PubMed

2009 Canadian Cardiovascular Society/Canadian guidelines for the diagnosis and treatment of dyslipidemia and prevention of cardiovascular disease in the adult - 2009 recommendations.

Genest J, McPherson R, Frohlich J, Anderson T, Campbell N, Carpentier A, Couture P, Dufour R, Fodor G, Francis GA, Grover S, Gupta M, Hegele RA, Lau DC, Leiter L, Lewis GF, Lonn E, Mancini GB, Ng D, Pearson GJ, Sniderman A, Stone JA, Ur E.

Can J Cardiol. 2009 Oct;25(10):567-79. Review.PMID: 19812802 [PubMed - indexed for MEDLINE]Related articles

The effect of high-dose sodium salicylate on chronically elevated plasma non-esterified fatty acid-induced insulin resistance and {beta}-cell dysfunction.

Xiao C, Giacca A, Lewis GF.

Am J Physiol Endocrinol Metab. 2009 Sep 15. [Epub ahead of print]PMID: 19755670 [PubMed - as supplied by publisher]Related articles

The remnants of galaxy formation from a panoramic survey of the region around M31.

McConnachie AW, Irwin MJ, Ibata RA, Dubinski J, Widrow LM, Martin NF, Côté P, Dotter AL, Navarro JF, Ferguson AM, Puzia TH, Lewis GF, Babul A, Barmby P, Bienaymé O, Chapman SC, Cockcroft R, Collins ML, Fardal MA, Harris WE, Huxor A, Mackey AD, Peñarrubia J, Rich RM, Richer HB, Siebert A, Tanvir N, Valls-Gabaud D, Venn KA.

Nature. 2009 Sep 3;461(7260):66-9.PMID: 19727194 [PubMed]Related articles

Acute dipeptidyl peptidase-4 inhibition rapidly enhances insulin-mediated suppression of endogenous glucose production in mice.

Duez H, Smith AC, Xiao C, Giacca A, Szeto L, Drucker DJ, Lewis GF.

Endocrinology. 2009 Jan;150(1):56-62. Epub 2008 Sep 18.PMID: 18801896 [PubMed - indexed for MEDLINE]Related articles

Mechanism of intestinal lipoprotein overproduction in insulin resistant humans.

Duez H, Pavlic M, Lewis GF.

Atheroscler Suppl. 2008 Sep;9(2):33-8. Epub 2008 Aug 3. Review.PMID: 18676184 [PubMed - indexed for MEDLINE]Related articles

Enhanced cellular uptake of remnant high-density lipoprotein particles: a mechanism for high-density lipoprotein lowering in insulin resistance and hypertriglyceridemia.

Xiao C, Watanabe T, Zhang Y, Trigatti B, Szeto L, Connelly PW, Marcovina S, Vaisar T, Heinecke JW, Lewis GF.

Circ Res. 2008 Jul 18;103(2):159-66. Epub 2008 Jun 12.PMID: 18556574 [PubMed - indexed for MEDLINE]Related articlesFree article

Triglyceride-rich lipoprotein-associated apolipoprotein C-III production is stimulated by plasma free fatty acids in humans.

Pavlic M, Valéro R, Duez H, Xiao C, Szeto L, Patterson BW, Lewis GF.

Arterioscler Thromb Vasc Biol. 2008 Sep;28(9):1660-5. Epub 2008 Jun 12.PMID: 18556566 [PubMed - indexed for MEDLINE]Related articlesFree article

Intestinal lipoprotein overproduction in insulin-resistant states.

Adeli K, Lewis GF.

Curr Opin Lipidol. 2008 Jun;19(3):221-8. Review.PMID: 18460911 [PubMed - indexed for MEDLINE]Related articles

Both intestinal and hepatic lipoprotein production are stimulated by an acute elevation of plasma free fatty acids in humans.

Duez H, Lamarche B, Valéro R, Pavlic M, Proctor S, Xiao C, Szeto L, Patterson BW, Lewis GF.

