PubMed

PACAP neurons in the hypothalamic ventromedial nucleus are targets of central leptin signaling.

Hawke Z, Ivanov TR, Bechtold DA, Dhillon H, Lowell BB, Luckman SM.

J Neurosci. 2009 Nov 25;29(47):14828-35.PMID: 19940178 [PubMed - in process]Related articles

Characterization of a novel ghrelin cell reporter mouse.

Sakata I, Nakano Y, Osborne-Lawrence S, Rovinsky SA, Lee CE, Perello M, Anderson JG, Coppari R, Xiao G, Lowell BB, Elmquist JK, Zigman JM.

Regul Pept. 2009 Jun 5;155(1-3):91-8. Epub 2009 Apr 8.PMID: 19361544 [PubMed - indexed for MEDLINE]Related articles

Neuromedin B and gastrin-releasing peptide excite arcuate nucleus neuropeptide Y neurons in a novel transgenic mouse expressing strong Renilla green fluorescent protein in NPY neurons.

van den Pol AN, Yao Y, Fu LY, Foo K, Huang H, Coppari R, Lowell BB, Broberger C.

J Neurosci. 2009 Apr 8;29(14):4622-39.PMID: 19357287 [PubMed - indexed for MEDLINE]Related articlesFree article

Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance.

Tong Q, Ye CP, Jones JE, Elmquist JK, Lowell BB.

Nat Neurosci. 2008 Sep;11(9):998-1000.PMID: 19160495 [PubMed - indexed for MEDLINE]Related articlesFree article

Monitoring FoxO1 localization in chemically identified neurons.

Fukuda M, Jones JE, Olson D, Hill J, Lee CE, Gautron L, Choi M, Zigman JM, Lowell BB, Elmquist JK.

J Neurosci. 2008 Dec 10;28(50):13640-8.PMID: 19074037 [PubMed - indexed for MEDLINE]Related articlesFree article

5-HT2CRs expressed by pro-opiomelanocortin neurons regulate energy homeostasis.

Xu Y, Jones JE, Kohno D, Williams KW, Lee CE, Choi MJ, Anderson JG, Heisler LK, Zigman JM, Lowell BB, Elmquist JK.

Neuron. 2008 Nov 26;60(4):582-9.PMID: 19038216 [PubMed - indexed for MEDLINE]Related articlesFree article

Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance.

Tong Q, Ye CP, Jones JE, Elmquist JK, Lowell BB.

Nat Neurosci. 2008 Aug 10. [Epub ahead of print]PMID: 18690230 [PubMed - as supplied by publisher]Related articles

Selective inactivation of Socs3 in SF1 neurons improves glucose homeostasis without affecting body weight.

Zhang R, Dhillon H, Yin H, Yoshimura A, Lowell BB, Maratos-Flier E, Flier JS.

Endocrinology. 2008 Nov;149(11):5654-61. Epub 2008 Jul 31.PMID: 18669597 [PubMed - indexed for MEDLINE]Related articlesFree article

Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice.

Hill JW, Williams KW, Ye C, Luo J, Balthasar N, Coppari R, Cowley MA, Cantley LC, Lowell BB, Elmquist JK.

J Clin Invest. 2008 May;118(5):1796-805.PMID: 18382766 [PubMed - indexed for MEDLINE]Related articlesFree article

Dual role of proapoptotic BAD in insulin secretion and beta cell survival.

Danial NN, Walensky LD, Zhang CY, Choi CS, Fisher JK, Molina AJ, Datta SR, Pitter KL, Bird GH, Wikstrom JD, Deeney JT, Robertson K, Morash J, Kulkarni A, Neschen S, Kim S, Greenberg ME, Corkey BE, Shirihai OS, Shulman GI, Lowell BB, Korsmeyer SJ.

