PubMed

Helicobacter pylori Stimulates Dendritic Cells to Induce IL-17 Expression From CD4+ T lymphocytes.

Khamri W, Walker MM, Clark P, Atherton JC, Thursz MR, Bamford KB, Lechler RI, Lombardi G.

Infect Immun. 2009 Nov 16. [Epub ahead of print]PMID: 19917709 [PubMed - as supplied by publisher]Related articles

Translational Mini-Review Series on Th17 Cells: Induction of interleukin-17 production by regulatory T cells.

Afzali B, Mitchell P, Lechler RI, John S, Lombardi G.

Clin Exp Immunol. 2009 Nov 11. [Epub ahead of print]PMID: 19912251 [PubMed - as supplied by publisher]Related articles

Regulation of rat and human T-cell immune response by pharmacologically modified dendritic cells.

Fazekasova H, Golshayan D, Read J, Tsallios A, Tsang JY, Dorling A, George AJ, Lechler RI, Lombardi G, Mirenda V.

Transplantation. 2009 Jun 15;87(11):1617-28.PMID: 19502952 [PubMed - indexed for MEDLINE]Related articles

Towards the identification of biomarkers of transplantation tolerance.

Turka LA, Lechler RI.

Nat Rev Immunol. 2009 Jul;9(7):521-6.PMID: 19483711 [PubMed - indexed for MEDLINE]Related articles

The T helper 17-regulatory T cell axis in transplant rejection and tolerance.

Mitchell P, Afzali B, Lombardi G, Lechler RI.

Curr Opin Organ Transplant. 2009 Aug;14(4):326-31. Review.PMID: 19448538 [PubMed - indexed for MEDLINE]Related articles

Transplantation tolerance induced by regulatory T cells: in vivo mechanisms and sites of action.

Golshayan D, Wyss JC, Abulker CW, Schaefer SC, Lechler RI, Lehr HA, Pascual M.

Int Immunopharmacol. 2009 Jun;9(6):683-8. Epub 2009 Jan 9.PMID: 19136078 [PubMed - indexed for MEDLINE]Related articles

Regulatory T cells as therapeutic cells.

Sagoo P, Lombardi G, Lechler RI.

Curr Opin Organ Transplant. 2008 Dec;13(6):645-53. Review.PMID: 19060557 [PubMed - indexed for MEDLINE]Related articles

Pathways of major histocompatibility complex allorecognition.

Afzali B, Lombardi G, Lechler RI.

Curr Opin Organ Transplant. 2008 Aug;13(4):438-44.PMID: 18685342 [PubMed - in process]Related articles

The importance of the indirect pathway of allorecognition in clinical transplantation.

Gökmen MR, Lombardi G, Lechler RI.

Curr Opin Immunol. 2008 Oct;20(5):568-74. Epub 2008 Aug 4. Review.PMID: 18655831 [PubMed - indexed for MEDLINE]Related articles

Retrospective tissue typing of the kidney donor from recipient urine.

Srikantha M, Sergeant R, Khan T, Lechler RI, Davey N, Hernandez-Fuentes MP, Warrens AN.

Kidney Int. 2008 Oct;74(7):952-5. Epub 2008 Jul 16.PMID: 18633344 [PubMed - indexed for MEDLINE]Related articles

A pig allograft model of antibody-mediated rejection.

Herbert PE, Morgan MF, Berton I, Lechler RI, Dorling A, Williams G, Warrens AN.

Transpl Immunol. 2008 Jul;19(3-4):167-72. Epub 2008 Jun 18.PMID: 18621532 [PubMed - indexed for MEDLINE]Related articles

Protease-activated receptor 1 activation is necessary for monocyte chemoattractant protein 1-dependent leukocyte recruitment in vivo.

Chen D, Carpenter A, Abrahams J, Chambers RC, Lechler RI, McVey JH, Dorling A.

J Exp Med. 2008 Aug 4;205(8):1739-46. Epub 2008 Jul 7.PMID: 18606855 [PubMed - indexed for MEDLINE]Related articlesFree article

Natural regulatory T cells: number and function are normal in the majority of patients with lupus nephritis.

Yates J, Whittington A, Mitchell P, Lechler RI, Lightstone L, Lombardi G.

Clin Exp Immunol. 2008 Jul;153(1):44-55. Epub 2008 May 23.PMID: 18505436 [PubMed - indexed for MEDLINE]Related articlesFree article

Expansion of hepatitis C-specific CD4+CD25+ regulatory T cells after viral clearance: a mechanism to limit collateral damage?

