PubMed

Pressure-induced vascular oxidative stress is mediated through activation of integrin-linked kinase 1/betaPIX/Rac-1 pathway.

Vecchione C, Carnevale D, Di Pardo A, Gentile MT, Damato A, Cocozza G, Antenucci G, Mascio G, Bettarini U, Landolfi A, Iorio L, Maffei A, Lembo G.

Hypertension. 2009 Nov;54(5):1028-34. Epub 2009 Sep 21.PMID: 19770407 [PubMed - indexed for MEDLINE]Related articles

Tumor necrosis factor-alpha mediates hemolysis-induced vasoconstriction and the cerebral vasospasm evoked by subarachnoid hemorrhage.

Vecchione C, Frati A, Di Pardo A, Cifelli G, Carnevale D, Gentile MT, Carangi R, Landolfi A, Carullo P, Bettarini U, Antenucci G, Mascio G, Busceti CL, Notte A, Maffei A, Cantore GP, Lembo G.

Hypertension. 2009 Jul;54(1):150-6. Epub 2009 May 26.PMID: 19470883 [PubMed - indexed for MEDLINE]Related articles

Nitric oxide mechanisms of nebivolol.

Maffei A, Lembo G.

Ther Adv Cardiovasc Dis. 2009 Aug;3(4):317-27. Epub 2009 May 14. Review.PMID: 19443516 [PubMed - indexed for MEDLINE]Related articles

Efficacy of aliskiren/hydrochlorothiazide single-pill combinations in aliskiren non-responders.

Nickenig G, Simanenkov V, Lembo G, Rodriguez P, Salko T, Ritter S, Zhang J.

Blood Press Suppl. 2008 Dec;2:31-40.PMID: 19203020 [PubMed - indexed for MEDLINE]Related articles

Efficacy of aliskiren/hydrochlorothiazide single-pill combinations in aliskiren non-responders.

Nickenig G, Simanenkov V, Lembo G, Rodriguez P, Salko T, Ritter S, Zhang J.

Blood Press. 2008;17 Suppl 2:31-40.PMID: 19085343 [PubMed - indexed for MEDLINE]Related articles

Myocardial Pitx2 differentially regulates the left atrial identity and ventricular asymmetric remodeling programs.

Tessari A, Pietrobon M, Notte A, Cifelli G, Gage PJ, Schneider MD, Lembo G, Campione M.

Circ Res. 2008 Apr 11;102(7):813-22. Epub 2008 Feb 21.PMID: 18292603 [PubMed - indexed for MEDLINE]Related articlesFree article

Professional's and non-professional's papular urticaria caused by Scleroderma domesticum.

Lembo S, Panariello L, d'Errico FP, Lembo G.

Contact Dermatitis. 2008 Jan;58(1):58-9. No abstract available. PMID: 18154565 [PubMed - indexed for MEDLINE]Related articles

Resistin impairs insulin-evoked vasodilation.

Gentile MT, Vecchione C, Marino G, Aretini A, Di Pardo A, Antenucci G, Maffei A, Cifelli G, Iorio L, Landolfi A, Frati G, Lembo G.

Diabetes. 2008 Mar;57(3):577-83. Epub 2007 Dec 7.PMID: 18065520 [PubMed - indexed for MEDLINE]Related articlesFree article

Antihypertensive efficacy and safety of manidipine versus amlodipine in elderly subjects with isolated systolic hypertension: MAISH study.

Payeras AC, Sladek K, Lembo G, Alberici M.

Clin Drug Investig. 2007;27(9):623-32.PMID: 17705571 [PubMed - indexed for MEDLINE]Related articles

Beta-amyloid deposition in brain is enhanced in mouse models of arterial hypertension.

Gentile MT, Poulet R, Di Pardo A, Cifelli G, Maffei A, Vecchione C, Passarelli F, Landolfi A, Carullo P, Lembo G.

