PubMed

Effects of experimental weight perturbation on skeletal muscle work efficiency, fuel utilization, and biochemistry in human subjects.

Goldsmith RL, Joanisse DR, Gallagher D, Pavlovich KH, Shamoon EL, Leibel RL, Rosenbaum M.

Am J Physiol Regul Integr Comp Physiol. 2009 Nov 4. [Epub ahead of print]PMID: 19889869 [PubMed - as supplied by publisher]Related articles

Generation of pluripotent stem cells from patients with type 1 diabetes.

Maehr R, Chen S, Snitow M, Ludwig T, Yagasaki L, Goland R, Leibel RL, Melton DA.

Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15768-73. Epub 2009 Aug 31.PMID: 19720998 [PubMed - indexed for MEDLINE]Related articlesFree article

In silico mutagenesis: a case study of the melanocortin 4 receptor.

Bromberg Y, Overton J, Vaisse C, Leibel RL, Rost B.

FASEB J. 2009 Sep;23(9):3059-69. Epub 2009 May 5.PMID: 19417090 [PubMed - indexed for MEDLINE]Related articlesFree article

11C-dihydrotetrabenazine PET of the pancreas in subjects with long-standing type 1 diabetes and in healthy controls.

Goland R, Freeby M, Parsey R, Saisho Y, Kumar D, Simpson N, Hirsch J, Prince M, Maffei A, Mann JJ, Butler PC, Van Heertum R, Leibel RL, Ichise M, Harris PE.

J Nucl Med. 2009 Mar;50(3):382-9. Epub 2009 Feb 17. Erratum in: J Nucl Med. 2009 Oct;50(10):1578. PMID: 19223416 [PubMed - indexed for MEDLINE]Related articles

Absence epilepsy in apathetic, a spontaneous mutant mouse lacking the h channel subunit, HCN2.

Chung WK, Shin M, Jaramillo TC, Leibel RL, LeDuc CA, Fischer SG, Tzilianos E, Gheith AA, Lewis AS, Chetkovich DM.

Neurobiol Dis. 2009 Mar;33(3):499-508. Epub 2008 Dec 25.PMID: 19150498 [PubMed - indexed for MEDLINE]Related articles

Molecular physiology of weight regulation in mice and humans.

Leibel RL.

Int J Obes (Lond). 2008 Dec;32 Suppl 7:S98-108. Review.PMID: 19136999 [PubMed - indexed for MEDLINE]Related articlesFree article

Analysis of 30 genes (355 SNPS) related to energy homeostasis for association with adiposity in European-American and Yup'ik Eskimo populations.

Chung WK, Patki A, Matsuoka N, Boyer BB, Liu N, Musani SK, Goropashnaya AV, Tan PL, Katsanis N, Johnson SB, Gregersen PK, Allison DB, Leibel RL, Tiwari HK.

Hum Hered. 2009;67(3):193-205. Epub 2008 Dec 15.PMID: 19077438 [PubMed - indexed for MEDLINE]Related articlesFree article

Energy in, energy out, and the effects of obesity-related genes.

Leibel RL.

N Engl J Med. 2008 Dec 11;359(24):2603-4. No abstract available. PMID: 19073980 [PubMed - indexed for MEDLINE]Related articles

Considerations regarding the genetics of obesity.

Chung WK, Leibel RL.

Obesity (Silver Spring). 2008 Dec;16 Suppl 3:S33-9.PMID: 19037210 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional consequences of the human leptin receptor (LEPR) Q223R transversion.

Stratigopoulos G, LeDuc CA, Matsuoka N, Gutman R, Rausch R, Robertson SA, Myers MG Jr, Chung WK, Chua SC Jr, Leibel RL.

Obesity (Silver Spring). 2009 Jan;17(1):126-35. Epub 2008 Nov 6.PMID: 18997673 [PubMed - indexed for MEDLINE]Related articles

Long-term persistence of adaptive thermogenesis in subjects who have maintained a reduced body weight.

Rosenbaum M, Hirsch J, Gallagher DA, Leibel RL.

Am J Clin Nutr. 2008 Oct;88(4):906-12.PMID: 18842775 [PubMed - indexed for MEDLINE]Related articlesFree article

Positional cloning of "Lisch-Like", a candidate modifier of susceptibility to type 2 diabetes in mice.

Dokmanovic-Chouinard M, Chung WK, Chevre JC, Watson E, Yonan J, Wiegand B, Bromberg Y, Wakae N, Wright CV, Overton J, Ghosh S, Sathe GM, Ammala CE, Brown KK, Ito R, LeDuc C, Solomon K, Fischer SG, Leibel RL.

PLoS Genet. 2008 Jul 25;4(7):e1000137.PMID: 18654634 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of vesicular monoamine transporter type 2 in rodent insulin secretion and glucose metabolism revealed by its specific antagonist tetrabenazine.

