PubMed

Evaluation of Post-Authorization Safety Studies in the First Cohort of EU Risk Management Plans at Time of Regulatory Approval.

Giezen TJ, Mantel-Teeuwisse AK, Straus SM, Egberts TC, Blackburn S, Persson I, Leufkens HG.

Drug Saf. 2009;32(12):1175-87. doi: 10.2165/11318980-000000000-00000.PMID: 19916584 [PubMed - in process]Related articles

Effects of glucocorticoids on the neutrophil count: A cohort study among hospitalized patients.

Velthove KJ, Leufkens HG, Souverein PC, Schweizer RC, Bracke M, van Solinge WW.

Pulm Pharmacol Ther. 2009 Oct 29. [Epub ahead of print]PMID: 19879372 [PubMed - as supplied by publisher]Related articles

Identification of exacerbations in obstructive lung disease through biomarkers.

Velthove KJ, Bracke M, Souverein PC, Schweizer RC, Ten Berg MJ, Leufkens HG, van Solinge WW.

Biomarkers. 2009 Nov;14(7):523-8.PMID: 19863191 [PubMed - in process]Related articles

Translation of rare disease research into orphan drug development: disease matters.

Heemstra HE, van Weely S, Büller HA, Leufkens HG, de Vrueh RL.

Drug Discov Today. 2009 Oct 7. [Epub ahead of print]PMID: 19818412 [PubMed - as supplied by publisher]Related articles

Effects of corticosteroid use on readmission in obstructive lung disease.

Velthove KJ, Souverein PC, van Solinge WW, Leufkens HG, Lammers JW.

Respir Med. 2009 Sep 23. [Epub ahead of print]PMID: 19781925 [PubMed - as supplied by publisher]Related articles

Identification of exacerbations in obstructive lung disease through biomarkers.

Velthove KJ, Bracke M, Souverein PC, Schweizer RC, Ten Berg MJ, Leufkens HG, van Solinge WW.

Biomarkers. 2009 Sep 7. [Epub ahead of print]PMID: 19735209 [PubMed - as supplied by publisher]Related articles

Pharmacovigilance of biopharmaceuticals: challenges remain.

Giezen TJ, Mantel-Teeuwisse AK, Leufkens HG.

Drug Saf. 2009;32(10):811-7. doi: 10.2165/11316550-000000000-00000.PMID: 19722725 [PubMed - in process]Related articles

Global strategies to reduce the price of antiretroviral medicines: evidence from transactional databases.

Waning B, Kaplan W, King AC, Lawrence DA, Leufkens HG, Fox MP.

Bull World Health Organ. 2009 Jul;87(7):520-8.PMID: 19649366 [PubMed - indexed for MEDLINE]Related articlesFree article

Risk of drug-induced photosensitivity: focus on spectroscopic and molecular characteristics.

Verdel BM, Souverein PC, Meyboom RH, Kardaun SH, Leufkens HG, Egberts AC.

Pharmacoepidemiol Drug Saf. 2009 Jul;18(7):602-9.PMID: 19415768 [PubMed - in process]Related articles

Cardiovascular and psychiatric risk profile and patterns of use in patients starting anti-obesity drugs.

Willemen MJ, Mantel-Teeuwisse AK, Straus SM, Leufkens HG, Egberts AC, Sturkenboom MC.

Pharmacoepidemiol Drug Saf. 2009 Jul;18(7):631-8.PMID: 19415767 [PubMed - in process]Related articles

Hematocytometry analysis as discriminative marker for asthma phenotypes.

Velthove KJ, van Solinge WW, Lammers JW, Leufkens HG, Schweizer RC, Bracke M.

Clin Chem Lab Med. 2009;47(5):573-8.PMID: 19397484 [PubMed - indexed for MEDLINE]Related articles

Use of anti-depressants and the risk of fracture of the hip or femur.

van den Brand MW, Samson MM, Pouwels S, van Staa TP, Thio B, Cooper C, Leufkens HG, Egberts AC, Verhaar HJ, de Vries F.

Osteoporos Int. 2009 Oct;20(10):1705-13. Epub 2009 Feb 24.PMID: 19238308 [PubMed - in process]Related articlesFree article

Antipsychotic use and the risk of hip/femur fracture: a population-based case-control study.

Pouwels S, van Staa TP, Egberts AC, Leufkens HG, Cooper C, de Vries F.

Osteoporos Int. 2009 Sep;20(9):1499-506. Epub 2009 Jan 21.PMID: 19156348 [PubMed - in process]Related articlesFree article

What drives prescribing of asthma medication to children? A multilevel population-based study.

