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RESTORING AS160 PHOSPHORYLATION RESCUES SKELETAL MUSCLE INSULIN RESISTANCE AND FATTY ACID OXIDATION WHILE NOT REDUCING INTRAMUSCULAR LIPIDS.

Alkhateeb H, Chabowski A, Glatz JF, Gurd B, Luiken JJ, Bonen A.

Am J Physiol Endocrinol Metab. 2009 Sep 1. [Epub ahead of print]PMID: 19724017 [PubMed - as supplied by publisher]Related articles

Cardiac and skeletal muscle fatty acid transport and transporters and triacylglycerol and fatty acid oxidation in lean and Zucker diabetic fatty rats.

Bonen A, Holloway GP, Tandon NN, Han XX, McFarlan J, Glatz JF, Luiken JJ.

Am J Physiol Regul Integr Comp Physiol. 2009 Oct;297(4):R1202-12. Epub 2009 Aug 12.PMID: 19675275 [PubMed - indexed for MEDLINE]Related articles

FAT/CD36-null mice reveal that mitochondrial FAT/CD36 is required to upregulate mitochondrial fatty acid oxidation in contracting muscle.

Holloway GP, Jain SS, Bezaire V, Han XX, Glatz JF, Luiken JJ, Harper ME, Bonen A.

Am J Physiol Regul Integr Comp Physiol. 2009 Oct;297(4):R960-7. Epub 2009 Jul 22.PMID: 19625692 [PubMed - indexed for MEDLINE]Related articles

Additive effects of insulin and muscle contraction on fatty acid transport and fatty acid transporters, FAT/CD36, FABPpm, FATP1, 4 and 6.

Jain SS, Chabowski A, Snook LA, Schwenk RW, Glatz JF, Luiken JJ, Bonen A.

FEBS Lett. 2009 Jul 7;583(13):2294-300. Epub 2009 Jun 13.PMID: 19527715 [PubMed - indexed for MEDLINE]Related articles

Sarcolemmal fatty acid uptake vs. mitochondrial beta-oxidation as target to regress cardiac insulin resistance.

Luiken JJ.

Appl Physiol Nutr Metab. 2009 Jun;34(3):473-80. Review.PMID: 19448717 [PubMed - indexed for MEDLINE]Related articles

Greater transport efficiencies of the membrane fatty acid transporters FAT/CD36 and FATP4 compared with FABPpm and FATP1 and differential effects on fatty acid esterification and oxidation in rat skeletal muscle.

Nickerson JG, Alkhateeb H, Benton CR, Lally J, Nickerson J, Han XX, Wilson MH, Jain SS, Snook LA, Glatz JF, Chabowski A, Luiken JJ, Bonen A.

J Biol Chem. 2009 Jun 12;284(24):16522-30. Epub 2009 Apr 20.PMID: 19380575 [PubMed - indexed for MEDLINE]Related articles

Permissive action of protein kinase C-zeta in insulin-induced CD36- and GLUT4 translocation in cardiac myocytes.

Luiken JJ, Ouwens DM, Habets DD, van der Zon GC, Coumans WA, Schwenk RW, Bonen A, Glatz JF.

J Endocrinol. 2009 May;201(2):199-209. Epub 2009 Mar 9.PMID: 19273501 [PubMed - indexed for MEDLINE]Related articles

Pyruvate dehydrogenase kinase 4 expression is synergistically induced by AMP-activated protein kinase and fatty acids.

Houten SM, Chegary M, Te Brinke H, Wijnen WJ, Glatz JF, Luiken JJ, Wijburg FA, Wanders RJ.

Cell Mol Life Sci. 2009 Apr;66(7):1283-94.PMID: 19224132 [PubMed - indexed for MEDLINE]Related articles

Crucial role for LKB1 to AMPKalpha2 axis in the regulation of CD36-mediated long-chain fatty acid uptake into cardiomyocytes.

Habets DD, Coumans WA, El Hasnaoui M, Zarrinpashneh E, Bertrand L, Viollet B, Kiens B, Jensen TE, Richter EA, Bonen A, Glatz JF, Luiken JJ.

Biochim Biophys Acta. 2009 Mar;1791(3):212-9. Epub 2008 Dec 30.PMID: 19159696 [PubMed - indexed for MEDLINE]Related articles

Contractions but not AICAR increase FABPpm content in rat muscle sarcolemma.

