PubMed

Liver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signaling in hepatic lipid metabolism.

Fan Y, Menon RK, Cohen P, Hwang D, Clemens T, DiGirolamo DJ, Kopchick JJ, Le Roith D, Trucco M, Sperling MA.

J Biol Chem. 2009 Jul 24;284(30):19937-44. Epub 2009 May 21.PMID: 19460757 [PubMed - indexed for MEDLINE]Related articles

The proposed terminology 'A(1c)-derived average glucose' is inherently imprecise and should not be adopted.

Bloomgarden ZT, Inzucchi SE, Karnieli E, Le Roith D.

Diabetologia. 2008 Jul;51(7):1111-4. Epub 2008 May 1. Review.PMID: 18449525 [PubMed - indexed for MEDLINE]Related articles

A functional insulin-like growth factor receptor is not necessary for load-induced skeletal muscle hypertrophy.

Spangenburg EE, Le Roith D, Ward CW, Bodine SC.

J Physiol. 2008 Jan 1;586(1):283-91. Epub 2007 Nov 1.PMID: 17974583 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin glargine and receptor-mediated signalling: clinical implications in treating type 2 diabetes.

Le Roith D.

Diabetes Metab Res Rev. 2007 Nov;23(8):593-9. Review.PMID: 17922476 [PubMed - indexed for MEDLINE]Related articles

Molecular mechanisms by which metabolic control may improve outcomes.

Le Roith D.

Endocr Pract. 2004 Mar-Apr;10 Suppl 2:57-62. Review.PMID: 15251642 [PubMed - indexed for MEDLINE]Related articles

Transcription coactivator PBP, the peroxisome proliferator-activated receptor (PPAR)-binding protein, is required for PPARalpha-regulated gene expression in liver.

Jia Y, Qi C, Kashireddi P, Surapureddi S, Zhu YJ, Rao MS, Le Roith D, Chambon P, Gonzalez FJ, Reddy JK.

J Biol Chem. 2004 Jun 4;279(23):24427-34. Epub 2004 Mar 29.PMID: 15150259 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic background (C57BL/6J versus FVB/N) strongly influences the severity of diabetes and insulin resistance in ob/ob mice.

Haluzik M, Colombo C, Gavrilova O, Chua S, Wolf N, Chen M, Stannard B, Dietz KR, Le Roith D, Reitman ML.

Endocrinology. 2004 Jul;145(7):3258-64. Epub 2004 Apr 1.PMID: 15059949 [PubMed - indexed for MEDLINE]Related articlesFree article

Multiple signaling pathways are involved in the regulation of IGF-I receptor inhibition of PTEN-enhanced apoptosis.

Wu Y, Karas M, Dupont J, Zhao H, Toyoshima Y, Le Roith D.

Growth Horm IGF Res. 2004 Feb;14(1):52-8.PMID: 14700555 [PubMed - indexed for MEDLINE]Related articles

The insulin-like growth factor system.

Le Roith D.

Exp Diabesity Res. 2003 Oct-Dec;4(4):205-12. Review.PMID: 14668044 [PubMed - indexed for MEDLINE]Related articlesFree article

Reduced expression of insulin-like growth factor I receptors in MCF-7 breast cancer cells leads to a more metastatic phenotype.

Pennisi PA, Barr V, Nunez NP, Stannard B, Le Roith D.

Cancer Res. 2002 Nov 15;62(22):6529-37.PMID: 12438247 [PubMed - indexed for MEDLINE]Related articlesFree article

Inactivation of muscle insulin and IGF-I receptors and insulin responsiveness.

Le Roith D, Kim H, Fernandez AM, Accili D.

Curr Opin Clin Nutr Metab Care. 2002 Jul;5(4):371-5. Review.PMID: 12107371 [PubMed - indexed for MEDLINE]Related articles

Current therapeutic algorithms for type 2 diabetes.

Le Roith D.

