PubMed

Initiating insulin therapy in type 2 diabetic patients failing on oral hypoglycemic agents: basal or prandial insulin? The APOLLO trial and beyond.

Bretzel RG, Eckhard M, Landgraf W, Owens DR, Linn T.

Diabetes Care. 2009 Nov;32 Suppl 2:S260-5. No abstract available. PMID: 19875561 [PubMed - in process]Related articles

Cytotoxic constituents of Soymida febrifuga from Myanmar.

Awale S, Miyamoto T, Linn TZ, Li F, Win NN, Tezuka Y, Esumi H, Kadota S.

J Nat Prod. 2009 Sep;72(9):1631-6.PMID: 19689125 [PubMed - indexed for MEDLINE]Related articles

Anti-inflammatory thalidomide improves islet grafts survival and functions in a xenogenic environment.

Chen C, Kuehn C, Bretzel RG, Linn T.

PLoS One. 2009 Jul 20;4(7):e6312.PMID: 19617916 [PubMed - indexed for MEDLINE]Related articlesFree article

Comparison of treatment costs in inadequately controlled type 2 diabetes in Germany based on the APOLLO trial with insulin glargine.

Bretzel RG, Dippel FW, Linn T, Neilson AR.

J Med Econ. 2009;12(2):87-97.PMID: 19473110 [PubMed - in process]Related articles

Impaired gastric acidification negatively affects calcium homeostasis and bone mass.

Schinke T, Schilling AF, Baranowsky A, Seitz S, Marshall RP, Linn T, Blaeker M, Huebner AK, Schulz A, Simon R, Gebauer M, Priemel M, Kornak U, Perkovic S, Barvencik F, Beil FT, Del Fattore A, Frattini A, Streichert T, Pueschel K, Villa A, Debatin KM, Rueger JM, Teti A, Zustin J, Sauter G, Amling M.

Nat Med. 2009 Jun;15(6):674-81.PMID: 19448635 [PubMed - indexed for MEDLINE]Related articles

Innate immunity and heat shock response in islet transplantation.

Lai Y, Chen C, Linn T.

Clin Exp Immunol. 2009 Jul;157(1):1-8. Epub 2009 Feb 4. Review.PMID: 19302242 [PubMed - indexed for MEDLINE]Related articles

Staple line haemorrhage following laparoscopic left-sided colorectal resections may be more common when the inferior mesenteric artery is preserved.

Linn TY, Moran BJ, Cecil TD.

Tech Coloproctol. 2008 Dec;12(4):289-93. Epub 2008 Nov 18.PMID: 19018473 [PubMed - indexed for MEDLINE]Related articles

Nocturnal glucose metabolism after bedtime injection of insulin glargine or neutral protamine hagedorn insulin in patients with type 2 diabetes.

Linn T, Fischer B, Soydan N, Eckhard M, Ehl J, Kunz C, Bretzel RG.

J Clin Endocrinol Metab. 2008 Oct;93(10):3839-46. Epub 2008 Jul 8.PMID: 18611975 [PubMed - indexed for MEDLINE]Related articlesFree article

Scalable selection of hepatocyte- and hepatocyte precursor-like cells from culture of differentiating transgenically modified murine embryonic stem cells.

Drobinskaya I, Linn T, Saric T, Bretzel RG, Bohlen H, Hescheler J, Kolossov E.

Stem Cells. 2008 Sep;26(9):2245-56. Epub 2008 Jun 12.PMID: 18556507 [PubMed - indexed for MEDLINE]Related articlesFree article

Effect of experimentally induced hypoglycemia and different insulin levels on feelings of hunger in type 1 diabetic patients.

Hermanns N, Plate M, Kulzer B, Fischer B, Linn T, Bretzel R, Haak T.

Exp Clin Endocrinol Diabetes. 2008 May;116(5):255-61.PMID: 18484559 [PubMed - indexed for MEDLINE]Related articles

Once-daily basal insulin glargine versus thrice-daily prandial insulin lispro in people with type 2 diabetes on oral hypoglycaemic agents (APOLLO): an open randomised controlled trial.

Bretzel RG, Nuber U, Landgraf W, Owens DR, Bradley C, Linn T.

Lancet. 2008 Mar 29;371(9618):1073-84. Erratum in: Lancet. 2008 Aug 30;372(9640):718. PMID: 18374840 [PubMed - indexed for MEDLINE]Related articles

A system for the construction of targeted unmarked gene deletions in the genus Burkholderia.

Flannagan RS, Linn T, Valvano MA.

Environ Microbiol. 2008 Jun;10(6):1652-60. Epub 2008 Mar 13.PMID: 18341581 [PubMed - indexed for MEDLINE]Related articles

Genetic modification of cells for transplantation.

