PubMed

Coexpression of the type 2 diabetes susceptibility gene variants KCNJ11 E23K and ABCC8 S1369A alter the ATP and sulfonylurea sensitivities of the ATP-sensitive K(+) channel.

Hamming KS, Soliman D, Matemisz LC, Niazi O, Lang Y, Gloyn AL, Light PE.

Diabetes. 2009 Oct;58(10):2419-24. Epub 2009 Jul 8.PMID: 19587354 [PubMed - indexed for MEDLINE]Related articles

Reactive oxygen species directly modify sodium-calcium exchanger activity in a splice variant-dependent manner.

Soliman D, Hamming KS, Matemisz LC, Light PE.

J Mol Cell Cardiol. 2009 Nov;47(5):595-602. Epub 2009 May 28.PMID: 19481548 [PubMed - in process]Related articles

Resveratrol prevents the prohypertrophic effects of oxidative stress on LKB1.

Dolinsky VW, Chan AY, Robillard Frayne I, Light PE, Des Rosiers C, Dyck JR.

Circulation. 2009 Mar 31;119(12):1643-52. Epub 2009 Mar 16.PMID: 19289642 [PubMed - indexed for MEDLINE]Related articles

Diastolic calcium is elevated in metabolic recovery of cardiomyocytes expressing elevated levels of the Na+/H+ exchanger.

Baczkó I, Mraiche F, Light PE, Fliegel L.

Can J Physiol Pharmacol. 2008 Dec;86(12):850-9.PMID: 19088806 [PubMed - indexed for MEDLINE]Related articles

The third intracellular loop stabilizes the inactive state of the neuropeptide Y1 receptor.

Chee MJ, Mörl K, Lindner D, Merten N, Zamponi GW, Light PE, Beck-Sickinger AG, Colmers WF.

J Biol Chem. 2008 Nov 28;283(48):33337-46. Epub 2008 Sep 23. Erratum in: J Biol Chem. 2009 Feb 6;284(6):4040. PMID: 18812316 [PubMed - indexed for MEDLINE]Related articles

Splice variant-dependent regulation of beta-cell sodium-calcium exchange by acyl-coenzyme As.

Hamming KS, Riedel MJ, Soliman D, Matemisz LC, Webster NJ, Searle GJ, MacDonald PE, Light PE.

Mol Endocrinol. 2008 Oct;22(10):2293-306. Epub 2008 Jul 17.PMID: 18635667 [PubMed - indexed for MEDLINE]Related articlesFree article

Resveratrol inhibits cardiac hypertrophy via AMP-activated protein kinase and Akt.

Chan AY, Dolinsky VW, Soltys CL, Viollet B, Baksh S, Light PE, Dyck JR.

J Biol Chem. 2008 Aug 29;283(35):24194-201. Epub 2008 Jun 18.PMID: 18562309 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypothalamic protein kinase C regulates glucose production.

Ross R, Wang PY, Chari M, Lam CK, Caspi L, Ono H, Muse ED, Li X, Gutierrez-Juarez R, Light PE, Schwartz GJ, Rossetti L, Lam TK.

Diabetes. 2008 Aug;57(8):2061-5. Epub 2008 May 28.PMID: 18511848 [PubMed - indexed for MEDLINE]Related articlesFree article

Upper intestinal lipids trigger a gut-brain-liver axis to regulate glucose production.

Wang PY, Caspi L, Lam CK, Chari M, Li X, Light PE, Gutierrez-Juarez R, Ang M, Schwartz GJ, Lam TK.

Nature. 2008 Apr 24;452(7190):1012-6. Epub 2008 Apr 9.PMID: 18401341 [PubMed - indexed for MEDLINE]Related articles

Elevation in intracellular long-chain acyl-coenzyme A esters lead to reduced beta-cell excitability via activation of adenosine 5'-triphosphate-sensitive potassium channels.

Webster NJ, Searle GJ, Lam PP, Huang YC, Riedel MJ, Harb G, Gaisano HY, Holt A, Light PE.

Endocrinology. 2008 Jul;149(7):3679-87. Epub 2008 Mar 27.PMID: 18372336 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of matrix metalloproteinases prevents peroxynitrite-induced contractile dysfunction in the isolated cardiac myocyte.

León H, Baczkó I, Sawicki G, Light PE, Schulz R.

Br J Pharmacol. 2008 Feb;153(4):676-83. Epub 2007 Dec 10.PMID: 18071296 [PubMed - indexed for MEDLINE]Related articlesFree article

Phosphodiesterase type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility.

