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Thiazolidinediones in prediabetes and early type 2 diabetes: what can be learned about that disease's pathogenesis.

Leahy JL.

Curr Diab Rep. 2009 Jun;9(3):215-20. Review.PMID: 19490823 [PubMed - indexed for MEDLINE]Related articles

Introducing a simplified approach to insulin therapy in type 2 diabetes: a comparison of two single-dose regimens of insulin glulisine plus insulin glargine and oral antidiabetic drugs.

Lankisch MR, Ferlinz KC, Leahy JL, Scherbaum WA; Orals Plus Apidra and LANTUS (OPAL) study group.

Diabetes Obes Metab. 2008 Dec;10(12):1178-85.PMID: 19040645 [PubMed - indexed for MEDLINE]Related articles

Mary, Mary, quite contrary, how do your beta-cells fail?

Leahy JL.

Diabetes. 2008 Oct;57(10):2563-4. No abstract available. PMID: 18820211 [PubMed - indexed for MEDLINE]Related articlesFree article

In vivo and in vitro studies of a functional peroxisome proliferator-activated receptor gamma response element in the mouse pdx-1 promoter.

Gupta D, Jetton TL, Mortensen RM, Duan SZ, Peshavaria M, Leahy JL.

J Biol Chem. 2008 Nov 21;283(47):32462-70. Epub 2008 Aug 21.PMID: 18718916 [PubMed - indexed for MEDLINE]Related articles

Enhanced beta-cell mass without increased proliferation following chronic mild glucose infusion.

Jetton TL, Everill B, Lausier J, Roskens V, Habibovic A, LaRock K, Gokin A, Peshavaria M, Leahy JL.

Am J Physiol Endocrinol Metab. 2008 Apr;294(4):E679-87. Epub 2008 Jan 29.PMID: 18230696 [PubMed - indexed for MEDLINE]Related articlesFree article

Peroxisome proliferator-activated receptor-gamma regulates expression of PDX-1 and NKX6.1 in INS-1 cells.

Moibi JA, Gupta D, Jetton TL, Peshavaria M, Desai R, Leahy JL.

Diabetes. 2007 Jan;56(1):88-95.PMID: 17192469 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of pancreatic beta-cell regeneration in the normoglycemic 60% partial-pancreatectomy mouse.

Peshavaria M, Larmie BL, Lausier J, Satish B, Habibovic A, Roskens V, Larock K, Everill B, Leahy JL, Jetton TL.

Diabetes. 2006 Dec;55(12):3289-98.PMID: 17130472 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin management of diabetic patients on general medical and surgical floors.

Leahy JL.

Endocr Pract. 2006 Jul-Aug;12 Suppl 3:86-90.PMID: 16905523 [PubMed - indexed for MEDLINE]Related articles

Beta cell compensation for insulin resistance in Zucker fatty rats: increased lipolysis and fatty acid signalling.

Nolan CJ, Leahy JL, Delghingaro-Augusto V, Moibi J, Soni K, Peyot ML, Fortier M, Guay C, Lamontagne J, Barbeau A, Przybytkowski E, Joly E, Masiello P, Wang S, Mitchell GA, Prentki M.

Diabetologia. 2006 Sep;49(9):2120-30. Epub 2006 Jul 26.PMID: 16868750 [PubMed - indexed for MEDLINE]Related articles

Basal-prandial insulin therapy: Scientific concept review and application.

Leahy JL.

Am J Med Sci. 2006 Jul;332(1):24-31. Review.PMID: 16845238 [PubMed - indexed for MEDLINE]Related articles

Mechanisms of compensatory beta-cell growth in insulin-resistant rats: roles of Akt kinase.

Jetton TL, Lausier J, LaRock K, Trotman WE, Larmie B, Habibovic A, Peshavaria M, Leahy JL.

Diabetes. 2005 Aug;54(8):2294-304.PMID: 16046294 [PubMed - indexed for MEDLINE]Related articlesFree article

Pathogenesis of type 2 diabetes mellitus.

Leahy JL.