Jeppesen J, Albers P, Luiken JJ, Glatz JF, Kiens B.

Mol Cell Biochem. 2009 Jun;326(1-2):45-53. Epub 2009 Jan 14.PMID: 19142713 [PubMed - indexed for MEDLINE]Related articles

In obese rat muscle transport of palmitate is increased and is channeled to triacylglycerol storage despite an increase in mitochondrial palmitate oxidation.

Holloway GP, Benton CR, Mullen KL, Yoshida Y, Snook LA, Han XX, Glatz JF, Luiken JJ, Lally J, Dyck DJ, Bonen A.

Am J Physiol Endocrinol Metab. 2009 Apr;296(4):E738-47. Epub 2009 Jan 13.PMID: 19141681 [PubMed - indexed for MEDLINE]Related articles

Etomoxir-induced partial carnitine palmitoyltransferase-I (CPT-I) inhibition in vivo does not alter cardiac long-chain fatty acid uptake and oxidation rates.

Luiken JJ, Niessen HE, Coort SL, Hoebers N, Coumans WA, Schwenk RW, Bonen A, Glatz JF.

Biochem J. 2009 Apr 15;419(2):447-55.PMID: 19138173 [PubMed - indexed for MEDLINE]Related articles

FAT/CD36 expression is not ablated in spontaneously hypertensive rats.

Bonen A, Han XX, Tandon NN, Glatz JF, Lally J, Snook LA, Luiken JJ.

J Lipid Res. 2009 Apr;50(4):740-8. Epub 2008 Dec 9.PMID: 19066404 [PubMed - indexed for MEDLINE]Related articles

Munc18c is not rate-limiting for glucose and long-chain fatty acid uptake in the heart.

Habets DD, Thurmond DC, Coumans WA, Bonen A, Glatz JF, Luiken JJ.

Mol Cell Biochem. 2009 Feb;322(1-2):81-6. Epub 2008 Nov 14.PMID: 19009238 [PubMed - indexed for MEDLINE]Related articles

Contribution of FAT/CD36 to the regulation of skeletal muscle fatty acid oxidation: an overview.

Holloway GP, Luiken JJ, Glatz JF, Spriet LL, Bonen A.

Acta Physiol (Oxf). 2008 Dec;194(4):293-309. Epub 2008 Jul 9. Review.PMID: 18510711 [PubMed - indexed for MEDLINE]Related articles

Dietary fructose during the suckling period increases body weight and fatty acid uptake into skeletal muscle in adult rats.

Huynh M, Luiken JJ, Coumans W, Bell RC.

Obesity (Silver Spring). 2008 Aug;16(8):1755-62. Epub 2008 May 15.PMID: 18483476 [PubMed - indexed for MEDLINE]Related articles

Regulation of sarcolemmal glucose and fatty acid transporters in cardiac disease.

Schwenk RW, Luiken JJ, Bonen A, Glatz JF.

Cardiovasc Res. 2008 Jul 15;79(2):249-58. Epub 2008 May 9. Review.PMID: 18469026 [PubMed - indexed for MEDLINE]Related articlesFree article

Sarcolemmal fatty acid transport in normal and diseased hearts.

Glatz JF, Bonen A, Luiken JJ.

Curr Hypertens Rep. 2007 Dec;9(6):450-4.PMID: 18367007 [PubMed - indexed for MEDLINE]Related articles

Evidence for concerted action of FAT/CD36 and FABPpm to increase fatty acid transport across the plasma membrane.

Chabowski A, Górski J, Luiken JJ, Glatz JF, Bonen A.

Prostaglandins Leukot Essent Fatty Acids. 2007 Nov-Dec;77(5-6):345-53. Review.PMID: 18240411 [PubMed - indexed for MEDLINE]Related articles

Rosiglitazone increases fatty acid oxidation and fatty acid translocase (FAT/CD36) but not carnitine palmitoyltransferase I in rat muscle mitochondria.

Benton CR, Holloway GP, Campbell SE, Yoshida Y, Tandon NN, Glatz JF, Luiken JJ, Spriet LL, Bonen A.

