PubMed

MiR-495 and miR-218 regulate the expression of the Onecut transcription factors HNF-6 and OC-2.

Simion A, Laudadio I, Prévot PP, Raynaud P, Lemaigre FP, Jacquemin P.

Biochem Biophys Res Commun. 2009 Nov 12. [Epub ahead of print]PMID: 19913497 [PubMed - as supplied by publisher]Related articles

Biliary differentiation and bile duct morphogenesis in development and disease.

Raynaud P, Carpentier R, Antoniou A, Lemaigre FP.

Int J Biochem Cell Biol. 2009 Sep 6. [Epub ahead of print]PMID: 19735739 [PubMed - as supplied by publisher]Related articles

Intrahepatic bile ducts develop according to a new mode of tubulogenesis regulated by the transcription factor SOX9.

Antoniou A, Raynaud P, Cordi S, Zong Y, Tronche F, Stanger BZ, Jacquemin P, Pierreux CE, Clotman F, Lemaigre FP.

Gastroenterology. 2009 Jun;136(7):2325-33. Epub 2009 Feb 21.PMID: 19403103 [PubMed - indexed for MEDLINE]Related articles

Mechanisms of liver development: concepts for understanding liver disorders and design of novel therapies.

Lemaigre FP.

Gastroenterology. 2009 Jul;137(1):62-79. Epub 2009 Mar 27. Review.PMID: 19328801 [PubMed - indexed for MEDLINE]Related articles

Notch signaling in bile duct development: new insights raise new questions.

Lemaigre FP.

Hepatology. 2008 Aug;48(2):358-60. No abstract available. PMID: 18666255 [PubMed - indexed for MEDLINE]Related articles

Role of metalloproteinases at the onset of liver development.

Margagliotti S, Clotman F, Pierreux CE, Lemoine P, Rousseau GG, Henriet P, Lemaigre FP.

Dev Growth Differ. 2008 Jun;50(5):331-8. Epub 2008 Apr 28.PMID: 18445063 [PubMed - indexed for MEDLINE]Related articles

Lack of cilia and differentiation defects in the liver of human foetuses with the Meckel syndrome.

Clotman F, Libbrecht L, Killingsworth MC, Loo CC, Roskams T, Lemaigre FP.

Liver Int. 2008 Mar;28(3):377-84. Epub 2007 Nov 1.PMID: 17976156 [PubMed - indexed for MEDLINE]Related articles

The Onecut transcription factors HNF-6/OC-1 and OC-2 regulate early liver expansion by controlling hepatoblast migration.

Margagliotti S, Clotman F, Pierreux CE, Beaudry JB, Jacquemin P, Rousseau GG, Lemaigre FP.

Dev Biol. 2007 Nov 15;311(2):579-89. Epub 2007 Sep 16.PMID: 17936262 [PubMed - indexed for MEDLINE]Related articles

Role of the Onecut transcription factors in pancreas morphogenesis and in pancreatic and enteric endocrine differentiation.

Vanhorenbeeck V, Jenny M, Cornut JF, Gradwohl G, Lemaigre FP, Rousseau GG, Jacquemin P.

Dev Biol. 2007 May 15;305(2):685-94. Epub 2007 Feb 28.PMID: 17400205 [PubMed - indexed for MEDLINE]Related articles

Threshold levels of hepatocyte nuclear factor 6 (HNF-6) acting in synergy with HNF-4 and PGC-1alpha are required for time-specific gene expression during liver development.

Beaudry JB, Pierreux CE, Hayhurst GP, Plumb-Rudewiez N, Weiss MC, Rousseau GG, Lemaigre FP.

Mol Cell Biol. 2006 Aug;26(16):6037-46.PMID: 16880515 [PubMed - indexed for MEDLINE]Related articlesFree article

The transcription factor hepatocyte nuclear factor-6 controls the development of pancreatic ducts in the mouse.

Pierreux CE, Poll AV, Kemp CR, Clotman F, Maestro MA, Cordi S, Ferrer J, Leyns L, Rousseau GG, Lemaigre FP.

Gastroenterology. 2006 Feb;130(2):532-41.PMID: 16472605 [PubMed - indexed for MEDLINE]Related articles

Eph receptors and their ephrin ligands are expressed in developing mouse pancreas.

van Eyll JM, Passante L, Pierreux CE, Lemaigre FP, Vanderhaeghen P, Rousseau GG.

Gene Expr Patterns. 2006 Apr;6(4):353-9. Epub 2006 Jan 30.PMID: 16446123 [PubMed - indexed for MEDLINE]Related articles

An endothelial-mesenchymal relay pathway regulates early phases of pancreas development.

Jacquemin P, Yoshitomi H, Kashima Y, Rousseau GG, Lemaigre FP, Zaret KS.

