidum Evolution: Toward Clarity?

Mulligan CJ, Norris SJ, Lukehart SA.

PLoS Negl Trop Dis. 2008 Jan 23;2(1):e184. No abstract available. PMID: 18357339 [PubMed - in process]Related articlesFree article

Scientific monogamy: thirty years dancing with the same bug: 2007 Thomas Parran Award Lecture.

Lukehart SA.

Sex Transm Dis. 2008 Jan;35(1):2-7. No abstract available. PMID: 18157060 [PubMed - indexed for MEDLINE]Related articles

Quantitation of rabbit cytokine mRNA by real-time RT-PCR.

Godornes C, Leader BT, Molini BJ, Centurion-Lara A, Lukehart SA.

Cytokine. 2007 Apr;38(1):1-7. Epub 2007 May 22.PMID: 17521914 [PubMed - indexed for MEDLINE]Related articlesFree article

CD4+ lymphocytes and gamma interferon predominate in local immune responses in early experimental syphilis.

Leader BT, Godornes C, VanVoorhis WC, Lukehart SA.

Infect Immun. 2007 Jun;75(6):3021-6. Epub 2007 Apr 2.PMID: 17403876 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanisms of decreased susceptibility to beta-defensins by Treponema denticola.

Brissette CA, Lukehart SA.

Infect Immun. 2007 May;75(5):2307-15. Epub 2007 Feb 26.PMID: 17325047 [PubMed - indexed for MEDLINE]Related articlesFree article

Excellence in sexually transmitted infection (STI) diagnostics: recognition of past successes and strategies for the future.

Ronald A, Kuypers J, Lukehart SA, Peeling RW, Pope V.

Sex Transm Infect. 2006 Dec;82 Suppl 5:v47-52. Epub 2006 Nov 29.PMID: 17135329 [PubMed - indexed for MEDLINE]Related articlesFree article

Antibiotic selection may contribute to increases in macrolide-resistant Treponema pallidum.

Marra CM, Colina AP, Godornes C, Tantalo LC, Puray M, Centurion-Lara A, Lukehart SA.

J Infect Dis. 2006 Dec 15;194(12):1771-3. Epub 2006 Nov 3.PMID: 17109351 [PubMed - indexed for MEDLINE]Related articles

Quantitative analysis of tpr gene expression in Treponema pallidum isolates: Differences among isolates and correlation with T-cell responsiveness in experimental syphilis.

Giacani L, Molini B, Godornes C, Barrett L, Van Voorhis W, Centurion-Lara A, Lukehart SA.

Infect Immun. 2007 Jan;75(1):104-12. Epub 2006 Oct 9.PMID: 17030565 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular differentiation of Treponema pallidum subspecies.

Centurion-Lara A, Molini BJ, Godornes C, Sun E, Hevner K, Van Voorhis WC, Lukehart SA.

J Clin Microbiol. 2006 Sep;44(9):3377-80.PMID: 16954278 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular evolution of the tprC, D, I, K, G, and J genes in the pathogenic genus Treponema.

Gray RR, Mulligan CJ, Molini BJ, Sun ES, Giacani L, Godornes C, Kitchen A, Lukehart SA, Centurion-Lara A.

Mol Biol Evol. 2006 Nov;23(11):2220-33. Epub 2006 Aug 22.PMID: 16926243 [PubMed - indexed for MEDLINE]Related articlesFree article

Antigenic variation of TprK V regions abrogates specific antibody binding in syphilis.

LaFond RE, Molini BJ, Van Voorhis WC, Lukehart SA.

Infect Immun. 2006 Nov;74(11):6244-51. Epub 2006 Aug 21.PMID: 16923793 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of rabbit interleukin-4 and characterization of its biologic activity on T and B-cells.

Leader BT, VanVoorhis WC, Lukehart SA.

