PubMed

Biological effects of growth hormone on carbohydrate and lipid metabolism.

Vijayakumar A, Novosyadlyy R, Wu Y, Yakar S, Leroith D.

Growth Horm IGF Res. 2009 Sep 30. [Epub ahead of print]PMID: 19800274 [PubMed - as supplied by publisher]Related articles

Pediatric endocrinology: part I. Foreword.

Leroith D.

Endocrinol Metab Clin North Am. 2009 Sep;38(3):xi-xiii. No abstract available. PMID: 19716998 [PubMed - indexed for MEDLINE]Related articles

Physical and functional interaction between polyoma virus middle T antigen and insulin and IGF-I receptors is required for oncogene activation and tumour initiation.

Novosyadlyy R, Vijayakumar A, Lann D, Fierz Y, Kurshan N, LeRoith D.

Oncogene. 2009 Oct 1;28(39):3477-86. Epub 2009 Jul 20.PMID: 19617901 [PubMed - indexed for MEDLINE]Related articles

Gender differences in metabolic disorders.

LeRoith D.

Gend Med. 2009;6 Suppl 1:1-3. No abstract available. PMID: 19318215 [PubMed - indexed for MEDLINE]Related articles

Elevated levels of insulin-like growth factor (IGF)-I in serum rescue the severe growth retardation of IGF-I null mice.

Wu Y, Sun H, Yakar S, LeRoith D.

Endocrinology. 2009 Sep;150(9):4395-403. Epub 2009 Jun 4.PMID: 19497975 [PubMed - indexed for MEDLINE]Related articles

Apolipoprotein E deficiency abrogates insulin resistance in a mouse model of type 2 diabetes mellitus.

Kawashima Y, Chen J, Sun H, Lann D, Hajjar RJ, Yakar S, Leroith D.

Diabetologia. 2009 Jul;52(7):1434-41. Epub 2009 May 13.PMID: 19436992 [PubMed - indexed for MEDLINE]Related articles

This issue of Endocrinology and Metabolism Clinics focuses on clinical and molecular advances in autoimmune endocrine conditions. Foreword.

LeRoith D.

Endocrinol Metab Clin North Am. 2009 Jun;38(2):xiii-xv. No abstract available. PMID: 19328408 [PubMed - indexed for MEDLINE]Related articles

Basic aspects and clinical applicability in the field of lipidology. Foreword.

LeRoith D.

Endocrinol Metab Clin North Am. 2009 Mar;38(1):xiii-xv. No abstract available. PMID: 19217508 [PubMed - indexed for MEDLINE]Related articles

Type 2 diabetic mice demonstrate slender long bones with increased fragility secondary to increased osteoclastogenesis.

Kawashima Y, Fritton JC, Yakar S, Epstein S, Schaffler MB, Jepsen KJ, LeRoith D.

Bone. 2009 Apr;44(4):648-55. Epub 2008 Dec 24.PMID: 19150422 [PubMed - indexed for MEDLINE]Related articles

Murine osteosarcoma primary tumour growth and metastatic progression is maintained after marked suppression of serum insulin-like growth factor I.

Hong SH, Briggs J, Newman R, Hoffman K, Mendoza A, LeRoith D, Helman L, Yakar S, Khanna C.

Int J Cancer. 2009 May 1;124(9):2042-9.PMID: 19132750 [PubMed - indexed for MEDLINE]Related articles

Rationale and strategies for early detection and management of diabetic kidney disease.

Radbill B, Murphy B, LeRoith D.

Mayo Clin Proc. 2008 Dec;83(12):1373-81. Review.PMID: 19046557 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of endocrine insulin-like growth factor-I and insulin in breast cancer.

Lann D, LeRoith D.

J Mammary Gland Biol Neoplasia. 2008 Dec;13(4):371-9. Epub 2008 Nov 22. Review.PMID: 19030972 [PubMed - indexed for MEDLINE]Related articles

Foreword. Control of feeding behavior and the peripheral metabolism by the hypothalamus.

Leroith D.

Endocrinol Metab Clin North Am. 2008 Dec;37(4):xi-xii. No abstract available. PMID: 19026931 [PubMed - indexed for MEDLINE]Related articles

Insulin-like growth factors and the brain.

LeRoith D.