Nat Med. 2008 Feb;14(2):144-53. Epub 2008 Jan 27.PMID: 18223655 [PubMed - indexed for MEDLINE]Related articles

Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion.

van de Wall E, Leshan R, Xu AW, Balthasar N, Coppari R, Liu SM, Jo YH, MacKenzie RG, Allison DB, Dun NJ, Elmquist J, Lowell BB, Barsh GS, de Luca C, Myers MG Jr, Schwartz GJ, Chua SC Jr.

Endocrinology. 2008 Apr;149(4):1773-85. Epub 2007 Dec 27.PMID: 18162515 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity.

Parton LE, Ye CP, Coppari R, Enriori PJ, Choi B, Zhang CY, Xu C, Vianna CR, Balthasar N, Lee CE, Elmquist JK, Cowley MA, Lowell BB.

Nature. 2007 Sep 13;449(7159):228-32. Epub 2007 Aug 29.PMID: 17728716 [PubMed - indexed for MEDLINE]Related articles

EP3 prostaglandin receptors in the median preoptic nucleus are critical for fever responses.

Lazarus M, Yoshida K, Coppari R, Bass CE, Mochizuki T, Lowell BB, Saper CB.

Nat Neurosci. 2007 Sep;10(9):1131-3. Epub 2007 Aug 5.PMID: 17676060 [PubMed - indexed for MEDLINE]Related articles

Dentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal network.

McHugh TJ, Jones MW, Quinn JJ, Balthasar N, Coppari R, Elmquist JK, Lowell BB, Fanselow MS, Wilson MA, Tonegawa S.

Science. 2007 Jul 6;317(5834):94-9. Epub 2007 Jun 7.PMID: 17556551 [PubMed - indexed for MEDLINE]Related articlesFree article

Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia.

Tong Q, Ye C, McCrimmon RJ, Dhillon H, Choi B, Kramer MD, Yu J, Yang Z, Christiansen LM, Lee CE, Choi CS, Zigman JM, Shulman GI, Sherwin RS, Elmquist JK, Lowell BB.

Cell Metab. 2007 May;5(5):383-93.PMID: 17488640 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypomorphic mutation of PGC-1beta causes mitochondrial dysfunction and liver insulin resistance.

Vianna CR, Huntgeburth M, Coppari R, Choi CS, Lin J, Krauss S, Barbatelli G, Tzameli I, Kim YB, Cinti S, Shulman GI, Spiegelman BM, Lowell BB.

Cell Metab. 2006 Dec;4(6):453-64.PMID: 17141629 [PubMed - indexed for MEDLINE]Related articlesFree article

Serotonin reciprocally regulates melanocortin neurons to modulate food intake.

Heisler LK, Jobst EE, Sutton GM, Zhou L, Borok E, Thornton-Jones Z, Liu HY, Zigman JM, Balthasar N, Kishi T, Lee CE, Aschkenasi CJ, Zhang CY, Yu J, Boss O, Mountjoy KG, Clifton PG, Lowell BB, Friedman JM, Horvath T, Butler AA, Elmquist JK, Cowley MA.

Neuron. 2006 Jul 20;51(2):239-49.PMID: 16846858 [PubMed - indexed for MEDLINE]Related articles

Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity- and high glucose-induced beta cell dysfunction in isolated pancreatic islets.

Zhang CY, Parton LE, Ye CP, Krauss S, Shen R, Lin CT, Porco JA Jr, Lowell BB.

Cell Metab. 2006 Jun;3(6):417-27.PMID: 16753577 [PubMed - indexed for MEDLINE]Related articles

Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis.

Dhillon H, Zigman JM, Ye C, Lee CE, McGovern RA, Tang V, Kenny CD, Christiansen LM, White RD, Edelstein EA, Coppari R, Balthasar N, Cowley MA, Chua S Jr, Elmquist JK, Lowell BB.

Neuron. 2006 Jan 19;49(2):191-203.PMID: 16423694 [PubMed - indexed for MEDLINE]Related articles

Mice lacking ghrelin receptors resist the development of diet-induced obesity.