Arch Med Res. 2005 May-Jun;36(3):197-209. Review.PMID: 15925010 [PubMed - indexed for MEDLINE]Related articles

Chronic high glucose lowers pyruvate dehydrogenase activity in islets through enhanced production of long chain acyl-CoA: prevention of impaired glucose oxidation by enhanced pyruvate recycling through the malate-pyruvate shuttle.

Liu YQ, Moibi JA, Leahy JL.

J Biol Chem. 2004 Feb 27;279(9):7470-5. Epub 2003 Dec 1.PMID: 14660628 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin therapy for type 2 diabetes.

Sasali A, Leahy JL.

Curr Diab Rep. 2003 Oct;3(5):378-85. Review.PMID: 12975027 [PubMed - indexed for MEDLINE]Related articles

Is metformin cardioprotective?

Sasali A, Leahy JL.

Diabetes Care. 2003 Jan;26(1):243-4. Review. No abstract available. PMID: 12502689 [PubMed - indexed for MEDLINE]Related articlesFree article

Characterization of a novel metabolic strategy used by drug-resistant tumor cells.

Harper ME, Antoniou A, Villalobos-Menuey E, Russo A, Trauger R, Vendemelio M, George A, Bartholomew R, Carlo D, Shaikh A, Kupperman J, Newell EW, Bespalov IA, Wallace SS, Liu Y, Rogers JR, Gibbs GL, Leahy JL, Camley RE, Melamede R, Newell MK.

FASEB J. 2002 Oct;16(12):1550-7.PMID: 12374777 [PubMed - indexed for MEDLINE]Related articlesFree article

beta-Cell adaptation to insulin resistance. Increased pyruvate carboxylase and malate-pyruvate shuttle activity in islets of nondiabetic Zucker fatty rats.

Liu YQ, Jetton TL, Leahy JL.

J Biol Chem. 2002 Oct 18;277(42):39163-8. Epub 2002 Jul 29.PMID: 12147706 [PubMed - indexed for MEDLINE]Related articlesFree article

Enhanced expression of insulin receptor substrate-2 and activation of protein kinase B/Akt in regenerating pancreatic duct epithelium of 60 %-partial pancreatectomy rats.

Jetton TL, Liu YQ, Trotman WE, Nevin PW, Sun XJ, Leahy JL.

Diabetologia. 2001 Nov;44(11):2056-65.PMID: 11719838 [PubMed - indexed for MEDLINE]Related articles

Increased islet DNA synthesis and glucose-derived lipid and amino acid production in association with beta-cell hyperproliferation in normoglycaemic 60 % pancreatectomy rats.

Liu YQ, Montanya E, Leahy JL.

Diabetologia. 2001 Aug;44(8):1026-33.PMID: 11484081 [PubMed - indexed for MEDLINE]Related articles

beta-cell adaptation in 60% pancreatectomy rats that preserves normoinsulinemia and normoglycemia.

Liu YQ, Nevin PW, Leahy JL.

Am J Physiol Endocrinol Metab. 2000 Jul;279(1):E68-73.PMID: 10893324 [PubMed - indexed for MEDLINE]Related articlesFree article

Glucose-fatty acid cycle to inhibit glucose utilization and oxidation is not operative in fatty acid-cultured islets.

Liu YQ, Tornheim K, Leahy JL.

Diabetes. 1999 Sep;48(9):1747-53.PMID: 10480604 [PubMed - indexed for MEDLINE]Related articlesFree article

Shared biochemical properties of glucotoxicity and lipotoxicity in islets decrease citrate synthase activity and increase phosphofructokinase activity.

Liu YQ, Tornheim K, Leahy JL.

Diabetes. 1998 Dec;47(12):1889-93.PMID: 9836520 [PubMed - indexed for MEDLINE]Related articlesFree article

Impaired phasic insulin and amylin secretion in diabetic rats.

Leahy JL, Fineman MS.

Am J Physiol. 1998 Sep;275(3 Pt 1):E457-62.PMID: 9725812 [PubMed - indexed for MEDLINE]Related articlesFree article

How is the insulin content regulated in nondiabetic hyperinsulinaemic, insulin resistant states? Study of spontaneously hypertensive rats.

Leahy JL, Chen C, Rhodes CJ.

