PubMed

Protection of insulin-producing cells against toxicity of dexamethasone by catalase overexpression.

Roma LP, Bosqueiro JR, Cunha DA, Carneiro EM, Gurgul-Convey E, Lenzen S, Boschero AC, Souza KL.

Free Radic Biol Med. 2009 Nov 15;47(10):1386-93. Epub 2009 Aug 18.PMID: 19698781 [PubMed - in process]Related articles

Increased Hsp70 expression attenuates cytokine-induced cell death in islets of Langerhans from Shb knockout mice.

Mokhtari D, Kerblom B, Mehmeti I, Wang X, Funa NS, Olerud J, Lenzen S, Welsh N, Welsh M.

Biochem Biophys Res Commun. 2009 Sep 25;387(3):553-7. Epub 2009 Jul 15.PMID: 19615333 [PubMed - indexed for MEDLINE]Related articles

Changes in gene expression and morphology of mouse embryonic stem cells on differentiation into insulin-producing cells in vitro and in vivo.

Naujok O, Francini F, Picton S, Bailey CJ, Lenzen S, Jörns A.

Diabetes Metab Res Rev. 2009 Jul;25(5):464-76.PMID: 19425055 [PubMed - indexed for MEDLINE]Related articles

Prevention of spontaneous immune-mediated diabetes development in the LEW.1AR1-iddm rat by selective CD8+ T cell transfer is associated with a cytokine shift in the pancreas-draining lymph nodes.

Arndt T, Wedekind D, Weiss H, Tiedge M, Lenzen S, Hedrich HJ, Jörns A.

Diabetologia. 2009 Jul;52(7):1381-90. Epub 2009 Apr 15.PMID: 19367386 [PubMed - indexed for MEDLINE]Related articles

A new experimental protocol for preferential differentiation of mouse embryonic stem cells into insulin-producing cells.

Naujok O, Francini F, Picton S, Jörns A, Bailey CJ, Lenzen S.

Cell Transplant. 2008;17(10-11):1231-42.PMID: 19181217 [PubMed - indexed for MEDLINE]Related articles

Kinetics of insulin secretion from MIN6 pseudoislets after encapsulation in a prototype device of a bioartificial pancreas.

Barrientos R, Baltrusch S, Sigrist S, Legeay G, Belcourt A, Lenzen S.

Horm Metab Res. 2009 Jan;41(1):5-9. Epub 2008 Oct 14.PMID: 18855306 [PubMed - indexed for MEDLINE]Related articles

An efficient experimental strategy for mouse embryonic stem cell differentiation and separation of a cytokeratin-19-positive population of insulin-producing cells.

Naujok O, Francini F, Jörns A, Lenzen S.

Cell Prolif. 2008 Aug;41(4):607-24. Epub 2008 Jun 19.PMID: 18616698 [PubMed - indexed for MEDLINE]Related articles

Prevention of insulin resistance and beta-cell loss by abrogating PKCepsilon-induced serine phosphorylation of muscle IRS-1 in Psammomys obesus.

Mack E, Ziv E, Reuveni H, Kalman R, Niv MY, Jörns A, Lenzen S, Shafrir E.

Diabetes Metab Res Rev. 2008 Oct;24(7):577-84.PMID: 18613220 [PubMed - indexed for MEDLINE]Related articles

Oxidative stress: the vulnerable beta-cell.

Lenzen S.

Biochem Soc Trans. 2008 Jun;36(Pt 3):343-7. Review.PMID: 18481954 [PubMed - indexed for MEDLINE]Related articles

Monitoring of glucose-regulated single insulin secretory granule movement by selective photoactivation.

Baltrusch S, Lenzen S.

Diabetologia. 2008 Jun;51(6):989-96. Epub 2008 Apr 4.PMID: 18389213 [PubMed - indexed for MEDLINE]Related articles

Interaction between pro-inflammatory and anti-inflammatory cytokines in insulin-producing cells.

Souza KL, Gurgul-Convey E, Elsner M, Lenzen S.

J Endocrinol. 2008 Apr;197(1):139-50.PMID: 18372240 [PubMed - indexed for MEDLINE]Related articlesFree article

The mutation of the LEW.1AR1-iddm rat maps to the telomeric end of rat chromosome 1.

Weiss H, Arndt T, Jörns A, Lenzen S, Cuppen E, Hedrich HJ, Tiedge M, Wedekind D.

Mamm Genome. 2008 Apr;19(4):292-7. Epub 2008 Mar 21.PMID: 18357488 [PubMed - indexed for MEDLINE]Related articles

Diabetes therapy by lentiviral hepatic insulin gene expression without transformation of liver.