Endocrinology. 2008 Dec;149(12):5951. Review. No abstract available. PMID: 19022901 [PubMed - indexed for MEDLINE]Related articles

Serum complexes of insulin-like growth factor-1 modulate skeletal integrity and carbohydrate metabolism.

Yakar S, Rosen CJ, Bouxsein ML, Sun H, Mejia W, Kawashima Y, Wu Y, Emerton K, Williams V, Jepsen K, Schaffler MB, Majeska RJ, Gavrilova O, Gutierrez M, Hwang D, Pennisi P, Frystyk J, Boisclair Y, Pintar J, Jasper H, Domene H, Cohen P, Clemmons D, LeRoith D.

FASEB J. 2009 Mar;23(3):709-19. Epub 2008 Oct 24.PMID: 18952711 [PubMed - indexed for MEDLINE]Related articles

Obesity and type 2 diabetes are associated with an increased risk of developing cancer and a worse prognosis; epidemiological and mechanistic evidence.

LeRoith D, Novosyadlyy R, Gallagher EJ, Lann D, Vijayakumar A, Yakar S.

Exp Clin Endocrinol Diabetes. 2008 Sep;116 Suppl 1:S4-6. Epub 2008 Sep 5. Review.PMID: 18777452 [PubMed - indexed for MEDLINE]Related articles

Insulin regulates glucagon-like peptide-1 secretion from the enteroendocrine L cell.

Lim GE, Huang GJ, Flora N, LeRoith D, Rhodes CJ, Brubaker PL.

Endocrinology. 2009 Feb;150(2):580-91. Epub 2008 Sep 25.PMID: 18818290 [PubMed - indexed for MEDLINE]Related articles

Insulin-like growth factor I receptor signaling is required for exercise-induced cardiac hypertrophy.

Kim J, Wende AR, Sena S, Theobald HA, Soto J, Sloan C, Wayment BE, Litwin SE, Holzenberger M, LeRoith D, Abel ED.

Mol Endocrinol. 2008 Nov;22(11):2531-43. Epub 2008 Sep 18.PMID: 18801929 [PubMed - indexed for MEDLINE]Related articlesFree article

The metabolic syndrome--from insulin resistance to obesity and diabetes.

Gallagher EJ, LeRoith D, Karnieli E.

Endocrinol Metab Clin North Am. 2008 Sep;37(3):559-79, vii. Review.PMID: 18775352 [PubMed - indexed for MEDLINE]Related articles

Endocrinology and metabolism clinics of North America. Foreword.

LeRoith D.

Endocrinol Metab Clin North Am. 2008 Sep;37(3):xiii-xvi. No abstract available. PMID: 18775350 [PubMed - indexed for MEDLINE]Related articles

Differential expression of IGF-I and insulin receptor isoforms in HPV positive and negative human cervical cancer cell lines.

Serrano ML, Sánchez-Gómez M, Bravo MM, Yakar S, LeRoith D.

Horm Metab Res. 2008 Oct;40(10):661-7. Epub 2008 Aug 18.PMID: 18711691 [PubMed - indexed for MEDLINE]Related articles

The role of insulin receptor signaling in zebrafish embryogenesis.

Toyoshima Y, Monson C, Duan C, Wu Y, Gao C, Yakar S, Sadler KC, LeRoith D.

Endocrinology. 2008 Dec;149(12):5996-6005. Epub 2008 Aug 7.PMID: 18687786 [PubMed - indexed for MEDLINE]Related articles

Clinical relevance of systemic and local IGF-I: lessons from animal models.

LeRoith D.

Pediatr Endocrinol Rev. 2008 Feb;5 Suppl 2:739-43. Review.PMID: 18317445 [PubMed - indexed for MEDLINE]Related articles

The articles cover all of the aspects from a basic and practical point of view. Foreword.

LeRoith D.

Endocrinol Metab Clin North Am. 2008 Jun;37(2):xiii-xv. No abstract available. PMID: 18502326 [PubMed - indexed for MEDLINE]Related articles

Insulin resistance and the metabolic syndrome.

Lann D, Gallagher E, Leroith D.

Minerva Med. 2008 Jun;99(3):253-62. Review.PMID: 18497723 [PubMed - indexed for MEDLINE]Related articles

Diabetes and fragility fractures - a burgeoning epidemic?