Raffo A, Hancock K, Polito T, Xie Y, Andan G, Witkowski P, Hardy M, Barba P, Ferrara C, Maffei A, Freeby M, Goland R, Leibel RL, Sweet IR, Harris PE.

J Endocrinol. 2008 Jul;198(1):41-9.PMID: 18577569 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin reverses weight loss-induced changes in regional neural activity responses to visual food stimuli.

Rosenbaum M, Sy M, Pavlovich K, Leibel RL, Hirsch J.

J Clin Invest. 2008 Jul;118(7):2583-91.PMID: 18568078 [PubMed - indexed for MEDLINE]Related articlesFree article

Location, location, location...

Harris RB, Leibel RL.

Cell Metab. 2008 May;7(5):359-61.PMID: 18460325 [PubMed - indexed for MEDLINE]Related articles

Leptin: a molecule integrating somatic energy stores, energy expenditure and fertility.

Rosenbaum M, Leibel RL.

Trends Endocrinol Metab. 1998 Apr;9(3):117-24.PMID: 18406252 [PubMed - in process]Related articles

Regulation of Fto/Ftm gene expression in mice and humans.

Stratigopoulos G, Padilla SL, LeDuc CA, Watson E, Hattersley AT, McCarthy MI, Zeltser LM, Chung WK, Leibel RL.

Am J Physiol Regul Integr Comp Physiol. 2008 Apr;294(4):R1185-96. Epub 2008 Feb 6. Erratum in: Am J Physiol Regul Integr Comp Physiol. 2008 Oct;295(4):R1360-3. PMID: 18256137 [PubMed - indexed for MEDLINE]Related articles

An apparent role for Alox15 in the pathogenesis of diabetes in the NOD mouse: parsing the supporting genetic data.

Weisberg SP, Leibel RL.

Diabetes. 2008 Jan;57(1):1-2. No abstract available. PMID: 18165353 [PubMed - indexed for MEDLINE]Related articlesFree article

Waist Circumference and Cardiometabolic Risk: a Consensus Statement from Shaping America's Health: Association for Weight Management and Obesity Prevention; NAASO, the Obesity Society; the American Society for Nutrition; and the American Diabetes Association.

Klein S, Allison DB, Heymsfield SB, Kelley DE, Leibel RL, Nonas C, Kahn R.

Obesity (Silver Spring). 2007 May;15(5):1061-7. Review. No abstract available. PMID: 17495180 [PubMed - indexed for MEDLINE]Related articles

Waist circumference and cardiometabolic risk: a consensus statement from Shaping America's Health: Association for Weight Management and Obesity Prevention; NAASO, The Obesity Society; the American Society for Nutrition; and the American Diabetes Association.

Klein S, Allison DB, Heymsfield SB, Kelley DE, Leibel RL, Nonas C, Kahn R; Association for Weight Management and Obesity Prevention; NAASO, The Obesity Society; American Society for Nutrition; American Diabetes Association.

Am J Clin Nutr. 2007 May;85(5):1197-202. No abstract available. PMID: 17490953 [PubMed - indexed for MEDLINE]Related articlesFree article

Waist circumference and cardiometabolic risk: a consensus statement from shaping America's health: Association for Weight Management and Obesity Prevention; NAASO, the Obesity Society; the American Society for Nutrition; and the American Diabetes Association.

Klein S, Allison DB, Heymsfield SB, Kelley DE, Leibel RL, Nonas C, Kahn R; Association for Weight Management and Obesity Prevention; NAASO; Obesity Society; American Society for Nutrition; American Diabetes Association.

Diabetes Care. 2007 Jun;30(6):1647-52. Epub 2007 Mar 14. No abstract available. PMID: 17360974 [PubMed - indexed for MEDLINE]Related articlesFree article

Monoclonal antibody antagonists of hypothalamic FGFR1 cause potent but reversible hypophagia and weight loss in rodents and monkeys.

Sun HD, Malabunga M, Tonra JR, DiRenzo R, Carrick FE, Zheng H, Berthoud HR, McGuinness OP, Shen J, Bohlen P, Leibel RL, Kussie P.

Am J Physiol Endocrinol Metab. 2007 Mar;292(3):E964-76. Epub 2006 Nov 28.PMID: 17132826 [PubMed - indexed for MEDLINE]Related articlesFree article

The links between obesity, leptin, and prostate cancer.

Chung WK, Leibel RL.

Cancer J. 2006 May-Jun;12(3):178-81. No abstract available. PMID: 16803674 [PubMed - indexed for MEDLINE]Related articles

The mahoganoid mutation (Mgrn1md) improves insulin sensitivity in mice with mutations in the melanocortin signaling pathway independently of effects on adiposity.

Phan LK, Chung WK, Leibel RL.