Neurobiol Aging. 2009 Feb;30(2):222-8. Epub 2007 Jul 27.PMID: 17673335 [PubMed - indexed for MEDLINE]Related articles

Nebivolol induces nitric oxide release in the heart through inducible nitric oxide synthase activation.

Maffei A, Di Pardo A, Carangi R, Carullo P, Poulet R, Gentile MT, Vecchione C, Lembo G.

Hypertension. 2007 Oct;50(4):652-6. Epub 2007 Jul 30.PMID: 17664392 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanisms of cardiac hypertrophy.

Selvetella G, Lembo G.

Heart Fail Clin. 2005 Jul;1(2):263-73. Review. No abstract available. PMID: 17386851 [PubMed - indexed for MEDLINE]Related articles

A novel mechanism of action for statins against diabetes-induced oxidative stress.

Vecchione C, Gentile MT, Aretini A, Marino G, Poulet R, Maffei A, Passarelli F, Landolfi A, Vasta A, Lembo G.

Diabetologia. 2007 Apr;50(4):874-80. Epub 2007 Feb 6.PMID: 17279352 [PubMed - indexed for MEDLINE]Related articles

Assessment of the antihypertensive efficacy of various doses of delapril by office and ambulatory blood pressure measurement: the DEFIND study.

Otero ML, Parisi G, Maffei A, Vecchione C, Lembo G; DEFIND Study Group.

Adv Ther. 2006 May-Jun;23(3):421-32.PMID: 16912024 [PubMed - indexed for MEDLINE]Related articles

Insulin resistance and cardiovascular risk: New insights from molecular and cellular biology.

Morisco C, Lembo G, Trimarco B.

Trends Cardiovasc Med. 2006 Aug;16(6):183-8. Review.PMID: 16839860 [PubMed - indexed for MEDLINE]Related articles

Characterization of nitric oxide release by nebivolol and its metabolites.

Maffei A, Vecchione C, Aretini A, Poulet R, Bettarini U, Gentile MT, Cifelli G, Lembo G.

Am J Hypertens. 2006 Jun;19(6):579-86.PMID: 16733229 [PubMed - indexed for MEDLINE]Related articles

Signaling through PI3Kgamma: a common platform for leukocyte, platelet and cardiovascular stress sensing.

Hirsch E, Lembo G, Montrucchio G, Rommel C, Costa C, Barberis L.

Thromb Haemost. 2006 Jan;95(1):29-35. Review.PMID: 16543958 [PubMed - indexed for MEDLINE]Related articles

Emilin1 links TGF-beta maturation to blood pressure homeostasis.

Zacchigna L, Vecchione C, Notte A, Cordenonsi M, Dupont S, Maretto S, Cifelli G, Ferrari A, Maffei A, Fabbro C, Braghetta P, Marino G, Selvetella G, Aretini A, Colonnese C, Bettarini U, Russo G, Soligo S, Adorno M, Bonaldo P, Volpin D, Piccolo S, Lembo G, Bressan GM.

Cell. 2006 Mar 10;124(5):929-42.PMID: 16530041 [PubMed - indexed for MEDLINE]Related articles

Integrin signalling: the tug-of-war in heart hypertrophy.

Brancaccio M, Hirsch E, Notte A, Selvetella G, Lembo G, Tarone G.

Cardiovasc Res. 2006 Jun 1;70(3):422-33. Epub 2006 Feb 8. Review. Erratum in: Cardiovasc Res. 2006 Dec 1;72(3):494. PMID: 16466704 [PubMed - indexed for MEDLINE]Related articlesFree article

Selective Rac-1 inhibition protects from diabetes-induced vascular injury.

Vecchione C, Aretini A, Marino G, Bettarini U, Poulet R, Maffei A, Sbroggiò M, Pastore L, Gentile MT, Notte A, Iorio L, Hirsch E, Tarone G, Lembo G.

Circ Res. 2006 Feb 3;98(2):218-25. Epub 2005 Dec 15.PMID: 16357302 [PubMed - indexed for MEDLINE]Related articlesFree article

Infliximab in the treatment of extra-intestinal manifestations of Crohn's disease.