Vet Immunol Immunopathol. 2006 Oct 15;113(3-4):421-7. Epub 2006 Aug 1.PMID: 16879875 [PubMed - indexed for MEDLINE]Related articles

Comparison of the diagnostic accuracy of a rapid immunochromatographic test and the rapid plasma reagin test for antenatal syphilis screening in Mozambique.

Montoya PJ, Lukehart SA, Brentlinger PE, Blanco AJ, Floriano F, Sairosse J, Gloyd S.

Bull World Health Organ. 2006 Feb;84(2):97-104. Epub 2006 Feb 23.PMID: 16501726 [PubMed - indexed for MEDLINE]Related articlesFree article

TprK sequence diversity accumulates during infection of rabbits with Treponema pallidum subsp. pallidum Nichols strain.

LaFond RE, Centurion-Lara A, Godornes C, Van Voorhis WC, Lukehart SA.

Infect Immun. 2006 Mar;74(3):1896-906.PMID: 16495565 [PubMed - indexed for MEDLINE]Related articlesFree article

Biological basis for syphilis.

Lafond RE, Lukehart SA.

Clin Microbiol Rev. 2006 Jan;19(1):29-49. Review.PMID: 16418521 [PubMed - indexed for MEDLINE]Related articlesFree article

Azithromycin-resistant syphilis infection: San Francisco, California, 2000-2004.

Mitchell SJ, Engelman J, Kent CK, Lukehart SA, Godornes C, Klausner JD.

Clin Infect Dis. 2006 Feb 1;42(3):337-45. Epub 2005 Dec 28.PMID: 16392078 [PubMed - indexed for MEDLINE]Related articles

Treponema pallidum strain-specific differences in neuroinvasion and clinical phenotype in a rabbit model.

Tantalo LC, Lukehart SA, Marra CM.

J Infect Dis. 2005 Jan 1;191(1):75-80. Epub 2004 Nov 30.PMID: 15593006 [PubMed - indexed for MEDLINE]Related articles

Tpr homologs in Treponema paraluiscuniculi Cuniculi A strain.

Giacani L, Sun ES, Hevner K, Molini BJ, Van Voorhis WC, Lukehart SA, Centurion-Lara A.

Infect Immun. 2004 Nov;72(11):6561-76.PMID: 15501788 [PubMed - indexed for MEDLINE]Related articlesFree article

Resistance to human beta-defensins is common among oral treponemes.

Brissette CA, Simonson LG, Lukehart SA.

Oral Microbiol Immunol. 2004 Dec;19(6):403-7.PMID: 15491467 [PubMed - indexed for MEDLINE]Related articles

Photochemical treatment of platelet concentrates with amotosalen and long-wavelength ultraviolet light inactivates a broad spectrum of pathogenic bacteria.

Lin L, Dikeman R, Molini B, Lukehart SA, Lane R, Dupuis K, Metzel P, Corash L.

Transfusion. 2004 Oct;44(10):1496-504.PMID: 15383024 [PubMed - indexed for MEDLINE]Related articles

Macrolide resistance in Treponema pallidum in the United States and Ireland.

Lukehart SA, Godornes C, Molini BJ, Sonnett P, Hopkins S, Mulcahy F, Engelman J, Mitchell SJ, Rompalo AM, Marra CM, Klausner JD.

N Engl J Med. 2004 Jul 8;351(2):154-8. No abstract available. PMID: 15247355 [PubMed - indexed for MEDLINE]Related articles

Subfamily I Treponema pallidum repeat protein family: sequence variation and immunity.

Sun ES, Molini BJ, Barrett LK, Centurion-Lara A, Lukehart SA, Van Voorhis WC.

Microbes Infect. 2004 Jul;6(8):725-37.PMID: 15207819 [PubMed - indexed for MEDLINE]Related articles

Gene conversion: a mechanism for generation of heterogeneity in the tprK gene of Treponema pallidum during infection.

Centurion-Lara A, LaFond RE, Hevner K, Godornes C, Molini BJ, Van Voorhis WC, Lukehart SA.