Zuidgeest MG, van Dijk L, Spreeuwenberg P, Smit HA, Brunekreef B, Arets HG, Bracke M, Leufkens HG.

Ann Fam Med. 2009 Jan-Feb;7(1):32-40.PMID: 19139447 [PubMed - indexed for MEDLINE]Related articlesFree article

Is new drug prescribing in primary care specialist induced?

Florentinus SR, Heerdink ER, van Dijk L, Griens AM, Groenewegen PP, Leufkens HG.

BMC Health Serv Res. 2009 Jan 11;9:6.PMID: 19134223 [PubMed - indexed for MEDLINE]Related articlesFree article

Safety review in 10,008 users of lansoprazole in daily practice.

Claessens AA, Heerdink ER, Van Eijk JT, Lamers CB, Leufkens HG.

Pharmacoepidemiol Drug Saf. 2000 Sep;9(5):383-91.PMID: 19025844 [PubMed - in process]Related articles

The use of a large pharmacoepidemiological database to study exposure to oral corticosteroids and risk of fractures: validation of study population and results.

Van Staa TP, Abenhaim L, Cooper C, Zhang B, Leufkens HG.

Pharmacoepidemiol Drug Saf. 2000 Sep;9(5):359-66.PMID: 19025840 [PubMed - in process]Related articles

Choice of comparator in active control trials of new drugs.

van Luijn JC, van Loenen AC, Gribnau FW, Leufkens HG.

Ann Pharmacother. 2008 Nov;42(11):1605-12. Epub 2008 Oct 28.PMID: 18957629 [PubMed - indexed for MEDLINE]Related articles

Safety-related regulatory actions for biologicals approved in the United States and the European Union.

Giezen TJ, Mantel-Teeuwisse AK, Straus SM, Schellekens H, Leufkens HG, Egberts AC.

JAMA. 2008 Oct 22;300(16):1887-96.PMID: 18940975 [PubMed - indexed for MEDLINE]Related articlesFree article

Impact analysis of the discontinuation of reimbursement: the case of oral contraceptives.

Stolk P, Schneeweiss S, Leufkens HG, Heerdink ER.

Contraception. 2008 Nov;78(5):399-404. Epub 2008 Aug 28.PMID: 18929737 [PubMed - indexed for MEDLINE]Related articles

Off-label use of medicines in children: can available evidence avoid useless paediatric trials? The case of proton pump inhibitors for the treatment of gastroesophageal reflux disease.

Tafuri G, Trotta F, Leufkens HG, Martini N, Sagliocca L, Traversa G.

Eur J Clin Pharmacol. 2009 Feb;65(2):209-16. Epub 2008 Sep 17.PMID: 18797857 [PubMed - indexed for MEDLINE]Related articles

Drug-related nephrotoxic and ototoxic reactions : a link through a predictive mechanistic commonality.

Verdel BM, van Puijenbroek EP, Souverein PC, Leufkens HG, Egberts AC.

Drug Saf. 2008;31(10):877-84.PMID: 18759511 [PubMed - indexed for MEDLINE]Related articles

Psychiatric and cardiovascular comorbidities in patients with diabetes mellitus starting antiobesity drugs.

Willemen MJ, Mantel-Teeuwisse AK, Straus SM, Leufkens HG, Egberts AC.

Obesity (Silver Spring). 2008 Oct;16(10):2331-5. Epub 2008 Jul 24.PMID: 18719629 [PubMed - indexed for MEDLINE]Related articles

Changes in the characteristics of patients prescribed selective cyclooxygenase 2 inhibitors after the 2004 withdrawal of rofecoxib.

Setakis E, Leufkens HG, van Staa TP.

Arthritis Rheum. 2008 Aug 15;59(8):1105-11.PMID: 18668614 [PubMed - indexed for MEDLINE]Related articlesFree article

Does the varied use of NSAIDs explain the differences in the risk of myocardial infarction?

van Staa TP, Rietbrock S, Setakis E, Leufkens HG.

J Intern Med. 2008 Nov;264(5):481-92. Epub 2008 Jun 25.PMID: 18624902 [PubMed - indexed for MEDLINE]Related articles

Persistence of asthma medication use in preschool children.

Zuidgeest MG, Smit HA, Bracke M, Wijga AH, Brunekreef B, Hoekstra MO, Gerritsen J, Kerkhof M, de Jongste JC, Leufkens HG; PIAMA-Study Group.

