PubMed

The inhibition of pyruvate dehydrogenase kinase improves impaired cardiac function and electrical remodeling in two models of right ventricular hypertrophy: resuscitating the hibernating right ventricle.

Piao L, Fang YH, Cadete VJ, Wietholt C, Urboniene D, Toth PT, Marsboom G, Zhang HJ, Haber I, Rehman J, Lopaschuk GD, Archer SL.

J Mol Med. 2009 Dec 1. [Epub ahead of print]PMID: 19949938 [PubMed - as supplied by publisher]Related articles

Type 1 diabetic cardiomyopathy in the Akita (Ins2WT/C96Y) mouse model is characterized by lipotoxicity and diastolic dysfunction with preserved systolic function.

Basu R, Oudit GY, Wang X, Zhang L, Ussher JR, Lopaschuk GD, Kassiri Z.

Am J Physiol Heart Circ Physiol. 2009 Dec;297(6):H2096-108. Epub 2009 Oct 2.PMID: 19801494 [PubMed - in process]Related articles

Role of fatty acid uptake and fatty acid beta-oxidation in mediating insulin resistance in heart and skeletal muscle.

Zhang L, Keung W, Samokhvalov V, Wang W, Lopaschuk GD.

Biochim Biophys Acta. 2010 Jan;1801(1):1-22. Epub 2009 Sep 24.PMID: 19782765 [PubMed - in process]Related articles

Role of the atypical protein kinase Czeta in regulation of 5'-AMP-activated protein kinase in cardiac and skeletal muscle.

Ussher JR, Jaswal JS, Wagg CS, Armstrong HE, Lopaschuk DG, Keung W, Lopaschuk GD.

Am J Physiol Endocrinol Metab. 2009 Aug;297(2):E349-57.PMID: 19625676 [PubMed - indexed for MEDLINE]Related articles

Tumor necrosis factor-alpha-converting enzyme is a key regulator of agonist-induced cardiac hypertrophy and fibrosis.

Wang X, Oka T, Chow FL, Cooper SB, Odenbach J, Lopaschuk GD, Kassiri Z, Fernandez-Patron C.

Hypertension. 2009 Sep;54(3):575-82. Epub 2009 Jul 6.PMID: 19581512 [PubMed - indexed for MEDLINE]Related articles

Insulin-stimulated cardiac glucose oxidation is increased in high-fat diet-induced obese mice lacking malonyl CoA decarboxylase.

Ussher JR, Koves TR, Jaswal JS, Zhang L, Ilkayeva O, Dyck JR, Muoio DM, Lopaschuk GD.

Diabetes. 2009 Aug;58(8):1766-75. Epub 2009 May 28. Erratum in: Diabetes. 2009 Oct;58(10):2425. PMID: 19478144 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased glucose uptake and oxidation in mouse hearts prevent high fatty acid oxidation but cause cardiac dysfunction in diet-induced obesity.

Yan J, Young ME, Cui L, Lopaschuk GD, Liao R, Tian R.

Circulation. 2009 Jun 2;119(21):2818-28. Epub 2009 May 18.PMID: 19451348 [PubMed - indexed for MEDLINE]Related articles

Suppression of 5'-AMP-activated protein kinase activity does not impair recovery of contractile function during reperfusion of ischemic hearts.

Folmes CD, Wagg CS, Shen M, Clanachan AS, Tian R, Lopaschuk GD.

Am J Physiol Heart Circ Physiol. 2009 Jul;297(1):H313-21. Epub 2009 May 8.PMID: 19429810 [PubMed - indexed for MEDLINE]Related articles

Matrix metalloproteinase-7 and ADAM-12 (a disintegrin and metalloproteinase-12) define a signaling axis in agonist-induced hypertension and cardiac hypertrophy.

Wang X, Chow FL, Oka T, Hao L, Lopez-Campistrous A, Kelly S, Cooper S, Odenbach J, Finegan BA, Schulz R, Kassiri Z, Lopaschuk GD, Fernandez-Patron C.