Mol Microbiol. 2004 Jun;52(6):1579-96.PMID: 15186410 [PubMed - indexed for MEDLINE]Related articles

Normalization of cerebrospinal fluid abnormalities after neurosyphilis therapy: does HIV status matter?

Marra CM, Maxwell CL, Tantalo L, Eaton M, Rompalo AM, Raines C, Stoner BP, Corbett JJ, Augenbraun M, Zajackowski M, Kee R, Lukehart SA.

Clin Infect Dis. 2004 Apr 1;38(7):1001-6. Epub 2004 Mar 16.PMID: 15034833 [PubMed - indexed for MEDLINE]Related articles

Cerebrospinal fluid abnormalities in patients with syphilis: association with clinical and laboratory features.

Marra CM, Maxwell CL, Smith SL, Lukehart SA, Rompalo AM, Eaton M, Stoner BP, Augenbraun M, Barker DE, Corbett JJ, Zajackowski M, Raines C, Nerad J, Kee R, Barnett SH.

J Infect Dis. 2004 Feb 1;189(3):369-76. Epub 2004 Jan 27.PMID: 14745693 [PubMed - indexed for MEDLINE]Related articles

Periodontitis vaccine decreases local prostaglandin E2 levels in a primate model.

Roberts FA, Houston LS, Lukehart SA, Mancl LA, Persson GR, Page RC.

Infect Immun. 2004 Feb;72(2):1166-8.PMID: 14742568 [PubMed - indexed for MEDLINE]Related articlesFree article

Sequence diversity of Treponema pallidum subsp. pallidum tprK in human syphilis lesions and rabbit-propagated isolates.

LaFond RE, Centurion-Lara A, Godornes C, Rompalo AM, Van Voorhis WC, Lukehart SA.

J Bacteriol. 2003 Nov;185(21):6262-8.PMID: 14563860 [PubMed - indexed for MEDLINE]Related articlesFree article

Antibody responses elicited against the Treponema pallidum repeat proteins differ during infection with different isolates of Treponema pallidum subsp. pallidum.

Leader BT, Hevner K, Molini BJ, Barrett LK, Van Voorhis WC, Lukehart SA.

Infect Immun. 2003 Oct;71(10):6054-7.PMID: 14500529 [PubMed - indexed for MEDLINE]Related articlesFree article

Protection against syphilis correlates with specificity of antibodies to the variable regions of Treponema pallidum repeat protein K.

Morgan CA, Lukehart SA, Van Voorhis WC.

Infect Immun. 2003 Oct;71(10):5605-12.PMID: 14500480 [PubMed - indexed for MEDLINE]Related articlesFree article

Serodiagnosis of syphilis: antibodies to recombinant Tp0453, Tp92, and Gpd proteins are sensitive and specific indicators of infection by Treponema pallidum.

Van Voorhis WC, Barrett LK, Lukehart SA, Schmidt B, Schriefer M, Cameron CE.

J Clin Microbiol. 2003 Aug;41(8):3668-74.PMID: 12904373 [PubMed - indexed for MEDLINE]Related articlesFree article

Immunization with the N-terminal portion of Treponema pallidum repeat protein K attenuates syphilitic lesion development in the rabbit model.

Morgan CA, Lukehart SA, Van Voorhis WC.

Infect Immun. 2002 Dec;70(12):6811-6.PMID: 12438357 [PubMed - indexed for MEDLINE]Related articlesFree article

Barking up the wrong tree? Use of polymerase chain reaction to diagnose syphilitic aortitis.

O'Regan AW, Castro C, Lukehart SA, Kasznica JM, Rice PA, Joyce-Brady MF.

Thorax. 2002 Oct;57(10):917-8.PMID: 12324682 [PubMed - indexed for MEDLINE]Related articlesFree article

Segregation of B and T cell epitopes of Treponema pallidum repeat protein K to variable and conserved regions during experimental syphilis infection.

