PubMed

Antimicrobial mechanism of pore-forming protegrin peptides: 100 pores to kill E. coli.

Bolintineanu D, Hazrati E, Davis HT, Lehrer RI, Kaznessis YN.

Peptides. 2009 Nov 29. [Epub ahead of print]PMID: 19931583 [PubMed - as supplied by publisher]Related articles

Through the looking glass, mechanistic insights from enantiomeric human defensins.

Wei G, de Leeuw E, Pazgier M, Yuan W, Zou G, Wang J, Ericksen B, Lu WY, Lehrer RI, Lu W.

J Biol Chem. 2009 Oct 16;284(42):29180-92. Epub 2009 Jul 29.PMID: 19640840 [PubMed - in process]Related articles

Antimicrobial host defense peptides in an arteriviral infection: differential peptide expression and virus inactivation.

Sang Y, Ruchala P, Lehrer RI, Ross CR, Rowland RR, Blecha F.

Viral Immunol. 2009 Jul;22(4):235-42.PMID: 19594394 [PubMed - indexed for MEDLINE]Related articles

Human alpha-defensins inhibit hemolysis mediated by cholesterol-dependent cytolysins.

Lehrer RI, Jung G, Ruchala P, Wang W, Micewicz ED, Waring AJ, Gillespie EJ, Bradley KA, Ratner AJ, Rest RF, Lu W.

Infect Immun. 2009 Sep;77(9):4028-40. Epub 2009 Jul 6.PMID: 19581399 [PubMed - indexed for MEDLINE]Related articles

Multivalent binding of carbohydrates by the human alpha-defensin, HD5.

Lehrer RI, Jung G, Ruchala P, Andre S, Gabius HJ, Lu W.

J Immunol. 2009 Jul 1;183(1):480-90.PMID: 19542459 [PubMed - indexed for MEDLINE]Related articles

Interactions of alpha-, beta-, and theta-defensins with influenza A virus and surfactant protein D.

Doss M, White MR, Tecle T, Gantz D, Crouch EC, Jung G, Ruchala P, Waring AJ, Lehrer RI, Hartshorn KL.

J Immunol. 2009 Jun 15;182(12):7878-87.PMID: 19494312 [PubMed - indexed for MEDLINE]Related articles

Reawakening retrocyclins: ancestral human defensins active against HIV-1.

Venkataraman N, Cole AL, Ruchala P, Waring AJ, Lehrer RI, Stuchlik O, Pohl J, Cole AM.

PLoS Biol. 2009 Apr 28;7(4):e95.PMID: 19402752 [PubMed - indexed for MEDLINE]Related articlesFree article

Retrocyclin-2: a potent anti-HIV theta-defensin that forms a cyclic cystine ladder structural motif.

Daly NL, Chen YK, Rosengren KJ, Marx UC, Phillips ML, Waring AJ, Wang W, Lehrer RI, Craik DJ.

Adv Exp Med Biol. 2009;611:577-8. No abstract available. PMID: 19400321 [PubMed - indexed for MEDLINE]Related articles

A novel method for oral delivery of apolipoprotein mimetic peptides synthesized from all L-amino acids.

Navab M, Ruchala P, Waring AJ, Lehrer RI, Hama S, Hough G, Palgunachari MN, Anantharamaiah GM, Fogelman AM.

J Lipid Res. 2009 Aug;50(8):1538-47. Epub 2009 Feb 18.PMID: 19225094 [PubMed - indexed for MEDLINE]Related articles

Induction of group A Streptococcus virulence by a human antimicrobial peptide.

Gryllos I, Tran-Winkler HJ, Cheng MF, Chung H, Bolcome R 3rd, Lu W, Lehrer RI, Wessels MR.

Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16755-60. Epub 2008 Oct 20.PMID: 18936485 [PubMed - indexed for MEDLINE]Related articlesFree article

Anti-inflammatory apoA-I-mimetic peptides bind oxidized lipids with much higher affinity than human apoA-I.

Van Lenten BJ, Wagner AC, Jung CL, Ruchala P, Waring AJ, Lehrer RI, Watson AD, Hama S, Navab M, Anantharamaiah GM, Fogelman AM.

J Lipid Res. 2008 Nov;49(11):2302-11. Epub 2008 Jul 11. Erratum in: J Lipid Res. 2008 Dec;49(12):2698. PMID: 18621920 [PubMed - indexed for MEDLINE]Related articlesFree article

Correlation between simulated physicochemical properties and hemolycity of protegrin-like antimicrobial peptides: predicting experimental toxicity.

Langham AA, Khandelia H, Schuster B, Waring AJ, Lehrer RI, Kaznessis YN.