Godkin A, Ng WF, Gallagher K, Betts G, Thomas HC, Lechler RI.

J Allergy Clin Immunol. 2008 May;121(5):1277-1284.e3. Epub 2008 Mar 19.PMID: 18355912 [PubMed - indexed for MEDLINE]Related articles

Regenerative repair after endoluminal injury in mice with specific antagonism of protease activated receptors on CD34+ vascular progenitors.

Chen D, Abrahams JM, Smith LM, McVey JH, Lechler RI, Dorling A.

Blood. 2008 Apr 15;111(8):4155-64. Epub 2008 Feb 11.PMID: 18268094 [PubMed - indexed for MEDLINE]Related articlesFree article

The maintenance of human CD4+ CD25+ regulatory T cell function: IL-2, IL-4, IL-7 and IL-15 preserve optimal suppressive potency in vitro.

Yates J, Rovis F, Mitchell P, Afzali B, Tsang JY, Garin M, Lechler RI, Lombardi G, Garden OA.

Int Immunol. 2007 Jun;19(6):785-99. Epub 2007 Jun 1.PMID: 17545278 [PubMed - indexed for MEDLINE]Related articlesFree article

Intercellular transfer of MHC and immunological molecules: molecular mechanisms and biological significance.

Smyth LA, Afzali B, Tsang J, Lombardi G, Lechler RI.

Am J Transplant. 2007 Jun;7(6):1442-9. Review.PMID: 17511673 [PubMed - indexed for MEDLINE]Related articles

Allorecognition and the alloresponse: clinical implications.

Afzali B, Lechler RI, Hernandez-Fuentes MP.

Tissue Antigens. 2007 Jun;69(6):545-56. Review.PMID: 17498264 [PubMed - indexed for MEDLINE]Related articles

Induction of tumor-specific T-cell responses by vaccination with tumor lysate-loaded dendritic cells in colorectal cancer patients with carcinoembryonic-antigen positive tumors.

Tamir A, Basagila E, Kagahzian A, Jiao L, Jensen S, Nicholls J, Tate P, Stamp G, Farzaneh F, Harrison P, Stauss H, George AJ, Habib N, Lechler RI, Lombardi G.

Cancer Immunol Immunother. 2007 Dec;56(12):2003-16. Epub 2007 Feb 23.PMID: 17333181 [PubMed - indexed for MEDLINE]Related articles

The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease.

Afzali B, Lombardi G, Lechler RI, Lord GM.

Clin Exp Immunol. 2007 Apr;148(1):32-46. Review.PMID: 17328715 [PubMed - indexed for MEDLINE]Related articlesFree article

Generation and expansion of human CD4+ CD25+ regulatory T cells with indirect allospecificity: Potential reagents to promote donor-specific transplantation tolerance.

Jiang S, Tsang J, Game DS, Stevenson S, Lombardi G, Lechler RI.

Transplantation. 2006 Dec 27;82(12):1738-43.PMID: 17198269 [PubMed - indexed for MEDLINE]Related articles

From current immunosuppressive strategies to clinical tolerance of allografts.

Golshayan D, Buhler L, Lechler RI, Pascual M.

Transpl Int. 2007 Jan;20(1):12-24. Review.PMID: 17181648 [PubMed - indexed for MEDLINE]Related articles

Adoptive cell therapy using in vitro generated human CD4+ CD25+ regulatory t cells with indirect allospecificity to promote donor-specific transplantation tolerance.

Jiang S, Tsang J, Lechler RI.

Transplant Proc. 2006 Dec;38(10):3199-201.PMID: 17175221 [PubMed - indexed for MEDLINE]Related articles

CD4+CD25+ regulatory T-cell therapy for allergy, autoimmune disease and transplant rejection.

Jiang S, Lechler RI.

Inflamm Allergy Drug Targets. 2006 Dec;5(4):239-42. Review.PMID: 17168794 [PubMed - indexed for MEDLINE]Related articles

In-vitro generation and characterisation of murine CD4+CD25+ regulatory T cells with indirect allospecificity.

Tsang J, Jiang S, Tanriver Y, Leung E, Lombardi G, Lechler RI.

Int Immunopharmacol. 2006 Dec 20;6(13-14):1883-8. Epub 2006 Sep 1.PMID: 17161341 [PubMed - indexed for MEDLINE]Related articles

In vitro expanded alloantigen-specific CD4+CD25+ regulatory T cell treatment for the induction of donor-specific transplantation tolerance.

Jiang S, Golshayan D, Tsang J, Lombardi G, Lechler RI.