Am J Physiol Endocrinol Metab. 2006 Sep;291(3):E611-20. Epub 2006 Apr 25.PMID: 16638826 [PubMed - indexed for MEDLINE]Related articlesFree article

The molecular genetics of the melanocortin pathway and energy homeostasis.

Leibel RL.

Cell Metab. 2006 Feb;3(2):79-81.PMID: 16459307 [PubMed - indexed for MEDLINE]Related articles

CCR2 modulates inflammatory and metabolic effects of high-fat feeding.

Weisberg SP, Hunter D, Huber R, Lemieux J, Slaymaker S, Vaddi K, Charo I, Leibel RL, Ferrante AW Jr.

J Clin Invest. 2006 Jan;116(1):115-24. Epub 2005 Dec 8. Erratum in: J Clin Invest. 2006 May;116(5):1457. PMID: 16341265 [PubMed - indexed for MEDLINE]Related articlesFree article

Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight.

Rosenbaum M, Goldsmith R, Bloomfield D, Magnano A, Weimer L, Heymsfield S, Gallagher D, Mayer L, Murphy E, Leibel RL.

J Clin Invest. 2005 Dec;115(12):3579-86.PMID: 16322796 [PubMed - indexed for MEDLINE]Related articlesFree article

Association of K121Q polymorphism in ENPP1 (PC-1) with BMI in Caucasian and African-American adults.

Matsuoka N, Patki A, Tiwari HK, Allison DB, Johnson SB, Gregersen PK, Leibel RL, Chung WK.

Int J Obes (Lond). 2006 Feb;30(2):233-7.PMID: 16231022 [PubMed - indexed for MEDLINE]Related articles

Molecular physiology of syndromic obesities in humans.

Chung WK, Leibel RL.

Trends Endocrinol Metab. 2005 Aug;16(6):267-72. Review.PMID: 16005242 [PubMed - indexed for MEDLINE]Related articles

Body fat redistribution after weight gain in women with anorexia nervosa.

Mayer L, Walsh BT, Pierson RN Jr, Heymsfield SB, Gallagher D, Wang J, Parides MK, Leibel RL, Warren MP, Killory E, Glasofer D.

Am J Clin Nutr. 2005 Jun;81(6):1286-91.PMID: 15941877 [PubMed - indexed for MEDLINE]Related articlesFree article

Quantitative trait locus mapping of genetic modifiers of metabolic syndrome and atherosclerosis in low-density lipoprotein receptor-deficient mice: identification of a locus for metabolic syndrome and increased atherosclerosis on chromosome 4.

Seidelmann SB, De Luca C, Leibel RL, Breslow JL, Tall AR, Welch CL.

Arterioscler Thromb Vasc Biol. 2005 Jan;25(1):204-10. Epub 2004 Oct 28.PMID: 15514201 [PubMed - indexed for MEDLINE]Related articlesFree article

Toward optimal health: the experts discuss advances in diabetes management in women. Interview by Jodi Godfrey.

Nathan DM, Leibel RL.

J Womens Health (Larchmt). 2004 May;13(4):365-70. No abstract available. PMID: 15186652 [PubMed - indexed for MEDLINE]Related articles

Effects of obesity on the relationship of leptin mRNA expression and adipocyte size in anatomically distinct fat depots in mice.

Guo KY, Halo P, Leibel RL, Zhang Y.

Am J Physiol Regul Integr Comp Physiol. 2004 Jul;287(1):R112-9. Epub 2004 Mar 4.PMID: 15001430 [PubMed - indexed for MEDLINE]Related articles

Obesity is associated with macrophage accumulation in adipose tissue.

Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW Jr.

J Clin Invest. 2003 Dec;112(12):1796-808.PMID: 14679176 [PubMed - indexed for MEDLINE]Related articlesFree article

To eat or not to eat - how the gut talks to the brain.

Korner J, Leibel RL.

N Engl J Med. 2003 Sep 4;349(10):926-8. No abstract available. PMID: 12954739 [PubMed - indexed for MEDLINE]Related articles

Fat - feast or famine?

James WP, Leibel RL.

Growth Horm IGF Res. 2003 Aug;13 Suppl A:S3. No abstract available. PMID: 12914717 [PubMed - indexed for MEDLINE]Related articles

Haplotype analysis of the growth hormone releasing hormone receptor locus in three apparently unrelated kindreds from the indian subcontinent with the identical mutation in the GHRH receptor.

Wajnrajch MP, Gertner JM, Sokoloff AS, Ten I, Harbison MD, Netchine I, Maheshwari HG, Goldstein DB, Amselem S, Baumann G, Leibel RL.

Am J Med Genet A. 2003 Jul 1;120A(1):77-83.PMID: 12794696 [PubMed - indexed for MEDLINE]Related articles

Effects of experimental weight perturbation on skeletal muscle work efficiency in human subjects.

