PubMed

Cdcs1 a major colitis susceptibility locus in mice; Subcongenic analysis reveals genetic complexity.

Bleich A, Büchler G, Beckwith J, Petell LM, Affourtit JP, King BL, Shaffer DJ, Roopenian DC, Hedrich HJ, Sundberg JP, Leiter EH.

Inflamm Bowel Dis. 2009 Oct 23. [Epub ahead of print]PMID: 19856416 [PubMed - as supplied by publisher]Related articles

Mouse Models of Diabetic Nephropathy.

Brosius FC 3rd, Alpers CE, Bottinger EP, Breyer MD, Coffman TM, Gurley SB, Harris RC, Kakoki M, Kretzler M, Leiter EH, Levi M, McIndoe RA, Sharma K, Smithies O, Susztak K, Takahashi N, Takahashi T; for the Animal Models of Diabetic Complications Consortium.

J Am Soc Nephrol. 2009 Sep 3. [Epub ahead of print]PMID: 19729434 [PubMed - as supplied by publisher]Related articles

Selecting the "right" mouse model for metabolic syndrome and type 2 diabetes research.

Leiter EH.

Methods Mol Biol. 2009;560:1-17.PMID: 19504239 [PubMed - in process]Related articles

Four additional mouse crosses improve the lipid QTL landscape and identify Lipg as a QTL gene.

Su Z, Ishimori N, Chen Y, Leiter EH, Churchill GA, Paigen B, Stylianou IM.

J Lipid Res. 2009 May 12. [Epub ahead of print]PMID: 19436067 [PubMed - as supplied by publisher]Related articlesFree article

Type 1 diabetes genes in rats: few or many?

Leiter EH.

Diabetes. 2009 Apr;58(4):796-7. No abstract available. PMID: 19336688 [PubMed - indexed for MEDLINE]Related articlesFree article

NOD x 129.H2(g7) backcross delineates 129S1/SvImJ-derived genomic regions modulating type 1 diabetes development in mice.

Leiter EH, Reifsnyder PC, Wallace R, Li R, King B, Churchill GC.

Diabetes. 2009 Jul;58(7):1700-3. Epub 2009 Mar 31.PMID: 19336673 [PubMed - indexed for MEDLINE]Related articlesFree article

Bone marrow expressing a diabetes resistance MHC class II allele: diabetes deviation by chronic immune stimulation.

Reifsnyder P, Schott W, Pomerleau D, Lessard MD, Soper BW, Leiter EH.

Novartis Found Symp. 2008;292:32-46; discussion 46-9, 122-9, 202-3.PMID: 19203091 [PubMed - indexed for MEDLINE]Related articles

Commonalities of genetic resistance to spontaneous autoimmune and free radical--mediated diabetes.

Chen J, Lu Y, Lee CH, Li R, Leiter EH, Mathews CE.

Free Radic Biol Med. 2008 Nov 1;45(9):1263-70. Epub 2008 Jul 31.PMID: 18718526 [PubMed - indexed for MEDLINE]Related articles

The NOD mouse: a model for insulin-dependent diabetes mellitus.

Leiter EH.

Curr Protoc Immunol. 2001 May;Chapter 15:Unit 15.9.PMID: 18432739 [PubMed - indexed for MEDLINE]Related articles

Gene expression profiling of leukemic cells and primary thymocytes predicts a signature for apoptotic sensitivity to glucocorticoids.

Miller AL, Komak S, Webb MS, Leiter EH, Thompson EB.

Cancer Cell Int. 2007 Nov 28;7:18.PMID: 18045478 [PubMed - in process]Related articlesFree article

Unexpected functional consequences of xenogeneic transgene expression in beta-cells of NOD mice.

Leiter EH, Reifsnyder P, Driver J, Kamdar S, Choisy-Rossi C, Serreze DV, Hara M, Chervonsky A.

Diabetes Obes Metab. 2007 Nov;9 Suppl 2:14-22.PMID: 17919174 [PubMed - indexed for MEDLINE]Related articles

Adipokine and insulin profiles distinguish diabetogenic and non-diabetogenic obesities in mice.

Leiter EH, Reifsnyder PC, Xiao Q, Mistry J.

Obesity (Silver Spring). 2007 Aug;15(8):1961-8.PMID: 17712113 [PubMed - indexed for MEDLINE]Related articles

Hyperglycemia, maturity-onset obesity, and insulin resistance in NONcNZO10/LtJ males, a new mouse model of type 2 diabetes.

Cho YR, Kim HJ, Park SY, Ko HJ, Hong EG, Higashimori T, Zhang Z, Jung DY, Ola MS, Lanoue KF, Leiter EH, Kim JK.

Am J Physiol Endocrinol Metab. 2007 Jul;293(1):E327-36.PMID: 17616608 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin in autoimmunity: many questions, some answers.