Epstein S, Leroith D.

Bone. 2008 Jul;43(1):3-6. Epub 2008 Apr 8.PMID: 18486581 [PubMed - indexed for MEDLINE]Related articles

Reduced susceptibility to two-stage skin carcinogenesis in mice with low circulating insulin-like growth factor I levels.

Moore T, Carbajal S, Beltran L, Perkins SN, Yakar S, Leroith D, Hursting SD, Digiovanni J.

Cancer Res. 2008 May 15;68(10):3680-8.PMID: 18483250 [PubMed - indexed for MEDLINE]Related articlesFree article

Dyslipidemia and glucose dysregulation in overweight and obese patients.

LeRoith D.

Clin Cornerstone. 2007;8(3):38-52. Review.PMID: 18452841 [PubMed - indexed for MEDLINE]Related articles

Targeted deletion of hepatic Igf1 in TRAMP mice leads to dramatic alterations in the circulating insulin-like growth factor axis but does not reduce tumor progression.

Anzo M, Cobb LJ, Hwang DL, Mehta H, Said JW, Yakar S, LeRoith D, Cohen P.

Cancer Res. 2008 May 1;68(9):3342-9.PMID: 18451161 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-like growth factor-I protects cells from ER stress-induced apoptosis via enhancement of the adaptive capacity of endoplasmic reticulum.

Novosyadlyy R, Kurshan N, Lann D, Vijayakumar A, Yakar S, LeRoith D.

Cell Death Differ. 2008 Aug;15(8):1304-17. Epub 2008 Apr 25.PMID: 18437163 [PubMed - indexed for MEDLINE]Related articlesFree article

Our evolving understanding of getting to goal using insulin in type 2 diabetes.

Leroith D.

Endocrinol Metab Clin North Am. 2007 Dec;36 Suppl 2:9-19. Review. No abstract available. PMID: 18407030 [PubMed - indexed for MEDLINE]Related articles

ASpecial Focus on Obesity.

Leroith D.

Metab Syndr Relat Disord. 2006 Spring;4(1):35-6. No abstract available. PMID: 18370768 [PubMed - in process]Related articles

Treatment of diabetes: a clinical update on insulin trials.

LeRoith D.

Clin Cornerstone. 2007;8(2):21-9; discussion 30-2. Review.PMID: 18357953 [PubMed - indexed for MEDLINE]Related articles

Update on diabetes mellitus: prevention, treatment, and association with oral diseases.

Skamagas M, Breen TL, LeRoith D.

Oral Dis. 2008 Mar;14(2):105-14. Review.PMID: 18302671 [PubMed - indexed for MEDLINE]Related articles

The role of lipocalin 2 in the regulation of inflammation in adipocytes and macrophages.

Zhang J, Wu Y, Zhang Y, Leroith D, Bernlohr DA, Chen X.

Mol Endocrinol. 2008 Jun;22(6):1416-26. Epub 2008 Feb 21.PMID: 18292240 [PubMed - indexed for MEDLINE]Related articlesFree article

Mechanisms of disease: using genetically altered mice to study concepts of type 2 diabetes.

Leroith D, Accili D.

Nat Clin Pract Endocrinol Metab. 2008 Mar;4(3):164-72. Epub 2008 Jan 22. Review.PMID: 18212763 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-like growth factor-i regulates Kruppel-like factor-6 gene expression in a p53-dependent manner.

Bentov I, Narla G, Schayek H, Akita K, Plymate SR, LeRoith D, Friedman SL, Werner H.

Endocrinology. 2008 Apr;149(4):1890-7. Epub 2008 Jan 3.PMID: 18174288 [PubMed - indexed for MEDLINE]Related articlesFree article

The benefits of tight glycemic control in type 2 diabetes mellitus.

LeRoith D, Rayfield EJ.

Clin Cornerstone. 2007;8 Suppl 7:S19-29. Review.PMID: 18159646 [PubMed - indexed for MEDLINE]Related articles

Insulin resistance as the underlying cause for the metabolic syndrome.

Lann D, LeRoith D.

Med Clin North Am. 2007 Nov;91(6):1063-77, viii. Review.PMID: 17964909 [PubMed - indexed for MEDLINE]Related articles

Central actions of liver-derived insulin-like growth factor I underlying its pro-cognitive effects.