J Physiol. 2008 Mar 15;586(6):1755-66. Epub 2008 Jan 31.PMID: 18238811 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-induced translocation of CD36 to the plasma membrane is reversible and shows similarity to that of GLUT4.

van Oort MM, van Doorn JM, Bonen A, Glatz JF, van der Horst DJ, Rodenburg KW, Luiken JJ.

Biochim Biophys Acta. 2008 Jan-Feb;1781(1-2):61-71. Epub 2007 Dec 15.PMID: 18167317 [PubMed - indexed for MEDLINE]Related articles

Identification of protein kinase D as a novel contraction-activated kinase linked to GLUT4-mediated glucose uptake, independent of AMPK.

Luiken JJ, Vertommen D, Coort SL, Habets DD, El Hasnaoui M, Pelsers MM, Viollet B, Bonen A, Hue L, Rider MH, Glatz JF.

Cell Signal. 2008 Mar;20(3):543-56. Epub 2007 Nov 26.PMID: 18164589 [PubMed - indexed for MEDLINE]Related articles

Modest PGC-1alpha overexpression in muscle in vivo is sufficient to increase insulin sensitivity and palmitate oxidation in subsarcolemmal, not intermyofibrillar, mitochondria.

Benton CR, Nickerson JG, Lally J, Han XX, Holloway GP, Glatz JF, Luiken JJ, Graham TE, Heikkila JJ, Bonen A.

J Biol Chem. 2008 Feb 15;283(7):4228-40. Epub 2007 Dec 12.PMID: 18079123 [PubMed - indexed for MEDLINE]Related articlesFree article

Protein-mediated fatty acid uptake: regulation by contraction, AMP-activated protein kinase, and endocrine signals.

Nickerson JG, Momken I, Benton CR, Lally J, Holloway GP, Han XX, Glatz JF, Chabowski A, Luiken JJ, Bonen A.

Appl Physiol Nutr Metab. 2007 Oct;32(5):865-73. Review.PMID: 18059611 [PubMed - indexed for MEDLINE]Related articles

FIP2 and Rip11 specify Rab11a-mediated cellular distribution of GLUT4 and FAT/CD36 in H9c2-hIR cells.

Schwenk RW, Luiken JJ, Eckel J.

Biochem Biophys Res Commun. 2007 Nov 9;363(1):119-25. Epub 2007 Aug 28.PMID: 17854769 [PubMed - indexed for MEDLINE]Related articles

Cardiac contractile dysfunction in insulin-resistant rats fed a high-fat diet is associated with elevated CD36-mediated fatty acid uptake and esterification.

Ouwens DM, Diamant M, Fodor M, Habets DD, Pelsers MM, El Hasnaoui M, Dang ZC, van den Brom CE, Vlasblom R, Rietdijk A, Boer C, Coort SL, Glatz JF, Luiken JJ.

Diabetologia. 2007 Sep;50(9):1938-48. Epub 2007 Jul 18.PMID: 17639306 [PubMed - indexed for MEDLINE]Related articlesFree article

Metabolic challenges reveal impaired fatty acid metabolism and translocation of FAT/CD36 but not FABPpm in obese Zucker rat muscle.

Han XX, Chabowski A, Tandon NN, Calles-Escandon J, Glatz JF, Luiken JJ, Bonen A.

Am J Physiol Endocrinol Metab. 2007 Aug;293(2):E566-75. Epub 2007 May 22.PMID: 17519284 [PubMed - indexed for MEDLINE]Related articlesFree article

Fatty acid binding protein facilitates sarcolemmal fatty acid transport but not mitochondrial oxidation in rat and human skeletal muscle.

Holloway GP, Lally J, Nickerson JG, Alkhateeb H, Snook LA, Heigenhauser GJ, Calles-Escandon J, Glatz JF, Luiken JJ, Spriet LL, Bonen A.

J Physiol. 2007 Jul 1;582(Pt 1):393-405. Epub 2007 May 3.PMID: 17478525 [PubMed - indexed for MEDLINE]Related articlesFree article

Skeletal muscle fatty acid transporter protein expression in type 2 diabetes patients compared with overweight, sedentary men and age-matched, endurance-trained cyclists.

Pelsers MM, Tsintzas K, Boon H, Jewell K, Norton L, Luiken JJ, Glatz JF, van Loon LJ.

