PubMed

Selective Activation of PPAR{gamma} in Skeletal Muscle * Induces Endogenous Production of Adiponectin and Protects Mice From Diet-Induced Insulin Resistance.

Amin RH, Mathews ST, Camp HS, Ding L, Leff T.

Am J Physiol Endocrinol Metab. 2009 Oct 20. [Epub ahead of print]PMID: 19843873 [PubMed - as supplied by publisher]Related articles

Curcumin is not a ligand for peroxisome proliferator-activated receptor-gamma.

Narala VR, Smith MR, Adapala RK, Ranga R, Panati K, Moore BB, Leff T, Reddy VD, Kondapi AK, Reddy RC.

Gene Ther Mol Biol. 2009 Apr 1;13(1):20-25.PMID: 19644570 [PubMed]Related articlesFree article

Efficacy and safety of pioglitazone in treatment of a patient with an atypical partial lipodystrophy syndrome.

Sleilati GG, Leff T, Bonnett JW, Hegele RA.

Endocr Pract. 2007 Oct;13(6):656-61.PMID: 17954424 [PubMed - indexed for MEDLINE]Related articles

Familial partial lipodystrophy phenotype resulting from a single-base mutation in deoxyribonucleic acid-binding domain of peroxisome proliferator-activated receptor-gamma.

Monajemi H, Zhang L, Li G, Jeninga EH, Cao H, Maas M, Brouwer CB, Kalkhoven E, Stroes E, Hegele RA, Leff T.

J Clin Endocrinol Metab. 2007 May;92(5):1606-12. Epub 2007 Feb 13.PMID: 17299075 [PubMed - indexed for MEDLINE]Related articlesFree article

Altered promoter recycling rates contribute to dominant-negative activity of human peroxisome proliferator-activated receptor-gamma mutations associated with diabetes.

Li G, Leff T.

Mol Endocrinol. 2007 Apr;21(4):857-64. Epub 2007 Jan 16.PMID: 17227883 [PubMed - indexed for MEDLINE]Related articlesFree article

Peroxisomal proliferator activated receptor-gamma deficiency in a Canadian kindred with familial partial lipodystrophy type 3 (FPLD3).

Francis GA, Li G, Casey R, Wang J, Cao H, Leff T, Hegele RA.

BMC Med Genet. 2006 Jan 14;7:3.PMID: 16412238 [PubMed - indexed for MEDLINE]Related articlesFree article

Unbuckling lipodystrophy from insulin resistance and hypertension.

Hegele RA, Leff T.

J Clin Invest. 2004 Jul;114(2):163-5.PMID: 15254581 [PubMed - indexed for MEDLINE]Related articlesFree article

Review: peroxisome proliferator-activated receptor-gamma and its role in the development and treatment of diabetes.

Leff T, Mathews ST, Camp HS.

Exp Diabesity Res. 2004 Apr-Jun;5(2):99-109. Review.PMID: 15203881 [PubMed - indexed for MEDLINE]Related articlesFree article

Deactivation of murine alveolar macrophages by peroxisome proliferator-activated receptor-gamma ligands.

Reddy RC, Keshamouni VG, Jaigirdar SH, Zeng X, Leff T, Thannickal VJ, Standiford TJ.

Am J Physiol Lung Cell Mol Physiol. 2004 Mar;286(3):L613-9. Epub 2003 Nov 14.PMID: 14617516 [PubMed - indexed for MEDLINE]Related articlesFree article

AMP-activated protein kinase regulates HNF4alpha transcriptional activity by inhibiting dimer formation and decreasing protein stability.

Hong YH, Varanasi US, Yang W, Leff T.

J Biol Chem. 2003 Jul 25;278(30):27495-501. Epub 2003 May 9.PMID: 12740371 [PubMed - indexed for MEDLINE]Related articlesFree article

AMP-activated protein kinase regulates gene expression by direct phosphorylation of nuclear proteins.

Leff T.

Biochem Soc Trans. 2003 Feb;31(Pt 1):224-7. Review.PMID: 12546690 [PubMed - indexed for MEDLINE]Related articles

PPARG F388L, a transactivation-deficient mutant, in familial partial lipodystrophy.

Hegele RA, Cao H, Frankowski C, Mathews ST, Leff T.

Diabetes. 2002 Dec;51(12):3586-90.PMID: 12453919 [PubMed - indexed for MEDLINE]Related articlesFree article

Adipogenesis and fat-cell function in obesity and diabetes.

Camp HS, Ren D, Leff T.

Trends Mol Med. 2002 Sep;8(9):442-7. Review.PMID: 12223316 [PubMed - indexed for MEDLINE]Related articles

Regulation of transcription by AMP-activated protein kinase: phosphorylation of p300 blocks its interaction with nuclear receptors.