Zigman JM, Nakano Y, Coppari R, Balthasar N, Marcus JN, Lee CE, Jones JE, Deysher AE, Waxman AR, White RD, Williams TD, Lachey JL, Seeley RJ, Lowell BB, Elmquist JK.

J Clin Invest. 2005 Dec;115(12):3564-72.PMID: 16322794 [PubMed - indexed for MEDLINE]Related articlesFree article

Divergence of melanocortin pathways in the control of food intake and energy expenditure.

Balthasar N, Dalgaard LT, Lee CE, Yu J, Funahashi H, Williams T, Ferreira M, Tang V, McGovern RA, Kenny CD, Christiansen LM, Edelstein E, Choi B, Boss O, Aschkenasi C, Zhang CY, Mountjoy K, Kishi T, Elmquist JK, Lowell BB.

Cell. 2005 Nov 4;123(3):493-505.PMID: 16269339 [PubMed - indexed for MEDLINE]Related articles

Identifying hypothalamic pathways controlling food intake, body weight, and glucose homeostasis.

Elmquist JK, Coppari R, Balthasar N, Ichinose M, Lowell BB.

J Comp Neurol. 2005 Dec 5;493(1):63-71. Review.PMID: 16254991 [PubMed - indexed for MEDLINE]Related articles

The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activity.

Coppari R, Ichinose M, Lee CE, Pullen AE, Kenny CD, McGovern RA, Tang V, Liu SM, Ludwig T, Chua SC Jr, Lowell BB, Elmquist JK.

Cell Metab. 2005 Jan;1(1):63-72.PMID: 16054045 [PubMed - indexed for MEDLINE]Related articles

The mitochondrial uncoupling-protein homologues.

Krauss S, Zhang CY, Lowell BB.

Nat Rev Mol Cell Biol. 2005 Mar;6(3):248-61. Review.PMID: 15738989 [PubMed - indexed for MEDLINE]Related articles

Mitochondrial dysfunction and type 2 diabetes.

Lowell BB, Shulman GI.

Science. 2005 Jan 21;307(5708):384-7.PMID: 15662004 [PubMed - indexed for MEDLINE]Related articles

Thyroid hormones directly activate the expression of the human and mouse uncoupling protein-3 genes through a thyroid response element in the proximal promoter region.

Solanes G, Pedraza N, Calvo V, Vidal-Puig A, Lowell BB, Villarroya F.

Biochem J. 2005 Mar 15;386(Pt 3):505-13.PMID: 15496137 [PubMed - indexed for MEDLINE]Related articlesFree article

Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice.

Lin J, Wu PH, Tarr PT, Lindenberg KS, St-Pierre J, Zhang CY, Mootha VK, Jäger S, Vianna CR, Reznick RM, Cui L, Manieri M, Donovan MX, Wu Z, Cooper MP, Fan MC, Rohas LM, Zavacki AM, Cinti S, Shulman GI, Lowell BB, Krainc D, Spiegelman BM.

Cell. 2004 Oct 1;119(1):121-35.PMID: 15454086 [PubMed - indexed for MEDLINE]Related articles

Free fatty acid-induced beta-cell defects are dependent on uncoupling protein 2 expression.

Joseph JW, Koshkin V, Saleh MC, Sivitz WI, Zhang CY, Lowell BB, Chan CB, Wheeler MB.

J Biol Chem. 2004 Dec 3;279(49):51049-56. Epub 2004 Sep 23.PMID: 15448158 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis.

Balthasar N, Coppari R, McMinn J, Liu SM, Lee CE, Tang V, Kenny CD, McGovern RA, Chua SC Jr, Elmquist JK, Lowell BB.

Neuron. 2004 Jun 24;42(6):983-91.PMID: 15207242 [PubMed - indexed for MEDLINE]Related articles

Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction.