Clin Cornerstone. 2001;4(2):38-49. Review.PMID: 11838326 [PubMed - indexed for MEDLINE]Related articles

Pathogenesis of diabetes: our current understanding.

Pietropaolo M, Le Roith D.

Clin Cornerstone. 2001;4(2):1-16. Review.PMID: 11838323 [PubMed - indexed for MEDLINE]Related articles

Muscle-specific inactivation of the IGF-I receptor induces compensatory hyperplasia in skeletal muscle.

Fernández AM, Dupont J, Farrar RP, Lee S, Stannard B, Le Roith D.

J Clin Invest. 2002 Feb;109(3):347-55.PMID: 11827994 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional inactivation of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetes.

Fernández AM, Kim JK, Yakar S, Dupont J, Hernandez-Sanchez C, Castle AL, Filmore J, Shulman GI, Le Roith D.

Genes Dev. 2001 Aug 1;15(15):1926-34.PMID: 11485987 [PubMed - indexed for MEDLINE]Related articlesFree article

Insulin-like growth factor 1 and oestradiol promote cell proliferation of MCF-7 breast cancer cells: new insights into their synergistic effects.

Dupont J, Le Roith D.

Mol Pathol. 2001 Jun;54(3):149-54. Review.PMID: 11376126 [PubMed - indexed for MEDLINE]Related articlesFree article

The role of the insulin-like growth factors in cancer.

Le Roith D, Karas M, Yakar S, Qu BH, Wu Y, Blakesley VA.

Isr Med Assoc J. 1999 Sep;1(1):25-30. Review. No abstract available. PMID: 11370118 [PubMed - indexed for MEDLINE]Related articles

Liver-specific igf-1 gene deletion leads to muscle insulin insensitivity.

Yakar S, Liu JL, Fernandez AM, Wu Y, Schally AV, Frystyk J, Chernausek SD, Mejia W, Le Roith D.

Diabetes. 2001 May;50(5):1110-8.PMID: 11334415 [PubMed - indexed for MEDLINE]Related articlesFree article

Recent advances in our understanding of insulin action and insulin resistance.

Le Roith D, Zick Y.

Diabetes Care. 2001 Mar;24(3):588-97. Review. No abstract available. PMID: 11289486 [PubMed - indexed for MEDLINE]Related articlesFree article

Control of growth by the somatropic axis: growth hormone and the insulin-like growth factors have related and independent roles.

Butler AA, Le Roith D.

Annu Rev Physiol. 2001;63:141-64. Review.PMID: 11181952 [PubMed - indexed for MEDLINE]Related articles

Differential modulation of cellular and viral promoters by p73 and p53.

Deb D, Lanyi A, Scian M, Keiger J, Brown DR, Le Roith D, Deb SP, Deb S.

Int J Oncol. 2001 Feb;18(2):401-9.PMID: 11172610 [PubMed - indexed for MEDLINE]Related articles

What is the role of circulating IGF-I?

Le Roith D, Scavo L, Butler A.

Trends Endocrinol Metab. 2001 Mar;12(2):48-52. Review.PMID: 11167121 [PubMed - indexed for MEDLINE]Related articles

The somatomedin hypothesis: 2001.

Le Roith D, Bondy C, Yakar S, Liu JL, Butler A.

Endocr Rev. 2001 Feb;22(1):53-74. Review.PMID: 11159816 [PubMed - indexed for MEDLINE]Related articlesFree article

Research on growth hormone (GH) and the insulin-like growth factors (IGFs)

Le Roith D, Sonksen PH.

Growth Horm IGF Res. 1998 Feb;8(1):1-2. No abstract available. PMID: 10990438 [PubMed - indexed for MEDLINE]Related articles

Regulation of proliferation and apoptosis by the insulin-like growth factor I receptor.

Le Roith D.

Growth Horm IGF Res. 2000 Apr;10 Suppl A:S12-3. Review. No abstract available. PMID: 10984274 [PubMed - indexed for MEDLINE]Related articles

New concepts in regulation and function of the insulin-like growth factors: implications for understanding normal growth and neoplasia.