Elsner M, Jörns A, Lenzen S.

Diabetologia. 2008 Apr;51(4):694-5; author reply 696. Epub 2008 Feb 1. No abstract available. PMID: 18239907 [PubMed - indexed for MEDLINE]Related articles

Relation between triketone structure, generation of reactive oxygen species, and selective toxicity of the diabetogenic agent alloxan.

Elsner M, Gurgul-Convey E, Lenzen S.

Antioxid Redox Signal. 2008 Apr;10(4):691-9.PMID: 18177230 [PubMed - indexed for MEDLINE]Related articles

The mechanisms of alloxan- and streptozotocin-induced diabetes.

Lenzen S.

Diabetologia. 2008 Feb;51(2):216-26. Epub 2007 Dec 18. Review.PMID: 18087688 [PubMed - indexed for MEDLINE]Related articles

Impaired glucose-stimulated insulin secretion is coupled with exocrine pancreatic lesions in the Cohen diabetic rat.

Weksler-Zangen S, Raz I, Lenzen S, Jörns A, Ehrenfeld S, Amir G, Oprescu A, Yagil Y, Yagil C, Zangen DH, Kaiser N.

Diabetes. 2008 Feb;57(2):279-87. Epub 2007 Oct 31.PMID: 17977959 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of [Ca2+]i oscillations in mouse pancreatic islets by adrenergic agonists.

Baltrusch S, Lenzen S.

Biochem Biophys Res Commun. 2007 Nov 30;363(4):1038-43. Epub 2007 Sep 18.PMID: 17923116 [PubMed - indexed for MEDLINE]Related articles

Combination of biotransformation and chromatography for the isolation and purification of mannoheptulose.

Kappler-Tanudyaya N, Schmitt H, Tippkötter N, Meyer L, Lenzen S, Ulber R.

Biotechnol J. 2007 Jun;2(6):692-9.PMID: 17492712 [PubMed - indexed for MEDLINE]Related articles

Triiodothyronine (T3)-mediated toxicity and induction of apoptosis in insulin-producing INS-1 cells.

Ximenes HM, Lortz S, Jörns A, Lenzen S.

Life Sci. 2007 May 8;80(22):2045-50. Epub 2007 Mar 12.PMID: 17408701 [PubMed - indexed for MEDLINE]Related articles

Novel insights into the regulation of the bound and diffusible glucokinase in MIN6 beta-cells.

Baltrusch S, Lenzen S.

Diabetes. 2007 May;56(5):1305-15. Epub 2007 Feb 7.PMID: 17287461 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta cell death in hyperglycaemic Psammomys obesus is not cytokine-mediated.

Jörns A, Rath KJ, Bock O, Lenzen S.

Diabetologia. 2006 Nov;49(11):2704-12. Epub 2006 Sep 20.PMID: 17047921 [PubMed - indexed for MEDLINE]Related articles

Improved metabolic stimulus for glucose-induced insulin secretion through GK and PFK-2/FBPase-2 coexpression in insulin-producing RINm5F cells.

Baltrusch S, Langer S, Massa L, Tiedge M, Lenzen S.

Endocrinology. 2006 Dec;147(12):5768-76. Epub 2006 Sep 15.PMID: 16980436 [PubMed - indexed for MEDLINE]Related articlesFree article

Relative importance of cellular uptake and reactive oxygen species for the toxicity of alloxan and dialuric acid to insulin-producing cells.

Elsner M, Gurgul-Convey E, Lenzen S.

Free Radic Biol Med. 2006 Sep 1;41(5):825-34. Epub 2006 Jun 7.PMID: 16895803 [PubMed - indexed for MEDLINE]Related articles

Fatty acid-induced toxicity and neutral lipid accumulation in insulin-producing RINm5F cells.

Azevedo-Martins AK, Monteiro AP, Lima CL, Lenzen S, Curi R.

Toxicol In Vitro. 2006 Oct;20(7):1106-13. Epub 2006 Feb 28.PMID: 16644178 [PubMed - indexed for MEDLINE]Related articles

MIN6 beta-cell-beta-cell interactions influence insulin secretory responses to nutrients and non-nutrients.

Luther MJ, Hauge-Evans A, Souza KL, Jörns A, Lenzen S, Persaud SJ, Jones PM.

Biochem Biophys Res Commun. 2006 Apr 28;343(1):99-104. Epub 2006 Feb 10.PMID: 16529716 [PubMed - indexed for MEDLINE]Related articles

Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities.

