PubMed

Controlled delivery of nitric oxide inhibits leukocyte migration and prevents vasospasm in haptoglobin 2-2 mice after subarachnoid hemorrhage.

Momin EN, Schwab KE, Chaichana KL, Miller-Lotan R, Levy AP, Tamargo RJ.

Neurosurgery. 2009 Nov;65(5):937-45; discussion 945.PMID: 19834407 [PubMed - in process]Related articles

The haptoglobin 2-2 genotype is associated with increased redox active hemoglobin derived iron in the atherosclerotic plaque.

Kalet-Litman S, Moreno PR, Levy AP.

Atherosclerosis. 2009 Sep 6. [Epub ahead of print] No abstract available. PMID: 19775690 [PubMed - as supplied by publisher]Related articles

Haptoglobin genotype is a determinant of survival and cardiac remodeling after myocardial infarction in diabetic mice.

Asaf R, Blum S, Roguin A, Kalet-Litman S, Kheir J, Frisch A, Miller-Lotan R, Levy AP.

Cardiovasc Diabetol. 2009 Jun 2;8:29.PMID: 19490627 [PubMed - indexed for MEDLINE]Related articlesFree article

Antioxidants in the prevention of atherosclerosis: the importance of proper patient selection.

Levy Y, Blum S, Levy AP.

Clin Nutr. 2009 Oct;28(5):581-2. Epub 2009 May 22.PMID: 19464773 [PubMed - in process]Related articles

Haptoglobin genotype and endothelial function in diabetes mellitus: a pilot study.

Dayan L, Levy AP, Blum S, Miller-Lotan R, Melman U, Alshiek J, Jacob G.

Eur J Appl Physiol. 2009 Jul;106(4):639-44. Epub 2009 Apr 4.PMID: 19347351 [PubMed - indexed for MEDLINE]Related articles

Pharmacogenomic effect of vitamin E on kidney structure and function in transgenic mice with the haptoglobin 2-2 genotype and diabetes mellitus.

Nakhoul FM, Miller-Lotan R, Awad H, Asleh R, Jad K, Nakhoul N, Asaf R, Abu-Saleh N, Levy AP.

Am J Physiol Renal Physiol. 2009 Apr;296(4):F830-8. Epub 2009 Jan 28.PMID: 19176700 [PubMed - indexed for MEDLINE]Related articles

Haptoglobin genotype is a major determinant of the amount of iron in the human atherosclerotic plaque.

Moreno PR, Purushothaman KR, Purushothaman M, Muntner P, Levy NS, Fuster V, Fallon JT, Lento PA, Winterstern A, Levy AP.

J Am Coll Cardiol. 2008 Sep 23;52(13):1049-51.PMID: 18848136 [PubMed - indexed for MEDLINE]Related articles

Consumption of wonderful variety pomegranate juice and extract by diabetic patients increases paraoxonase 1 association with high-density lipoprotein and stimulates its catalytic activities.

Rock W, Rosenblat M, Miller-Lotan R, Levy AP, Elias M, Aviram M.

J Agric Food Chem. 2008 Sep 24;56(18):8704-13. Epub 2008 Aug 30.PMID: 18759451 [PubMed - indexed for MEDLINE]Related articles

Pharmacogenomic application of the haptoglobin genotype in the prevention of diabetic cardiovascular disease.

Blum S, Milman U, Shapira C, Levy AP.

Pharmacogenomics. 2008 Aug;9(8):989-91. No abstract available. PMID: 18681772 [PubMed - indexed for MEDLINE]Related articles

Correction of HDL dysfunction in individuals with diabetes and the haptoglobin 2-2 genotype.

Asleh R, Blum S, Kalet-Litman S, Alshiek J, Miller-Lotan R, Asaf R, Rock W, Aviram M, Milman U, Shapira C, Abassi Z, Levy AP.

Diabetes. 2008 Oct;57(10):2794-800. Epub 2008 Jul 3.PMID: 18599520 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of CD163 associated casein kinase II activity is haptoglobin genotype dependent.

Strauss M, Levy AP.

Mol Cell Biochem. 2008 Oct;317(1-2):131-5. Epub 2008 Jun 19.PMID: 18563533 [PubMed - indexed for MEDLINE]Related articles

Dual therapy with statins and antioxidants is superior to statins alone in decreasing the risk of cardiovascular disease in a subgroup of middle-aged individuals with both diabetes mellitus and the haptoglobin 2-2 genotype.

Blum S, Milman U, Shapira C, Miller-Lotan R, Bennett L, Kostenko M, Landau M, Keidar S, Levy Y, Khemlin A, Radan A, Levy AP.

