PubMed

Nitrate and nitrite in biology, nutrition and therapeutics.

Lundberg JO, Gladwin MT, Ahluwalia A, Benjamin N, Bryan NS, Butler A, Cabrales P, Fago A, Feelisch M, Ford PC, Freeman BA, Frenneaux M, Friedman J, Kelm M, Kevil CG, Kim-Shapiro DB, Kozlov AV, Lancaster JR Jr, Lefer DJ, McColl K, McCurry K, Patel RP, Petersson J, Rassaf T, Reutov VP, Richter-Addo GB, Schechter A, Shiva S, Tsuchiya K, van Faassen EE, Webb AJ, Zuckerbraun BS, Zweier JL, Weitzberg E.

Nat Chem Biol. 2009 Dec;5(12):865-9.PMID: 19915529 [PubMed - in process]Related articles

Clinical translation of nitrite therapy for cardiovascular diseases.

Calvert JW, Lefer DJ.

Nitric Oxide. 2009 Nov 10. [Epub ahead of print]PMID: 19909823 [PubMed - as supplied by publisher]Related articles

Emerging role of nitrite in myocardial protection.

Lefer DJ.

Arch Pharm Res. 2009 Aug;32(8):1127-38. Epub 2009 Aug 29. Review.PMID: 19727605 [PubMed - indexed for MEDLINE]Related articles

Hydrogen sulfide improves survival after cardiac arrest and cardiopulmonary resuscitation via a nitric oxide synthase 3-dependent mechanism in mice.

Minamishima S, Bougaki M, Sips PY, Yu JD, Minamishima YA, Elrod JW, Lefer DJ, Bloch KD, Ichinose F.

Circulation. 2009 Sep 8;120(10):888-96. Epub 2009 Aug 24.PMID: 19704099 [PubMed - indexed for MEDLINE]Related articles

Hydrogen sulfide mediates cardioprotection through Nrf2 signaling.

Calvert JW, Jha S, Gundewar S, Elrod JW, Ramachandran A, Pattillo CB, Kevil CG, Lefer DJ.

Circ Res. 2009 Aug 14;105(4):365-74. Epub 2009 Jul 16.PMID: 19608979 [PubMed - indexed for MEDLINE]Related articles

Sulfonylurea receptor 1 subunits of ATP-sensitive potassium channels and myocardial ischemia/reperfusion injury.

Lefer DJ, Nichols CG, Coetzee WA.

Trends Cardiovasc Med. 2009 Feb;19(2):61-7. Review.PMID: 19577714 [PubMed - indexed for MEDLINE]Related articles

Protective ischaemia in patients: preconditioning and postconditioning.

Granfeldt A, Lefer DJ, Vinten-Johansen J.

Cardiovasc Res. 2009 Jul 15;83(2):234-46. Epub 2009 Apr 27. Review.PMID: 19398470 [PubMed - indexed for MEDLINE]Related articles

Developmental programming resulting from maternal obesity in mice: effects on myocardial ischaemia-reperfusion injury.

Calvert JW, Lefer DJ, Gundewar S, Poston L, Coetzee WA.

Exp Physiol. 2009 Jul;94(7):805-14. Epub 2009 Apr 24.PMID: 19395658 [PubMed - indexed for MEDLINE]Related articles

Myocardial protection by nitrite.

Calvert JW, Lefer DJ.

Cardiovasc Res. 2009 Jul 15;83(2):195-203. Epub 2009 Feb 27. Review.PMID: 19251721 [PubMed - indexed for MEDLINE]Related articles

Activation of AMP-activated protein kinase by metformin improves left ventricular function and survival in heart failure.

Gundewar S, Calvert JW, Jha S, Toedt-Pingel I, Ji SY, Nunez D, Ramachandran A, Anaya-Cisneros M, Tian R, Lefer DJ.

