PubMed

Increased Basal Insulin Secretion in Pdzd2-deficient Mice.

Tsang SW, Shao D, Cheah KS, Okuse K, Leung PS, Yao KM.

Mol Cell Endocrinol. 2009 Nov 19. [Epub ahead of print]PMID: 19932150 [PubMed - as supplied by publisher]

Angiotensin II exerts glucose-dependent effects on Kv currents in mouse pancreatic beta cells via angiotensin II type 2 receptors.

Chu KY, Cheng Q, Chen C, Au LS, Seto SW, Tuo Y, Motin L, Kwan YW, Leung PS.

Am J Physiol Cell Physiol. 2009 Nov 4. [Epub ahead of print]PMID: 19889960 [PubMed - as supplied by publisher]Related articles

Modulation of LMP2A expression by a newly identified Epstein-Barr virus-encoded microRNA miR-BART22.

Lung RW, Tong JH, Sung YM, Leung PS, Ng DC, Chau SL, Chan AW, Ng EK, Lo KW, To KF.

Neoplasia. 2009 Nov;11(11):1174-84.PMID: 19881953 [PubMed - in process]Related articlesFree article

Gene therapy in autoimmune diseases: Challenges and opportunities.

Leung PS, Dhirapong A, Wu PY, Tao MH.

Autoimmun Rev. 2009 Oct 23. [Epub ahead of print]PMID: 19854300 [PubMed - as supplied by publisher]Related articles

Diabetes mellitus and expression of the enterocyte renin-angiotensin system: implications for control of glucose transport across the brush border membrane.

Wong TP, Debnam ES, Leung PS.

Am J Physiol Cell Physiol. 2009 Sep;297(3):C601-10. Epub 2009 Jun 17.PMID: 19535516 [PubMed - indexed for MEDLINE]Related articles

Bruceine D induces apoptosis in pancreatic adenocarcinoma cell line PANC-1 through the activation of p38-mitogen activated protein kinase.

Lau ST, Lin ZX, Liao Y, Zhao M, Cheng CH, Leung PS.

Cancer Lett. 2009 Aug 18;281(1):42-52. Epub 2009 Mar 14.PMID: 19286308 [PubMed - indexed for MEDLINE]Related articles

Angiotensin II in type 2 diabetes mellitus.

Chu KY, Leung PS.

Curr Protein Pept Sci. 2009 Feb;10(1):75-84. Review.PMID: 19275674 [PubMed - indexed for MEDLINE]Related articles

The roles of the PDZ-containing proteins bridge-1 and PDZD2 in the regulation of insulin production and pancreatic beta-cell mass.

Thomas MK, Tsang SW, Yeung ML, Leung PS, Yao KM.

Curr Protein Pept Sci. 2009 Feb;10(1):30-6. Review.PMID: 19275670 [PubMed - indexed for MEDLINE]Related articles

Novel peptides and proteins in diabetes mellitus.

Leung PS, de Gasparo M.

Curr Protein Pept Sci. 2009 Feb;10(1):1. No abstract available. PMID: 19275666 [PubMed - indexed for MEDLINE]Related articles

Involvement of redox-sensitive extracellular-regulated kinases in angiotensin II-induced interleukin-6 expression in pancreatic acinar cells.

Chan YC, Leung PS.

J Pharmacol Exp Ther. 2009 May;329(2):450-8. Epub 2009 Feb 11.PMID: 19211919 [PubMed - indexed for MEDLINE]Related articles

Novel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic (+db/+db) mice.

Seto SW, Lam TY, Tam HL, Au AL, Chan SW, Wu JH, Yu PH, Leung GP, Ngai SM, Yeung JH, Leung PS, Lee SM, Kwan YW.

Phytomedicine. 2009 May;16(5):426-36. Epub 2008 Dec 23.PMID: 19109000 [PubMed - indexed for MEDLINE]Related articles

Induction of autoimmune cholangitis in non-obese diabetic (NOD).1101 mice following a chemical xenobiotic immunization.

Wakabayashi K, Yoshida K, Leung PS, Moritoki Y, Yang GX, Tsuneyama K, Lian ZX, Hibi T, Ansari AA, Wicker LS, Ridgway WM, Coppel RL, Mackay IR, Gershwin ME.

Clin Exp Immunol. 2009 Mar;155(3):577-86. Epub 2008 Dec 15.PMID: 19094117 [PubMed - indexed for MEDLINE]Related articles

PDZ-domain containing-2 (PDZD2) drives the maturity of human fetal pancreatic progenitor-derived islet-like cell clusters with functional responsiveness against membrane depolarization.