Rispo A, Scarpa R, Di Girolamo E, Cozzolino A, Lembo G, Atteno M, De Falco T, Lo Presti M, Castiglione F.

Scand J Rheumatol. 2005 Sep-Oct;34(5):387-91.PMID: 16234187 [PubMed - indexed for MEDLINE]Related articles

Acute hypertension induces oxidative stress in brain tissues.

Poulet R, Gentile MT, Vecchione C, Distaso M, Aretini A, Fratta L, Russo G, Echart C, Maffei A, De Simoni MG, Lembo G.

J Cereb Blood Flow Metab. 2006 Feb;26(2):253-62.PMID: 16079792 [PubMed - indexed for MEDLINE]Related articles

Replacement of K-Ras with H-Ras supports normal embryonic development despite inducing cardiovascular pathology in adult mice.

Potenza N, Vecchione C, Notte A, De Rienzo A, Rosica A, Bauer L, Affuso A, De Felice M, Russo T, Poulet R, Cifelli G, De Vita G, Lembo G, Di Lauro R.

EMBO Rep. 2005 May;6(5):432-7.PMID: 15864294 [PubMed - indexed for MEDLINE]Related articlesFree article

Cardiac overexpression of melusin protects from dilated cardiomyopathy due to long-standing pressure overload.

De Acetis M, Notte A, Accornero F, Selvetella G, Brancaccio M, Vecchione C, Sbroggiò M, Collino F, Pacchioni B, Lanfranchi G, Aretini A, Ferretti R, Maffei A, Altruda F, Silengo L, Tarone G, Lembo G.

Circ Res. 2005 May 27;96(10):1087-94. Epub 2005 Apr 28. Erratum in: Circ Res. 2005 Jul 8;97(1):e5. PMID: 15860758 [PubMed - indexed for MEDLINE]Related articlesFree article

Angiotensin II type 2 receptors contribute to vascular responses in spontaneously hypertensive rats treated with angiotensin II type 1 receptor antagonists.

Cosentino F, Savoia C, De Paolis P, Francia P, Russo A, Maffei A, Venturelli V, Schiavoni M, Lembo G, Volpe M.

Am J Hypertens. 2005 Apr;18(4 Pt 1):493-9.PMID: 15831358 [PubMed - indexed for MEDLINE]Related articles

Protection from angiotensin II-mediated vasculotoxic and hypertensive response in mice lacking PI3Kgamma.

Vecchione C, Patrucco E, Marino G, Barberis L, Poulet R, Aretini A, Maffei A, Gentile MT, Storto M, Azzolino O, Brancaccio M, Colussi GL, Bettarini U, Altruda F, Silengo L, Tarone G, Wymann MP, Hirsch E, Lembo G.

J Exp Med. 2005 Apr 18;201(8):1217-28. Epub 2005 Apr 11.PMID: 15824082 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanisms of soluble beta-amyloid impairment of endothelial function.

Gentile MT, Vecchione C, Maffei A, Aretini A, Marino G, Poulet R, Capobianco L, Selvetella G, Lembo G.

J Biol Chem. 2004 Nov 12;279(46):48135-42. Epub 2004 Aug 19.PMID: 15319431 [PubMed - indexed for MEDLINE]Related articlesFree article

PI3Kgamma modulates the cardiac response to chronic pressure overload by distinct kinase-dependent and -independent effects.

Patrucco E, Notte A, Barberis L, Selvetella G, Maffei A, Brancaccio M, Marengo S, Russo G, Azzolino O, Rybalkin SD, Silengo L, Altruda F, Wetzker R, Wymann MP, Lembo G, Hirsch E.

Cell. 2004 Aug 6;118(3):375-87.PMID: 15294162 [PubMed - indexed for MEDLINE]Related articles

Adaptive and maladaptive hypertrophic pathways: points of convergence and divergence.

Selvetella G, Hirsch E, Notte A, Tarone G, Lembo G.