Acta Physiol (Oxf). 2007 Jul;190(3):209-19. Epub 2007 Mar 30.PMID: 17394567 [PubMed - indexed for MEDLINE]Related articles

Is membrane transport of FFA mediated by lipid, protein, or both? Mechanisms and regulation of protein-mediated cellular fatty acid uptake: molecular, biochemical, and physiological evidence.

Bonen A, Chabowski A, Luiken JJ, Glatz JF.

Physiology (Bethesda). 2007 Feb;22:15-29. Review. No abstract available. PMID: 17342856 [PubMed - indexed for MEDLINE]Related articlesFree article

AMPK-mediated increase in myocardial long-chain fatty acid uptake critically depends on sarcolemmal CD36.

Habets DD, Coumans WA, Voshol PJ, den Boer MA, Febbraio M, Bonen A, Glatz JF, Luiken JJ.

Biochem Biophys Res Commun. 2007 Mar 30;355(1):204-10. Epub 2007 Feb 2.PMID: 17292863 [PubMed - indexed for MEDLINE]Related articles

A null mutation in skeletal muscle FAT/CD36 reveals its essential role in insulin- and AICAR-stimulated fatty acid metabolism.

Bonen A, Han XX, Habets DD, Febbraio M, Glatz JF, Luiken JJ.

Am J Physiol Endocrinol Metab. 2007 Jun;292(6):E1740-9. Epub 2007 Jan 30.PMID: 17264223 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of sarcolemmal transport of substrates in the healthy and diseased heart.

Glatz JF, Bonen A, Ouwens DM, Luiken JJ.

Cardiovasc Drugs Ther. 2006 Dec;20(6):471-6. Review.PMID: 17119873 [PubMed - indexed for MEDLINE]Related articles

Arsenite modulates cardiac substrate preference by translocation of GLUT4, but not CD36, independent of mitogen-activated protein kinase signaling.

Luiken JJ, Momken I, Habets DD, El Hasnaoui M, Coumans WA, Koonen DP, Glatz JF, Bonen A.

Endocrinology. 2006 Nov;147(11):5205-16. Epub 2006 Oct 12.PMID: 17038550 [PubMed - indexed for MEDLINE]Related articlesFree article

Cardiac substrate uptake and metabolism in obesity and type-2 diabetes: role of sarcolemmal substrate transporters.

Coort SL, Bonen A, van der Vusse GJ, Glatz JF, Luiken JJ.

Mol Cell Biochem. 2007 May;299(1-2):5-18. Review.PMID: 16988889 [PubMed - indexed for MEDLINE]Related articles

Tissue-specific and fatty acid transporter-specific changes in heart and soleus muscle over a 1-yr period.

Bonen A, Nickerson JG, Momken I, Chabowski A, Calles-Escandon J, Tandon NN, Glatz JF, Luiken JJ.

Mol Cell Biochem. 2006 Oct;291(1-2):145-54. Epub 2006 May 23.PMID: 16718359 [PubMed - indexed for MEDLINE]Related articles

Prolonged AMPK activation increases the expression of fatty acid transporters in cardiac myocytes and perfused hearts.

Chabowski A, Momken I, Coort SL, Calles-Escandon J, Tandon NN, Glatz JF, Luiken JJ, Bonen A.

Mol Cell Biochem. 2006 Aug;288(1-2):201-12. Epub 2006 May 19.PMID: 16710744 [PubMed - indexed for MEDLINE]Related articles

Fatty acid transport and FAT/CD36 are increased in red but not in white skeletal muscle of ZDF rats.

Chabowski A, Chatham JC, Tandon NN, Calles-Escandon J, Glatz JF, Luiken JJ, Bonen A.

Am J Physiol Endocrinol Metab. 2006 Sep;291(3):E675-82. Epub 2006 May 9.PMID: 16684853 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential effects of contraction and PPAR agonists on the expression of fatty acid transporters in rat skeletal muscle.

Benton CR, Koonen DP, Calles-Escandon J, Tandon NN, Glatz JF, Luiken JJ, Heikkila JJ, Bonen A.

J Physiol. 2006 May 15;573(Pt 1):199-210. Epub 2006 Feb 16.PMID: 16484294 [PubMed - indexed for MEDLINE]Related articlesFree article

The fatty acid transporter FAT/CD36 is upregulated in subcutaneous and visceral adipose tissues in human obesity and type 2 diabetes.

Bonen A, Tandon NN, Glatz JF, Luiken JJ, Heigenhauser GJ.