Circulation. 2008 May 6;117(18):2369-76. Epub 2008 Apr 28.PMID: 18443237 [PubMed - indexed for MEDLINE]Related articlesFree article

Dissociation between the insulin-sensitizing effect of rosiglitazone and its effect on hepatic and intestinal lipoprotein production.

Duez H, Lamarche B, Uffelman KD, Valéro R, Szeto L, Lemieux S, Cohn JS, Lewis GF.

J Clin Endocrinol Metab. 2008 May;93(5):1722-9. Epub 2008 Feb 19.PMID: 18285418 [PubMed - indexed for MEDLINE]Related articlesFree article

The cosmic web in our own backyard.

Ibata RA, Lewis GF.

Science. 2008 Jan 4;319(5859):50-2.PMID: 18174430 [PubMed]Related articlesFree article

Oral taurine but not N-acetylcysteine ameliorates NEFA-induced impairment in insulin sensitivity and beta cell function in obese and overweight, non-diabetic men.

Xiao C, Giacca A, Lewis GF.

Diabetologia. 2008 Jan;51(1):139-46. Epub 2007 Nov 17.PMID: 18026714 [PubMed - indexed for MEDLINE]Related articles

Free fatty acid-induced reduction in glucose-stimulated insulin secretion: evidence for a role of oxidative stress in vitro and in vivo.

Oprescu AI, Bikopoulos G, Naassan A, Allister EM, Tang C, Park E, Uchino H, Lewis GF, Fantus IG, Rozakis-Adcock M, Wheeler MB, Giacca A.

Diabetes. 2007 Dec;56(12):2927-37. Epub 2007 Aug 23.PMID: 17717282 [PubMed - indexed for MEDLINE]Related articlesFree article

Thiazolidinediones: novel treatments for cognitive deficits in mood disorders?

McIntyre RS, Soczynska JK, Woldeyohannes HO, Lewis GF, Leiter LA, MacQueen GM, Miranda A, Fulgosi D, Konarski JZ, Kennedy SH.

Expert Opin Pharmacother. 2007 Aug;8(11):1615-28. Review.PMID: 17685880 [PubMed - indexed for MEDLINE]Related articles

Lipid-induced beta-cell dysfunction in vivo in models of progressive beta-cell failure.

Goh TT, Mason TM, Gupta N, So A, Lam TK, Lam L, Lewis GF, Mari A, Giacca A.

Am J Physiol Endocrinol Metab. 2007 Feb;292(2):E549-60. Epub 2006 Sep 26.PMID: 17003242 [PubMed - indexed for MEDLINE]Related articlesFree article

Enhancement of muscle glucose uptake by the vasopeptidase inhibitor, omapatrilat, is independent of insulin signaling and the AMP kinase pathway.

Wong V, Szeto L, Uffelman K, Fantus IG, Lewis GF.

J Endocrinol. 2006 Aug;190(2):441-50.PMID: 16899577 [PubMed - indexed for MEDLINE]Related articlesFree article

Managing psychiatric disorders with antidiabetic agents: translational research and treatment opportunities.

McIntyre RS, Soczynska JK, Lewis GF, MacQueen GM, Konarski JZ, Kennedy SH.

Expert Opin Pharmacother. 2006 Jul;7(10):1305-21.PMID: 16805717 [PubMed - indexed for MEDLINE]Related articles

Are the lipid-modifying effects of fibrates mediated by alterations in plasma lipid transfer activity?

Lewis GF.

Clin Sci (Lond). 2006 Sep;111(3):185-7.PMID: 16761953 [PubMed - indexed for MEDLINE]Related articles

Determinants of plasma HDL concentrations and reverse cholesterol transport.

Lewis GF.

Curr Opin Cardiol. 2006 Jul;21(4):345-52. Review.PMID: 16755204 [PubMed - indexed for MEDLINE]Related articles

Thematic review series: patient-oriented research. What have we learned about HDL metabolism from kinetics studies in humans?

Rashid S, Patterson BW, Lewis GF.