Lai Y, Drobinskaya I, Kolossov E, Chen C, Linn T.

Adv Drug Deliv Rev. 2008 Jan 14;60(2):146-59. Epub 2007 Oct 18. Review.PMID: 18037530 [PubMed - indexed for MEDLINE]Related articles

Case report: herpes meningitis complicating genital herpes presenting as anal fissure.

Marudanayagam R, Linn T, Fox AD.

Herpes. 2007 Sep;14(2):48-9.PMID: 17939904 [PubMed - indexed for MEDLINE]Related articles

Isolated pancreatic islets in three-dimensional matrices are responsive to stimulators and inhibitors of angiogenesis.

Kidszun A, Schneider D, Erb D, Hertl G, Schmidt V, Eckhard M, Preissner KT, Breier G, Bretzel RG, Linn T.

Cell Transplant. 2006;15(6):489-97.PMID: 17121160 [PubMed - indexed for MEDLINE]Related articles

Antimalarial activity of cassane- and norcassane-type diterpenes from Caesalpinia crista and their structure-activity relationship.

Kalauni SK, Awale S, Tezuka Y, Banskota AH, Linn TZ, Asih PB, Syafruddin D, Kadota S.

Biol Pharm Bull. 2006 May;29(5):1050-2.PMID: 16651745 [PubMed - indexed for MEDLINE]Related articlesFree article

Ischaemia is linked to inflammation and induction of angiogenesis in pancreatic islets.

Linn T, Schmitz J, Hauck-Schmalenberger I, Lai Y, Bretzel RG, Brandhorst H, Brandhorst D.

Clin Exp Immunol. 2006 May;144(2):179-87. Review.PMID: 16634789 [PubMed - indexed for MEDLINE]Related articlesFree article

Constituents of Caesalpinia crista from Indonesia.

Awale S, Linn TZ, Tezuka Y, Kalauni SK, Banskota AH, Attamimi F, Ueda JY, Kadota S.

Chem Pharm Bull (Tokyo). 2006 Feb;54(2):213-8.PMID: 16462066 [PubMed - indexed for MEDLINE]Related articlesFree article

The extracellular adherence protein (Eap) of Staphylococcus aureus inhibits wound healing by interfering with host defense and repair mechanisms.

Athanasopoulos AN, Economopoulou M, Orlova VV, Sobke A, Schneider D, Weber H, Augustin HG, Eming SA, Schubert U, Linn T, Nawroth PP, Hussain M, Hammes HP, Herrmann M, Preissner KT, Chavakis T.

Blood. 2006 Apr 1;107(7):2720-7. Epub 2005 Nov 29.PMID: 16317095 [PubMed - indexed for MEDLINE]Related articlesFree article

Methyl migrated cassane-type furanoditerpenes of Caesalpinia crista from Myanmar.

Kalauni SK, Awale S, Tezuka Y, Banskota AH, Linn TZ, Kadota S.

Chem Pharm Bull (Tokyo). 2005 Oct;53(10):1300-4.PMID: 16204987 [PubMed - indexed for MEDLINE]Related articlesFree article

Uptake and transport of PEG-graft-trimethyl-chitosan copolymer-insulin nanocomplexes by epithelial cells.

Mao S, Germershaus O, Fischer D, Linn T, Schnepf R, Kissel T.

Pharm Res. 2005 Dec;22(12):2058-68. Epub 2005 Sep 26.PMID: 16170693 [PubMed - indexed for MEDLINE]Related articles

A potential important role of skeletal muscle in human counterregulation of hypoglycemia.

Meyer C, Saar P, Soydan N, Eckhard M, Bretzel RG, Gerich J, Linn T.

J Clin Endocrinol Metab. 2005 Nov;90(11):6244-50. Epub 2005 Sep 6. Erratum in: J Clin Endocrinol Metab. 2006 Jan;91(1):27. PMID: 16144954 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin containing nanocomplexes formed by self-assembly from biodegradable amine-modified poly(vinyl alcohol)-graft-poly(L-lactide): bioavailability and nasal tolerability in rats.

Simon M, Wittmar M, Kissel T, Linn T.

Pharm Res. 2005 Nov;22(11):1879-86. Epub 2005 Aug 26.PMID: 16132341 [PubMed - indexed for MEDLINE]Related articles

Vascular endothelial growth factor increases functional beta-cell mass by improvement of angiogenesis of isolated human and murine pancreatic islets.

Lai Y, Schneider D, Kidszun A, Hauck-Schmalenberger I, Breier G, Brandhorst D, Brandhorst H, Iken M, Brendel MD, Bretzel RG, Linn T.