Cnop M, Welsh N, Jonas JC, Jörns A, Lenzen S, Eizirik DL.

Diabetes. 2005 Dec;54 Suppl 2:S97-107. Review.PMID: 16306347 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of polyinosinic-polycytidylic acid and adoptive transfer of immune cells in the Lew.1AR1-iddm rat and in its coisogenic LEW.1AR1 background strain.

Wedekind D, Weiss H, Jörns A, Lenzen S, Tiedge M, Hedrich HJ.

Autoimmunity. 2005 Jun;38(4):265-75.PMID: 16206509 [PubMed - indexed for MEDLINE]Related articles

Interaction of glucokinase with the liver regulatory protein is conferred by leucine-asparagine motifs of the enzyme.

Baltrusch S, Francini F, Lenzen S, Tiedge M.

Diabetes. 2005 Oct;54(10):2829-37.PMID: 16186382 [PubMed - indexed for MEDLINE]Related articlesFree article

Prevention of nutritionally induced diabetes by rosiglitazone in the gerbil Psammomys obesus.

Hefetz S, Ziv E, Jörns A, Lenzen S, Shafrir E.

Diabetes Metab Res Rev. 2006 Mar-Apr;22(2):139-45.PMID: 16088969 [PubMed - indexed for MEDLINE]Related articles

Genetic analysis of the LEW.1AR1-iddm rat: an animal model for spontaneous diabetes mellitus.

Weiss H, Bleich A, Hedrich HJ, Kölsch B, Elsner M, Jörns A, Lenzen S, Tiedge M, Wedekind D.

Mamm Genome. 2005 Jun;16(6):432-41.PMID: 16075370 [PubMed - indexed for MEDLINE]Related articles

Importance of mitochondrial superoxide dismutase expression in insulin-producing cells for the toxicity of reactive oxygen species and proinflammatory cytokines.

Lortz S, Gurgul-Convey E, Lenzen S, Tiedge M.

Diabetologia. 2005 Aug;48(8):1541-8. Epub 2005 Jun 29.PMID: 15986238 [PubMed - indexed for MEDLINE]Related articles

Immune cell infiltration, cytokine expression, and beta-cell apoptosis during the development of type 1 diabetes in the spontaneously diabetic LEW.1AR1/Ztm-iddm rat.

Jörns A, Günther A, Hedrich HJ, Wedekind D, Tiedge M, Lenzen S.

Diabetes. 2005 Jul;54(7):2041-52.PMID: 15983205 [PubMed - indexed for MEDLINE]Related articlesFree article

Mitochondrial catalase overexpression protects insulin-producing cells against toxicity of reactive oxygen species and proinflammatory cytokines.

Gurgul E, Lortz S, Tiedge M, Jörns A, Lenzen S.

Diabetes. 2004 Sep;53(9):2271-80.PMID: 15331536 [PubMed - indexed for MEDLINE]Related articlesFree article

Cytokines activate genes of the endocytotic pathway in insulin-producing RINm5F cells.

Souza KL, Elsner M, Mathias PC, Lenzen S, Tiedge M.

Diabetologia. 2004 Jul;47(7):1292-302. Epub 2004 Jul 10.PMID: 15248046 [PubMed - indexed for MEDLINE]Related articles

Interaction of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/FBPase-2) with glucokinase activates glucose phosphorylation and glucose metabolism in insulin-producing cells.

Massa L, Baltrusch S, Okar DA, Lange AJ, Lenzen S, Tiedge M.

Diabetes. 2004 Apr;53(4):1020-9.PMID: 15047617 [PubMed - indexed for MEDLINE]Related articlesFree article

Pathology of the pancreas and other organs in the diabetic LEW.1AR1/Ztm- iddm rat, a new model of spontaneous insulin-dependent diabetes mellitus.

Jörns A, Kubat B, Tiedge M, Wedekind D, Hedrich HJ, Klöppel G, Lenzen S.

Virchows Arch. 2004 Feb;444(2):183-9. Epub 2004 Jan 20.PMID: 14735361 [PubMed - indexed for MEDLINE]Related articles

Cytokines and nitric oxide inhibit the enzyme activity of catalase but not its protein or mRNA expression in insulin-producing cells.

Sigfrid LA, Cunningham JM, Beeharry N, Lortz S, Tiedge M, Lenzen S, Carlsson C, Green IC.

J Mol Endocrinol. 2003 Dec;31(3):509-18.PMID: 14664711 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanism underlying resistance of human pancreatic beta cells against toxicity of streptozotocin and alloxan.

Elsner M, Tiedge M, Lenzen S.