J Lipid Res. 2006 Aug;47(8):1631-42. Epub 2006 May 9. Review.PMID: 16685079 [PubMed - indexed for MEDLINE]Related articlesFree article

Hyperinsulinemia is associated with increased production rate of intestinal apolipoprotein B-48-containing lipoproteins in humans.

Duez H, Lamarche B, Uffelman KD, Valero R, Cohn JS, Lewis GF.

Arterioscler Thromb Vasc Biol. 2006 Jun;26(6):1357-63. Epub 2006 Apr 13.PMID: 16614317 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential effects of monounsaturated, polyunsaturated and saturated fat ingestion on glucose-stimulated insulin secretion, sensitivity and clearance in overweight and obese, non-diabetic humans.

Xiao C, Giacca A, Carpentier A, Lewis GF.

Diabetologia. 2006 Jun;49(6):1371-9. Epub 2006 Apr 5.PMID: 16596361 [PubMed - indexed for MEDLINE]Related articles

Objective evidence for the reversibility of nerve injury in diabetic neuropathic cachexia.

Grewal J, Bril V, Lewis GF, Perkins BA.

Diabetes Care. 2006 Feb;29(2):473-4. No abstract available. Erratum in: Diabetes Care. 2006 Sep;29(9):2185. Lewis, Gary [corrected to Lewis, Gary F]. PMID: 16443922 [PubMed - indexed for MEDLINE]Related articlesFree article

Atorvastatin induces insulin sensitization in Zucker lean and fatty rats.

Wong V, Stavar L, Szeto L, Uffelman K, Wang CH, Fantus IG, Lewis GF.

Atherosclerosis. 2006 Feb;184(2):348-55. Epub 2005 Jul 5.PMID: 15998521 [PubMed - indexed for MEDLINE]Related articles

New insights into the regulation of HDL metabolism and reverse cholesterol transport.

Lewis GF, Rader DJ.

Circ Res. 2005 Jun 24;96(12):1221-32. Review.PMID: 15976321 [PubMed - indexed for MEDLINE]Related articlesFree article

The mechanisms of differential glucocorticoid and mineralocorticoid action in the brain and peripheral tissues.

Rashid S, Lewis GF.

Clin Biochem. 2005 May;38(5):401-9. Review.PMID: 15820768 [PubMed - indexed for MEDLINE]Related articles

Mechanism of highly active anti-retroviral therapy-induced hyperlipidemia in HIV-infected individuals.

Carpentier A, Patterson BW, Uffelman KD, Salit I, Lewis GF.

Atherosclerosis. 2005 Jan;178(1):165-72.PMID: 15585214 [PubMed - indexed for MEDLINE]Related articles

Hepatic PTP-1B expression regulates the assembly and secretion of apolipoprotein B-containing lipoproteins: evidence from protein tyrosine phosphatase-1B overexpression, knockout, and RNAi studies.

Qiu W, Avramoglu RK, Dubé N, Chong TM, Naples M, Au C, Sidiropoulos KG, Lewis GF, Cohn JS, Tremblay ML, Adeli K.

Diabetes. 2004 Dec;53(12):3057-66.PMID: 15561934 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatic lipase mRNA, protein, and plasma enzyme activity is increased in the insulin-resistant, fructose-fed Syrian golden hamster and is partially normalized by the insulin sensitizer rosiglitazone.

Lewis GF, Murdoch S, Uffelman K, Naples M, Szeto L, Albers A, Adeli K, Brunzell JD.

Diabetes. 2004 Nov;53(11):2893-900.PMID: 15504970 [PubMed - indexed for MEDLINE]Related articlesFree article

Intestinal lipoprotein overproduction, a newly recognized component of insulin resistance, is ameliorated by the insulin sensitizer rosiglitazone: studies in the fructose-fed Syrian golden hamster.

Lewis GF, Uffelman K, Naples M, Szeto L, Haidari M, Adeli K.