Peptides. 2008 Jul;29(7):1085-93. Epub 2008 Mar 28.PMID: 18455267 [PubMed - indexed for MEDLINE]Related articlesFree article

Dual mechanism of bacterial lethality for a cationic sequence-random copolymer that mimics host-defense antimicrobial peptides.

Epand RF, Mowery BP, Lee SE, Stahl SS, Lehrer RI, Gellman SH, Epand RM.

J Mol Biol. 2008 May 23;379(1):38-50. Epub 2008 Mar 28.PMID: 18440552 [PubMed - indexed for MEDLINE]Related articles

Effects of guanidinium-phosphate hydrogen bonding on the membrane-bound structure and activity of an arginine-rich membrane peptide from solid-state NMR spectroscopy.

Tang M, Waring AJ, Lehrer RI, Hong M.

Angew Chem Int Ed Engl. 2008;47(17):3202-5. No abstract available. PMID: 18338418 [PubMed - indexed for MEDLINE]Related articles

Retrocyclin RC-101 overcomes cationic mutations on the heptad repeat 2 region of HIV-1 gp41.

Fuhrman CA, Warren AD, Waring AJ, Dutz SM, Sharma S, Lehrer RI, Cole AL, Cole AM.

FEBS J. 2007 Dec;274(24):6477-87. Epub 2007 Nov 19.PMID: 18028423 [PubMed - indexed for MEDLINE]Related articles

Evaluation of a theta-defensin in a Murine model of herpes simplex virus type 1 keratitis.

Brandt CR, Akkarawongsa R, Altmann S, Jose G, Kolb AW, Waring AJ, Lehrer RI.

Invest Ophthalmol Vis Sci. 2007 Nov;48(11):5118-24.PMID: 17962464 [PubMed - indexed for MEDLINE]Related articlesFree article

alpha-Defensin inhibits influenza virus replication by cell-mediated mechanism(s).

Salvatore M, Garcia-Sastre A, Ruchala P, Lehrer RI, Chang T, Klotman ME.

J Infect Dis. 2007 Sep 15;196(6):835-43. Epub 2007 Aug 10.PMID: 17703413 [PubMed - indexed for MEDLINE]Related articles

Retrocyclin-2: structural analysis of a potent anti-HIV theta-defensin.

Daly NL, Chen YK, Rosengren KJ, Marx UC, Phillips ML, Waring AJ, Wang W, Lehrer RI, Craik DJ.

Biochemistry. 2007 Sep 4;46(35):9920-8. Epub 2007 Aug 8.PMID: 17685559 [PubMed - indexed for MEDLINE]Related articles

Paradoxical effects of two theta-defensins on HIV type 1 infection.

Wang Q, Wang W, Zheng J, Tabibian S, Xie Y, Song J, Waring AJ, Chiu R, Yang OO, Chen IS, Lehrer RI, Pang S.

AIDS Res Hum Retroviruses. 2007 Apr;23(4):508-14.PMID: 17506607 [PubMed - indexed for MEDLINE]Related articles

Avian beta-defensin nomenclature: a community proposed update.

Lynn DJ, Higgs R, Lloyd AT, O'Farrelly C, Hervé-Grépinet V, Nys Y, Brinkman FS, Yu PL, Soulier A, Kaiser P, Zhang G, Lehrer RI.

Immunol Lett. 2007 May 15;110(1):86-9. Epub 2007 Apr 23. No abstract available. PMID: 17467809 [PubMed - indexed for MEDLINE]Related articles

The innate immune system: a repository for future drugs?

Sambhara S, Lehrer RI.

Expert Rev Anti Infect Ther. 2007 Feb;5(1):1-5. No abstract available. PMID: 17266447 [PubMed - indexed for MEDLINE]Related articles

The retrocyclin analogue RC-101 prevents human immunodeficiency virus type 1 infection of a model human cervicovaginal tissue construct.

Cole AL, Herasimtschuk A, Gupta P, Waring AJ, Lehrer RI, Cole AM.

Immunology. 2007 May;121(1):140-5. Epub 2007 Jan 23.PMID: 17250585 [PubMed - indexed for MEDLINE]Related articlesFree article

Human alpha- and beta-defensins block multiple steps in herpes simplex virus infection.

Hazrati E, Galen B, Lu W, Wang W, Ouyang Y, Keller MJ, Lehrer RI, Herold BC.

J Immunol. 2006 Dec 15;177(12):8658-66.PMID: 17142766 [PubMed - indexed for MEDLINE]Related articlesFree article

Multispecific myeloid defensins.

Lehrer RI.

Curr Opin Hematol. 2007 Jan;14(1):16-21. Review.PMID: 17133095 [PubMed - indexed for MEDLINE]Related articles

Membrane-dependent oligomeric structure and pore formation of a beta-hairpin antimicrobial peptide in lipid bilayers from solid-state NMR.