Krauss S, Zhang CY, Scorrano L, Dalgaard LT, St-Pierre J, Grey ST, Lowell BB.

J Clin Invest. 2003 Dec;112(12):1831-42.PMID: 14679178 [PubMed - indexed for MEDLINE]Related articlesFree article

BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis.

Danial NN, Gramm CF, Scorrano L, Zhang CY, Krauss S, Ranger AM, Datta SR, Greenberg ME, Licklider LJ, Lowell BB, Gygi SP, Korsmeyer SJ.

Nature. 2003 Aug 21;424(6951):952-6.PMID: 12931191 [PubMed - indexed for MEDLINE]Related articles

Quantitation of brown adipose tissue perfusion in transgenic mice using near-infrared fluorescence imaging.

Nakayama A, Bianco AC, Zhang CY, Lowell BB, Frangioni JV.

Mol Imaging. 2003 Jan;2(1):37-49.PMID: 12926236 [PubMed - indexed for MEDLINE]Related articles

Suppression of beta cell energy metabolism and insulin release by PGC-1alpha.

Yoon JC, Xu G, Deeney JT, Yang SN, Rhee J, Puigserver P, Levens AR, Yang R, Zhang CY, Lowell BB, Berggren PO, Newgard CB, Bonner-Weir S, Weir G, Spiegelman BM.

Dev Cell. 2003 Jul;5(1):73-83.PMID: 12852853 [PubMed - indexed for MEDLINE]Related articles

Beta-Adrenergic receptors, diet-induced thermogenesis, and obesity.

Lowell BB, Bachman ES.

J Biol Chem. 2003 Aug 8;278(32):29385-8. Epub 2003 Jun 4. Review. No abstract available. PMID: 12788929 [PubMed - indexed for MEDLINE]Related articlesFree article

Uncoupling protein 2 knockout mice have enhanced insulin secretory capacity after a high-fat diet.

Joseph JW, Koshkin V, Zhang CY, Wang J, Lowell BB, Chan CB, Wheeler MB.

Diabetes. 2002 Nov;51(11):3211-9.PMID: 12401712 [PubMed - indexed for MEDLINE]Related articlesFree article

Human alpha 2A-adrenergic receptor gene expressed in transgenic mouse adipose tissue under the control of its regulatory elements.

Boucher J, Castan-Laurell I, Le Lay S, Grujic D, Sibrac D, Krief S, Lafontan M, Lowell BB, Dugail I, Saulnier-Blache JS, Valet P.

J Mol Endocrinol. 2002 Oct;29(2):251-64.PMID: 12370125 [PubMed - indexed for MEDLINE]Related articlesFree article

Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres.

Lin J, Wu H, Tarr PT, Zhang CY, Wu Z, Boss O, Michael LF, Puigserver P, Isotani E, Olson EN, Lowell BB, Bassel-Duby R, Spiegelman BM.

Nature. 2002 Aug 15;418(6899):797-801.PMID: 12181572 [PubMed - indexed for MEDLINE]Related articles

betaAR signaling required for diet-induced thermogenesis and obesity resistance.

Bachman ES, Dhillon H, Zhang CY, Cinti S, Bianco AC, Kobilka BK, Lowell BB.

Science. 2002 Aug 2;297(5582):843-5.PMID: 12161655 [PubMed - indexed for MEDLINE]Related articlesFree article

Adipose tissue mass can be regulated through the vasculature.

Rupnick MA, Panigrahy D, Zhang CY, Dallabrida SM, Lowell BB, Langer R, Folkman MJ.

Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10730-5. Epub 2002 Jul 29.PMID: 12149466 [PubMed - indexed for MEDLINE]Related articlesFree article

Atypical beta-adrenergic effects on insulin signaling and action in beta(3)-adrenoceptor-deficient brown adipocytes.

Jost P, Fasshauer M, Kahn CR, Benito M, Meyer M, Ott V, Lowell BB, Klein HH, Klein J.