Leung KK, Suen PM, Lau TK, Ko WH, Yao KM, Leung PS.

Stem Cells Dev. 2009 Sep;18(7):979-90.PMID: 19046020 [PubMed - in process]Related articles

Carotid Body AT(4) Receptor Expression and its Upregulation in Chronic Hypoxia.

Fung ML, Lam SY, Wong TP, Tjong YW, Leung PS.

Open Cardiovasc Med J. 2007;1:1-7. Epub 2007 Jun 11.PMID: 18949084 [PubMed - in process]Related articlesFree article

Role of oxidative stress in pancreatic inflammation.

Leung PS, Chan YC.

Antioxid Redox Signal. 2009 Jan;11(1):135-65. Review.PMID: 18837654 [PubMed - indexed for MEDLINE]Related articles

Combination of the dipeptidyl peptidase IV inhibitor LAF237 [(S)-1-[(3-hydroxy-1-adamantyl)ammo]acetyl-2-cyanopyrrolidine] with the angiotensin II type 1 receptor antagonist valsartan [N-(1-oxopentyl)-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]methyl]-L-valine] enhances pancreatic islet morphology and function in a mouse model of type 2 diabetes.

Cheng Q, Law PK, de Gasparo M, Leung PS.

J Pharmacol Exp Ther. 2008 Dec;327(3):683-91. Epub 2008 Sep 11.PMID: 18787107 [PubMed - indexed for MEDLINE]Related articles

Induction of shrimp tropomyosin-specific hypersensitivity in mice.

Leung PS, Lee YS, Tang CY, Kung WY, Chuang YH, Chiang BL, Fung MC, Chu KH.

Int Arch Allergy Immunol. 2008;147(4):305-14. Epub 2008 Jul 11.PMID: 18617750 [PubMed - indexed for MEDLINE]Related articles

Loss of tolerance in C57BL/6 mice to the autoantigen E2 subunit of pyruvate dehydrogenase by a xenobiotic with ensuing biliary ductular disease.

Wakabayashi K, Lian ZX, Leung PS, Moritoki Y, Tsuneyama K, Kurth MJ, Lam KS, Yoshida K, Yang GX, Hibi T, Ansari AA, Ridgway WM, Coppel RL, Mackay IR, Gershwin ME.

Hepatology. 2008 Aug;48(2):531-40.PMID: 18563844 [PubMed - indexed for MEDLINE]Related articles

Enantiospecific synthesis of pseudoacarviosin as a potential antidiabetic agent.

Shing TK, Cheng HM, Wong WF, Kwong CS, Li J, Lau CB, Leung PS, Cheng CH.

Org Lett. 2008 Jul 17;10(14):3145-8. Epub 2008 Jun 17.PMID: 18557625 [PubMed - indexed for MEDLINE]Related articles

Effects of hyperglycemia on angiotensin II receptor type 1 expression and insulin secretion in an INS-1E pancreatic beta-cell line.

Leung KK, Leung PS.

JOP. 2008 May 8;9(3):290-9.PMID: 18469441 [PubMed - indexed for MEDLINE]Related articlesFree article

Brucea javanica fruit induces cytotoxicity and apoptosis in pancreatic adenocarcinoma cell lines.

Lau ST, Lin ZX, Zhao M, Leung PS.

Phytother Res. 2008 Apr;22(4):477-86.PMID: 18386257 [PubMed - indexed for MEDLINE]Related articles

Diarylheptanoids and a monoterpenoid from the rhizomes of Zingiber officinale: antioxidant and cytoprotective properties.

Tao QF, Xu Y, Lam RY, Schneider B, Dou H, Leung PS, Shi SY, Zhou CX, Yang LX, Zhang RP, Xiao YC, Wu X, Stöckigt J, Zeng S, Cheng CH, Zhao Y.

J Nat Prod. 2008 Jan;71(1):12-7. Epub 2008 Jan 5.PMID: 18177011 [PubMed - indexed for MEDLINE]Related articles

PDZ-domain containing-2 (PDZD2) is a novel factor that affects the growth and differentiation of human fetal pancreatic progenitor cells.

Suen PM, Zou C, Zhang YA, Lau TK, Chan J, Yao KM, Leung PS.

Int J Biochem Cell Biol. 2008;40(4):789-803. Epub 2007 Oct 24.PMID: 18037333 [PubMed - indexed for MEDLINE]Related articles

A mechanism to explain how regular exercise might reduce the risk for clinical prostate cancer.

Barnard RJ, Leung PS, Aronson WJ, Cohen P, Golding LA.