Mani R, Cady SD, Tang M, Waring AJ, Lehrer RI, Hong M.

Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16242-7. Epub 2006 Oct 23.PMID: 17060626 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanism of supported membrane disruption by antimicrobial peptide protegrin-1.

Lam KL, Ishitsuka Y, Cheng Y, Chien K, Waring AJ, Lehrer RI, Lee KY.

J Phys Chem B. 2006 Oct 26;110(42):21282-6.PMID: 17048957 [PubMed - indexed for MEDLINE]Related articles

Insertion selectivity of antimicrobial peptide protegrin-1 into lipid monolayers: effect of head group electrostatics and tail group packing.

Ishitsuka Y, Pham DS, Waring AJ, Lehrer RI, Lee KY.

Biochim Biophys Acta. 2006 Sep;1758(9):1450-60. Epub 2006 Aug 5.PMID: 16989771 [PubMed - indexed for MEDLINE]Related articles

alpha-Defensins from blood leukocytes of the monkey Papio hamadryas.

Tsvetkova EV, Aleshina GM, Shamova OV, Leonova LE, Lehrer RI, Kokryakov VN.

Biochemistry (Mosc). 2006 Aug;71(8):879-83.PMID: 16978151 [PubMed - indexed for MEDLINE]Related articles

Retrocyclins kill bacilli and germinating spores of Bacillus anthracis and inactivate anthrax lethal toxin.

Wang W, Mulakala C, Ward SC, Jung G, Luong H, Pham D, Waring AJ, Kaznessis Y, Lu W, Bradley KA, Lehrer RI.

J Biol Chem. 2006 Oct 27;281(43):32755-64. Epub 2006 Jun 21.PMID: 16790431 [PubMed - indexed for MEDLINE]Related articlesFree article

HIV-1 adapts to a retrocyclin with cationic amino acid substitutions that reduce fusion efficiency of gp41.

Cole AL, Yang OO, Warren AD, Waring AJ, Lehrer RI, Cole AM.

J Immunol. 2006 Jun 1;176(11):6900-5.PMID: 16709850 [PubMed - indexed for MEDLINE]Related articlesFree article

Theta-defensins prevent HIV-1 Env-mediated fusion by binding gp41 and blocking 6-helix bundle formation.

Gallo SA, Wang W, Rawat SS, Jung G, Waring AJ, Cole AM, Lu H, Yan X, Daly NL, Craik DJ, Jiang S, Lehrer RI, Blumenthal R.

J Biol Chem. 2006 Jul 7;281(27):18787-92. Epub 2006 Apr 28.PMID: 16648135 [PubMed - indexed for MEDLINE]Related articlesFree article

Orientation of a beta-hairpin antimicrobial peptide in lipid bilayers from two-dimensional dipolar chemical-shift correlation NMR.

Tang M, Waring AJ, Lehrer RI, Hong M.

Biophys J. 2006 May 15;90(10):3616-24. Epub 2006 Feb 24.PMID: 16500957 [PubMed - indexed for MEDLINE]Related articlesFree article

Cervicovaginal secretions contribute to innate resistance to herpes simplex virus infection.

John M, Keller MJ, Fam EH, Cheshenko N, Hogarty K, Kasowitz A, Wallenstein S, Carlucci MJ, Tuyama AC, Lu W, Klotman ME, Lehrer RI, Herold BC.

J Infect Dis. 2005 Nov 15;192(10):1731-40. Epub 2005 Oct 13.PMID: 16235171 [PubMed - indexed for MEDLINE]Related articles

Plectasin is a peptide antibiotic with therapeutic potential from a saprophytic fungus.

Mygind PH, Fischer RL, Schnorr KM, Hansen MT, Sönksen CP, Ludvigsen S, Raventós D, Buskov S, Christensen B, De Maria L, Taboureau O, Yaver D, Elvig-Jørgensen SG, Sørensen MV, Christensen BE, Kjaerulff S, Frimodt-Moller N, Lehrer RI, Zasloff M, Kristensen HH.

Nature. 2005 Oct 13;437(7061):975-80.PMID: 16222292 [PubMed - indexed for MEDLINE]Related articles

Membrane-disruptive abilities of beta-hairpin antimicrobial peptides correlate with conformation and activity: a 31P and 1H NMR study.

Mani R, Waring AJ, Lehrer RI, Hong M.

Biochim Biophys Acta. 2005 Oct 1;1716(1):11-8.PMID: 16182236 [PubMed - indexed for MEDLINE]Related articles

Carbohydrate-binding molecules inhibit viral fusion and entry by crosslinking membrane glycoproteins.