Diabetologia. 2003 Dec;46(12):1713-4. Epub 2003 Nov 12. No abstract available. PMID: 14614558 [PubMed - indexed for MEDLINE]Related articles

Improvement of the mitochondrial antioxidant defense status prevents cytokine-induced nuclear factor-kappaB activation in insulin-producing cells.

Azevedo-Martins AK, Lortz S, Lenzen S, Curi R, Eizirik DL, Tiedge M.

Diabetes. 2003 Jan;52(1):93-101.PMID: 12502498 [PubMed - indexed for MEDLINE]Related articlesFree article

Importance of the GLUT2 glucose transporter for pancreatic beta cell toxicity of alloxan.

Elsner M, Tiedge M, Guldbakke B, Munday R, Lenzen S.

Diabetologia. 2002 Nov;45(11):1542-9. Epub 2002 Oct 2.PMID: 12436338 [PubMed - indexed for MEDLINE]Related articles

Thyroxine induces pancreatic beta cell apoptosis in rats.

Jörns A, Tiedge M, Lenzen S.

Diabetologia. 2002 Jun;45(6):851-5. Epub 2002 May 17.PMID: 12107729 [PubMed - indexed for MEDLINE]Related articles

Gradual loss of pancreatic beta-cell insulin, glucokinase and GLUT2 glucose transporter immunoreactivities during the time course of nutritionally induced type-2 diabetes in Psammomys obesus (sand rat).

Jörns A, Tiedge M, Ziv E, Shafrir E, Lenzen S.

Virchows Arch. 2002 Jan;440(1):63-9.PMID: 11942578 [PubMed - indexed for MEDLINE]Related articles

The LEW.1AR1/Ztm-iddm rat: a new model of spontaneous insulin-dependent diabetes mellitus.

Lenzen S, Tiedge M, Elsner M, Lortz S, Weiss H, Jörns A, Klöppel G, Wedekind D, Prokop CM, Hedrich HJ.

Diabetologia. 2001 Sep;44(9):1189-96.PMID: 11596676 [PubMed - indexed for MEDLINE]Related articles

Effects of tolbutamide and N-benzoyl-D-phenylalanine (NBDP) on the regulation of [Ca2+]i oscillations in mouse pancreatic islets.

Lenzen S, Peckmann T.

Biochem Pharmacol. 2001 Oct 1;62(7):923-8.PMID: 11543727 [PubMed - indexed for MEDLINE]Related articles

Characterization of glucokinase-binding protein epitopes by a phage-displayed peptide library. Identification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as a novel interaction partner.

Baltrusch S, Lenzen S, Okar DA, Lange AJ, Tiedge M.

J Biol Chem. 2001 Nov 23;276(47):43915-23. Epub 2001 Aug 24.PMID: 11522786 [PubMed - indexed for MEDLINE]Related articlesFree article

Recovery of pancreatic beta cells in response to long-term normoglycemia after pancreas or islet transplantation in severely streptozotocin diabetic adult rats.

Jörns A, Klempnauer J, Tiedge M, Lenzen S.

Pancreas. 2001 Aug;23(2):186-96.PMID: 11484921 [PubMed - indexed for MEDLINE]Related articles

Relative importance of transport and alkylation for pancreatic beta-cell toxicity of streptozotocin.

Elsner M, Guldbakke B, Tiedge M, Munday R, Lenzen S.

Diabetologia. 2000 Dec;43(12):1528-33.PMID: 11151762 [PubMed - indexed for MEDLINE]Related articles

Differential regulation of [Ca2+]i oscillations in mouse pancreatic islets by glucose, alpha-ketoisocaproic acid, glyceraldehyde and glycolytic intermediates.

Lenzen S, Lerch M, Peckmann T, Tiedge M.

Biochim Biophys Acta. 2000 Sep 1;1523(1):65-72.PMID: 11099859 [PubMed - indexed for MEDLINE]Related articles

Importance of lactate dehydrogenase for the regulation of glycolytic flux and insulin secretion in insulin-producing cells.

Alcazar O, Tiedge M, Lenzen S.

Biochem J. 2000 Dec 1;352 Pt 2:373-80.PMID: 11085930 [PubMed - indexed for MEDLINE]Related articlesFree article

Protection of insulin-producing RINm5F cells against cytokine-mediated toxicity through overexpression of antioxidant enzymes.

Lortz S, Tiedge M, Nachtwey T, Karlsen AE, Nerup J, Lenzen S.

Diabetes. 2000 Jul;49(7):1123-30.PMID: 10909968 [PubMed - indexed for MEDLINE]Related articlesFree article