Eur J Cancer Prev. 2007 Oct;16(5):415-21.PMID: 17923812 [PubMed - indexed for MEDLINE]Related articles

The ghrelin system in acinar cells: localization, expression, and regulation in the exocrine pancreas.

Lai KC, Cheng CH, Leung PS.

Pancreas. 2007 Oct;35(3):e1-8.PMID: 17895831 [PubMed - indexed for MEDLINE]Related articles

Effect of angiotensin AT1 receptor antagonist on D-galactosamine-induced acute liver injury.

Chan H, Leung PS, Tam MS.

Clin Exp Pharmacol Physiol. 2007 Oct;34(10):985-91.PMID: 17714083 [PubMed - indexed for MEDLINE]Related articles

Involvement of an enterocyte renin-angiotensin system in the local control of SGLT1-dependent glucose uptake across the rat small intestinal brush border membrane.

Wong TP, Debnam ES, Leung PS.

J Physiol. 2007 Oct 15;584(Pt 2):613-23. Epub 2007 Aug 16.PMID: 17702818 [PubMed - indexed for MEDLINE]Related articlesFree article

Involvement of the pancreatic renin-angiotensin system in insulin resistance and the metabolic syndrome.

Leung PS, de Gasparo M.

J Cardiometab Syndr. 2006 Summer;1(3):197-203. Review.PMID: 17679833 [PubMed - indexed for MEDLINE]Related articles

Induction of primary biliary cirrhosis in guinea pigs following chemical xenobiotic immunization.

Leung PS, Park O, Tsuneyama K, Kurth MJ, Lam KS, Ansari AA, Coppel RL, Gershwin ME.

J Immunol. 2007 Aug 15;179(4):2651-7.PMID: 17675529 [PubMed - indexed for MEDLINE]Related articlesFree article

Antimitochondrial antibodies in acute liver failure: implications for primary biliary cirrhosis.

Leung PS, Rossaro L, Davis PA, Park O, Tanaka A, Kikuchi K, Miyakawa H, Norman GL, Lee W, Gershwin ME; Acute Liver Failure Study Group.

Hepatology. 2007 Nov;46(5):1436-42.PMID: 17657817 [PubMed - indexed for MEDLINE]Related articles

Antioxidant actions of phenolic compounds found in dietary plants on low-density lipoprotein and erythrocytes in vitro.

Lam RY, Woo AY, Leung PS, Cheng CH.

J Am Coll Nutr. 2007 Jun;26(3):233-42.PMID: 17634168 [PubMed - indexed for MEDLINE]Related articlesFree article

Angiotensin II type 1 receptor-dependent nuclear factor-kappaB activation-mediated proinflammatory actions in a rat model of obstructive acute pancreatitis.

Chan YC, Leung PS.

J Pharmacol Exp Ther. 2007 Oct;323(1):10-8. Epub 2007 Jul 6.PMID: 17616560 [PubMed - indexed for MEDLINE]Related articlesFree article

PGE suppresses excessive anti-IgE induced cysteinyl leucotrienes production in mast cells of patients with aspirin exacerbated respiratory disease.

Wang XS, Wu AY, Leung PS, Lau HY.

Allergy. 2007 Jun;62(6):620-7.PMID: 17508965 [PubMed - indexed for MEDLINE]Related articles

Angiotensin II Type 1 receptor antagonism mediates uncoupling protein 2-driven oxidative stress and ameliorates pancreatic islet beta-cell function in young Type 2 diabetic mice.

Chu KY, Leung PS.

Antioxid Redox Signal. 2007 Jul;9(7):869-78.PMID: 17508912 [PubMed - indexed for MEDLINE]Related articles

A sensitive bead assay for antimitochondrial antibodies: Chipping away at AMA-negative primary biliary cirrhosis.

Oertelt S, Rieger R, Selmi C, Invernizzi P, Ansari AA, Coppel RL, Podda M, Leung PS, Gershwin ME.

Hepatology. 2007 Mar;45(3):659-65.PMID: 17326160 [PubMed - indexed for MEDLINE]Related articles

Mechanisms of protective effects induced by blockade of the renin-angiotensin system: novel role of the pancreatic islet angiotensin-generating system in Type 2 diabetes.

Leung PS.

Diabet Med. 2007 Feb;24(2):110-6. Review.PMID: 17257271 [PubMed - indexed for MEDLINE]Related articles

The physiology of a local renin-angiotensin system in the pancreas.

Leung PS.

J Physiol. 2007 Apr 1;580(Pt 1):31-7. Epub 2007 Jan 11. Review.PMID: 17218353 [PubMed - indexed for MEDLINE]Related articlesFree article

Acute pancreatitis: animal models and recent advances in basic research.