Diabetologia. 1998 Jul;41(7):855-9. No abstract available. PMID: 9686930 [PubMed - indexed for MEDLINE]Related articles

Fatty acid-induced beta cell hypersensitivity to glucose. Increased phosphofructokinase activity and lowered glucose-6-phosphate content.

Liu YQ, Tornheim K, Leahy JL.

J Clin Invest. 1998 May 1;101(9):1870-5.PMID: 9576750 [PubMed - indexed for MEDLINE]Related articlesFree article

Parallel reduction of pancreas insulin content and insulin secretion in 48-h tolbutamide-infused normoglycemic rats.

Hosokawa YA, Leahy JL.

Diabetes. 1997 May;46(5):808-13.PMID: 9133548 [PubMed - indexed for MEDLINE]Related articles

Beta-cell hypersensitivity to glucose following 24-h exposure of rat islets to fatty acids.

Hosokawa H, Corkey BE, Leahy JL.

Diabetologia. 1997 Apr;40(4):392-7.PMID: 9112015 [PubMed - indexed for MEDLINE]Related articles

Mechanism of impaired glucose-potentiated insulin secretion in diabetic 90% pancreatectomy rats. Study using glucagonlike peptide-1 (7-37).

Hosokawa YA, Hosokawa H, Chen C, Leahy JL.

J Clin Invest. 1996 Jan 1;97(1):180-6.PMID: 8550831 [PubMed - indexed for MEDLINE]Related articlesFree article

Upregulated hexokinase activity in isolated islets from diabetic 90% pancreatectomized rats.

Hosokawa H, Hosokawa YA, Leahy JL.

Diabetes. 1995 Nov;44(11):1328-33.PMID: 7589832 [PubMed - indexed for MEDLINE]Related articles

Increased secretory demand rather than a defect in the proinsulin conversion mechanism causes hyperproinsulinemia in a glucose-infusion rat model of non-insulin-dependent diabetes mellitus.

Alarcón C, Leahy JL, Schuppin GT, Rhodes CJ.

J Clin Invest. 1995 Mar;95(3):1032-9.PMID: 7883951 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulatory effects of glucose on the catalytic activity and cellular content of glucokinase in the pancreatic beta cell. Study using cultured rat islets.

Chen C, Hosokawa H, Bumbalo LM, Leahy JL.

J Clin Invest. 1994 Oct;94(4):1616-20.PMID: 7929837 [PubMed - indexed for MEDLINE]Related articlesFree article

Pancreatic Reg/pancreatic stone protein (PSP) gene expression does not correlate with beta-cell growth and regeneration in rats.

Smith FE, Bonner-Weir S, Leahy JL, Laufgraben MJ, Ogawa Y, Rosen KM, Villa-Komaroff L.

Diabetologia. 1994 Oct;37(10):994-9.PMID: 7851694 [PubMed - indexed for MEDLINE]Related articles

Mechanism of compensatory hyperinsulinemia in normoglycemic insulin-resistant spontaneously hypertensive rats. Augmented enzymatic activity of glucokinase in beta-cells.

Chen C, Hosokawa H, Bumbalo LM, Leahy JL.

J Clin Invest. 1994 Jul;94(1):399-404.PMID: 8040280 [PubMed - indexed for MEDLINE]Related articlesFree article

Increased catalytic activity of glucokinase in isolated islets from hyperinsulinemic rats.

Chen C, Bumbalo L, Leahy JL.

Diabetes. 1994 May;43(5):684-9.PMID: 8168646 [PubMed - indexed for MEDLINE]Related articles

Diazoxide causes recovery of beta-cell glucose responsiveness in 90% pancreatectomized diabetic rats.

Leahy JL, Bumbalo LM, Chen C.

Diabetes. 1994 Feb;43(2):173-9.PMID: 8288040 [PubMed - indexed for MEDLINE]Related articles

Beta-cell hypersensitivity for glucose precedes loss of glucose-induced insulin secretion in 90% pancreatectomized rats.

Leahy JL, Bumbalo LM, Chen C.

Diabetologia. 1993 Dec;36(12):1238-44.PMID: 8307250 [PubMed - indexed for MEDLINE]Related articles

Diabetes genes in non-insulin-dependent diabetes mellitus.