Dev Biol. 2006 Feb 1;290(1):189-99. Epub 2006 Jan 4.PMID: 16386727 [PubMed - indexed for MEDLINE]Related articles

A vHNF1/TCF2-HNF6 cascade regulates the transcription factor network that controls generation of pancreatic precursor cells.

Poll AV, Pierreux CE, Lokmane L, Haumaitre C, Achouri Y, Jacquemin P, Rousseau GG, Cereghini S, Lemaigre FP.

Diabetes. 2006 Jan;55(1):61-9.PMID: 16380477 [PubMed - indexed for MEDLINE]Related articlesFree article

Control of hepatic differentiation by activin/TGFbeta signaling.

Clotman F, Lemaigre FP.

Cell Cycle. 2006 Jan;5(2):168-71. Epub 2006 Jan 16.PMID: 16357531 [PubMed - indexed for MEDLINE]Related articlesFree article

Control of liver cell fate decision by a gradient of TGF beta signaling modulated by Onecut transcription factors.

Clotman F, Jacquemin P, Plumb-Rudewiez N, Pierreux CE, Van der Smissen P, Dietz HC, Courtoy PJ, Rousseau GG, Lemaigre FP.

Genes Dev. 2005 Aug 15;19(16):1849-54.PMID: 16103213 [PubMed - indexed for MEDLINE]Related articlesFree article

Gene transfer into mouse prepancreatic endoderm by whole embryo electroporation.

Pierreux CE, Poll AV, Jacquemin P, Lemaigre FP, Rousseau GG.

JOP. 2005 Mar 10;6(2):128-35.PMID: 15767728 [PubMed - indexed for MEDLINE]Related articlesFree article

Transcription factor HNF-6/OC-1 inhibits the stimulation of the HNF-3alpha/Foxa1 gene by TGF-beta in mouse liver.

Plumb-Rudewiez N, Clotman F, Strick-Marchand H, Pierreux CE, Weiss MC, Rousseau GG, Lemaigre FP.

Hepatology. 2004 Dec;40(6):1266-74.PMID: 15562441 [PubMed - indexed for MEDLINE]Related articles

The transcription factor hepatocyte nuclear factor-6/Onecut-1 controls the expression of its paralog Onecut-3 in developing mouse endoderm.

Pierreux CE, Vanhorenbeeck V, Jacquemin P, Lemaigre FP, Rousseau GG.

J Biol Chem. 2004 Dec 3;279(49):51298-304. Epub 2004 Sep 20.PMID: 15381696 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of the alpha7 isoform of hepatocyte nuclear factor (HNF) 4 is activated by HNF6/OC-2 and HNF1 and repressed by HNF4alpha1 in the liver.

Briançon N, Bailly A, Clotman F, Jacquemin P, Lemaigre FP, Weiss MC.

J Biol Chem. 2004 Aug 6;279(32):33398-408. Epub 2004 May 24.PMID: 15159395 [PubMed - indexed for MEDLINE]Related articlesFree article

Shh-dependent differentiation of intestinal tissue from embryonic pancreas by activin A.

van Eyll JM, Pierreux CE, Lemaigre FP, Rousseau GG.

J Cell Sci. 2004 Apr 15;117(Pt 10):2077-86. Epub 2004 Mar 30.PMID: 15054113 [PubMed - indexed for MEDLINE]Related articlesFree article

Hnf6 and Tcf2 (MODY5) are linked in a gene network operating in a precursor cell domain of the embryonic pancreas.

Maestro MA, Boj SF, Luco RF, Pierreux CE, Cabedo J, Servitja JM, German MS, Rousseau GG, Lemaigre FP, Ferrer J.

Hum Mol Genet. 2003 Dec 15;12(24):3307-14. Epub 2003 Oct 21.PMID: 14570708 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatic artery malformations associated with a primary defect in intrahepatic bile duct development.

Clotman F, Libbrecht L, Gresh L, Yaniv M, Roskams T, Rousseau GG, Lemaigre FP.

J Hepatol. 2003 Nov;39(5):686-92.PMID: 14568248 [PubMed - indexed for MEDLINE]Related articles

Cloning and embryonic expression pattern of the mouse Onecut transcription factor OC-2.

Jacquemin P, Pierreux CE, Fierens S, van Eyll JM, Lemaigre FP, Rousseau GG.

Gene Expr Patterns. 2003 Oct;3(5):639-44.PMID: 12971999 [PubMed - indexed for MEDLINE]Related articles

The onecut transcription factor hepatocyte nuclear factor-6 controls B lymphopoiesis in fetal liver.

Bouzin C, Clotman F, Renauld JC, Lemaigre FP, Rousseau GG.