Int J Obes (Lond). 2006 Jun;30(6):877-83.PMID: 16418758 [PubMed - indexed for MEDLINE]Related articles

Mitochondrial long chain fatty acid oxidation, fatty acid translocase/CD36 content and carnitine palmitoyltransferase I activity in human skeletal muscle during aerobic exercise.

Holloway GP, Bezaire V, Heigenhauser GJ, Tandon NN, Glatz JF, Luiken JJ, Bonen A, Spriet LL.

J Physiol. 2006 Feb 15;571(Pt 1):201-10. Epub 2005 Dec 15. Erratum in: J Physiol. 2006 Mar 1;571(Pt 2):500. PMID: 16357012 [PubMed - indexed for MEDLINE]Related articlesFree article

Up-regulation of CD36/FAT in preadipocytes in familial combined hyperlipidemia.

Meex SJ, van der Kallen CJ, van Greevenbroek MM, Eurlings PM, El Hasnaoui M, Evelo CT, Lindsey PJ, Luiken JJ, Glatz JF, de Bruin TW.

FASEB J. 2005 Dec;19(14):2063-5. Epub 2005 Oct 11.PMID: 16219805 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of fatty acid translocase on human skeletal muscle mitochondrial membranes: essential role in fatty acid oxidation.

Bezaire V, Bruce CR, Heigenhauser GJ, Tandon NN, Glatz JF, Luiken JJ, Bonen A, Spriet LL.

Am J Physiol Endocrinol Metab. 2006 Mar;290(3):E509-15. Epub 2005 Oct 11.PMID: 16219667 [PubMed - indexed for MEDLINE]Related articlesFree article

Long-chain fatty acid uptake and FAT/CD36 translocation in heart and skeletal muscle.

Koonen DP, Glatz JF, Bonen A, Luiken JJ.

Biochim Biophys Acta. 2005 Oct 1;1736(3):163-80. Review.PMID: 16198626 [PubMed - indexed for MEDLINE]Related articles

The subcellular compartmentation of fatty acid transporters is regulated differently by insulin and by AICAR.

Chabowski A, Coort SL, Calles-Escandon J, Tandon NN, Glatz JF, Luiken JJ, Bonen A.

FEBS Lett. 2005 Apr 25;579(11):2428-32.PMID: 15848183 [PubMed - indexed for MEDLINE]Related articles

Divergent effects of rosiglitazone on protein-mediated fatty acid uptake in adipose and in muscle tissues of Zucker rats.

Coort SL, Coumans WA, Bonen A, van der Vusse GJ, Glatz JF, Luiken JJ.

J Lipid Res. 2005 Jun;46(6):1295-302. Epub 2005 Mar 16.PMID: 15772429 [PubMed - indexed for MEDLINE]Related articlesFree article

Signalling components involved in contraction-inducible substrate uptake into cardiac myocytes.

Luiken JJ, Coort SL, Koonen DP, Bonen A, Glatz JF.

Proc Nutr Soc. 2004 May;63(2):251-8. Review.PMID: 15294039 [PubMed - indexed for MEDLINE]Related articles

Regulation of fatty acid transport by fatty acid translocase/CD36.

Bonen A, Campbell SE, Benton CR, Chabowski A, Coort SL, Han XX, Koonen DP, Glatz JF, Luiken JJ.

Proc Nutr Soc. 2004 May;63(2):245-9. Review.PMID: 15294038 [PubMed - indexed for MEDLINE]Related articles

Enhanced sarcolemmal FAT/CD36 content and triacylglycerol storage in cardiac myocytes from obese zucker rats.

Coort SL, Hasselbaink DM, Koonen DP, Willems J, Coumans WA, Chabowski A, van der Vusse GJ, Bonen A, Glatz JF, Luiken JJ.

Diabetes. 2004 Jul;53(7):1655-63.PMID: 15220187 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin stimulates fatty acid transport by regulating expression of FAT/CD36 but not FABPpm.

Chabowski A, Coort SL, Calles-Escandon J, Tandon NN, Glatz JF, Luiken JJ, Bonen A.

Am J Physiol Endocrinol Metab. 2004 Oct;287(4):E781-9. Epub 2004 May 27.PMID: 15166001 [PubMed - indexed for MEDLINE]Related articlesFree article