Arterioscler Thromb Vasc Biol. 2008 Mar;28(3):e18-20. No abstract available. PMID: 18296583 [PubMed - indexed for MEDLINE]Related articlesFree article

Pharmacogenomics in prevention of diabetic cardiovascular disease: utilization of the haptoglobin genotype in determining benefit from vitamin E.

Levy AP, Blum S.

Expert Rev Cardiovasc Ther. 2007 Nov;5(6):1105-11. Review.PMID: 18035926 [PubMed - indexed for MEDLINE]Related articles

Vitamin E supplementation reduces cardiovascular events in a subgroup of middle-aged individuals with both type 2 diabetes mellitus and the haptoglobin 2-2 genotype: a prospective double-blinded clinical trial.

Milman U, Blum S, Shapira C, Aronson D, Miller-Lotan R, Anbinder Y, Alshiek J, Bennett L, Kostenko M, Landau M, Keidar S, Levy Y, Khemlin A, Radan A, Levy AP.

Arterioscler Thromb Vasc Biol. 2008 Feb;28(2):341-7. Epub 2007 Nov 21.PMID: 18032779 [PubMed - indexed for MEDLINE]Related articlesFree article

Haptoglobin 2-2 genotype determines chronic vasospasm after experimental subarachnoid hemorrhage.

Chaichana KL, Levy AP, Miller-Lotan R, Shakur S, Tamargo RJ.

Stroke. 2007 Dec;38(12):3266-71. Epub 2007 Oct 25.PMID: 17962599 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypothesis--haptoglobin genotype and diabetic nephropathy.

Nakhoul FM, Miller-Lotan R, Awaad H, Asleh R, Levy AP.

Nat Clin Pract Nephrol. 2007 Jun;3(6):339-44. Review.PMID: 17525716 [PubMed - indexed for MEDLINE]Related articles

Downregulation of the hemoglobin scavenger receptor in individuals with diabetes and the Hp 2-2 genotype: implications for the response to intraplaque hemorrhage and plaque vulnerability.

Levy AP, Purushothaman KR, Levy NS, Purushothaman M, Strauss M, Asleh R, Marsh S, Cohen O, Moestrup SK, Moller HJ, Zias EA, Benhayon D, Fuster V, Moreno PR.

Circ Res. 2007 Jul 6;101(1):106-10. Epub 2007 May 24.PMID: 17525367 [PubMed - indexed for MEDLINE]Related articlesFree article

In vivo and in vitro studies establishing haptoglobin as a major susceptibility gene for diabetic vascular disease.

Asleh R, Levy AP.

Vasc Health Risk Manag. 2005;1(1):19-28. Review.PMID: 17319095 [PubMed - indexed for MEDLINE]Related articlesFree article

Haptoglobin genotype determines myocardial infarct size in diabetic mice.

Blum S, Asaf R, Guetta J, Miller-Lotan R, Asleh R, Kremer R, Levy NS, Berger FG, Aronson D, Fu X, Zhang R, Hazen SL, Levy AP.

J Am Coll Cardiol. 2007 Jan 2;49(1):82-7. Epub 2006 Dec 13.PMID: 17207726 [PubMed - indexed for MEDLINE]Related articles

Haptoglobin genotype is a regulator of reverse cholesterol transport in diabetes in vitro and in vivo.

Asleh R, Miller-Lotan R, Aviram M, Hayek T, Yulish M, Levy JE, Miller B, Blum S, Milman U, Shapira C, Levy AP.

Circ Res. 2006 Dec 8;99(12):1419-25. Epub 2006 Nov 2.PMID: 17082477 [PubMed - indexed for MEDLINE]Related articlesFree article

Haptoglobin genotype is a determinant of iron, lipid peroxidation, and macrophage accumulation in the atherosclerotic plaque.

Levy AP, Levy JE, Kalet-Litman S, Miller-Lotan R, Levy NS, Asaf R, Guetta J, Yang C, Purushothaman KR, Fuster V, Moreno PR.

Arterioscler Thromb Vasc Biol. 2007 Jan;27(1):134-40. Epub 2006 Oct 26.PMID: 17068284 [PubMed - indexed for MEDLINE]Related articlesFree article

Intraplaque hemorrhage.

Levy AP, Moreno PR.

Curr Mol Med. 2006 Aug;6(5):479-88. Review.PMID: 16918369 [PubMed - indexed for MEDLINE]Related articles

Application of pharmacogenomics in the prevention of diabetic cardiovascular disease: mechanistic basis and clinical evidence for utilization of the haptoglobin genotype in determining benefit from antioxidant therapy.

Levy AP.

Pharmacol Ther. 2006 Nov;112(2):501-12. Epub 2006 Jul 18. Review.PMID: 16854468 [PubMed - indexed for MEDLINE]Related articles

Haptoglobin genotype modulates the balance of Th1/Th2 cytokines produced by macrophages exposed to free hemoglobin.