Transplantation. 2005 Jun 15;79(11):1530-6.PMID: 15940042 [PubMed - indexed for MEDLINE]Related articles

Glucose evaluation trial for remission (GETREM) in type 1 diabetes: a European multicentre study.

Pozzilli P, Manfrini S, Buzzetti R, Lampeter E, Leeuw ID, Iafusco D, Prisco M, Ionescu-Tirgoviste C, Kolouskovà S, Linn T, Ludvigsson J, Madàcsy L, Mrozikiewicz AS, Mrozikiewicz PM, Podar T, Vavrinec J, Vialettes B, Visalli N, Yilmaz T, Browne PD; IMDIAB group.

Diabetes Res Clin Pract. 2005 Jun;68(3):258-64. Epub 2004 Nov 21.PMID: 15936469 [PubMed - indexed for MEDLINE]Related articles

Cassane- and norcassane-type diterpenes from Caesalpinia crista of Indonesia and their antimalarial activity against the growth of Plasmodium falciparum.

Linn TZ, Awale S, Tezuka Y, Banskota AH, Kalauni SK, Attamimi F, Ueda JY, Asih PB, Syafruddin D, Tanaka K, Kadota S.

J Nat Prod. 2005 May;68(5):706-10.PMID: 15921414 [PubMed - indexed for MEDLINE]Related articles

New cassane-type diterpenes of Caesalpinia crista from Myanmar.

Kalauni SK, Awale S, Tezuka Y, Banskota AH, Linn TZ, Kadota S.

Chem Pharm Bull (Tokyo). 2005 Feb;53(2):214-8.PMID: 15684521 [PubMed - indexed for MEDLINE]Related articlesFree article

Cassane- and norcassane-type diterpenes of Caesalpinia crista from Myanmar.

Kalauni SK, Awale S, Tezuka Y, Banskota AH, Linn TZ, Kadota S.

J Nat Prod. 2004 Nov;67(11):1859-63.PMID: 15568776 [PubMed - indexed for MEDLINE]Related articles

A direct efficacy and safety comparison of insulin aspart, human soluble insulin, and human premix insulin (70/30) in patients with type 2 diabetes.

Bretzel RG, Arnolds S, Medding J, Linn T.

Diabetes Care. 2004 May;27(5):1023-7.PMID: 15111514 [PubMed - indexed for MEDLINE]Related articlesFree article

[Continuation 50. Type 2 diabetes: possibilities and limitations of pharmacological therapy]

Kellerer M, Jakob S, Linn T, Haslbeck M.

MMW Fortschr Med. 2003 Dec 18;145(51-52):I-X; quiz XI-XII. Review. German. No abstract available. PMID: 14974337 [PubMed - indexed for MEDLINE]Related articles

Randomised prospective study for the effect of therapy on residual beta cell function in type-1 diabetes mellitus [ISRCTN70703138].

Linn T, Mann M, Mann M, Bretzel RG, Boedeker RH.

BMC Endocr Disord. 2003 Dec 10;3(1):5.PMID: 14667244 [PubMed - as supplied by publisher]Related articlesFree article

Polymers for induction of revascularization in the rat fascial flap: application of vascular endothelial growth factor and pancreatic islet cells.

Linn T, Erb D, Schneider D, Kidszun A, Elçin AE, Bretzel RG, Elçin YM.

Cell Transplant. 2003;12(7):769-78.PMID: 14653623 [PubMed - indexed for MEDLINE]Related articles

The pattern recognition receptor (RAGE) is a counterreceptor for leukocyte integrins: a novel pathway for inflammatory cell recruitment.

Chavakis T, Bierhaus A, Al-Fakhri N, Schneider D, Witte S, Linn T, Nagashima M, Morser J, Arnold B, Preissner KT, Nawroth PP.

J Exp Med. 2003 Nov 17;198(10):1507-15.PMID: 14623906 [PubMed - indexed for MEDLINE]Related articlesFree article

Why is a new trial required to define the role of insulin reserve in newly diagnosed adult type 1 diabetes?

Linn T, Mann M, Mann M, Boedeker RH, Bretzel RG.

Exp Clin Endocrinol Diabetes. 2003 Sep;111(6):319-21. No abstract available. PMID: 14520595 [PubMed - indexed for MEDLINE]Related articles

Pancreatic islet culture and transplantation using chitosan and PLGA scaffolds.

Elçin YM, Elçin AE, Bretzel RG, Linn T.

Adv Exp Med Biol. 2003;534:255-64. No abstract available. PMID: 12903725 [PubMed - indexed for MEDLINE]Related articles

Angiogenic capacity of endothelial cells in islets of Langerhans.

Linn T, Schneider K, Hammes HP, Preissner KT, Brandhorst H, Morgenstern E, Kiefer F, Bretzel RG.