Leahy JL, Boyd AE 3rd.

N Engl J Med. 1993 Jan 7;328(1):56-7. No abstract available. PMID: 8416271 [PubMed - indexed for MEDLINE]Related articles

Increased proinsulin/insulin ratio in pancreas extracts of hyperglycemic rats.

Leahy JL.

Diabetes. 1993 Jan;42(1):22-7.PMID: 8420818 [PubMed - indexed for MEDLINE]Related articles

Recovery of glucose-induced insulin secretion in a rat model of NIDDM is not accompanied by return of the B-cell GLUT2 glucose transporter.

Chen C, Thorens B, Bonner-Weir S, Weir GC, Leahy JL.

Diabetes. 1992 Oct;41(10):1320-7.PMID: 1397706 [PubMed - indexed for MEDLINE]Related articles

The loss of GLUT2 expression by glucose-unresponsive beta cells of db/db mice is reversible and is induced by the diabetic environment.

Thorens B, Wu YJ, Leahy JL, Weir GC.

J Clin Invest. 1992 Jul;90(1):77-85.PMID: 1634622 [PubMed - indexed for MEDLINE]Related articlesFree article

Beta-cell dysfunction induced by chronic hyperglycemia. Current ideas on mechanism of impaired glucose-induced insulin secretion.

Leahy JL, Bonner-Weir S, Weir GC.

Diabetes Care. 1992 Mar;15(3):442-55. Review.PMID: 1559411 [PubMed - indexed for MEDLINE]Related articles

Beta-cell dysfunction in hyperglycaemic rat models: recovery of glucose-induced insulin secretion with lowering of the ambient glucose level.

Leahy JL, Weir GC.

Diabetologia. 1991 Sep;34(9):640-7.PMID: 1955096 [PubMed - indexed for MEDLINE]Related articles

Relative hypersecretion of proinsulin in rat model of NIDDM.

Leahy JL, Halban PA, Weir GC.

Diabetes. 1991 Aug;40(8):985-9.PMID: 1860563 [PubMed - indexed for MEDLINE]Related articles

Natural history of beta-cell dysfunction in NIDDM.

Leahy JL.

Diabetes Care. 1990 Sep;13(9):992-1010. Review.PMID: 2226113 [PubMed - indexed for MEDLINE]Related articles

Reduced expression of the liver/beta-cell glucose transporter isoform in glucose-insensitive pancreatic beta cells of diabetic rats.

Thorens B, Weir GC, Leahy JL, Lodish HF, Bonner-Weir S.

Proc Natl Acad Sci U S A. 1990 Sep;87(17):6492-6.PMID: 2204056 [PubMed - indexed for MEDLINE]Related articlesFree article

Islet mass and function in diabetes and transplantation.

Weir GC, Bonner-Weir S, Leahy JL.

Diabetes. 1990 Apr;39(4):401-5. Review.PMID: 2108068 [PubMed - indexed for MEDLINE]Related articles

Insulin-like growth factor-I at physiological concentrations is a potent inhibitor of insulin secretion.

Leahy JL, Vandekerkhove KM.

Endocrinology. 1990 Mar;126(3):1593-8.PMID: 2407519 [PubMed - indexed for MEDLINE]Related articles

Compensatory adaption to partial pancreatectomy in the rat.

Lee HC, Bonner-Weir S, Weir GC, Leahy JL.

Endocrinology. 1989 Mar;124(3):1571-5.PMID: 2645116 [PubMed - indexed for MEDLINE]Related articles

Compensatory growth of pancreatic beta-cells in adult rats after short-term glucose infusion.

Bonner-Weir S, Deery D, Leahy JL, Weir GC.

Diabetes. 1989 Jan;38(1):49-53.PMID: 2642434 [PubMed - indexed for MEDLINE]Related articles

Minimal chronic hyperglycemia is a critical determinant of impaired insulin secretion after an incomplete pancreatectomy.

Leahy JL, Bonner-Weir S, Weir GC.

J Clin Invest. 1988 May;81(5):1407-14.PMID: 3284912 [PubMed - indexed for MEDLINE]Related articlesFree article