Guetta J, Strauss M, Levy NS, Fahoum L, Levy AP.

Atherosclerosis. 2007 Mar;191(1):48-53. Epub 2006 Jul 3.PMID: 16820150 [PubMed - indexed for MEDLINE]Related articles

Haptoglobin 1-1 genotype and the risk of life-threatening Streptococcus infection: evolutionary implications.

Wasserzug O, Blum S, Klement E, Lejbkowicz F, Miller-Lotan R, Levy AP.

J Infect. 2007 Apr;54(4):410. Epub 2006 Jun 30. No abstract available. PMID: 16815553 [PubMed - indexed for MEDLINE]Related articles

Retinal capillary basement membrane thickness in diabetic mice genetically modified at the haptoglobin locus.

Miller-Lotan R, Miller B, Nakhoul F, Aronson D, Asaf R, Levy AP.

Diabetes Metab Res Rev. 2007 Feb;23(2):152-6.PMID: 16742000 [PubMed - indexed for MEDLINE]Related articles

Neovascularization in human atherosclerosis.

Moreno PR, Purushothaman KR, Sirol M, Levy AP, Fuster V.

Circulation. 2006 May 9;113(18):2245-52. Review. No abstract available. PMID: 16684874 [PubMed - indexed for MEDLINE]Related articlesFree article

Haptoglobin phenotypes, which one is better and when?

Zvi B, Levy AP.

Clin Lab. 2006;52(1-2):29-35. Review.PMID: 16506361 [PubMed - indexed for MEDLINE]Related articles

Angiogenesis--an update.

Roguin A, Levy AP.

Pediatr Endocrinol Rev. 2005 Mar;2(3):391-8. Review.PMID: 16429116 [PubMed - indexed for MEDLINE]Related articles

Haptoglobin phenotype, sleep-disordered breathing, and the prevalence of cardiovascular disease: the Sleep Heart Health Study.

Levy AP, Zhang L, Miller-Lotan R, Redline S, O'Connor GT, Quan SF, Resnick HE.

Sleep. 2005 Feb 1;28(2):207-13.PMID: 16171245 [PubMed - indexed for MEDLINE]Related articles

Haptoglobin polymorphism predicts 30-day mortality and heart failure in patients with diabetes and acute myocardial infarction.

Suleiman M, Aronson D, Asleh R, Kapeliovich MR, Roguin A, Meisel SR, Shochat M, Sulieman A, Reisner SA, Markiewicz W, Hammerman H, Lotan R, Levy NS, Levy AP.

Diabetes. 2005 Sep;54(9):2802-6.PMID: 16123372 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased blood vessel density provides the mole rat physiological tolerance to its hypoxic subterranean habitat.

Avivi A, Shams I, Joel A, Lache O, Levy AP, Nevo E.

FASEB J. 2005 Aug;19(10):1314-6. Epub 2005 Jun 13.PMID: 16000366 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased renal hypertrophy in diabetic mice genetically modified at the haptoglobin locus.

Miller-Lotan R, Herskowitz Y, Kalet-Litman S, Nakhoul F, Aronson D, Zoabi R, Asaf R, Ben-Izhak O, Sabo E, Lim SK, Baumann H, Berger FG, Levy AP.

Diabetes Metab Res Rev. 2005 Jul-Aug;21(4):332-7.PMID: 15852445 [PubMed - indexed for MEDLINE]Related articles

New horizons for VEGF. Is there a role for nuclear localization?

Lejbkowicz F, Goldberg-Cohen I, Levy AP.

Acta Histochem. 2005;106(6):405-11. Epub 2005 Jan 13.PMID: 15707649 [PubMed - indexed for MEDLINE]Related articles

Haptoglobin genotype- and diabetes-dependent differences in iron-mediated oxidative stress in vitro and in vivo.

Asleh R, Guetta J, Kalet-Litman S, Miller-Lotan R, Levy AP.

Circ Res. 2005 Mar 4;96(4):435-41. Epub 2005 Jan 20.PMID: 15662028 [PubMed - indexed for MEDLINE]Related articlesFree article

Haptoglobin phenotype as a predictive factor of mortality in diabetic haemodialysis patients.

Burbea Z, Nakhoul F, Zoabi R, Hochberg I, Levy NS, Benchetrit S, Weissgarten J, Tovbin D, Knecht A, Iaina A, Herman M, Kristal B, Levy AP.

Ann Clin Biochem. 2004 Nov;41(Pt 6):469-73.PMID: 15588436 [PubMed - indexed for MEDLINE]Related articles

The effect of vitamin E supplementation on cardiovascular risk in diabetic individuals with different haptoglobin phenotypes.

Levy AP, Gerstein HC, Miller-Lotan R, Ratner R, McQueen M, Lonn E, Pogue J.