Int Immunopharmacol. 2006 Dec 20;6(13-14):1879-82. Epub 2006 Aug 15.PMID: 17161340 [PubMed - indexed for MEDLINE]Related articles

Knockdown of mouse VCAM-1 by vector-based siRNA.

Alam AK, Florey O, Weber M, Pillai RG, Chan C, Tan PH, Lechler RI, McClure MO, Haskard DO, George AJ.

Transpl Immunol. 2006 Nov;16(3-4):185-93. Epub 2006 Sep 1.PMID: 17138052 [PubMed - indexed for MEDLINE]Related articles

Physiologic and aberrant regulation of memory T-cell trafficking by the costimulatory molecule CD28.

Mirenda V, Jarmin SJ, David R, Dyson J, Scott D, Gu Y, Lechler RI, Okkenhaug K, Marelli-Berg FM.

Blood. 2007 Apr 1;109(7):2968-77.PMID: 17119120 [PubMed - indexed for MEDLINE]Related articlesFree article

Galectin-1: a key effector of regulation mediated by CD4+CD25+ T cells.

Garín MI, Chu CC, Golshayan D, Cernuda-Morollón E, Wait R, Lechler RI.

Blood. 2007 Mar 1;109(5):2058-65. Epub 2006 Nov 16.PMID: 17110462 [PubMed - indexed for MEDLINE]Related articlesFree article

Chronic exposure to Helicobacter pylori impairs dendritic cell function and inhibits Th1 development.

Mitchell P, Germain C, Fiori PL, Khamri W, Foster GR, Ghosh S, Lechler RI, Bamford KB, Lombardi G.

Infect Immun. 2007 Feb;75(2):810-9. Epub 2006 Nov 13.PMID: 17101659 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential effects of immunosuppressive drugs on T-cell motility.

Datta A, David R, Glennie S, Scott D, Cernuda-Morollon E, Lechler RI, Ridley AJ, Marelli-Berg FM.

Am J Transplant. 2006 Dec;6(12):2871-83.PMID: 17061998 [PubMed - indexed for MEDLINE]Related articles

Regulatory T cells and transplantation tolerance.

Jiang S, Lechler RI, He XS, Huang JF.

Hum Immunol. 2006 Oct;67(10):765-76. Epub 2006 Aug 24. Review.PMID: 17055353 [PubMed - indexed for MEDLINE]Related articles

In vitro-expanded donor alloantigen-specific CD4+CD25+ regulatory T cells promote experimental transplantation tolerance.

Golshayan D, Jiang S, Tsang J, Garin MI, Mottet C, Lechler RI.

Blood. 2007 Jan 15;109(2):827-35. Epub 2006 Sep 26.PMID: 17003369 [PubMed - indexed for MEDLINE]Related articlesFree article

CD4+CD25+ regulatory T cell therapy for the induction of donor-specific clinical transplantation tolerance.

Jiang S, Lechler RI, He XS, Huang JF.

Expert Opin Biol Ther. 2006 Oct;6(10):1003-9. Review.PMID: 16989582 [PubMed - indexed for MEDLINE]Related articles

A novel pathway of antigen presentation by dendritic and endothelial cells: Implications for allorecognition and infectious diseases.

Smyth LA, Herrera OB, Golshayan D, Lombardi G, Lechler RI.

Transplantation. 2006 Jul 15;82(1 Suppl):S15-8. Review.PMID: 16829787 [PubMed - indexed for MEDLINE]Related articles

Postinjury vascular intimal hyperplasia in mice is completely inhibited by CD34+ bone marrow-derived progenitor cells expressing membrane-tethered anticoagulant fusion proteins.

Chen D, Weber M, Shiels PG, Dong R, Webster Z, McVey JH, Kemball-Cook G, Tuddenham EG, Lechler RI, Dorling A.

J Thromb Haemost. 2006 Oct;4(10):2191-8. Epub 2006 Jun 27.PMID: 16803463 [PubMed - indexed for MEDLINE]Related articles

Role of alloantibodies in the pathogenesis of graft arteriosclerosis in cardiac transplantation.

Soleimani B, Lechler RI, Hornick PI, George AJ.

Am J Transplant. 2006 Aug;6(8):1781-5. Epub 2006 Jun 12. Review.PMID: 16771817 [PubMed - indexed for MEDLINE]Related articles

Expression of indoleamine 2,3-dioxygenase (IDO) by endothelial cells: implications for the control of alloresponses.

Beutelspacher SC, Tan PH, McClure MO, Larkin DF, Lechler RI, George AJ.