Circulation. 2009 May 12;119(18):2480-9. Epub 2009 Apr 27.PMID: 19398663 [PubMed - indexed for MEDLINE]Related articles

High rates of residual fatty acid oxidation during mild ischemia decrease cardiac work and efficiency.

Folmes CD, Sowah D, Clanachan AS, Lopaschuk GD.

J Mol Cell Cardiol. 2009 Jul;47(1):142-8. Epub 2009 Mar 19.PMID: 19303418 [PubMed - in process]Related articles

Targeting malonyl CoA inhibition of mitochondrial fatty acid uptake as an approach to treat cardiac ischemia/reperfusion.

Ussher JR, Lopaschuk GD.

Basic Res Cardiol. 2009 Mar;104(2):203-10. Epub 2009 Feb 26. Review.PMID: 19242641 [PubMed - indexed for MEDLINE]Related articles

Diastolic dysfunction in familial hypertrophic cardiomyopathy transgenic model mice.

Abraham TP, Jones M, Kazmierczak K, Liang HY, Pinheiro AC, Wagg CS, Lopaschuk GD, Szczesna-Cordary D.

Cardiovasc Res. 2009 Apr 1;82(1):84-92. Epub 2009 Jan 15.PMID: 19150977 [PubMed - indexed for MEDLINE]Related articles

H(2)O(2)-induced left ventricular dysfunction in isolated working rat hearts is independent of calcium accumulation.

Wang L, Lopaschuk GD, Clanachan AS.

J Mol Cell Cardiol. 2008 Dec;45(6):787-95. Epub 2008 Sep 6.PMID: 18817782 [PubMed - indexed for MEDLINE]Related articles

AMP-activated protein kinase control of energy metabolism in the ischemic heart.

Lopaschuk GD.

Int J Obes (Lond). 2008 Sep;32 Suppl 4:S29-35. Review.PMID: 18719595 [PubMed - indexed for MEDLINE]Related articles

Transient activation of p38 MAP kinase and up-regulation of Pim-1 kinase in cardiac hypertrophy despite no activation of AMPK.

Lei B, Chess DJ, Keung W, O'Shea KM, Lopaschuk GD, Stanley WC.

J Mol Cell Cardiol. 2008 Sep;45(3):404-10. Epub 2008 Jul 1.PMID: 18639556 [PubMed - indexed for MEDLINE]Related articles

Myocardial hypertrophy and the maturation of fatty acid oxidation in the newborn human heart.

Yatscoff MA, Jaswal JS, Grant MR, Greenwood R, Lukat T, Beker DL, Rebeyka IM, Lopaschuk GD.

Pediatr Res. 2008 Dec;64(6):643-7.PMID: 18614968 [PubMed - indexed for MEDLINE]Related articles

Proteomic analysis of cardiac metabolic enzymes in asphyxiated newborn piglets.

Fert-Bober J, Sawicki G, Lopaschuk GD, Cheung PY.

Mol Cell Biochem. 2008 Nov;318(1-2):13-21. Epub 2008 Jul 8.PMID: 18607691 [PubMed - indexed for MEDLINE]Related articles

Cyclic GMP signaling in cardiomyocytes modulates fatty acid trafficking and prevents triglyceride accumulation.

Khairallah RJ, Khairallah M, Gélinas R, Bouchard B, Young ME, Allen BG, Lopaschuk GD, Deschepper CF, Des Rosiers C.

J Mol Cell Cardiol. 2008 Aug;45(2):230-9. Epub 2008 May 27.PMID: 18590915 [PubMed - indexed for MEDLINE]Related articles

Signalling in cardiac metabolism.

Lopaschuk GD, Kelly DP.

Cardiovasc Res. 2008 Jul 15;79(2):205-7. Epub 2008 May 31. No abstract available. PMID: 18515845 [PubMed - indexed for MEDLINE]Related articlesFree article

The malonyl CoA axis as a potential target for treating ischaemic heart disease.