Trejo JL, Piriz J, Llorens-Martin MV, Fernandez AM, Bolós M, LeRoith D, Nuñez A, Torres-Aleman I.

Mol Psychiatry. 2007 Dec;12(12):1118-28. Epub 2007 Sep 11.PMID: 17848918 [PubMed - indexed for MEDLINE]Related articles

[Evaluation of adiponectin and TNFalpha genes expression in women with gestational diabetes. Preliminary results]

Kuźmicki M, Szamatowicz J, Kretowski A, Kuć P, Kretowski M, Wawrusiewicz N, Okruszko A, Leroith D, Górska M.

Ginekol Pol. 2006 Dec;77(12):930-6. Polish. PMID: 17373119 [PubMed - indexed for MEDLINE]Related articles

Mechanisms of disease: metabolic effects of growth hormone and insulin-like growth factor 1.

LeRoith D, Yakar S.

Nat Clin Pract Endocrinol Metab. 2007 Mar;3(3):302-10. Review.PMID: 17315038 [PubMed - indexed for MEDLINE]Related articles

A familial insulin-like growth factor-I receptor mutant leads to short stature: clinical and biochemical characterization.

Inagaki K, Tiulpakov A, Rubtsov P, Sverdlova P, Peterkova V, Yakar S, Terekhov S, LeRoith D.

J Clin Endocrinol Metab. 2007 Apr;92(4):1542-8. Epub 2007 Jan 30.PMID: 17264177 [PubMed - indexed for MEDLINE]Related articlesFree article

Diabetes cure--is the glass half full?

Bromberg JS, LeRoith D.

N Engl J Med. 2006 Sep 28;355(13):1372-4. No abstract available. PMID: 17005956 [PubMed - indexed for MEDLINE]Related articles

Increased tumor growth in mice with diet-induced obesity: impact of ovarian hormones.

Yakar S, Nunez NP, Pennisi P, Brodt P, Sun H, Fallavollita L, Zhao H, Scavo L, Novosyadlyy R, Kurshan N, Stannard B, East-Palmer J, Smith NC, Perkins SN, Fuchs-Young R, Barrett JC, Hursting SD, LeRoith D.

Endocrinology. 2006 Dec;147(12):5826-34. Epub 2006 Sep 7.PMID: 16959846 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of the IGF system in cancer growth and metastasis: overview and recent insights.

Samani AA, Yakar S, LeRoith D, Brodt P.

Endocr Rev. 2007 Feb;28(1):20-47. Epub 2006 Aug 24. Review.PMID: 16931767 [PubMed - indexed for MEDLINE]Related articlesFree article

Epithelial-specific and stage-specific functions of insulin-like growth factor-I during postnatal mammary development.

Loladze AV, Stull MA, Rowzee AM, Demarco J, Lantry JH 3rd, Rosen CJ, Leroith D, Wagner KU, Hennighausen L, Wood TL.

Endocrinology. 2006 Nov;147(11):5412-23. Epub 2006 Aug 10.PMID: 16901968 [PubMed - indexed for MEDLINE]Related articlesFree article

Absence of the full-length breast cancer-associated gene-1 leads to increased expression of insulin-like growth factor signaling axis members.

Shukla V, Coumoul X, Cao L, Wang RH, Xiao C, Xu X, Andò S, Yakar S, Leroith D, Deng C.

Cancer Res. 2006 Jul 15;66(14):7151-7.PMID: 16849561 [PubMed - indexed for MEDLINE]Related articlesFree article

Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice.

Xu X, Kobayashi S, Qiao W, Li C, Xiao C, Radaeva S, Stiles B, Wang RH, Ohara N, Yoshino T, LeRoith D, Torbenson MS, Gores GJ, Wu H, Gao B, Deng CX.

J Clin Invest. 2006 Jul;116(7):1843-52. Epub 2006 Jun 8.PMID: 16767220 [PubMed - indexed for MEDLINE]Related articlesFree article

Intensive insulin therapy in the medical ICU.

Tamler R, LeRoith D, Roth J.

N Engl J Med. 2006 May 11;354(19):2069-71; author reply 2069-71. No abstract available. PMID: 16696140 [PubMed - indexed for MEDLINE]Related articles