Endocrinology. 2005 Jan;146(1):247-55. Epub 2004 Oct 14.PMID: 15486228 [PubMed - indexed for MEDLINE]Related articlesFree article

Intestinal lipoprotein production is stimulated by an acute elevation of plasma free fatty acids in the fasting state: studies in insulin-resistant and insulin-sensitized Syrian golden hamsters.

Lewis GF, Naples M, Uffelman K, Leung N, Szeto L, Adeli K.

Endocrinology. 2004 Nov;145(11):5006-12. Epub 2004 Jul 22.PMID: 15271878 [PubMed - indexed for MEDLINE]Related articlesFree article

Lipid metabolism.

Lewis GF.

Curr Opin Lipidol. 2004 Feb;15(1):85-7. No abstract available. PMID: 15166814 [PubMed - indexed for MEDLINE]Related articles

Rosiglitazone improves intestinal lipoprotein overproduction in the fat-fed Syrian Golden hamster, an animal model of nutritionally-induced insulin resistance.

Leung N, Naples M, Uffelman K, Szeto L, Adeli K, Lewis GF.

Atherosclerosis. 2004 Jun;174(2):235-41.PMID: 15136053 [PubMed - indexed for MEDLINE]Related articles

Overexpression of the endoplasmic reticulum 60 protein ER-60 downregulates apoB100 secretion by inducing its intracellular degradation via a nonproteasomal pathway: evidence for an ER-60-mediated and pCMB-sensitive intracellular degradative pathway.

Qiu W, Kohen-Avramoglu R, Rashid-Kolvear F, Au CS, Chong TM, Lewis GF, Trinh DK, Austin RC, Urade R, Adeli K.

Biochemistry. 2004 Apr 27;43(16):4819-31.PMID: 15096051 [PubMed - indexed for MEDLINE]Related articles

Prolonged increase of plasma non-esterified fatty acids fully abolishes the stimulatory effect of 24 hours of moderate hyperglycaemia on insulin sensitivity and pancreatic beta-cell function in obese men.

Leung N, Sakaue T, Carpentier A, Uffelman K, Giacca A, Lewis GF.

Diabetologia. 2004 Feb;47(2):204-13. Epub 2004 Jan 8.PMID: 14712348 [PubMed - indexed for MEDLINE]Related articles

Mechanisms of HDL lowering in insulin resistant, hypertriglyceridemic states: the combined effect of HDL triglyceride enrichment and elevated hepatic lipase activity.

Rashid S, Watanabe T, Sakaue T, Lewis GF.

Clin Biochem. 2003 Sep;36(6):421-9. Review.PMID: 12951168 [PubMed - indexed for MEDLINE]Related articles

Expression of human hepatic lipase in the rabbit model preferentially enhances the clearance of triglyceride-enriched versus native high-density lipoprotein apolipoprotein A-I.

Rashid S, Trinh DK, Uffelman KD, Cohn JS, Rader DJ, Lewis GF.

Circulation. 2003 Jun 24;107(24):3066-72. Epub 2003 Jun 9.PMID: 12796142 [PubMed - indexed for MEDLINE]Related articlesFree article

Free fatty acid-mediated impairment of glucose-stimulated insulin secretion in nondiabetic Oji-Cree individuals from the Sandy Lake community of Ontario, Canada: a population at very high risk for developing type 2 diabetes.

Carpentier A, Zinman B, Leung N, Giacca A, Hanley AJ, Harris SB, Hegele RA, Lewis GF.

Diabetes. 2003 Jun;52(6):1485-95.PMID: 12765961 [PubMed - indexed for MEDLINE]Related articlesFree article

A molecular Einstein ring: imaging a starburst disk surrounding a quasi-stellar object.

Carilli CL, Lewis GF, Djorgovski SG, Mahabal A, Cox P, Bertoldi F, Omont A.

Science. 2003 May 2;300(5620):773-5. Epub 2003 Apr 3.PMID: 12677071 [PubMed]Related articlesFree article

Mechanisms of the free fatty acid-induced increase in hepatic glucose production.