Nagendran J, Archer SL, Soliman D, Gurtu V, Moudgil R, Haromy A, St Aubin C, Webster L, Rebeyka IM, Ross DB, Light PE, Dyck JR, Michelakis ED.

Circulation. 2007 Jul 17;116(3):238-48. Epub 2007 Jul 2.PMID: 17606845 [PubMed - indexed for MEDLINE]Related articlesFree article

Carbonic anhydrase inhibition prevents and reverts cardiomyocyte hypertrophy.

Alvarez BV, Johnson DE, Sowah D, Soliman D, Light PE, Xia Y, Karmazyn M, Casey JR.

J Physiol. 2007 Feb 15;579(Pt 1):127-45. Epub 2006 Nov 23.PMID: 17124262 [PubMed - indexed for MEDLINE]Related articlesFree article

Ranolazine decreases diastolic calcium accumulation caused by ATX-II or ischemia in rat hearts.

Fraser H, Belardinelli L, Wang L, Light PE, McVeigh JJ, Clanachan AS.

J Mol Cell Cardiol. 2006 Dec;41(6):1031-8. Epub 2006 Oct 5.PMID: 17027025 [PubMed - indexed for MEDLINE]Related articles

Inhibition of cardiac voltage-gated sodium channels by grape polyphenols.

Wallace CH, Baczkó I, Jones L, Fercho M, Light PE.

Br J Pharmacol. 2006 Nov;149(6):657-65. Epub 2006 Oct 3.PMID: 17016511 [PubMed - indexed for MEDLINE]Related articlesFree article

Metabolic regulation of sodium-calcium exchange by intracellular acyl CoAs.

Riedel MJ, Baczkó I, Searle GJ, Webster N, Fercho M, Jones L, Lang J, Lytton J, Dyck JR, Light PE.

EMBO J. 2006 Oct 4;25(19):4605-14. Epub 2006 Sep 14.PMID: 16977318 [PubMed - indexed for MEDLINE]Related articlesFree article

Familial Wolff-Parkinson-White Syndrome: a disease of glycogen storage or ion channel dysfunction?

Light PE.

J Cardiovasc Electrophysiol. 2006 May;17 Suppl 1:S158-S161. Review.PMID: 16686673 [PubMed - indexed for MEDLINE]Related articles

Saturated and cis/trans unsaturated acyl CoA esters differentially regulate wild-type and polymorphic beta-cell ATP-sensitive K+ channels.

Riedel MJ, Light PE.

Diabetes. 2005 Jul;54(7):2070-9.PMID: 15983208 [PubMed - indexed for MEDLINE]Related articlesFree article

Plasma membrane KATP channel-mediated cardioprotection involves posthypoxic reductions in calcium overload and contractile dysfunction: mechanistic insights into cardioplegia.

Baczkó I, Jones L, McGuigan CF, Manning Fox JE, Gandhi M, Giles WR, Clanachan AS, Light PE.

FASEB J. 2005 Jun;19(8):980-2. Epub 2005 Mar 16.PMID: 15774423 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification and pharmacological characterization of sarcolemmal ATP-sensitive potassium channels in the murine atrial HL-1 cell line.

Fox JE, Jones L, Light PE.

J Cardiovasc Pharmacol. 2005 Jan;45(1):30-5.PMID: 15613976 [PubMed - indexed for MEDLINE]Related articles

Current status of the E23K Kir6.2 polymorphism: implications for type-2 diabetes.

Riedel MJ, Steckley DC, Light PE.

Hum Genet. 2005 Feb;116(3):133-45. Epub 2004 Nov 23. Review.PMID: 15565284 [PubMed - indexed for MEDLINE]Related articles

Syntaxin-1A inhibits cardiac KATP channels by its actions on nucleotide binding folds 1 and 2 of sulfonylurea receptor 2A.

Kang Y, Leung YM, Manning-Fox JE, Xia F, Xie H, Sheu L, Tsushima RG, Light PE, Gaisano HY.

J Biol Chem. 2004 Nov 5;279(45):47125-31. Epub 2004 Aug 31.PMID: 15339904 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin reduces glucose transport and cellular ATP levels in INS-1 beta-cells.

Lam NT, Cheung AT, Riedel MJ, Light PE, Cheeseman CI, Kieffer TJ.

J Mol Endocrinol. 2004 Apr;32(2):415-24.PMID: 15072548 [PubMed - indexed for MEDLINE]Related articlesFree article

Pharmacological activation of plasma-membrane KATP channels reduces reoxygenation-induced Ca(2+) overload in cardiac myocytes via modulation of the diastolic membrane potential.