Cardiovasc Res. 2004 Aug 15;63(3):373-80. Review.PMID: 15276462 [PubMed - indexed for MEDLINE]Related articlesFree article

Successful treatment of therapy-resistant metastatic Crohn's disease with infliximab.

Rispo A, Lembo G, Insabato L, Cozzolino A, Pesce G, Castiglione F.

Br J Dermatol. 2004 May;150(5):1045-6. No abstract available. PMID: 15149534 [PubMed - indexed for MEDLINE]Related articles

Phosphoinositide 3-kinase gamma: kinase-dependent and -independent activities in cardiovascular function and disease.

Alloatti G, Montrucchio G, Lembo G, Hirsch E.

Biochem Soc Trans. 2004 Apr;32(Pt 2):383-6. Review.PMID: 15046613 [PubMed - indexed for MEDLINE]Related articles

Polymorphisms in human endothelin-converting enzyme (ECE-1) promoter can modulate ECE-1 gene expression.

Gentile MT, Lembo G.

J Hypertens. 2003 Nov;21(11):2013-4. No abstract available. PMID: 14597841 [PubMed - indexed for MEDLINE]Related articles

Molecular interplay between mechanical and humoral signalling in cardiac hypertrophy.

Tarone G, Lembo G.

Trends Mol Med. 2003 Sep;9(9):376-82. Review.PMID: 13129703 [PubMed - indexed for MEDLINE]Related articles

Alpha-1B adrenergic receptor knockout mice are protected against methamphetamine toxicity.

Battaglia G, Fornai F, Busceti CL, Lembo G, Nicoletti F, De Blasi A.

J Neurochem. 2003 Jul;86(2):413-21.PMID: 12871582 [PubMed - indexed for MEDLINE]Related articles

Cooperation between insulin and leptin in the modulation of vascular tone.

Vecchione C, Aretini A, Maffei A, Marino G, Selvetella G, Poulet R, Trimarco V, Frati G, Lembo G.

Hypertension. 2003 Aug;42(2):166-70. Epub 2003 Jun 30.PMID: 12835332 [PubMed - indexed for MEDLINE]Related articlesFree article

Left ventricular hypertrophy is associated with asymptomatic cerebral damage in hypertensive patients.

Selvetella G, Notte A, Maffei A, Calistri V, Scamardella V, Frati G, Trimarco B, Colonnese C, Lembo G.

Stroke. 2003 Jul;34(7):1766-70. Epub 2003 Jun 12.PMID: 12805496 [PubMed - indexed for MEDLINE]Related articlesFree article

Erythrocyte-derived depressing factor: a novel cardiovascular player?

Selvetella G, Maffei A, Lembo G.

J Hypertens. 2003 Jun;21(6):1087-8. Review. No abstract available. PMID: 12777944 [PubMed - indexed for MEDLINE]Related articles

Melusin, a muscle-specific integrin beta1-interacting protein, is required to prevent cardiac failure in response to chronic pressure overload.

Brancaccio M, Fratta L, Notte A, Hirsch E, Poulet R, Guazzone S, De Acetis M, Vecchione C, Marino G, Altruda F, Silengo L, Tarone G, Lembo G.

Nat Med. 2003 Jan;9(1):68-75. Epub 2002 Dec 23.PMID: 12496958 [PubMed - indexed for MEDLINE]Related articles

Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways.

Crackower MA, Oudit GY, Kozieradzki I, Sarao R, Sun H, Sasaki T, Hirsch E, Suzuki A, Shioi T, Irie-Sasaki J, Sah R, Cheng HY, Rybin VO, Lembo G, Fratta L, Oliveira-dos-Santos AJ, Benovic JL, Kahn CR, Izumo S, Steinberg SF, Wymann MP, Backx PH, Penninger JM.

Cell. 2002 Sep 20;110(6):737-49.PMID: 12297047 [PubMed - indexed for MEDLINE]Related articles

Increased basal nitric oxide release despite enhanced free radical production in hypertension.