Circ Res. 2009 Feb 13;104(3):403-11. Epub 2008 Dec 18.PMID: 19096023 [PubMed - indexed for MEDLINE]Related articles

Differential structure of atrial and ventricular KATP: atrial KATP channels require SUR1.

Flagg TP, Kurata HT, Masia R, Caputa G, Magnuson MA, Lefer DJ, Coetzee WA, Nichols CG.

Circ Res. 2008 Dec 5;103(12):1458-65. Epub 2008 Oct 30.PMID: 18974387 [PubMed - indexed for MEDLINE]Related articles

Potential importance of alterations in hydrogen sulphide (H2S) bioavailability in diabetes.

Lefer DJ.

Br J Pharmacol. 2008 Nov;155(5):617-9. Epub 2008 Sep 22. Erratum in: Br J Pharmacol. 2008 Dec;155(8):1308. PMID: 18806820 [PubMed - indexed for MEDLINE]Related articlesFree article

REVIEW paper: pathophysiology of myocardial reperfusion injury: the role of genetically engineered mouse models.

Ramachandran A, Jha S, Lefer DJ.

Vet Pathol. 2008 Sep;45(5):698-706. Review.PMID: 18725477 [PubMed - indexed for MEDLINE]Related articlesFree article

Nitric oxide promotes distant organ protection: evidence for an endocrine role of nitric oxide.

Elrod JW, Calvert JW, Gundewar S, Bryan NS, Lefer DJ.

Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11430-5. Epub 2008 Aug 6.PMID: 18685092 [PubMed - indexed for MEDLINE]Related articlesFree article

Hydrogen sulfide attenuates hepatic ischemia-reperfusion injury: role of antioxidant and antiapoptotic signaling.

Jha S, Calvert JW, Duranski MR, Ramachandran A, Lefer DJ.

Am J Physiol Heart Circ Physiol. 2008 Aug;295(2):H801-6. Epub 2008 Jun 20.PMID: 18567706 [PubMed - indexed for MEDLINE]Related articlesFree article

Chronic sodium nitrite therapy augments ischemia-induced angiogenesis and arteriogenesis.

Kumar D, Branch BG, Pattillo CB, Hood J, Thoma S, Simpson S, Illum S, Arora N, Chidlow JH Jr, Langston W, Teng X, Lefer DJ, Patel RP, Kevil CG.

Proc Natl Acad Sci U S A. 2008 May 27;105(21):7540-5. Epub 2008 May 27.PMID: 18508974 [PubMed - indexed for MEDLINE]Related articlesFree article

Dietary nitrite restores NO homeostasis and is cardioprotective in endothelial nitric oxide synthase-deficient mice.

Bryan NS, Calvert JW, Gundewar S, Lefer DJ.

Free Radic Biol Med. 2008 Aug 15;45(4):468-74. Epub 2008 May 5.PMID: 18501719 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of sulfonylurea receptor type 1 subunits of ATP-sensitive potassium channels in myocardial ischemia/reperfusion injury.

Elrod JW, Harrell M, Flagg TP, Gundewar S, Magnuson MA, Nichols CG, Coetzee WA, Lefer DJ.

Circulation. 2008 Mar 18;117(11):1405-13. Epub 2008 Mar 3. Erratum in: Circulation.2008 May 6;117(18):e332. PMID: 18316485 [PubMed - indexed for MEDLINE]Related articlesFree article

Acute metformin therapy confers cardioprotection against myocardial infarction via AMPK-eNOS-mediated signaling.

Calvert JW, Gundewar S, Jha S, Greer JJ, Bestermann WH, Tian R, Lefer DJ.

Diabetes. 2008 Mar;57(3):696-705. Epub 2007 Dec 14.PMID: 18083782 [PubMed - indexed for MEDLINE]Related articlesFree article

Dietary nitrite supplementation protects against myocardial ischemia-reperfusion injury.

Bryan NS, Calvert JW, Elrod JW, Gundewar S, Ji SY, Lefer DJ.