FASEB J. 2003 May;17(8):881-3. Epub 2003 Mar 28.PMID: 12670881 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin resistance in patients with the mitochondrial tRNA(Leu(UUR)) gene mutation at position 3243.

Becker R, Laube H, Linn T, Damian MS.

Exp Clin Endocrinol Diabetes. 2002 Sep;110(6):291-7.PMID: 12373633 [PubMed - indexed for MEDLINE]Related articles

VDR gene polymorphisms are overrepresented in german patients with type 1 diabetes compared to healthy controls without effect on biochemical parameters of bone metabolism.

Fassbender WJ, Goertz B, Weismüller K, Steinhauer B, Stracke H, Auch D, Linn T, Bretzel RG.

Horm Metab Res. 2002 Jun;34(6):330-7. Erratum in: Horm Metab Res 2002 Sep;34(9):536.. PMID: 12173074 [PubMed - indexed for MEDLINE]Related articles

Impaired glucose effectiveness in chronic progressive external ophthalmoplegia.

Becker R, Laube H, Laube H, Linn T, Pabst W, Damian MS.

Metabolism. 2002 Jun;51(6):796-800.PMID: 12037739 [PubMed - indexed for MEDLINE]Related articles

Kinetics of integrin expression in the mouse model of proliferative retinopathy and success of secondary intervention with cyclic RGD peptides.

Chavakis E, Riecke B, Lin J, Linn T, Bretzel RG, Preissner KT, Brownlee M, Hammes HP.

Diabetologia. 2002 Feb;45(2):262-7.PMID: 11935158 [PubMed - indexed for MEDLINE]Related articles

Enhancement of beta-cell sensitivity to glucose by oral fat load.

Wuesten O, Balz CH, Kloer HU, Bretzel RG, Linn T.

Horm Metab Res. 2001 Sep;33(9):548-53.PMID: 11561215 [PubMed - indexed for MEDLINE]Related articles

Topical application of integrin antagonists inhibits proliferative retinopathy.

Riecke B, Chavakis E, Bretzel RG, Linn T, Preissner KT, Brownlee M, Hammes HP.

Horm Metab Res. 2001 May;33(5):307-11.PMID: 11440278 [PubMed - indexed for MEDLINE]Related articles

Effect of long-term dietary protein intake on glucose metabolism in humans.

Linn T, Santosa B, Grönemeyer D, Aygen S, Scholz N, Busch M, Bretzel RG.

Diabetologia. 2000 Oct;43(10):1257-65.PMID: 11079744 [PubMed - indexed for MEDLINE]Related articles

Diet promotes beta-cell loss by apoptosis in prediabetic nonobese diabetic mice.

Linn T, Strate C, Schneider K.

Endocrinology. 1999 Aug;140(8):3767-73.PMID: 10433238 [PubMed - indexed for MEDLINE]Related articlesFree article

The effect of acarbose on insulin sensitivity and proinsulin in overweight subjects with impaired glucose tolerance.

Laube H, Linn T, Heyen P.

Exp Clin Endocrinol Diabetes. 1998;106(3):231-3.PMID: 9710365 [PubMed - indexed for MEDLINE]Related articles

Adhesion molecules and microvascular changes in the nonobese diabetic (NOD) mouse pancreas. An NO-inhibitor (L-NAME) is unable to block adhesion inflammation-induced activation.

Papaccio G, Latronico MV, Pisanti FA, Federlin K, Linn T.

Autoimmunity. 1998;27(2):65-77.PMID: 9583738 [PubMed - indexed for MEDLINE]Related articles

Diabetes in pregnancy.

Linn T, Bretzel RG.

Eur J Obstet Gynecol Reprod Biol. 1997 Dec;75(1):37-41. Review.PMID: 9447345 [PubMed - indexed for MEDLINE]Related articles

Transcription-frequency-dependent modulation of an attenuator in a ribosomal protein-RNA polymerase operon requires an upstream site.

Steward KL, St Pierre R, Linn T.

Microbiology. 1997 Nov;143 ( Pt 11):3501-11.PMID: 9387228 [PubMed - indexed for MEDLINE]Related articlesFree article

Mapping of sequences required for the translation of the beta subunit of Escherichia coli RNA polymerase.

Passador L, Linn T.

Can J Microbiol. 1997 Sep;43(9):819-26.PMID: 9336945 [PubMed - indexed for MEDLINE]Related articles

An efficient protocol for linker scanning mutagenesis: analysis of the translational regulation of an Escherichia coli RNA polymerase subunit gene.

Dykxhoorn DM, St Pierre R, Van Ham O, Linn T.

Nucleic Acids Res. 1997 Nov 1;25(21):4209-18.PMID: 9336448 [PubMed - indexed for MEDLINE]Related articlesFree article