Respir Med. 2008 Oct;102(10):1446-51. Epub 2008 Jun 30.PMID: 18590955 [PubMed - indexed for MEDLINE]Related articles

Orphan drug development across Europe: bottlenecks and opportunities.

Heemstra HE, de Vrueh RL, van Weely S, Büller HA, Leufkens HG.

Drug Discov Today. 2008 Aug;13(15-16):670-6. Epub 2008 Jun 24. Review.PMID: 18583178 [PubMed - indexed for MEDLINE]Related articles

Variable access to clopidogrel in a harmonized EU market.

Stolk P, Belitser SV, Leufkens HG, Heerdink ER.

Value Health. 2008 Sep-Oct;11(5):989-95. Epub 2008 May 16.PMID: 18489520 [PubMed - indexed for MEDLINE]Related articles

Evaluating drug toxicity signals: is a hierarchical classification of evidence useful or a hindrance?

van Staa TP, Smeeth L, Persson I, Parkinson J, Leufkens HG.

Pharmacoepidemiol Drug Saf. 2008 May;17(5):475-84.PMID: 18322905 [PubMed - indexed for MEDLINE]Related articles

Gap in publication of comparative information on new medicines.

van Luijn JC, Stolk P, Gribnau FW, Leufkens HG.

Br J Clin Pharmacol. 2008 May;65(5):716-22. Epub 2008 Feb 21. Review.PMID: 18294324 [PubMed - indexed for MEDLINE]Related articlesFree article

What is the harm-benefit ratio of Cox-2 inhibitors?

van Staa TP, Smeeth L, Persson I, Parkinson J, Leufkens HG.

Int J Epidemiol. 2008 Apr;37(2):405-13. Epub 2008 Feb 8.PMID: 18263647 [PubMed - indexed for MEDLINE]Related articlesFree article

Prescription of respiratory medication without an asthma diagnosis in children: a population based study.

Zuidgeest MG, van Dijk L, Smit HA, van der Wouden JC, Brunekreef B, Leufkens HG, Bracke M.

BMC Health Serv Res. 2008 Jan 22;8:16.PMID: 18211673 [PubMed - indexed for MEDLINE]Related articlesFree article

Prevalence and determinants of pharmacy shopping behaviour.

Buurma H, Bouvy ML, De Smet PA, Floor-Schreudering A, Leufkens HG, Egberts AC.

J Clin Pharm Ther. 2008 Feb;33(1):17-23.PMID: 18211612 [PubMed - indexed for MEDLINE]Related articles

Predictors of orphan drug approval in the European Union.

Heemstra HE, de Vrueh RL, van Weely S, Büller HA, Leufkens HG.

Eur J Clin Pharmacol. 2008 May;64(5):545-52. Epub 2008 Jan 22.PMID: 18210097 [PubMed - indexed for MEDLINE]Related articlesFree article

Beliefs about medicines predict refill adherence to inhaled corticosteroids.

Menckeberg TT, Bouvy ML, Bracke M, Kaptein AA, Leufkens HG, Raaijmakers JA, Horne R.

J Psychosom Res. 2008 Jan;64(1):47-54.PMID: 18157999 [PubMed - indexed for MEDLINE]Related articles

Prior outpatient antibiotic use as predictor for microbial aetiology of community-acquired pneumonia: hospital-based study.

van de Garde EM, Endeman H, van Hemert RN, Voorn GP, Deneer VH, Leufkens HG, van den Bosch JM, Biesma DH.

Eur J Clin Pharmacol. 2008 Apr;64(4):405-10. Epub 2007 Nov 30.PMID: 18060396 [PubMed - indexed for MEDLINE]Related articlesFree article

Angiotensin-converting enzyme insertion/deletion polymorphism and risk and outcome of pneumonia.

van de Garde EM, Endeman H, Deneer VH, Biesma DH, Sayed-Tabatabaei FA, Ruven HJ, Leufkens HG, van den Bosch JM.

Chest. 2008 Jan;133(1):220-5. Epub 2007 Oct 1.PMID: 17908703 [PubMed - indexed for MEDLINE]Related articlesFree article

The cost-effectiveness of bisphosphonates in postmenopausal women based on individual long-term fracture risks.

van Staa TP, Kanis JA, Geusens P, Boonen A, Leufkens HG, Cooper C.

Value Health. 2007 Sep-Oct;10(5):348-57.PMID: 17888099 [PubMed - indexed for MEDLINE]Related articles

Individualizing the risks and benefits of postmenopausal hormone therapy.

van Staa TP, Cooper C, Barlow D, Leufkens HG.