Proc Natl Acad Sci U S A. 2007 Nov 27;104(48):19144-9. Epub 2007 Nov 19.PMID: 18025468 [PubMed - indexed for MEDLINE]Related articlesFree article

Thrombopoietin emerges as a new haematopoietic cytokine that confers cardioprotection against acute myocardial infarction.

Calvert JW, Lefer DJ.

Cardiovasc Res. 2008 Jan;77(1):2-3. Epub 2007 Nov 10. No abstract available. PMID: 18006435 [PubMed - indexed for MEDLINE]Related articlesFree article

A new gaseous signaling molecule emerges: cardioprotective role of hydrogen sulfide.

Lefer DJ.

Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):17907-8. Epub 2007 Nov 8. No abstract available. PMID: 17991773 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of N-ethylmaleimide-sensitive factor protects against myocardial ischemia/reperfusion injury.

Calvert JW, Gundewar S, Yamakuchi M, Park PC, Baldwin WM 3rd, Lefer DJ, Lowenstein CJ.

Circ Res. 2007 Dec 7;101(12):1247-54. Epub 2007 Oct 11.PMID: 17932325 [PubMed - indexed for MEDLINE]Related articlesFree article

Sphingolipid therapy in myocardial ischemia-reperfusion injury.

Gundewar S, Lefer DJ.

Biochim Biophys Acta. 2008 Mar;1780(3):571-6. Epub 2007 Sep 6. Review.PMID: 17928150 [PubMed - indexed for MEDLINE]Related articlesFree article

Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function.

Elrod JW, Calvert JW, Morrison J, Doeller JE, Kraus DW, Tao L, Jiao X, Scalia R, Kiss L, Szabo C, Kimura H, Chow CW, Lefer DJ.

Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15560-5. Epub 2007 Sep 18.PMID: 17878306 [PubMed - indexed for MEDLINE]Related articlesFree article

Nitrite augments tolerance to ischemia/reperfusion injury via the modulation of mitochondrial electron transfer.

Shiva S, Sack MN, Greer JJ, Duranski M, Ringwood LA, Burwell L, Wang X, MacArthur PH, Shoja A, Raghavachari N, Calvert JW, Brookes PS, Lefer DJ, Gladwin MT.

J Exp Med. 2007 Sep 3;204(9):2089-102. Epub 2007 Aug 6.PMID: 17682069 [PubMed - indexed for MEDLINE]Related articlesFree article

Cytoprotective effects of N,N,N-trimethylsphingosine during ischemia- reperfusion injury are lost in the setting of obesity and diabetes.

Gundewar S, Calvert JW, Elrod JW, Lefer DJ.

Am J Physiol Heart Circ Physiol. 2007 Oct;293(4):H2462-71. Epub 2007 Jul 13.PMID: 17630348 [PubMed - indexed for MEDLINE]Related articlesFree article

Sildenafil promotes ischemia-induced angiogenesis through a PKG-dependent pathway.

Senthilkumar A, Smith RD, Khitha J, Arora N, Veerareddy S, Langston W, Chidlow JH Jr, Barlow SC, Teng X, Patel RP, Lefer DJ, Kevil CG.

Arterioscler Thromb Vasc Biol. 2007 Sep;27(9):1947-54. Epub 2007 Jun 21.PMID: 17585066 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of endothelial glutathione by ICAM-1 governs VEGF-A-mediated eNOS activity and angiogenesis.

Langston W, Chidlow JH Jr, Booth BA, Barlow SC, Lefer DJ, Patel RP, Kevil CG.

Free Radic Biol Med. 2007 Mar 1;42(5):720-9. Epub 2006 Dec 16.PMID: 17291995 [PubMed - indexed for MEDLINE]Related articlesFree article

The apoptosis inhibitor ARC undergoes ubiquitin-proteasomal-mediated degradation in response to death stimuli: identification of a degradation-resistant mutant.