Yang W, Hong YH, Shen XQ, Frankowski C, Camp HS, Leff T.

J Biol Chem. 2001 Oct 19;276(42):38341-4. Epub 2001 Aug 22.PMID: 11518699 [PubMed - indexed for MEDLINE]Related articlesFree article

A novel potent antagonist of peroxisome proliferator-activated receptor gamma blocks adipocyte differentiation but does not revert the phenotype of terminally differentiated adipocytes.

Camp HS, Chaudhry A, Leff T.

Endocrinology. 2001 Jul;142(7):3207-13.PMID: 11416043 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential activation of peroxisome proliferator-activated receptor-gamma by troglitazone and rosiglitazone.

Camp HS, Li O, Wise SC, Hong YH, Frankowski CL, Shen X, Vanbogelen R, Leff T.

Diabetes. 2000 Apr;49(4):539-47.PMID: 10871190 [PubMed - indexed for MEDLINE]Related articlesFree article

Mitogen-activated protein kinase regulates transcription of the ApoCIII gene. Involvement of the orphan nuclear receptor HNF4.

Reddy S, Yang W, Taylor DG, Shen X, Oxender D, Kust G, Leff T.

J Biol Chem. 1999 Nov 12;274(46):33050-6.PMID: 10551874 [PubMed - indexed for MEDLINE]Related articlesFree article

Troglitazone, an antidiabetic agent, inhibits cholesterol biosynthesis through a mechanism independent of peroxisome proliferator-activated receptor-gamma.

Wang M, Wise SC, Leff T, Su TZ.

Diabetes. 1999 Feb;48(2):254-60.PMID: 10334298 [PubMed - indexed for MEDLINE]Related articlesFree article

c-Jun N-terminal kinase phosphorylates peroxisome proliferator-activated receptor-gamma1 and negatively regulates its transcriptional activity.

Camp HS, Tafuri SR, Leff T.

Endocrinology. 1999 Jan;140(1):392-7.PMID: 9886850 [PubMed - indexed for MEDLINE]Related articlesFree article

A common Hpa I RFLP of apolipoprotein C-I increases gene transcription and exhibits an ethnically distinct pattern of linkage disequilibrium with the alleles of apolipoprotein E.

Xu Y, Berglund L, Ramakrishnan R, Mayeux R, Ngai C, Holleran S, Tycko B, Leff T, Shachter NS.

J Lipid Res. 1999 Jan;40(1):50-8.PMID: 9869649 [PubMed - indexed for MEDLINE]Related articlesFree article

Three isoforms of a hepatocyte nuclear factor-4 transcription factor with tissue- and stage-specific expression in the adult mosquito.

Kapitskaya MZ, Dittmer NT, Deitsch KW, Cho WL, Taylor DG, Leff T, Raikhel AS.

J Biol Chem. 1998 Nov 6;273(45):29801-10.PMID: 9792695 [PubMed - indexed for MEDLINE]Related articlesFree article

A novel compound that elevates high density lipoprotein and activates the peroxisome proliferator activated receptor.

Bisgaier CL, Essenburg AD, Barnett BC, Auerbach BJ, Haubenwallner S, Leff T, White AD, Creger P, Pape ME, Rea TJ, Newton RS.

J Lipid Res. 1998 Jan;39(1):17-30. Erratum in: J Lipid Res 1998 Jun;39(6):1317. PMID: 9469582 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of a dominant negative mutant form of the HNF-4 orphan receptor.

Taylor DG, Haubenwallner S, Leff T.

Nucleic Acids Res. 1996 Aug 1;24(15):2930-5.PMID: 8760876 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypolipidemic activity of select fibrates correlates to changes in hepatic apolipoprotein C-III expression: a potential physiologic basis for their mode of action.

Haubenwallner S, Essenburg AD, Barnett BC, Pape ME, DeMattos RB, Krause BR, Minton LL, Auerbach BJ, Newton RS, Leff T, et al.

J Lipid Res. 1995 Dec;36(12):2541-51.PMID: 8847480 [PubMed - indexed for MEDLINE]Related articlesFree article

Common genetic variation in the promoter of the human apo CIII gene abolishes regulation by insulin and may contribute to hypertriglyceridemia.

Li WW, Dammerman MM, Smith JD, Metzger S, Breslow JL, Leff T.

J Clin Invest. 1995 Dec;96(6):2601-5.PMID: 8675624 [PubMed - indexed for MEDLINE]Related articlesFree article

Transcriptional regulation of the apoC-III gene by insulin in diabetic mice: correlation with changes in plasma triglyceride levels.

Chen M, Breslow JL, Li W, Leff T.

J Lipid Res. 1994 Nov;35(11):1918-24.PMID: 7868970 [PubMed - indexed for MEDLINE]Related articlesFree article

Apo CIII gene transcription is regulated by a cytokine inducible NF-kappa B element.