Baczkó I, Giles WR, Light PE.

Br J Pharmacol. 2004 Mar;141(6):1059-67. Epub 2004 Mar 1.PMID: 14993099 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of adenosine triphosphate-sensitive potassium channels by acyl coenzyme A esters involves multiple phosphatidylinositol 4,5-bisphosphate-interacting residues.

Manning Fox JE, Nichols CG, Light PE.

Mol Endocrinol. 2004 Mar;18(3):679-86. Epub 2003 Dec 23.PMID: 14694085 [PubMed - indexed for MEDLINE]Related articlesFree article

Acyl coenzyme A esters differentially activate cardiac and beta-cell adenosine triphosphate-sensitive potassium channels in a side-chain length-specific manner.

Fox JE, Magga J, Giles WR, Light PE.

Metabolism. 2003 Oct;52(10):1313-9.PMID: 14564684 [PubMed - indexed for MEDLINE]Related articles

Kir6.2 polymorphisms sensitize beta-cell ATP-sensitive potassium channels to activation by acyl CoAs: a possible cellular mechanism for increased susceptibility to type 2 diabetes?

Riedel MJ, Boora P, Steckley D, de Vries G, Light PE.

Diabetes. 2003 Oct;52(10):2630-5.PMID: 14514649 [PubMed - indexed for MEDLINE]Related articlesFree article

Experiments to test the role of phosphatidylinositol 4,5-bisphosphate in neurotransmitter-induced M-channel closure in bullfrog sympathetic neurons.

Ford CP, Stemkowski PL, Light PE, Smith PA.

J Neurosci. 2003 Jun 15;23(12):4931-41.PMID: 12832515 [PubMed - indexed for MEDLINE]Related articlesFree article

Resting membrane potential regulates Na(+)-Ca2+ exchange-mediated Ca2+ overload during hypoxia-reoxygenation in rat ventricular myocytes.

Baczkó I, Giles WR, Light PE.

J Physiol. 2003 Aug 1;550(Pt 3):889-98. Epub 2003 Jun 13.PMID: 12807988 [PubMed - indexed for MEDLINE]Related articlesFree article

Constitutively active adenosine monophosphate-activated protein kinase regulates voltage-gated sodium channels in ventricular myocytes.

Light PE, Wallace CH, Dyck JR.

Circulation. 2003 Apr 22;107(15):1962-5. Epub 2003 Apr 7.PMID: 12682004 [PubMed - indexed for MEDLINE]Related articlesFree article

The phosphatidylinositol 3-kinase inhibitor LY294002 potently blocks K(V) currents via a direct mechanism.

El-Kholy W, Macdonald PE, Lin JH, Wang J, Fox JM, Light PE, Wang Q, Tsushima RG, Wheeler MB.

FASEB J. 2003 Apr;17(6):720-2. Epub 2003 Feb 5.PMID: 12586735 [PubMed - indexed for MEDLINE]Related articlesFree article

The multiple actions of GLP-1 on the process of glucose-stimulated insulin secretion.

MacDonald PE, El-Kholy W, Riedel MJ, Salapatek AM, Light PE, Wheeler MB.

Diabetes. 2002 Dec;51 Suppl 3:S434-42. Review.PMID: 12475787 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucagon-like peptide-1 inhibits pancreatic ATP-sensitive potassium channels via a protein kinase A- and ADP-dependent mechanism.

Light PE, Manning Fox JE, Riedel MJ, Wheeler MB.

Mol Endocrinol. 2002 Sep;16(9):2135-44.PMID: 12198249 [PubMed - indexed for MEDLINE]Related articlesFree article

Protein kinase C modulation of recombinant ATP-sensitive K(+) channels composed of Kir6.1 and/or Kir6.2 expressed with SUR2B.

Thorneloe KS, Maruyama Y, Malcolm AT, Light PE, Walsh MP, Cole WC.

J Physiol. 2002 May 15;541(Pt 1):65-80.PMID: 12015420 [PubMed - indexed for MEDLINE]Related articlesFree article

Cardioselectivity of the sulphonylurea HMR 1098: studies on native and recombinant cardiac and pancreatic K(ATP) channels.

Manning Fox JE, Kanji HD, French RJ, Light PE.

Br J Pharmacol. 2002 Jan;135(2):480-8.PMID: 11815384 [PubMed - indexed for MEDLINE]Related articlesFree article

Distinct myoprotective roles of cardiac sarcolemmal and mitochondrial KATP channels during metabolic inhibition and recovery.