Nam YJ, Mani K, Wu L, Peng CF, Calvert JW, Foo RS, Krishnamurthy B, Miao W, Ashton AW, Lefer DJ, Kitsis RN.

J Biol Chem. 2007 Feb 23;282(8):5522-8. Epub 2006 Dec 1.PMID: 17142452 [PubMed - indexed for MEDLINE]Related articlesFree article

Sildenafil-mediated acute cardioprotection is independent of the NO/cGMP pathway.

Elrod JW, Greer JJ, Lefer DJ.

Am J Physiol Heart Circ Physiol. 2007 Jan;292(1):H342-7. Epub 2006 Sep 1.PMID: 16951048 [PubMed - indexed for MEDLINE]Related articlesFree article

Statin therapy and myocardial no-reflow.

Calvert JW, Lefer DJ.

Br J Pharmacol. 2006 Oct;149(3):229-31. Epub 2006 Aug 21.PMID: 16921390 [PubMed - indexed for MEDLINE]Related articlesFree article

Simvastatin treatment ameliorates autoimmune disease associated with accelerated atherosclerosis in a murine lupus model.

Aprahamian T, Bonegio R, Rizzo J, Perlman H, Lefer DJ, Rifkin IR, Walsh K.

J Immunol. 2006 Sep 1;177(5):3028-34.PMID: 16920939 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic overexpression of eNOS attenuates hepatic ischemia-reperfusion injury.

Duranski MR, Elrod JW, Calvert JW, Bryan NS, Feelisch M, Lefer DJ.

Am J Physiol Heart Circ Physiol. 2006 Dec;291(6):H2980-6. Epub 2006 Jul 28.PMID: 16877550 [PubMed - indexed for MEDLINE]Related articlesFree article

Low-dose simvastatin improves survival and ventricular function via eNOS in congestive heart failure.

Greer JJ, Kakkar AK, Elrod JW, Watson LJ, Jones SP, Lefer DJ.

Am J Physiol Heart Circ Physiol. 2006 Dec;291(6):H2743-51. Epub 2006 Jul 14.PMID: 16844920 [PubMed - indexed for MEDLINE]Related articlesFree article

eNOS gene therapy exacerbates hepatic ischemia-reperfusion injury in diabetes: a role for eNOS uncoupling.

Elrod JW, Duranski MR, Langston W, Greer JJ, Tao L, Dugas TR, Kevil CG, Champion HC, Lefer DJ.

Circ Res. 2006 Jul 7;99(1):78-85. Epub 2006 Jun 8.PMID: 16763164 [PubMed - indexed for MEDLINE]Related articlesFree article

Cardiomyocyte-specific overexpression of NO synthase-3 protects against myocardial ischemia-reperfusion injury.

Elrod JW, Greer JJ, Bryan NS, Langston W, Szot JF, Gebregzlabher H, Janssens S, Feelisch M, Lefer DJ.

Arterioscler Thromb Vasc Biol. 2006 Jul;26(7):1517-23. Epub 2006 Apr 27.PMID: 16645153 [PubMed - indexed for MEDLINE]Related articlesFree article

Critical role of endothelial cell-derived nitric oxide synthase in sickle cell disease-induced microvascular dysfunction.

Wood KC, Hebbel RP, Lefer DJ, Granger DN.

Free Radic Biol Med. 2006 Apr 15;40(8):1443-53. Epub 2006 Jan 17.PMID: 16631534 [PubMed - indexed for MEDLINE]Related articles

Nitrite therapy for protection against ischemia-reperfusion injury.

Lefer DJ.

Am J Physiol Renal Physiol. 2006 Apr;290(4):F777-8. No abstract available. PMID: 16527923 [PubMed - indexed for MEDLINE]Related articlesFree article

Induction of HIF-1alpha and iNOS with siRNA: a novel mechanism for myocardial protection.

Lefer DJ.