Chan YC, Leung PS.

Pancreas. 2007 Jan;34(1):1-14. Review.PMID: 17198179 [PubMed - indexed for MEDLINE]Related articles

Mitogen-activated protein kinases and chemoresistance in pancreatic cancer cells.

Zhao Y, Shen S, Guo J, Chen H, Greenblatt DY, Kleeff J, Liao Q, Chen G, Friess H, Leung PS.

J Surg Res. 2006 Dec;136(2):325-35. Epub 2006 Oct 19.PMID: 17054996 [PubMed - indexed for MEDLINE]Related articles

Desoxyrhaponticin (3,5-dihydroxy-4'-methoxystilbene 3-O-beta-D-glucoside) inhibits glucose uptake in the intestine and kidney: In vitro and in vivo studies.

Li JM, Che CT, Lau CB, Leung PS, Cheng CH.

J Pharmacol Exp Ther. 2007 Jan;320(1):38-46. Epub 2006 Oct 12.PMID: 17038511 [PubMed - indexed for MEDLINE]Related articlesFree article

Identification of 2-nonynoic acid, a cosmetic component, as a potential trigger of primary biliary cirrhosis.

Rieger R, Leung PS, Jeddeloh MR, Kurth MJ, Nantz MH, Lam KS, Barsky D, Ansari AA, Coppel RL, Mackay IR, Gershwin ME.

J Autoimmun. 2006 Aug;27(1):7-16. Epub 2006 Jul 28.PMID: 16876981 [PubMed - indexed for MEDLINE]Related articles

Novel roles of a local angiotensin-generating system in the carotid body.

Leung PS.

J Physiol. 2006 Aug 15;575(Pt 1):4. Epub 2006 Jun 29. No abstract available. PMID: 16809356 [PubMed - indexed for MEDLINE]Related articlesFree article

NOD.c3c4 congenic mice develop autoimmune biliary disease that serologically and pathogenetically models human primary biliary cirrhosis.

Irie J, Wu Y, Wicker LS, Rainbow D, Nalesnik MA, Hirsch R, Peterson LB, Leung PS, Cheng C, Mackay IR, Gershwin ME, Ridgway WM.

J Exp Med. 2006 May 15;203(5):1209-19. Epub 2006 Apr 24.PMID: 16636131 [PubMed - indexed for MEDLINE]Related articlesFree article

Cells of the anterior pituitary.

Yeung CM, Chan CB, Leung PS, Cheng CH.

Int J Biochem Cell Biol. 2006;38(9):1441-9. Epub 2006 Mar 3. Review.PMID: 16621669 [PubMed - indexed for MEDLINE]Related articles

Frontiers in diabetic research.

Leung PS, Hayek A, de Gasparo M.

Int J Biochem Cell Biol. 2006;38(5-6):687-8. Epub 2006 Feb 2. No abstract available. PMID: 16481209 [PubMed - indexed for MEDLINE]Related articles

Angiotensin II type 1 receptor blockade improves beta-cell function and glucose tolerance in a mouse model of type 2 diabetes.

Chu KY, Lau T, Carlsson PO, Leung PS.

Diabetes. 2006 Feb;55(2):367-74.PMID: 16443769 [PubMed - indexed for MEDLINE]Related articlesFree article

AT1 receptor antagonism ameliorates acute pancreatitis-associated pulmonary injury.

Chan YC, Leung PS.

Regul Pept. 2006 Mar 15;134(1):46-53. Epub 2006 Jan 27.PMID: 16443293 [PubMed - indexed for MEDLINE]Related articles

Isolation and in vitro characterization of pancreatic progenitor cells from the islets of diabetic monkey models.

Zou C, Suen PM, Zhang Y, Wang Z, Chan P, Leung PS, Zhang YA.

Int J Biochem Cell Biol. 2006;38(5-6):973-84. Epub 2006 Jan 6.PMID: 16431150 [PubMed - indexed for MEDLINE]Related articles

Pancreatic acinar cell: its role in acute pancreatitis.

Leung PS, Ip SP.

Int J Biochem Cell Biol. 2006;38(7):1024-30. Epub 2005 Dec 28. Review.PMID: 16423553 [PubMed - indexed for MEDLINE]Related articles

Secreted PDZD2 exerts concentration-dependent effects on the proliferation of INS-1E cells.

Ma RY, Tam TS, Suen AP, Yeung PM, Tsang SW, Chung SK, Thomas MK, Leung PS, Yao KM.

Int J Biochem Cell Biol. 2006;38(5-6):1015-22. Epub 2005 Dec 19.PMID: 16413998 [PubMed - indexed for MEDLINE]Related articles