Matarese G, Leiter EH, La Cava A.

Tissue Antigens. 2007 Aug;70(2):87-95. Review.PMID: 17610413 [PubMed - indexed for MEDLINE]Related articles

A polymorphism in New Zealand inbred mouse strains that inactivates phosphatidylcholine transfer protein.

Pan HJ, Agate DS, King BL, Wu MK, Roderick SL, Leiter EH, Cohen DE.

FEBS Lett. 2006 Oct 30;580(25):5953-8. Epub 2006 Oct 6.PMID: 17046758 [PubMed - indexed for MEDLINE]Related articlesFree article

CD38 is required for the peripheral survival of immunotolerogenic CD4+ invariant NK T cells in nonobese diabetic mice.

Chen YG, Chen J, Osborne MA, Chapman HD, Besra GS, Porcelli SA, Leiter EH, Wilson SB, Serreze DV.

J Immunol. 2006 Sep 1;177(5):2939-47.PMID: 16920929 [PubMed - indexed for MEDLINE]Related articlesFree article

Resistance of C57BL/6 mice to amoebiasis is mediated by nonhemopoietic cells but requires hemopoietic IL-10 production.

Hamano S, Asgharpour A, Stroup SE, Wynn TA, Leiter EH, Houpt E.

J Immunol. 2006 Jul 15;177(2):1208-13.PMID: 16818779 [PubMed - indexed for MEDLINE]Related articlesFree article

The diabetes-prone NZO/Hl strain. Proliferation capacity of beta cells in hyperinsulinemia and hyperglycemia.

Lange C, Jeruschke K, Herberg L, Leiter EH, Junger E.

Arch Physiol Biochem. 2006 Feb;112(1):49-58.PMID: 16754203 [PubMed - indexed for MEDLINE]Related articles

Adverse hepatic and cardiac responses to rosiglitazone in a new mouse model of type 2 diabetes: relation to dysregulated phosphatidylcholine metabolism.

Pan HJ, Lin Y, Chen YE, Vance DE, Leiter EH.

Vascul Pharmacol. 2006 Jul;45(1):65-71. Epub 2006 Jun 5.PMID: 16750656 [PubMed - indexed for MEDLINE]Related articles

Targeted disruption of CD38 accelerates autoimmune diabetes in NOD/Lt mice by enhancing autoimmunity in an ADP-ribosyltransferase 2-dependent fashion.

Chen J, Chen YG, Reifsnyder PC, Schott WH, Lee CH, Osborne M, Scheuplein F, Haag F, Koch-Nolte F, Serreze DV, Leiter EH.

J Immunol. 2006 Apr 15;176(8):4590-9.PMID: 16585549 [PubMed - indexed for MEDLINE]Related articlesFree article

Novel leptin receptor mutation in NOD/LtJ mice suppresses type 1 diabetes progression: II. Immunologic analysis.

Lee CH, Chen YG, Chen J, Reifsnyder PC, Serreze DV, Clare-Salzler M, Rodriguez M, Wasserfall C, Atkinson MA, Leiter EH.

Diabetes. 2006 Jan;55(1):171-8.PMID: 16380490 [PubMed - indexed for MEDLINE]Related articlesFree article

Mouse models and the genetics of diabetes: is there evidence for genetic overlap between type 1 and type 2 diabetes?

Leiter EH, Lee CH.

Diabetes. 2005 Dec;54 Suppl 2:S151-8. Review.PMID: 16306333 [PubMed - indexed for MEDLINE]Related articlesFree article

Cdcs1, a major colitogenic locus in mice, regulates innate and adaptive immune response to enteric bacterial antigens.

Beckwith J, Cong Y, Sundberg JP, Elson CO, Leiter EH.

Gastroenterology. 2005 Nov;129(5):1473-84.PMID: 16285949 [PubMed - indexed for MEDLINE]Related articles

"Agouti NOD": identification of a CBA-derived Idd locus on Chromosome 7 and its use for chimera production with NOD embryonic stem cells.

Chen J, Reifsnyder PC, Scheuplein F, Schott WH, Mileikovsky M, Soodeen-Karamath S, Nagy A, Dosch MH, Ellis J, Koch-Nolte F, Leiter EH.

Mamm Genome. 2005 Oct;16(10):775-83. Epub 2005 Oct 29.PMID: 16261419 [PubMed - indexed for MEDLINE]Related articles

Differential endocrine responses to rosiglitazone therapy in new mouse models of type 2 diabetes.

Leiter EH, Reifsnyder PC, Zhang W, Pan HJ, Xiao Q, Mistry J.