Light PE, Kanji HD, Fox JE, French RJ.

FASEB J. 2001 Dec;15(14):2586-94.PMID: 11726534 [PubMed - indexed for MEDLINE]Related articlesFree article

Electrophysiological characterization and ionic stoichiometry of the rat brain K(+)-dependent NA(+)/CA(2+) exchanger, NCKX2.

Dong H, Light PE, French RJ, Lytton J.

J Biol Chem. 2001 Jul 13;276(28):25919-28. Epub 2001 May 7.PMID: 11342562 [PubMed - indexed for MEDLINE]Related articlesFree article

Molecular basis of protein kinase C-induced activation of ATP-sensitive potassium channels.

Light PE, Bladen C, Winkfein RJ, Walsh MP, French RJ.

Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):9058-63.PMID: 10908656 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition by protein kinase C of the K(NDP) subtype of vascular smooth muscle ATP-sensitive potassium channel.

Cole WC, Malcolm T, Walsh MP, Light PE.

Circ Res. 2000 Jul 21;87(2):112-7.PMID: 10903994 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification and properties of ATP-sensitive potassium channels in myocytes from rabbit Purkinje fibres.

Light PE, Cordeiro JM, French RJ.

Cardiovasc Res. 1999 Nov;44(2):356-69.PMID: 10690312 [PubMed - indexed for MEDLINE]Related articlesFree article

Cardiac KATP channels and ischemic preconditioning: current perspectives.

Light PE.

Can J Cardiol. 1999 Oct;15(10):1123-30. Review.PMID: 10523479 [PubMed - indexed for MEDLINE]Related articlesFree article

Altered ATP sensitivity of ATP-dependent K+ channels in diabetic rat hearts.

Shimoni Y, Light PE, French RJ.

Am J Physiol. 1998 Oct;275(4 Pt 1):E568-76.PMID: 9755074 [PubMed - indexed for MEDLINE]Related articlesFree article

Protein kinase C-induced changes in the stoichiometry of ATP binding activate cardiac ATP-sensitive K+ channels. A possible mechanistic link to ischemic preconditioning.

Light PE, Sabir AA, Allen BG, Walsh MP, French RJ.

Circ Res. 1996 Sep;79(3):399-406.PMID: 8781473 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification and properties of an ATP-sensitive K+ current in rabbit sino-atrial node pacemaker cells.

Han X, Light PE, Giles WR, French RJ.

J Physiol. 1996 Jan 15;490 ( Pt 2):337-50.PMID: 8821133 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of adenosine triphosphate-sensitive potassium channels from rabbit ventricular myocytes by protein kinase C and type 2A protein phosphatase.

Light PE, Allen BG, Walsh MP, French RJ.

Biochemistry. 1995 May 30;34(21):7252-7.PMID: 7766636 [PubMed - indexed for MEDLINE]Related articles

Glibenclamide selectively blocks ATP-sensitive K+ channels reconstituted from skeletal muscle.

Light PE, French RJ.

Eur J Pharmacol. 1994 Jul 11;259(3):219-22.PMID: 7982447 [PubMed - indexed for MEDLINE]Related articles

The effect of glibenclamide on frog skeletal muscle: evidence for K+ATP channel activation during fatigue.

Light PE, Comtois AS, Renaud JM.

J Physiol. 1994 Mar 15;475(3):495-507.PMID: 8006831 [PubMed - indexed for MEDLINE]Related articlesFree article

Stimulation of miniature end-plate potential frequency by fluoride may involve activation of protein kinase C.

Light PE, Publicover SJ.

Eur J Pharmacol. 1991 Oct 15;203(2):311-4.PMID: 1800124 [PubMed - indexed for MEDLINE]Related articles

The effects of a diacylglycerol kinase inhibitor at mammalian and amphibian neuromuscular junctions in vitro.

Murphy RL, Light PE, Publicover SJ, Smith ME.

Brain Res. 1991 Jul 19;554(1-2):308-11.PMID: 1657292 [PubMed - indexed for MEDLINE]Related articles

Stimulation of spontaneous transmitter release at the frog neuromuscular junction by 12-O-tetradecanoylphorbol-13-acetate occurs in the absence of extracellular Ca2+ and is enhanced by depolarization.

Light PE, Sahaf ZY, Publicover SJ.

Naunyn Schmiedebergs Arch Pharmacol. 1988 Oct;338(4):339-44.PMID: 2907607 [PubMed - indexed for MEDLINE]Related articles