Ussher JR, Lopaschuk GD.

Cardiovasc Res. 2008 Jul 15;79(2):259-68. Epub 2008 May 22. Review.PMID: 18499682 [PubMed - indexed for MEDLINE]Related articlesFree article

Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance.

Koves TR, Ussher JR, Noland RC, Slentz D, Mosedale M, Ilkayeva O, Bain J, Stevens R, Dyck JR, Newgard CB, Lopaschuk GD, Muoio DM.

Cell Metab. 2008 Jan;7(1):45-56.PMID: 18177724 [PubMed - indexed for MEDLINE]Related articles

Metabolic response to an acute jump in cardiac workload: effects on malonyl-CoA, mechanical efficiency, and fatty acid oxidation.

Zhou L, Huang H, Yuan CL, Keung W, Lopaschuk GD, Stanley WC.

Am J Physiol Heart Circ Physiol. 2008 Feb;294(2):H954-60. Epub 2007 Dec 14.PMID: 18083904 [PubMed - indexed for MEDLINE]Related articlesFree article

Metabolic therapy for the treatment of ischemic heart disease: reality and expectations.

Wang W, Lopaschuk GD.

Expert Rev Cardiovasc Ther. 2007 Nov;5(6):1123-34. Review.PMID: 18035928 [PubMed - indexed for MEDLINE]Related articles

Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake.

Gao S, Kinzig KP, Aja S, Scott KA, Keung W, Kelly S, Strynadka K, Chohnan S, Smith WW, Tamashiro KL, Ladenheim EE, Ronnett GV, Tu Y, Birnbaum MJ, Lopaschuk GD, Moran TH.

Proc Natl Acad Sci U S A. 2007 Oct 30;104(44):17358-63. Epub 2007 Oct 23.PMID: 17956983 [PubMed - indexed for MEDLINE]Related articlesFree article

Alterations in energy metabolism in cardiomyopathies.

Taha M, Lopaschuk GD.

Ann Med. 2007;39(8):594-607. Review.PMID: 17934906 [PubMed - indexed for MEDLINE]Related articles

Cardiac energy metabolism in obesity.

Lopaschuk GD, Folmes CD, Stanley WC.

Circ Res. 2007 Aug 17;101(4):335-47. Review.PMID: 17702980 [PubMed - indexed for MEDLINE]Related articlesFree article

Substantial working muscle glycerol turnover during two-legged cycle ergometry.

Wallis GA, Friedlander AL, Jacobs KA, Horning MA, Fattor JA, Wolfel EE, Lopaschuk GD, Brooks GA.

Am J Physiol Endocrinol Metab. 2007 Oct;293(4):E950-7. Epub 2007 Jul 10.PMID: 17623753 [PubMed - indexed for MEDLINE]Related articlesFree article

Myosin regulatory light chain E22K mutation results in decreased cardiac intracellular calcium and force transients.

Szczesna-Cordary D, Jones M, Moore JR, Watt J, Kerrick WG, Xu Y, Wang Y, Wagg C, Lopaschuk GD.

FASEB J. 2007 Dec;21(14):3974-85. Epub 2007 Jul 2.PMID: 17606808 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanisms responsible for enhanced fatty acid utilization by perfused hearts from type 2 diabetic db/db mice.

Carley AN, Atkinson LL, Bonen A, Harper ME, Kunnathu S, Lopaschuk GD, Severson DL.

Arch Physiol Biochem. 2007 Apr;113(2):65-75.PMID: 17558605 [PubMed - indexed for MEDLINE]Related articles

Alpha-catalytic subunits of 5'AMP-activated protein kinase display fiber-specific expression and are upregulated by chronic low-frequency stimulation in rat muscle.

Putman CT, Martins KJ, Gallo ME, Lopaschuk GD, Pearcey JA, MacLean IM, Saranchuk RJ, Pette D.