Menopause. 2008 Mar-Apr;15(2):374-81.PMID: 17882009 [PubMed - indexed for MEDLINE]Related articles

Angiotensin-converting enzyme (ACE) I/D corrected serum ACE activity and severity assessment of community-acquired pneumonia.

van de Garde EM, Endeman H, Deneer VH, Biesma DH, Ruven HJ, van Velzen-Blad H, Leufkens HG, van den Bosch JM.

Clin Chem Lab Med. 2007;45(10):1326-31.PMID: 17727310 [PubMed - indexed for MEDLINE]Related articles

Expression of activated Fc gamma RII discriminates between multiple granulocyte-priming phenotypes in peripheral blood of allergic asthmatic subjects.

Kanters D, ten Hove W, Luijk B, van Aalst C, Schweizer RC, Lammers JW, Leufkens HG, Raaijmakers JA, Bracke M, Koenderman L.

J Allergy Clin Immunol. 2007 Nov;120(5):1073-81. Epub 2007 Aug 13.PMID: 17697704 [PubMed - indexed for MEDLINE]Related articles

Distinguishing patterns in the dynamics of long-term medication use by Markov analysis: beyond persistence.

Menckeberg TT, Belitser SV, Bouvy ML, Bracke M, Lammers JW, Raaijmakers JA, Leufkens HG.

BMC Health Serv Res. 2007 Jul 10;7:106.PMID: 17620145 [PubMed - indexed for MEDLINE]Related articlesFree article

International classification of diseases codes showed modest sensitivity for detecting community-acquired pneumonia.

van de Garde EM, Oosterheert JJ, Bonten M, Kaplan RC, Leufkens HG.

J Clin Epidemiol. 2007 Aug;60(8):834-8. Epub 2007 Feb 23.PMID: 17606180 [PubMed - indexed for MEDLINE]Related articles

The association between exposure to COX-2 inhibitors and schizophrenia deterioration. A nested case-control study.

Stolk P, Souverein PC, Leufkens HG, Weil JG, Egberts AC, Heerdink ER.

Pharmacopsychiatry. 2007 May;40(3):111-5.PMID: 17541886 [PubMed - indexed for MEDLINE]Related articles

Drug administration errors in an institution for individuals with intellectual disability: an observational study.

van den Bemt PM, Robertz R, de Jong AL, van Roon EN, Leufkens HG.

J Intellect Disabil Res. 2007 Jul;51(Pt 7):528-36.PMID: 17537166 [PubMed - indexed for MEDLINE]Related articles

Functional foods: the case for closer evaluation.

de Jong N, Klungel OH, Verhagen H, Wolfs MC, Ocké MC, Leufkens HG.

BMJ. 2007 May 19;334(7602):1037-9. No abstract available. PMID: 17510152 [PubMed - indexed for MEDLINE]Related articles

Use of beta-blockers and the risk of hip/femur fracture in the United Kingdom and The Netherlands.

de Vries F, Souverein PC, Cooper C, Leufkens HG, van Staa TP.

Calcif Tissue Int. 2007 Feb;80(2):69-75. Epub 2007 Feb 2.PMID: 17308987 [PubMed - indexed for MEDLINE]Related articlesFree article

Lithium use and the risk of fractures.

Wilting I, de Vries F, Thio BM, Cooper C, Heerdink ER, Leufkens HG, Nolen WA, Egberts AC, van Staa TP.

Bone. 2007 May;40(5):1252-8. Epub 2006 Dec 21.PMID: 17258948 [PubMed - indexed for MEDLINE]Related articles

The effect of pharmacotherapy audit meetings on early new drug prescribing by general practitioners.

Florentinus SR, van Hulten R, Kloth ME, Heerdink ER, Griens AM, Leufkens HG, Groenewegen PP; Netherlands Institute for Health Services Research.

Ann Pharmacother. 2007 Feb;41(2):319-24. Epub 2007 Jan 23.PMID: 17244644 [PubMed - indexed for MEDLINE]Related articles

Use of inhaled and oral glucocorticoids, severity of inflammatory disease and risk of hip/femur fracture: a population-based case-control study.

de Vries F, Pouwels S, Lammers JW, Leufkens HG, Bracke M, Cooper C, van Staa TP.

J Intern Med. 2007 Feb;261(2):170-7.PMID: 17241182 [PubMed - indexed for MEDLINE]Related articles