Diabetes Care. 2004 Nov;27(11):2767. No abstract available. PMID: 15505023 [PubMed - indexed for MEDLINE]Related articlesFree article

Serum chelatable redox-active iron is an independent predictor of mortality after myocardial infarction in individuals with diabetes.

Sulieman M, Asleh R, Cabantchik ZI, Breuer W, Aronson D, Suleiman A, Miller-Lotan R, Hammerman H, Levy AP.

Diabetes Care. 2004 Nov;27(11):2730-2. No abstract available. PMID: 15505013 [PubMed - indexed for MEDLINE]Related articlesFree article

ELISA for determination of the haptoglobin phenotype.

Levy NS, Levy AP.

Clin Chem. 2004 Nov;50(11):2148-50. No abstract available. PMID: 15502083 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of haptoglobin phenotype in end-stage kidney disease.

Burbea Z, Nakhoul F, Rosenberg S, Zoabi R, Skorecki K, Hochberg I, Miller-Lotan R, Benchetrit S, Weissgarten J, Knecht A, Tovbin D, Levy NS, Levy AP.

Nephron Exp Nephrol. 2004;97(2):e71-6.PMID: 15218325 [PubMed - indexed for MEDLINE]Related articles

Haptoglobin: a major susceptibility gene for diabetic cardiovascular disease.

Levy AP.

Isr Med Assoc J. 2004 May;6(5):308-10. Review. No abstract available. PMID: 15151377 [PubMed - indexed for MEDLINE]Related articlesFree article

The effect of vitamin therapy on the progression of coronary artery atherosclerosis varies by haptoglobin type in postmenopausal women.

Levy AP, Friedenberg P, Lotan R, Ouyang P, Tripputi M, Higginson L, Cobb FR, Tardif JC, Bittner V, Howard BV.

Diabetes Care. 2004 Apr;27(4):925-30.PMID: 15047650 [PubMed - indexed for MEDLINE]Related articlesFree article

Haptoglobin phenotype and prevalent coronary heart disease in the Framingham offspring cohort.

Levy AP, Larson MG, Corey D, Lotan R, Vita JA, Benjamin EJ.

Atherosclerosis. 2004 Feb;172(2):361-5.PMID: 15019547 [PubMed - indexed for MEDLINE]Related articles

Hypoxic regulation of VEGF mRNA stability by RNA-binding proteins.

Levy AP.

Trends Cardiovasc Med. 1998 Aug;8(6):246-50.PMID: 14987559 [PubMed]Related articles

Genetics of diabetic cardiovascular disease: identification of a major susceptibility gene.

Levy AP.

Acta Diabetol. 2003 Dec;40 Suppl 2:S330-3. Review.PMID: 14704863 [PubMed - indexed for MEDLINE]Related articles

Vascular endothelial growth factor (VEGF) fails to improve blood flow and to promote collateralization in a diabetic mouse ischemic hindlimb model.

Roguin A, Nitecki S, Rubinstein I, Nevo E, Avivi A, Levy NS, Abassi ZA, Sabo E, Lache O, Frank M, Hoffman A, Levy AP.

Cardiovasc Diabetol. 2003 Dec 18;2:18.PMID: 14683529 [PubMed]Related articlesFree article

Haptoglobin phenotype in age-related macular degeneration patients.

Seider N, Beiran I, Miller-Lotan R, Dori D, Karp J, Miller B, Levy AP.

Am J Ophthalmol. 2003 Nov;136(5):911-4.PMID: 14597045 [PubMed - indexed for MEDLINE]Related articles

Tyrosine kinases inhibitors block Fas-mediated deleterious effects in normoxic and hypoxic ventricular myocytes.

Shilkrut M, Yaniv G, Asleh R, Levy AP, Larisch S, Binah O.

J Mol Cell Cardiol. 2003 Oct;35(10):1229-40.PMID: 14519433 [PubMed - indexed for MEDLINE]Related articles

Haptoglobin type and 30-day mortality in diabetic individuals presenting with acute myocardial infarction.

Suleiman M, Kapeliovich MR, Roguin A, Aronson D, Meisel SR, Shochat M, Reisner SA, Hammerman H, Lotan R, Levy NS, Levy AP.

Diabetes Care. 2003 Sep;26(9):2699-700. No abstract available. PMID: 12941748 [PubMed - indexed for MEDLINE]Related articlesFree article

Haptoglobin genotype is predictive of major adverse cardiac events in the 1-year period after percutaneous transluminal coronary angioplasty in individuals with diabetes.

Roguin A, Koch W, Kastrati A, Aronson D, Schomig A, Levy AP.

Diabetes Care. 2003 Sep;26(9):2628-31.PMID: 12941730 [PubMed - indexed for MEDLINE]Related articlesFree article