Leikina E, Delanoe-Ayari H, Melikov K, Cho MS, Chen A, Waring AJ, Wang W, Xie Y, Loo JA, Lehrer RI, Chernomordik LV.

Nat Immunol. 2005 Oct;6(10):995-1001. Epub 2005 Sep 11.PMID: 16155572 [PubMed - indexed for MEDLINE]Related articles

Headgroup structure and fatty acid chain length of the acidic phospholipids modulate the interaction of membrane mimetic vesicles with the antimicrobial peptide protegrin-1.

Jing W, Prenner EJ, Vogel HJ, Waring AJ, Lehrer RI, Lohner K.

J Pept Sci. 2005 Nov;11(11):735-43.PMID: 16059971 [PubMed - indexed for MEDLINE]Related articles

In defense of skin.

Lehrer RI.

J Invest Dermatol. 2005 Jul;125(1):viii-ix; discussion x-xi. No abstract available. PMID: 15982292 [PubMed - indexed for MEDLINE]Related articlesFree article

Human neutrophil alpha-defensin 4 inhibits HIV-1 infection in vitro.

Wu Z, Cocchi F, Gentles D, Ericksen B, Lubkowski J, Devico A, Lehrer RI, Lu W.

FEBS Lett. 2005 Jan 3;579(1):162-6.PMID: 15620707 [PubMed - indexed for MEDLINE]Related articles

Antibacterial activity and specificity of the six human {alpha}-defensins.

Ericksen B, Wu Z, Lu W, Lehrer RI.

Antimicrob Agents Chemother. 2005 Jan;49(1):269-75.PMID: 15616305 [PubMed - indexed for MEDLINE]Related articlesFree article

RC-101, a retrocyclin-1 analogue with enhanced activity against primary HIV type 1 isolates.

Owen SM, Rudolph DL, Wang W, Cole AM, Waring AJ, Lal RB, Lehrer RI.

AIDS Res Hum Retroviruses. 2004 Nov;20(11):1157-65.PMID: 15588337 [PubMed - indexed for MEDLINE]Related articles

Retrocyclins: using past as prologue.

Cole AM, Wang W, Waring AJ, Lehrer RI.

Curr Protein Pept Sci. 2004 Oct;5(5):373-81. Review.PMID: 15544532 [PubMed - indexed for MEDLINE]Related articles

Solid-state NMR investigation of the selective disruption of lipid membranes by protegrin-1.

Mani R, Buffy JJ, Waring AJ, Lehrer RI, Hong M.

Biochemistry. 2004 Nov 2;43(43):13839-48.PMID: 15504046 [PubMed - indexed for MEDLINE]Related articles

Primate defensins.

Lehrer RI.

Nat Rev Microbiol. 2004 Sep;2(9):727-38. Review.PMID: 15372083 [PubMed - indexed for MEDLINE]Related articles

Paradise lost and paradigm found.

Lehrer RI.

Nat Immunol. 2004 Aug;5(8):775-6. No abstract available. PMID: 15282557 [PubMed - indexed for MEDLINE]Related articles

Solid-state NMR investigation of the selective perturbation of lipid bilayers by the cyclic antimicrobial peptide RTD-1.

Buffy JJ, McCormick MJ, Wi S, Waring A, Lehrer RI, Hong M.

Biochemistry. 2004 Aug 3;43(30):9800-12.PMID: 15274634 [PubMed - indexed for MEDLINE]Related articles

Activity of alpha- and theta-defensins against primary isolates of HIV-1.

Wang W, Owen SM, Rudolph DL, Cole AM, Hong T, Waring AJ, Lal RB, Lehrer RI.

J Immunol. 2004 Jul 1;173(1):515-20.PMID: 15210812 [PubMed - indexed for MEDLINE]Related articlesFree article

A theta-defensin composed exclusively of D-amino acids is active against HIV-1.

Owen SM, Rudolph D, Wang W, Cole AM, Sherman MA, Waring AJ, Lehrer RI, Lal RB.

J Pept Res. 2004 Jun;63(6):469-76.PMID: 15175019 [PubMed - indexed for MEDLINE]Related articles

Theta defensins protect cells from infection by herpes simplex virus by inhibiting viral adhesion and entry.

Yasin B, Wang W, Pang M, Cheshenko N, Hong T, Waring AJ, Herold BC, Wagar EA, Lehrer RI.

J Virol. 2004 May;78(10):5147-56.PMID: 15113897 [PubMed - indexed for MEDLINE]Related articlesFree article

Susceptibility of Treponema pallidum to host-derived antimicrobial peptides.

Cox DL, Sun Y, Liu H, Lehrer RI, Shafer WM.

Peptides. 2003 Nov;24(11):1741-6.PMID: 15019205 [PubMed - indexed for MEDLINE]Related articles