PubMed

Specific regulation of IRS-2 expression by glucose in rat primary pancreatic islet beta-cells.

Lingohr MK, Briaud I, Dickson LM, McCuaig JF, Alárcon C, Wicksteed BL, Rhodes CJ.

J Biol Chem. 2006 Jun 9;281(23):15884-92. Epub 2006 Mar 30. Erratum in: J Biol Chem. 2006 Aug 11;281(32):23296. PMID: 16574657 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin receptor substrate-2 proteasomal degradation mediated by a mammalian target of rapamycin (mTOR)-induced negative feedback down-regulates protein kinase B-mediated signaling pathway in beta-cells.

Briaud I, Dickson LM, Lingohr MK, McCuaig JF, Lawrence JC, Rhodes CJ.

J Biol Chem. 2005 Jan 21;280(3):2282-93. Epub 2004 Nov 9.PMID: 15537654 [PubMed - indexed for MEDLINE]Related articlesFree article

Decreasing IRS-2 expression in pancreatic beta-cells (INS-1) promotes apoptosis, which can be compensated for by introduction of IRS-4 expression.

Lingohr MK, Dickson LM, Wrede CE, Briaud I, McCuaig JF, Myers MG Jr, Rhodes CJ.

Mol Cell Endocrinol. 2003 Nov 14;209(1-2):17-31.PMID: 14604813 [PubMed - indexed for MEDLINE]Related articles

Glucose-induced translational control of proinsulin biosynthesis is proportional to preproinsulin mRNA levels in islet beta-cells but not regulated via a positive feedback of secreted insulin.

Wicksteed B, Alarcon C, Briaud I, Lingohr MK, Rhodes CJ.

J Biol Chem. 2003 Oct 24;278(43):42080-90. Epub 2003 Aug 18.PMID: 12928442 [PubMed - indexed for MEDLINE]Related articlesFree article

IRS-3 inhibits IRS-2-mediated signaling in pancreatic beta-cells.

Lingohr MK, Dickson LM, Wrede CE, McCuaig JF, Myers MG Jr, Rhodes CJ.

Mol Cell Endocrinol. 2003 Jun 30;204(1-2):85-99.PMID: 12850284 [PubMed - indexed for MEDLINE]Related articles

Fatty acid and phorbol ester-mediated interference of mitogenic signaling via novel protein kinase C isoforms in pancreatic beta-cells (INS-1).

Wrede CE, Dickson LM, Lingohr MK, Briaud I, Rhodes CJ.

J Mol Endocrinol. 2003 Jun;30(3):271-86.PMID: 12790799 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential activation mechanisms of Erk-1/2 and p70(S6K) by glucose in pancreatic beta-cells.

Briaud I, Lingohr MK, Dickson LM, Wrede CE, Rhodes CJ.

Diabetes. 2003 Apr;52(4):974-83.PMID: 12663469 [PubMed - indexed for MEDLINE]Related articlesFree article

Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1).

Wrede CE, Dickson LM, Lingohr MK, Briaud I, Rhodes CJ.

J Biol Chem. 2002 Dec 20;277(51):49676-84. Epub 2002 Oct 21.PMID: 12393870 [PubMed - indexed for MEDLINE]Related articlesFree article

Dichloroacetate stimulates glycogen accumulation in primary hepatocytes through an insulin-independent mechanism.

Lingohr MK, Bull RJ, Kato-Weinstein J, Thrall BD.

Toxicol Sci. 2002 Aug;68(2):508-15.PMID: 12151648 [PubMed - indexed for MEDLINE]Related articlesFree article

Pancreatic beta-cell growth and survival--a role in obesity-linked type 2 diabetes?

Lingohr MK, Buettner R, Rhodes CJ.

Trends Mol Med. 2002 Aug;8(8):375-84. Review.PMID: 12127723 [PubMed - indexed for MEDLINE]Related articles

Contribution of dichloroacetate and trichloroacetate to liver tumor induction in mice by trichloroethylene.

Bull RJ, Orner GA, Cheng RS, Stillwell L, Stauber AJ, Sasser LB, Lingohr MK, Thrall BD.

Toxicol Appl Pharmacol. 2002 Jul 1;182(1):55-65.PMID: 12127263 [PubMed - indexed for MEDLINE]Related articles

Activation of IRS-2-mediated signal transduction by IGF-1, but not TGF-alpha or EGF, augments pancreatic beta-cell proliferation.

Lingohr MK, Dickson LM, McCuaig JF, Hugl SR, Twardzik DR, Rhodes CJ.

Diabetes. 2002 Apr;51(4):966-76.PMID: 11916914 [PubMed - indexed for MEDLINE]Related articlesFree article

Cooperativity between the preproinsulin mRNA untranslated regions is necessary for glucose-stimulated translation.

Wicksteed B, Herbert TP, Alarcon C, Lingohr MK, Moss LG, Rhodes CJ.

J Biol Chem. 2001 Jun 22;276(25):22553-8. Epub 2001 Apr 10.PMID: 11297542 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential activation of protein kinase B and p70(S6)K by glucose and insulin-like growth factor 1 in pancreatic beta-cells (INS-1).

Dickson LM, Lingohr MK, McCuaig J, Hugl SR, Snow L, Kahn BB, Myers MG Jr, Rhodes CJ.

J Biol Chem. 2001 Jun 15;276(24):21110-20. Epub 2001 Mar 27.PMID: 11274216 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of dichloroacetate (DCA) on serum insulin levels and insulin-controlled signaling proteins in livers of male B6C3F1 mice.

Lingohr MK, Thrall BD, Bull RJ.

Toxicol Sci. 2001 Jan;59(1):178-84.PMID: 11134557 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of dichloroacetate on glycogen metabolism in B6C3F1 mice.

Kato-Weinstein J, Lingohr MK, Orner GA, Thrall BD, Bull RJ.

Toxicology. 1998 Sep 15;130(2-3):141-54.PMID: 9865481 [PubMed - indexed for MEDLINE]Related articles