Rosenbaum M, Vandenborne K, Goldsmith R, Simoneau JA, Heymsfield S, Joanisse DR, Hirsch J, Murphy E, Matthews D, Segal KR, Leibel RL.

Am J Physiol Regul Integr Comp Physiol. 2003 Jul;285(1):R183-92. Epub 2003 Feb 27.PMID: 12609816 [PubMed - indexed for MEDLINE]Related articles

Dietary fat is not a major determinant of body fat.

Willett WC, Leibel RL.

Am J Med. 2002 Dec 30;113 Suppl 9B:47S-59S. Review.PMID: 12566139 [PubMed - indexed for MEDLINE]Related articles

Is the energy homeostasis system inherently biased toward weight gain?

Schwartz MW, Woods SC, Seeley RJ, Barsh GS, Baskin DG, Leibel RL.

Diabetes. 2003 Feb;52(2):232-8.PMID: 12540591 [PubMed - indexed for MEDLINE]Related articlesFree article

Metabolic and hemodynamic responses to exercise in subcutaneous adipose tissue and skeletal muscle.

Boschmann M, Rosenbaum M, Leibel RL, Segal KR.

Int J Sports Med. 2002 Nov;23(8):537-43.PMID: 12439767 [PubMed - indexed for MEDLINE]Related articles

The mouse mahoganoid coat color mutation disrupts a novel C3HC4 RING domain protein.

Phan LK, Lin F, LeDuc CA, Chung WK, Leibel RL.

J Clin Invest. 2002 Nov;110(10):1449-59.PMID: 12438443 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of leptin in the control of body weight.

Leibel RL.

Nutr Rev. 2002 Oct;60(10 Pt 2):S15-9; discussion S68-84, 85-7. Review.PMID: 12403079 [PubMed - indexed for MEDLINE]Related articles

The physiology of body weight regulation: relevance to the etiology of obesity in children.

Rosenbaum M, Leibel RL.

Pediatrics. 1998 Mar;101(3 Pt 2):525-39. Review.PMID: 12224659 [PubMed - indexed for MEDLINE]Related articles

Identifying functional relationships among human genes by systematic analysis of biological literature.

Tao YC, Leibel RL.

BMC Bioinformatics. 2002 Jun 7;3:16.PMID: 12067419 [PubMed - indexed for MEDLINE]Related articlesFree article

A meta-analytic investigation of linkage and association of common leptin receptor (LEPR) polymorphisms with body mass index and waist circumference.

Heo M, Leibel RL, Fontaine KR, Boyer BB, Chung WK, Koulu M, Karvonen MK, Pesonen U, Rissanen A, Laakso M, Uusitupa MI, Chagnon Y, Bouchard C, Donohoue PA, Burns TL, Shuldiner AR, Silver K, Andersen RE, Pedersen O, Echwald S, Sørensen TI, Behn P, Permutt MA, Jacobs KB, Elston RC, Hoffman DJ, Gropp E, Allison DB.

Int J Obes Relat Metab Disord. 2002 May;26(5):640-6.PMID: 12032747 [PubMed - indexed for MEDLINE]Related articlesFree article

Low dose leptin administration reverses effects of sustained weight-reduction on energy expenditure and circulating concentrations of thyroid hormones.

Rosenbaum M, Murphy EM, Heymsfield SB, Matthews DE, Leibel RL.

J Clin Endocrinol Metab. 2002 May;87(5):2391-4.PMID: 11994393 [PubMed - indexed for MEDLINE]Related articlesFree article

Determinants of leptin gene expression in fat depots of lean mice.

Zhang Y, Guo KY, Diaz PA, Heo M, Leibel RL.

Am J Physiol Regul Integr Comp Physiol. 2002 Jan;282(1):R226-34.PMID: 11742842 [PubMed - indexed for MEDLINE]Related articles

Leptin regulation of Agrp and Npy mRNA in the rat hypothalamus.

Korner J, Savontaus E, Chua SC Jr, Leibel RL, Wardlaw SL.

J Neuroendocrinol. 2001 Nov;13(11):959-66.PMID: 11737554 [PubMed - indexed for MEDLINE]Related articles

Pooling analysis of genetic data: the association of leptin receptor (LEPR) polymorphisms with variables related to human adiposity.

Heo M, Leibel RL, Boyer BB, Chung WK, Koulu M, Karvonen MK, Pesonen U, Rissanen A, Laakso M, Uusitupa MI, Chagnon Y, Bouchard C, Donohoue PA, Burns TL, Shuldiner AR, Silver K, Andersen RE, Pedersen O, Echwald S, Sørensen TI, Behn P, Permutt MA, Jacobs KB, Elston RC, Hoffman DJ, Allison DB.

Genetics. 2001 Nov;159(3):1163-78.PMID: 11729160 [PubMed - indexed for MEDLINE]Related articlesFree article