Endocrinology. 2006 Feb;147(2):919-26. Epub 2005 Oct 27.PMID: 16254032 [PubMed - indexed for MEDLINE]Related articlesFree article

Novel leptin receptor mutation in NOD/LtJ mice suppresses type 1 diabetes progression: I. Pathophysiological analysis.

Lee CH, Reifsnyder PC, Naggert JK, Wasserfall C, Atkinson MA, Chen J, Leiter EH.

Diabetes. 2005 Sep;54(9):2525-32.PMID: 16123339 [PubMed - indexed for MEDLINE]Related articlesFree article

Conditioning the genome identifies additional diabetes resistance loci in Type I diabetes resistant NOR/Lt mice.

Reifsnyder PC, Li R, Silveira PA, Churchill G, Serreze DV, Leiter EH.

Genes Immun. 2005 Sep;6(6):528-38. Erratum in: Genes Immun. 2006 Mar;7(2):184. PMID: 16015371 [PubMed - indexed for MEDLINE]Related articles

Mechanisms underlying resistance of pancreatic islets from ALR/Lt mice to cytokine-induced destruction.

Mathews CE, Suarez-Pinzon WL, Baust JJ, Strynadka K, Leiter EH, Rabinovitch A.

J Immunol. 2005 Jul 15;175(2):1248-56.PMID: 16002729 [PubMed - indexed for MEDLINE]Related articlesFree article

Pharmacogenetic analysis of rosiglitazone-induced hepatosteatosis in new mouse models of type 2 diabetes.

Pan HJ, Reifsnyder P, Vance DE, Xiao Q, Leiter EH.

Diabetes. 2005 Jun;54(6):1854-62.PMID: 15919809 [PubMed - indexed for MEDLINE]Related articlesFree article

Major histocompatibility complex-linked diabetes susceptibility in NOD/Lt mice: subcongenic analysis localizes a component of Idd16 at the H2-D end of the diabetogenic H2(g7) complex.

Pomerleau DP, Bagley RJ, Serreze DV, Mathews CE, Leiter EH.

Diabetes. 2005 May;54(5):1603-6.PMID: 15855353 [PubMed - indexed for MEDLINE]Related articlesFree article

Nonobese diabetic mice and the genetics of diabetes susceptibility.

Leiter EH.

Curr Diab Rep. 2005 Apr;5(2):141-8. Review.PMID: 15794919 [PubMed - indexed for MEDLINE]Related articles

CD38 controls ADP-ribosyltransferase-2-catalyzed ADP-ribosylation of T cell surface proteins.

Krebs C, Adriouch S, Braasch F, Koestner W, Leiter EH, Seman M, Lund FE, Oppenheimer N, Haag F, Koch-Nolte F.

J Immunol. 2005 Mar 15;174(6):3298-305.PMID: 15749861 [PubMed - indexed for MEDLINE]Related articlesFree article

Proteasome inhibition alters glucose-stimulated (pro)insulin secretion and turnover in pancreatic {beta}-cells.

Kitiphongspattana K, Mathews CE, Leiter EH, Gaskins HR.

J Biol Chem. 2005 Apr 22;280(16):15727-34. Epub 2005 Feb 9.PMID: 15705591 [PubMed - indexed for MEDLINE]Related articlesFree article

P2X7 receptor-dependent and -independent T cell death is induced by nicotinamide adenine dinucleotide.

Kawamura H, Aswad F, Minagawa M, Malone K, Kaslow H, Koch-Nolte F, Schott WH, Leiter EH, Dennert G.

J Immunol. 2005 Feb 15;174(4):1971-9.PMID: 15699125 [PubMed - indexed for MEDLINE]Related articlesFree article

mt-Nd2 Allele of the ALR/Lt mouse confers resistance against both chemically induced and autoimmune diabetes.

Mathews CE, Leiter EH, Spirina O, Bykhovskaya Y, Gusdon AM, Ringquist S, Fischel-Ghodsian N.

Diabetologia. 2005 Feb;48(2):261-7. Epub 2005 Feb 4.PMID: 15692809 [PubMed - indexed for MEDLINE]Related articles

Refined histopathologic scoring system improves power to detect colitis QTL in mice.

Bleich A, Mähler M, Most C, Leiter EH, Liebler-Tenorio E, Elson CO, Hedrich HJ, Schlegelberger B, Sundberg JP.

Mamm Genome. 2004 Nov;15(11):865-71.PMID: 15672590 [PubMed - indexed for MEDLINE]Related articles

Anti-insulin receptor autoantibodies are not required for type 2 diabetes pathogenesis in NZL/Lt mice, a New Zealand obese (NZO)-derived mouse strain.

McInerney MF, Najjar SM, Brickley D, Lutzke M, Abou-Rjaily GA, Reifsnyder P, Haskell BD, Flurkey K, Zhang YJ, Pietropaolo SL, Pietropaolo M, Byers JP, Leiter EH.