J Immunol. 2003 Aug 1;171(3):1297-303.PMID: 12874218 [PubMed - indexed for MEDLINE]Related articlesFree article

The Onecut transcription factor HNF-6 (OC-1) is required for timely specification of the pancreas and acts upstream of Pdx-1 in the specification cascade.

Jacquemin P, Lemaigre FP, Rousseau GG.

Dev Biol. 2003 Jun 1;258(1):105-16.PMID: 12781686 [PubMed - indexed for MEDLINE]Related articles

HNF-6-independent differentiation of mouse embryonic stem cells into insulin-producing cells.

Houard N, Rousseau GG, Lemaigre FP.

Diabetologia. 2003 Mar;46(3):378-85. Epub 2003 Feb 27.PMID: 12687336 [PubMed - indexed for MEDLINE]Related articles

Development of the biliary tract.

Lemaigre FP.

Mech Dev. 2003 Jan;120(1):81-7. Review. No abstract available. PMID: 12490298 [PubMed - indexed for MEDLINE]Related articles

Hepatocyte nuclear factor-6 stimulates transcription of the alpha-fetoprotein gene and synergizes with the retinoic-acid-receptor-related orphan receptor alpha-4.

Nacer-Cherif H, Bois-Joyeux B, Rousseau GG, Lemaigre FP, Danan JL.

Biochem J. 2003 Feb 1;369(Pt 3):583-91.PMID: 12379144 [PubMed - indexed for MEDLINE]Related articlesFree article

Liver glucokinase gene expression is controlled by the onecut transcription factor hepatocyte nuclear factor-6.

Lannoy VJ, Decaux JF, Pierreux CE, Lemaigre FP, Rousseau GG.

Diabetologia. 2002 Aug;45(8):1136-41. Epub 2002 Jun 6. Erratum in: Diabetologia. 2002 Dec;45(12):1744. PMID: 12189444 [PubMed - indexed for MEDLINE]Related articles

OC-3, a novel mammalian member of the ONECUT class of transcription factors.

Vanhorenbeeck V, Jacquemin P, Lemaigre FP, Rousseau GG.

Biochem Biophys Res Commun. 2002 Apr 12;292(4):848-54.PMID: 11944891 [PubMed - indexed for MEDLINE]Related articles

The onecut transcription factor HNF6 is required for normal development of the biliary tract.

Clotman F, Lannoy VJ, Reber M, Cereghini S, Cassiman D, Jacquemin P, Roskams T, Rousseau GG, Lemaigre FP.

Development. 2002 Apr;129(8):1819-28.PMID: 11934848 [PubMed - indexed for MEDLINE]Related articlesFree article

The transcription factor onecut-2 controls the microphthalmia-associated transcription factor gene.

Jacquemin P, Lannoy VJ, O'Sullivan J, Read A, Lemaigre FP, Rousseau GG.

Biochem Biophys Res Commun. 2001 Aug 3;285(5):1200-5.PMID: 11478782 [PubMed - indexed for MEDLINE]Related articles

Control of gene expression by growth hormone in liver: key role of a network of transcription factors.

Rastegar M, Lemaigre FP, Rousseau GG.

Mol Cell Endocrinol. 2000 Jun;164(1-2):1-4. Review.PMID: 11026552 [PubMed - indexed for MEDLINE]Related articles

Transcription factor hepatocyte nuclear factor 6 regulates pancreatic endocrine cell differentiation and controls expression of the proendocrine gene ngn3.

Jacquemin P, Durviaux SM, Jensen J, Godfraind C, Gradwohl G, Guillemot F, Madsen OD, Carmeliet P, Dewerchin M, Collen D, Rousseau GG, Lemaigre FP.

Mol Cell Biol. 2000 Jun;20(12):4445-54.PMID: 10825208 [PubMed - indexed for MEDLINE]Related articlesFree article

Transcriptional stimulation by hepatocyte nuclear factor-6. Target-specific recruitment of either CREB-binding protein (CBP) or p300/CBP-associated factor (p/CAF).

Lannoy VJ, Rodolosse A, Pierreux CE, Rousseau GG, Lemaigre FP.

J Biol Chem. 2000 Jul 21;275(29):22098-103.PMID: 10811635 [PubMed - indexed for MEDLINE]Related articlesFree article

CCAAT/enhancer-binding protein-alpha is a component of the growth hormone-regulated network of liver transcription factors.

Rastegar M, Rousseau GG, Lemaigre FP.

Endocrinology. 2000 May;141(5):1686-92.PMID: 10803577 [PubMed - indexed for MEDLINE]Related articlesFree article

Involvement of STAT5 (signal transducer and activator of transcription 5) and HNF-4 (hepatocyte nuclear factor 4) in the transcriptional control of the hnf6 gene by growth hormone.