Morgan CA, Molini BJ, Lukehart SA, Van Voorhis WC.

J Immunol. 2002 Jul 15;169(2):952-7.PMID: 12097401 [PubMed - indexed for MEDLINE]Related articlesFree article

Treponema denticola is resistant to human beta-defensins.

Brissette CA, Lukehart SA.

Infect Immun. 2002 Jul;70(7):3982-4.PMID: 12065549 [PubMed - indexed for MEDLINE]Related articlesFree article

The endemic treponematoses.

Antal GM, Lukehart SA, Meheus AZ.

Microbes Infect. 2002 Jan;4(1):83-94. Review.PMID: 11825779 [PubMed - indexed for MEDLINE]Related articles

Opsonic potential, protective capacity, and sequence conservation of the Treponema pallidum subspecies pallidum Tp92.

Cameron CE, Lukehart SA, Castro C, Molini B, Godornes C, Van Voorhis WC.

J Infect Dis. 2000 Apr;181(4):1401-13. Epub 2000 Apr 13.PMID: 10762571 [PubMed - indexed for MEDLINE]Related articles

Multiple alleles of Treponema pallidum repeat gene D in Treponema pallidum isolates.

Centurion-Lara A, Sun ES, Barrett LK, Castro C, Lukehart SA, Van Voorhis WC.

J Bacteriol. 2000 Apr;182(8):2332-5.PMID: 10735882 [PubMed - indexed for MEDLINE]Related articlesFree article

The tprK gene is heterogeneous among Treponema pallidum strains and has multiple alleles.

Centurion-Lara A, Godornes C, Castro C, Van Voorhis WC, Lukehart SA.

Infect Immun. 2000 Feb;68(2):824-31.PMID: 10639452 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of Treponema pallidum subspecies pallidum in a 200-year-old skeletal specimen.

Kolman CJ, Centurion-Lara A, Lukehart SA, Owsley DW, Tuross N.

J Infect Dis. 1999 Dec;180(6):2060-3.PMID: 10558971 [PubMed - indexed for MEDLINE]Related articles

T-Cell responses to Treponema pallidum subsp. pallidum antigens during the course of experimental syphilis infection.

Arroll TW, Centurion-Lara A, Lukehart SA, Van Voorhis WC.

Infect Immun. 1999 Sep;67(9):4757-63.PMID: 10456928 [PubMed - indexed for MEDLINE]Related articlesFree article

Sequence conservation of glycerophosphodiester phosphodiesterase among Treponema pallidum strains.

Cameron CE, Castro C, Lukehart SA, Van Voorhis WC.

Infect Immun. 1999 Jun;67(6):3168-70.PMID: 10338539 [PubMed - indexed for MEDLINE]Related articlesFree article

Function of anti-Porphyromonas gingivalis immunoglobulin classes in immunized Macaca fascicularis.

Houston LS, Lukehart SA, Persson GR, Page RC.

Oral Microbiol Immunol. 1999 Apr;14(2):86-91.PMID: 10219166 [PubMed - indexed for MEDLINE]Related articles

Treponema pallidum major sheath protein homologue Tpr K is a target of opsonic antibody and the protective immune response.

Centurion-Lara A, Castro C, Barrett L, Cameron C, Mostowfi M, Van Voorhis WC, Lukehart SA.

J Exp Med. 1999 Feb 15;189(4):647-56. Erratum in: J Exp Med 1999 Jun 7;189(11):following 1852. PMID: 9989979 [PubMed - indexed for MEDLINE]Related articlesFree article

Function and protective capacity of Treponema pallidum subsp. pallidum glycerophosphodiester phosphodiesterase.

Cameron CE, Castro C, Lukehart SA, Van Voorhis WC.

Infect Immun. 1998 Dec;66(12):5763-70.PMID: 9826352 [PubMed - indexed for MEDLINE]Related articlesFree article