Exp Diabesity Res. 2004 Jul-Sep;5(3):177-85.PMID: 15512785 [PubMed - indexed for MEDLINE]Related articlesFree article

Animal models have little to teach us about type 1 diabetes: 2. In opposition to this proposal.

Leiter EH, von Herrath M.

Diabetologia. 2004 Oct;47(10):1657-60. Epub 2004 Oct 19. Review. No abstract available. PMID: 15502929 [PubMed - indexed for MEDLINE]Related articles

Absence of a reductase, NCB5OR, causes insulin-deficient diabetes.

Xie J, Zhu H, Larade K, Ladoux A, Seguritan A, Chu M, Ito S, Bronson RT, Leiter EH, Zhang CY, Rosen ED, Bunn HF.

Proc Natl Acad Sci U S A. 2004 Jul 20;101(29):10750-5. Epub 2004 Jul 9.PMID: 15247412 [PubMed - indexed for MEDLINE]Related articlesFree article

Contributions of dysregulated energy metabolism to type 2 diabetes development in NZO/H1Lt mice with polygenic obesity.

Koza RA, Flurkey K, Graunke DM, Braun C, Pan HJ, Reifsnyder PC, Kozak LP, Leiter EH.

Metabolism. 2004 Jun;53(6):799-808.PMID: 15164332 [PubMed - indexed for MEDLINE]Related articles

ALS/Lt: a new type 2 diabetes mouse model associated with low free radical scavenging potential.

Mathews CE, Bagley R, Leiter EH.

Diabetes. 2004 Feb;53 Suppl 1:S125-9. Erratum in: Diabetes. 2004 Apr;53(4):1177-8. PMID: 14749277 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential levels of diabetogenic stress in two new mouse models of obesity and type 2 diabetes.

Leiter EH, Reifsnyder PC.

Diabetes. 2004 Feb;53 Suppl 1:S4-11. Review.PMID: 14749259 [PubMed - indexed for MEDLINE]Related articlesFree article

Caspase-1 is not required for type 1 diabetes in the NOD mouse.

Schott WH, Haskell BD, Tse HM, Milton MJ, Piganelli JD, Choisy-Rossi CM, Reifsnyder PC, Chervonsky AV, Leiter EH.

Diabetes. 2004 Jan;53(1):99-104.PMID: 14693703 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic analysis of resistance to Type-1 Diabetes in ALR/Lt mice, a NOD-related strain with defenses against autoimmune-mediated diabetogenic stress.

Mathews CE, Graser RT, Bagley RJ, Caldwell JW, Li R, Churchill GA, Serreze DV, Leiter EH.

Immunogenetics. 2003 Oct;55(7):491-6. Epub 2003 Sep 25.PMID: 14513297 [PubMed - indexed for MEDLINE]Related articles

Tracking autoimmune T cells in diabetes.

Serreze DV, Leiter EH.

J Clin Invest. 2003 Sep;112(6):826-8.PMID: 12975466 [PubMed - indexed for MEDLINE]Related articlesFree article

Adoptive transfer of islet antigen-autoreactive T cell clones to transgenic NOD.Ea(d)mice induces diabetes indicating a lack of I-E mediated protection against activated effector T cells.

Roberts SA, Barbour G, Matarrese MR, Mason DL, Leiter EH, Haskins K, Hanson MS.

J Autoimmun. 2003 Sep;21(2):139-47.PMID: 12935783 [PubMed - indexed for MEDLINE]Related articles

Flow cytometric and immunoblot assays for cell surface ADP-ribosylation using a monoclonal antibody specific for ethenoadenosine.

Krebs C, Koestner W, Nissen M, Welge V, Parusel I, Malavasi F, Leiter EH, Santella RM, Haag F, Koch-Nolte F.

Anal Biochem. 2003 Mar 1;314(1):108-15.PMID: 12633608 [PubMed - indexed for MEDLINE]Related articles

Genetic and environmental context determines the course of colitis developing in IL-10-deficient mice.

Mähler M, Leiter EH.

Inflamm Bowel Dis. 2002 Sep;8(5):347-55. Review.PMID: 12479650 [PubMed - indexed for MEDLINE]Related articles

Lipid metabolome-wide effects of the PPARgamma agonist rosiglitazone.

Watkins SM, Reifsnyder PR, Pan HJ, German JB, Leiter EH.

J Lipid Res. 2002 Nov;43(11):1809-17.PMID: 12401879 [PubMed - indexed for MEDLINE]Related articlesFree article

The diabetes-prone NZO/Hl strain. II. Pancreatic immunopathology.

Junger E, Herberg L, Jeruschke K, Leiter EH.

Lab Invest. 2002 Jul;82(7):843-53.PMID: 12118086 [PubMed - indexed for MEDLINE]Related articles