Am J Physiol Endocrinol Metab. 2002 Jul;283(1):E146-53.PMID: 12067855 [PubMed - indexed for MEDLINE]Related articlesFree article

Obesity-related fatty liver is unchanged in mice deficient for mitochondrial uncoupling protein 2.

Baffy G, Zhang CY, Glickman JN, Lowell BB.

Hepatology. 2002 Apr;35(4):753-61.PMID: 11915020 [PubMed - indexed for MEDLINE]Related articles

A significant portion of mitochondrial proton leak in intact thymocytes depends on expression of UCP2.

Krauss S, Zhang CY, Lowell BB.

Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):118-22. Epub 2001 Dec 26.PMID: 11756659 [PubMed - indexed for MEDLINE]Related articlesFree article

Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1.

Puigserver P, Rhee J, Lin J, Wu Z, Yoon JC, Zhang CY, Krauss S, Mootha VK, Lowell BB, Spiegelman BM.

Mol Cell. 2001 Nov;8(5):971-82.PMID: 11741533 [PubMed - indexed for MEDLINE]Related articles

Mouse melanocortin-4 receptor gene 5'-flanking region imparts cell specific expression in vitro.

Dumont LM, Wu CS, Aschkenasi CJ, Elmquist JK, Lowell BB, Mountjoy KG.

Mol Cell Endocrinol. 2001 Nov 26;184(1-2):173-85.PMID: 11694353 [PubMed - indexed for MEDLINE]Related articles

Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes.

Zhang CY, Baffy G, Perret P, Krauss S, Peroni O, Grujic D, Hagen T, Vidal-Puig AJ, Boss O, Kim YB, Zheng XX, Wheeler MB, Shulman GI, Chan CB, Lowell BB.

Cell. 2001 Jun 15;105(6):745-55.PMID: 11440717 [PubMed - indexed for MEDLINE]Related articles

Cloning and functional characterization of an uncoupling protein homolog in hummingbirds.

Vianna CR, Hagen T, Zhang CY, Bachman E, Boss O, Gereben B, Moriscot AS, Lowell BB, Bicudo JE, Bianco AC.

Physiol Genomics. 2001 Apr 2;5(3):137-45.PMID: 11285367 [PubMed - indexed for MEDLINE]Related articles

Uncoupling protein 3 (UCP3) stimulates glucose uptake in muscle cells through a phosphoinositide 3-kinase-dependent mechanism.

Huppertz C, Fischer BM, Kim YB, Kotani K, Vidal-Puig A, Slieker LJ, Sloop KW, Lowell BB, Kahn BB.

J Biol Chem. 2001 Apr 20;276(16):12520-9. Epub 2001 Jan 12.PMID: 11278970 [PubMed - indexed for MEDLINE]Related articlesFree article

In vivo effects of uncoupling protein-3 gene disruption on mitochondrial energy metabolism.

Cline GW, Vidal-Puig AJ, Dufour S, Cadman KS, Lowell BB, Shulman GI.

J Biol Chem. 2001 Jun 8;276(23):20240-4. Epub 2001 Mar 27.PMID: 11274222 [PubMed - indexed for MEDLINE]Related articlesFree article

Frataxin activates mitochondrial energy conversion and oxidative phosphorylation.

Ristow M, Pfister MF, Yee AJ, Schubert M, Michael L, Zhang CY, Ueki K, Michael MD 2nd, Lowell BB, Kahn CR.

Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):12239-43.PMID: 11035806 [PubMed - indexed for MEDLINE]Related articlesFree article

Chimeric proteins between UCP1 and UCP3: the middle third of UCP1 is necessary and sufficient for activation by fatty acids.

Hagen T, Lowell BB.

Biochem Biophys Res Commun. 2000 Sep 24;276(2):642-8.PMID: 11027525 [PubMed - indexed for MEDLINE]Related articles