Lahuna O, Rastegar M, Maiter D, Thissen JP, Lemaigre FP, Rousseau GG.

Mol Endocrinol. 2000 Feb;14(2):285-94.PMID: 10674400 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatocyte nuclear factor-6: associations between genetic variability and type II diabetes and between genetic variability and estimates of insulin secretion.

Møller AM, Ek J, Durviaux SM, Urhammer SA, Clausen JO, Eiberg H, Hansen T, Rousseau GG, Lemaigre FP, Pedersen O.

Diabetologia. 1999 Aug;42(8):1011-6.PMID: 10491763 [PubMed - indexed for MEDLINE]Related articles

Antiglucocorticoid activity of hepatocyte nuclear factor-6.

Pierreux CE, Stafford J, Demonte D, Scott DK, Vandenhaute J, O'Brien RM, Granner DK, Rousseau GG, Lemaigre FP.

Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):8961-6.PMID: 10430878 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin inhibition of glucocorticoid-stimulated gene transcription: requirement for an insulin response element?

Pierreux CE, Rousseau GG, Lemaigre FP.

Mol Cell Endocrinol. 1999 Jan 25;147(1-2):1-5. Review.PMID: 10195686 [PubMed - indexed for MEDLINE]Related articles

OC-2, a novel mammalian member of the ONECUT class of homeodomain transcription factors whose function in liver partially overlaps with that of hepatocyte nuclear factor-6.

Jacquemin P, Lannoy VJ, Rousseau GG, Lemaigre FP.

J Biol Chem. 1999 Jan 29;274(5):2665-71.PMID: 9915796 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition by insulin of glucocorticoid-induced gene transcription: involvement of the ligand-binding domain of the glucocorticoid receptor and independence from the phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways.

Pierreux CE, Ursø B, De Meyts P, Rousseau GG, Lemaigre FP.

Mol Endocrinol. 1998 Sep;12(9):1343-54.PMID: 9731703 [PubMed - indexed for MEDLINE]Related articlesFree article

Hepatocyte nuclear factor 6: organization and chromosomal assignment of the rat gene and characterization of its promoter.

Rastegar M, Szpirer C, Rousseau GG, Lemaigre FP.

Biochem J. 1998 Sep 15;334 ( Pt 3):565-9.PMID: 9729463 [PubMed - indexed for MEDLINE]Related articlesFree article

Isoforms of hepatocyte nuclear factor-6 differ in DNA-binding properties, contain a bifunctional homeodomain, and define the new ONECUT class of homeodomain proteins.

Lannoy VJ, Bürglin TR, Rousseau GG, Lemaigre FP.

J Biol Chem. 1998 May 29;273(22):13552-62.PMID: 9593691 [PubMed - indexed for MEDLINE]Related articlesFree article

Type I protein C deficiency caused by disruption of a hepatocyte nuclear factor (HNF)-6/HNF-1 binding site in the human protein C gene promoter.

Spek CA, Lannoy VJ, Lemaigre FP, Rousseau GG, Bertina RM, Reitsma PH.

J Biol Chem. 1998 Apr 24;273(17):10168-73.PMID: 9553065 [PubMed - indexed for MEDLINE]Related articlesFree article

HNF-6 is expressed in endoderm derivatives and nervous system of the mouse embryo and participates to the cross-regulatory network of liver-enriched transcription factors.

Landry C, Clotman F, Hioki T, Oda H, Picard JJ, Lemaigre FP, Rousseau GG.

Dev Biol. 1997 Dec 15;192(2):247-57.PMID: 9441665 [PubMed - indexed for MEDLINE]Related articles

Expression of hepatocyte nuclear factor 6 in rat liver is sex-dependent and regulated by growth hormone.

Lahuna O, Fernandez L, Karlsson H, Maiter D, Lemaigre FP, Rousseau GG, Gustafsson J, Mode A.

Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12309-13.PMID: 9356445 [PubMed - indexed for MEDLINE]Related articlesFree article

In vivo protein-DNA interactions on a glucocorticoid response unit of a liver-specific gene: hormone-induced transcription factor binding to constitutively open chromatin.

Zimmermann PL, Pierreux CE, Rigaud G, Rousseau GG, Lemaigre FP.

DNA Cell Biol. 1997 Jun;16(6):713-23. Erratum in: DNA Cell Biol 1997 Sep;16(9):1132. PMID: 9212165 [PubMed - indexed for MEDLINE]Related articles

Hepatocyte nuclear factor 6, a transcription factor that contains a novel type of homeodomain and a single cut domain.

Lemaigre FP, Durviaux SM, Truong O, Lannoy VJ, Hsuan JJ, Rousseau GG.

Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9460-4.PMID: 8790352 [PubMed - indexed for MEDLINE]Related articlesFree article