Gruber PJ, Torres-Rosado A, Wolak ML, Leff T.

Nucleic Acids Res. 1994 Jun 25;22(12):2417-22.PMID: 8036173 [PubMed - indexed for MEDLINE]Related articlesFree article

c-Myc does not require max for transcriptional activity in PC-12 cells.

Ribon V, Leff T, Saltiel AR.

Mol Cell Neurosci. 1994 Jun;5(3):277-82.PMID: 8087425 [PubMed - indexed for MEDLINE]Related articles

Overexpression of apolipoprotein CII causes hypertriglyceridemia in transgenic mice.

Shachter NS, Hayek T, Leff T, Smith JD, Rosenberg DW, Walsh A, Ramakrishnan R, Goldberg IJ, Ginsberg HN, Breslow JL.

J Clin Invest. 1994 Apr;93(4):1683-90.PMID: 8163669 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of cytochrome P450 in cultured human colonic cells.

Rosenberg DW, Leff T.

Arch Biochem Biophys. 1993 Jan;300(1):186-92.PMID: 8380963 [PubMed - indexed for MEDLINE]Related articles

Nuclear factors AF-1 and C/EBP bind to the human ApoB gene promoter and modulate its transcriptional activity in hepatic cells.

Metzger S, Leff T, Breslow JL.

J Biol Chem. 1990 Jun 15;265(17):9978-83.PMID: 2161847 [PubMed - indexed for MEDLINE]Related articlesFree article

A regulatory element in the ApoCIII promoter that directs hepatic specific transcription binds to proteins in expressing and nonexpressing cell types.

Leff T, Reue K, Melian A, Culver H, Breslow JL.

J Biol Chem. 1989 Sep 25;264(27):16132-7.PMID: 2777781 [PubMed - indexed for MEDLINE]Related articlesFree article

Studies of heterologous promoter trans-activation by the HTLV-II tax protein.

Williams JL, Cann AJ, Leff T, Sassone-Corsi P, Chen IS.

Nucleic Acids Res. 1989 Jul 25;17(14):5737-49.PMID: 2527355 [PubMed - indexed for MEDLINE]Related articlesFree article

Cell type-specific expression of the human apoB gene is controlled by two cis-acting regulatory regions.

Das HK, Leff T, Breslow JL.

J Biol Chem. 1988 Aug 15;263(23):11452-8.PMID: 3165376 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of the human apolipoprotein E gene is regulated by multiple positive and negative elements.

Smith JD, Melián A, Leff T, Breslow JL.

J Biol Chem. 1988 Jun 15;263(17):8300-8.PMID: 3372525 [PubMed - indexed for MEDLINE]Related articlesFree article

Human apolipoprotein CIII gene expression is regulated by positive and negative cis-acting elements and tissue-specific protein factors.

Reue K, Leff T, Breslow JL.

J Biol Chem. 1988 May 15;263(14):6857-64.PMID: 2834395 [PubMed - indexed for MEDLINE]Related articlesFree article

The human apolipoprotein C-II gene sequence contains a novel chromosome 19-specific minisatellite in its third intron.

Das HK, Jackson CL, Miller DA, Leff T, Breslow JL.

J Biol Chem. 1987 Apr 5;262(10):4787-93.PMID: 3558370 [PubMed - indexed for MEDLINE]Related articlesFree article

Sequence-specific activation of transcription by adenovirus EIa products is observed in HeLa cells but not in 293 cells.

Leff T, Chambon P.

Mol Cell Biol. 1986 Jan;6(1):201-8.PMID: 2946930 [PubMed - indexed for MEDLINE]Related articlesFree article

Transcriptional analysis of the adenovirus-5 EIII promoter: absence of sequence specificity for stimulation by EIa gene products.

Leff T, Corden J, Elkaim R, Sassone-Corsi P.

Nucleic Acids Res. 1985 Feb 25;13(4):1209-21.PMID: 4000937 [PubMed - indexed for MEDLINE]Related articlesFree article

Individual products of the adenovirus 12S and 13S EIa mRNAs stimulate viral EIIa and EIII expression at the transcriptional level.

Leff T, Elkaim R, Goding CR, Jalinot P, Sassone-Corsi P, Perricaudet M, Kédinger C, Chambon P.

Proc Natl Acad Sci U S A. 1984 Jul;81(14):4381-5.PMID: 6336330 [PubMed - indexed for MEDLINE]Related articlesFree article

Far upstream sequences are required for efficient transcription from the adenovirus-2 E1A transcription unit.

Sassone-Corsi P, Hen R, Borrelli E, Leff T, Chambon P.

Nucleic Acids Res. 1983 Dec 20;11(24):8735-45.PMID: 6324098 [PubMed - indexed for MEDLINE]Related articlesFree article