Am J Physiol Regul Integr Comp Physiol. 2007 Sep;293(3):R1325-34. Epub 2007 Jun 6.PMID: 17553841 [PubMed - indexed for MEDLINE]Related articles

Alpha-lipoic acid increases cardiac glucose oxidation independent of AMP-activated protein kinase in isolated working rat hearts.

Onay-Besikci A, Wagg C, Lopaschuk TP, Keung W, Lopaschuk GD.

Basic Res Cardiol. 2007 Sep;102(5):436-44. Epub 2007 May 29.PMID: 17530314 [PubMed - indexed for MEDLINE]Related articles

Anti-anginal effects of partial fatty acid oxidation inhibitors.

Lam A, Lopaschuk GD.

Curr Opin Pharmacol. 2007 Apr;7(2):179-85. Epub 2007 Feb 20. Review.PMID: 17307396 [PubMed - indexed for MEDLINE]Related articles

A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth.

Bonnet S, Archer SL, Allalunis-Turner J, Haromy A, Beaulieu C, Thompson R, Lee CT, Lopaschuk GD, Puttagunta L, Bonnet S, Harry G, Hashimoto K, Porter CJ, Andrade MA, Thebaud B, Michelakis ED.

Cancer Cell. 2007 Jan;11(1):37-51.PMID: 17222789 [PubMed - indexed for MEDLINE]Related articles

Malonyl-CoA decarboxylase inhibition as a novel approach to treat ischemic heart disease.

Lopaschuk GD, Stanley WC.

Cardiovasc Drugs Ther. 2006 Dec;20(6):433-9. Review.PMID: 17136490 [PubMed - indexed for MEDLINE]Related articles

Role of malonyl-CoA in heart disease and the hypothalamic control of obesity.

Folmes CD, Lopaschuk GD.

Cardiovasc Res. 2007 Jan 15;73(2):278-87. Epub 2006 Oct 20. Review.PMID: 17126822 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of an active LKB1 complex in cardiac myocytes results in decreased protein synthesis associated with phenylephrine-induced hypertrophy.

Noga AA, Soltys CL, Barr AJ, Kovacic S, Lopaschuk GD, Dyck JR.

Am J Physiol Heart Circ Physiol. 2007 Mar;292(3):H1460-9. Epub 2006 Nov 10.PMID: 17098823 [PubMed - indexed for MEDLINE]Related articlesFree article

Absence of malonyl coenzyme A decarboxylase in mice increases cardiac glucose oxidation and protects the heart from ischemic injury.

Dyck JR, Hopkins TA, Bonnet S, Michelakis ED, Young ME, Watanabe M, Kawase Y, Jishage K, Lopaschuk GD.

Circulation. 2006 Oct 17;114(16):1721-8. Epub 2006 Oct 9.PMID: 17030679 [PubMed - indexed for MEDLINE]Related articlesFree article

Optimizing cardiac fatty acid and glucose metabolism as an approach to treating heart failure.

Lopaschuk GD.

Semin Cardiothorac Vasc Anesth. 2006 Sep;10(3):228-30.PMID: 16959756 [PubMed - indexed for MEDLINE]Related articles

Cardiac energy metabolism alterations in angiotensin II induced hypertrophy.

Lopaschuk GD.

J Mol Cell Cardiol. 2006 Sep;41(3):418-20. Epub 2006 Jul 28. No abstract available. PMID: 16876818 [PubMed - indexed for MEDLINE]Related articles

Discovery of potent and orally available malonyl-CoA decarboxylase inhibitors as cardioprotective agents.

Cheng JF, Huang Y, Penuliar R, Nishimoto M, Liu L, Arrhenius T, Yang G, O'leary E, Barbosa M, Barr R, Dyck JR, Lopaschuk GD, Nadzan AM.

J Med Chem. 2006 Jul 13;49(14):4055-8.PMID: 16821767 [PubMed - indexed for MEDLINE]Related articles

Fatty acids attenuate insulin regulation of 5'-AMP-activated protein kinase and insulin cardioprotection after ischemia.

Folmes CD, Clanachan AS, Lopaschuk GD.