Lam TK, Carpentier A, Lewis GF, van de Werve G, Fantus IG, Giacca A.

Am J Physiol Endocrinol Metab. 2003 May;284(5):E863-73. Review.PMID: 12676648 [PubMed - indexed for MEDLINE]Related articlesFree article

Vasopeptidase inhibitor omapatrilat induces profound insulin sensitization and increases myocardial glucose uptake in Zucker fatty rats: Studies comparing a vasopeptidase inhibitor, angiotensin-converting enzyme inhibitor, and angiotensin II type I receptor blocker.

Wang CH, Leung N, Lapointe N, Szeto L, Uffelman KD, Giacca A, Rouleau JL, Lewis GF.

Circulation. 2003 Apr 15;107(14):1923-9. Epub 2003 Mar 31.PMID: 12668518 [PubMed - indexed for MEDLINE]Related articlesFree article

Lipid metabolism.

Lewis GF.

Curr Opin Lipidol. 2003 Feb;14(1):103-6. No abstract available. PMID: 12544666 [PubMed - indexed for MEDLINE]Related articles

Effect of atorvastatin on high-density lipoprotein apolipoprotein A-I production and clearance in the New Zealand white rabbit.

Rashid S, Uffelman KD, Barrett PH, Lewis GF.

Circulation. 2002 Dec 3;106(23):2955-60.PMID: 12460878 [PubMed - indexed for MEDLINE]Related articlesFree article

Rapid development of massive tendon xanthomas following highly active antiretroviral therapy.

Leung N, Hegele RA, Lewis GF.

Ann Intern Med. 2002 Oct 1;137(7):624. No abstract available. PMID: 12353964 [PubMed - indexed for MEDLINE]Related articlesFree article

Fasting and postprandial overproduction of intestinally derived lipoproteins in an animal model of insulin resistance. Evidence that chronic fructose feeding in the hamster is accompanied by enhanced intestinal de novo lipogenesis and ApoB48-containing lipoprotein overproduction.

Haidari M, Leung N, Mahbub F, Uffelman KD, Kohen-Avramoglu R, Lewis GF, Adeli K.

J Biol Chem. 2002 Aug 30;277(35):31646-55. Epub 2002 Jun 17.PMID: 12070142 [PubMed - indexed for MEDLINE]Related articlesFree article

Ameliorated hepatic insulin resistance is associated with normalization of microsomal triglyceride transfer protein expression and reduction in very low density lipoprotein assembly and secretion in the fructose-fed hamster.

Carpentier A, Taghibiglou C, Leung N, Szeto L, Van Iderstine SC, Uffelman KD, Buckingham R, Adeli K, Lewis GF.

J Biol Chem. 2002 Aug 9;277(32):28795-802. Epub 2002 Jun 4.PMID: 12048212 [PubMed - indexed for MEDLINE]Related articlesFree article

Sensitivity to acute insulin-mediated suppression of plasma free fatty acids is not a determinant of fasting VLDL triglyceride secretion in healthy humans.

Carpentier A, Patterson BW, Leung N, Lewis GF.

Diabetes. 2002 Jun;51(6):1867-75.PMID: 12031975 [PubMed - indexed for MEDLINE]Related articlesFree article

Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes.

Lewis GF, Carpentier A, Adeli K, Giacca A.

Endocr Rev. 2002 Apr;23(2):201-29.PMID: 11943743 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanism of HDL lowering in insulin resistant states.

Lewis GF, Rashid S, Uffelman KD, Lamarche B.

Adv Exp Med Biol. 2001;498:273-7. Review. No abstract available. PMID: 11900379 [PubMed - indexed for MEDLINE]Related articles

Lipolytically modified triglyceride-enriched HDLs are rapidly cleared from the circulation.

Rashid S, Barrett PH, Uffelman KD, Watanabe T, Adeli K, Lewis GF.

Arterioscler Thromb Vasc Biol. 2002 Mar 1;22(3):483-7.PMID: 11884294 [PubMed - indexed for MEDLINE]Related articlesFree article