Circ Res. 2006 Jan 6;98(1):10-1. No abstract available. PMID: 16397152 [PubMed - indexed for MEDLINE]Related articlesFree article

Myocardial infarction and heart failure in the db/db diabetic mouse.

Greer JJ, Ware DP, Lefer DJ.

Am J Physiol Heart Circ Physiol. 2006 Jan;290(1):H146-53. Epub 2005 Aug 19.PMID: 16113078 [PubMed - indexed for MEDLINE]Related articlesFree article

Colonic blood flow responses in experimental colitis: time course and underlying mechanisms.

Mori M, Stokes KY, Vowinkel T, Watanabe N, Elrod JW, Harris NR, Lefer DJ, Hibi T, Granger DN.

Am J Physiol Gastrointest Liver Physiol. 2005 Dec;289(6):G1024-9. Epub 2005 Aug 4.PMID: 16081759 [PubMed - indexed for MEDLINE]Related articlesFree article

The effects of statins on endothelium, inflammation and cardioprotection.

Elrod JW, Lefer DJ.

Drug News Perspect. 2005 May;18(4):229-36. Review.PMID: 16034478 [PubMed - indexed for MEDLINE]Related articles

Cardioprotection before revascularization in ischemic myocardial injury and the potential role of hemoglobin-based oxygen carriers.

Burkhoff D, Lefer DJ.

Am Heart J. 2005 Apr;149(4):573-9. Review.PMID: 15990736 [PubMed - indexed for MEDLINE]Related articles

Statin mediated protection of the ischemic myocardium.

Wright DG, Lefer DJ.

Vascul Pharmacol. 2005 Apr-May;42(5-6):265-70. Epub 2005 Mar 23. Review.PMID: 15922259 [PubMed - indexed for MEDLINE]Related articles

HMG-CoA reductase inhibitors inhibit endothelial exocytosis and decrease myocardial infarct size.

Yamakuchi M, Greer JJ, Cameron SJ, Matsushita K, Morrell CN, Talbot-Fox K, Baldwin WM 3rd, Lefer DJ, Lowenstein CJ.

Circ Res. 2005 Jun 10;96(11):1185-92. Epub 2005 May 19. Erratum in: Circ Res. 2005 Jul 8;97(1):e6. PMID: 15905463 [PubMed - indexed for MEDLINE]Related articlesFree article

Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver.

Duranski MR, Greer JJ, Dejam A, Jaganmohan S, Hogg N, Langston W, Patel RP, Yet SF, Wang X, Kevil CG, Gladwin MT, Lefer DJ.

J Clin Invest. 2005 May;115(5):1232-40. Epub 2005 Apr 14.PMID: 15841216 [PubMed - indexed for MEDLINE]Related articlesFree article

A novel hemoglobin-based blood substitute protects against myocardial reperfusion injury.

Caswell JE, Strange MB, Rimmer DM 3rd, Gibson MF, Cole P, Lefer DJ.

Am J Physiol Heart Circ Physiol. 2005 Apr;288(4):H1796-801.PMID: 15772335 [PubMed - indexed for MEDLINE]Related articlesFree article

Deficiency of iNOS does not attenuate severe congestive heart failure in mice.

Jones SP, Greer JJ, Ware PD, Yang J, Walsh K, Lefer DJ.

Am J Physiol Heart Circ Physiol. 2005 Jan;288(1):H365-70. Epub 2004 Aug 19.PMID: 15319210 [PubMed - indexed for MEDLINE]Related articlesFree article

Control of myocardial oxygen consumption in transgenic mice overexpressing vascular eNOS.

Walsh EK, Huang H, Wang Z, Williams J, de Crom R, van Haperen R, Thompson CI, Lefer DJ, Hintze TH.

Am J Physiol Heart Circ Physiol. 2004 Nov;287(5):H2115-21. Epub 2004 Jul 29.PMID: 15284070 [PubMed - indexed for MEDLINE]Related articlesFree article