Circ Res. 2006 Jul 7;99(1):61-8. Epub 2006 Jun 1.PMID: 16741157 [PubMed - indexed for MEDLINE]Related articlesFree article

AMPK alterations in cardiac physiology and pathology: enemy or ally?

Dyck JR, Lopaschuk GD.

J Physiol. 2006 Jul 1;574(Pt 1):95-112. Epub 2006 May 11. Review.PMID: 16690706 [PubMed - indexed for MEDLINE]Related articlesFree article

Heteroaryl substituted bis-trifluoromethyl carbinols as malonyl-CoA decarboxylase inhibitors.

Cheng JF, Mak CC, Huang Y, Penuliar R, Nishimoto M, Zhang L, Chen M, Wallace D, Arrhenius T, Chu D, Yang G, Barbosa M, Barr R, Dyck JR, Lopaschuk GD, Nadzan AM.

Bioorg Med Chem Lett. 2006 Jul 1;16(13):3484-8. Epub 2006 Apr 27.PMID: 16644218 [PubMed - indexed for MEDLINE]Related articles

Synthesis and structure-activity relationship of small-molecule malonyl coenzyme A decarboxylase inhibitors.

Cheng JF, Chen M, Wallace D, Tith S, Haramura M, Liu B, Mak CC, Arrhenius T, Reily S, Brown S, Thorn V, Harmon C, Barr R, Dyck JR, Lopaschuk GD, Nadzan AM.

J Med Chem. 2006 Mar 9;49(5):1517-25.PMID: 16509570 [PubMed - indexed for MEDLINE]Related articles

Validation of 18F-fluoro-4-thia-palmitate as a PET probe for myocardial fatty acid oxidation: effects of hypoxia and composition of exogenous fatty acids.

DeGrado TR, Kitapci MT, Wang S, Ying J, Lopaschuk GD.

J Nucl Med. 2006 Jan;47(1):173-81.PMID: 16391202 [PubMed - indexed for MEDLINE]Related articlesFree article

Liver triglyceride secretion and lipid oxidative metabolism are rapidly altered by leptin in vivo.

Huang W, Dedousis N, Bandi A, Lopaschuk GD, O'Doherty RM.

Endocrinology. 2006 Mar;147(3):1480-7. Epub 2005 Dec 8.PMID: 16339207 [PubMed - indexed for MEDLINE]Related articlesFree article

Chronic activation of PPARalpha is detrimental to cardiac recovery after ischemia.

Sambandam N, Morabito D, Wagg C, Finck BN, Kelly DP, Lopaschuk GD.

Am J Physiol Heart Circ Physiol. 2006 Jan;290(1):H87-95. Epub 2005 Sep 9.PMID: 16155108 [PubMed - indexed for MEDLINE]Related articlesFree article

Malonyl-CoA decarboxylase inhibition suppresses fatty acid oxidation and reduces lactate production during demand-induced ischemia.

Stanley WC, Morgan EE, Huang H, McElfresh TA, Sterk JP, Okere IC, Chandler MP, Cheng J, Dyck JR, Lopaschuk GD.

Am J Physiol Heart Circ Physiol. 2005 Dec;289(6):H2304-9. Epub 2005 Aug 12.PMID: 16100246 [PubMed - indexed for MEDLINE]Related articlesFree article

Myocardial substrate metabolism in the normal and failing heart.

Stanley WC, Recchia FA, Lopaschuk GD.

Physiol Rev. 2005 Jul;85(3):1093-129. Review.PMID: 15987803 [PubMed - indexed for MEDLINE]Related articlesFree article

Selective versus nonselective beta-adrenergic receptor blockade in chronic heart failure: differential effects on myocardial energy substrate utilization.

Al-Hesayen A, Azevedo ER, Floras JS, Hollingshead S, Lopaschuk GD, Parker JD.

Eur J Heart Fail. 2005 Jun;7(4):618-23.PMID: 15921803 [PubMed - indexed for MEDLINE]Related articles