Maffei A, Poulet R, Vecchione C, Colella S, Fratta L, Frati G, Trimarco V, Trimarco B, Lembo G.

J Hypertens. 2002 Jun;20(6):1135-42.PMID: 12023683 [PubMed - indexed for MEDLINE]Related articles

Cardiovascular influences of alpha1b-adrenergic receptor defect in mice.

Vecchione C, Fratta L, Rizzoni D, Notte A, Poulet R, Porteri E, Frati G, Guelfi D, Trimarco V, Mulvany MJ, Agabiti-Rosei E, Trimarco B, Cotecchia S, Lembo G.

Circulation. 2002 Apr 9;105(14):1700-7.PMID: 11940550 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin effect on endothelial nitric oxide is mediated through Akt-endothelial nitric oxide synthase phosphorylation pathway.

Vecchione C, Maffei A, Colella S, Aretini A, Poulet R, Frati G, Gentile MT, Fratta L, Trimarco V, Trimarco B, Lembo G.

Diabetes. 2002 Jan;51(1):168-73.PMID: 11756337 [PubMed - indexed for MEDLINE]Related articlesFree article

A truncated form of teratocarcinoma-derived growth factor-1 (cripto-1) mRNA expressed in human colon carcinoma cell lines and tumors.

Baldassarre G, Tucci M, Lembo G, Pacifico FM, Dono R, Lago CT, Barra A, Bianco C, Viglietto G, Salomon D, Persico MG.

Tumour Biol. 2001 Sep-Oct;22(5):286-93.PMID: 11553858 [PubMed - indexed for MEDLINE]Related articles

Impaired insulin-like growth factor I vasorelaxant effects in hypertension.

Vecchione C, Colella S, Fratta L, Gentile MT, Selvetella G, Frati G, Trimarco B, Lembo G.

Hypertension. 2001 Jun;37(6):1480-5.PMID: 11408398 [PubMed - indexed for MEDLINE]Related articlesFree article

A common variant of endothelial nitric oxide synthase (Glu298Asp) is an independent risk factor for carotid atherosclerosis.

Lembo G, De Luca N, Battagli C, Iovino G, Aretini A, Musicco M, Frati G, Pompeo F, Vecchione C, Trimarco B.

Stroke. 2001 Mar;32(3):735-40.PMID: 11239195 [PubMed - indexed for MEDLINE]Related articlesFree article

Muscle sympathetic nerve activity in patients with acromegaly.

Capaldo B, Lembo G, Rendina V, Guida R, Marzullo P, Colao A, Lombardi G, Saccà L.

J Clin Endocrinol Metab. 2000 Sep;85(9):3203-7.PMID: 10999809 [PubMed - indexed for MEDLINE]Related articlesFree article

Noradrenergic vascular hyper-responsiveness in human hypertension is dependent on oxygen free radical impairment of nitric oxide activity.

Lembo G, Vecchione C, Izzo R, Fratta L, Fontana D, Marino G, Pilato G, Trimarco B.

Circulation. 2000 Aug 1;102(5):552-7.PMID: 10920068 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin induces direct vasodilation through distinct endothelial mechanisms.

Lembo G, Vecchione C, Fratta L, Marino G, Trimarco V, d'Amati G, Trimarco B.

Diabetes. 2000 Feb;49(2):293-7.PMID: 10868946 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-stimulated cardiac glucose uptake is impaired in spontaneously hypertensive rats: role of early steps of insulin signalling.

Morisco C, Condorelli G, Orzi F, Vigliotta G, Di Grezia R, Beguinot F, Trimarco B, Lembo G.

J Hypertens. 2000 Apr;18(4):465-73.PMID: 10779099 [PubMed - indexed for MEDLINE]Related articles

Lack of effect of insulin on glucose utilization of the hypothalamus in normotensive and hypertensive rats.

Orzi F, Morisco C, Colangelo V, Di Grezia R, Lembo G.

Neurosci Lett. 2000 Jan 7;278(1-2):29-32.PMID: 10643793 [PubMed - indexed for MEDLINE]Related articles