Am J Transplant. 2006 Jun;6(6):1320-30.PMID: 16686756 [PubMed - indexed for MEDLINE]Related articles

Helicobacter pylori has stimulatory effects on naive T cells.

Malfitano AM, Cahill R, Mitchell P, Frankel G, Dougan G, Bifulco M, Lombardi G, Lechler RI, Bamford KB.

Helicobacter. 2006 Feb;11(1):21-30.PMID: 16423086 [PubMed - indexed for MEDLINE]Related articles

Interferon-alpha2a is sufficient for promoting dendritic cell immunogenicity.

Tamir A, Jordan WJ, Ritter M, Habib N, Lechler RI, Foster GR, Lombardi G.

Clin Exp Immunol. 2005 Dec;142(3):471-80.PMID: 16297159 [PubMed - indexed for MEDLINE]Related articlesFree article

Arvanil inhibits T lymphocyte activation and ameliorates autoimmune encephalomyelitis.

Malfitano AM, Matarese G, Pisanti S, Grimaldi C, Laezza C, Bisogno T, Di Marzo V, Lechler RI, Bifulco M.

J Neuroimmunol. 2006 Feb;171(1-2):110-9. Epub 2005 Oct 18.PMID: 16239036 [PubMed - indexed for MEDLINE]Related articles

Distinct effects of CD86-mediated costimulation on resting versus activated human CD4+ T cells.

Rogers NJ, Game DS, Camara NO, Jackson IM, Lombardi G, Lechler RI.

Eur J Immunol. 2005 Oct;35(10):2909-19.PMID: 16180251 [PubMed - indexed for MEDLINE]Related articles

Qualitatively distinct patterns of cytokines are released by human dendritic cells in response to different pathogens.

Scott K, Manunta M, Germain C, Smith P, Jones M, Mitchell P, Dessi D, Branigan Bamford K, Lechler RI, Fiori PL, Foster GR, Lombardi G.

Immunology. 2005 Oct;116(2):245-54.PMID: 16162273 [PubMed - indexed for MEDLINE]Related articlesFree article

Creation of tolerogenic human dendritic cells via intracellular CTLA4: a novel strategy with potential in clinical immunosuppression.

Tan PH, Yates JB, Xue SA, Chan C, Jordan WJ, Harper JE, Watson MP, Dong R, Ritter MA, Lechler RI, Lombardi G, George AJ.

Blood. 2005 Nov 1;106(9):2936-43. Epub 2005 Jun 30.PMID: 15994283 [PubMed - indexed for MEDLINE]Related articlesFree article

Tolerant T cells display impaired trafficking ability.

Mirenda V, Millington O, Lechler RI, Scott D, Hernandez-Fuentes MP, Read J, Tan PH, George AJ, Garside P, Marelli-Berg FM.

Eur J Immunol. 2005 Jul;35(7):2146-56.PMID: 15948215 [PubMed - indexed for MEDLINE]Related articles

Acquisition of HLA-DR and costimulatory molecules by T cells from allogeneic antigen presenting cells.

Game DS, Rogers NJ, Lechler RI.

Am J Transplant. 2005 Jul;5(7):1614-25.PMID: 15943619 [PubMed - indexed for MEDLINE]Related articles

Organ transplantation--how much of the promise has been realized?

Lechler RI, Sykes M, Thomson AW, Turka LA.

Nat Med. 2005 Jun;11(6):605-13. Review.PMID: 15937473 [PubMed - indexed for MEDLINE]Related articles

MRL/Mp CD4+,CD25- T cells show reduced sensitivity to suppression by CD4+,CD25+ regulatory T cells in vitro: a novel defect of T cell regulation in systemic lupus erythematosus.

Monk CR, Spachidou M, Rovis F, Leung E, Botto M, Lechler RI, Garden OA.

Arthritis Rheum. 2005 Apr;52(4):1180-4.PMID: 15818683 [PubMed - indexed for MEDLINE]Related articlesFree article

Achieving permanent survival of islet xenografts by independent manipulation of direct and indirect T-cell responses.

Mirenda V, Golshayan D, Read J, Berton I, Warrens AN, Dorling A, Lechler RI.

Diabetes. 2005 Apr;54(4):1048-55.PMID: 15793243 [PubMed - indexed for MEDLINE]Related articlesFree article

Activated CD1d-restricted natural killer T cells secrete IL-2: innate help for CD4+CD25+ regulatory T cells?

Jiang S, Game DS, Davies D, Lombardi G, Lechler RI.

Eur J Immunol. 2005 Apr;35(4):1193-200.PMID: 15770696 [PubMed - indexed for MEDLINE]Related articles