Werner H, Le Roith D.

Cell Mol Life Sci. 2000 Jun;57(6):932-42. Review.PMID: 10950308 [PubMed - indexed for MEDLINE]Related articles

The growth hormone/insulin-like growth factor-I system: implications for organ growth and development.

Yakar S, Liu JL, Le Roith D.

Pediatr Nephrol. 2000 Jul;14(7):544-9. Review.PMID: 10912516 [PubMed - indexed for MEDLINE]Related articles

Insulin-like growth factors in pediatric health and disease.

Le Roith D, Butler AA.

J Clin Endocrinol Metab. 1999 Dec;84(12):4355-61. Review. No abstract available. PMID: 10599688 [PubMed - indexed for MEDLINE]Related articlesFree article

Editorial

Le Roith D.

Growth Horm IGF Res. 1999 Oct;9(5):279. No abstract available. PMID: 10543934 [PubMed - as supplied by publisher]Related articles

Tumor necrosis factor alpha and interferon gamma--induced cell growth arrest is mediated via insulin-like growth factor binding protein-3.

Katz J, Nasatzky E, Werner H, Le Roith D, Shemer J.

Growth Horm IGF Res. 1999 Jun;9(3):174-8.PMID: 10502453 [PubMed - indexed for MEDLINE]Related articles

Tumor-induced hypoglycemia.

Le Roith D.

N Engl J Med. 1999 Sep 2;341(10):757-8. No abstract available. PMID: 10471466 [PubMed - indexed for MEDLINE]Related articles

Although both rhGh and rhIGF-I have the potential to provide clinical benefit, each also has the potential to produce unwanted side-effects.

Le Roith D.

Growth Horm IGF Res. 1999 Apr;9(2):83. No abstract available. PMID: 10373340 [PubMed - indexed for MEDLINE]Related articles

Insulin-like growth factor.

Le Roith D.

Horm Metab Res. 1999 Feb-Mar;31(2-3):41-2. No abstract available. PMID: 10226779 [PubMed - indexed for MEDLINE]Related articles

Insulin-like growth factor-I inhibits the stress-activated protein kinase/c-Jun N-terminal kinase.

Okubo Y, Blakesley VA, Stannard B, Gutkind S, Le Roith D.

J Biol Chem. 1998 Oct 2;273(40):25961-6.PMID: 9748273 [PubMed - indexed for MEDLINE]Related articlesFree article

The insulin-like growth factor-I receptor and apoptosis. Implications for the aging progress.

Le Roith D, Parrizas M, Blakesley VA.

Endocrine. 1997 Aug;7(1):103-5. Review. No abstract available. PMID: 9449043 [PubMed - indexed for MEDLINE]Related articles

The proto-oncogene Crk-II enhances apoptosis by a Ras-dependent, Raf-1/MAP kinase-independent pathway.

Parrizas M, Blakesley VA, Beitner-Johnson D, Le Roith D.

Biochem Biophys Res Commun. 1997 May 29;234(3):616-20.PMID: 9175762 [PubMed - indexed for MEDLINE]Related articles

Seminars in medicine of the Beth Israel Deaconess Medical Center. Insulin-like growth factors.

Le Roith D.

N Engl J Med. 1997 Feb 27;336(9):633-40. Review. No abstract available. PMID: 9032050 [PubMed - indexed for MEDLINE]Related articles

The insulin-like growth factor-I receptor signaling pathways are important for tumorigenesis and inhibition of apoptosis.

Werner H, Le Roith D.

Crit Rev Oncog. 1997;8(1):71-92. Review.PMID: 9516087 [PubMed - indexed for MEDLINE]Related articles

The yin and the yang of the IGF system: immunological manifestations of GH resistance.

Le Roith D, Blakesley VA.

Eur J Endocrinol. 1997 Jan;136(1):33-4. No abstract available. PMID: 9037121 [PubMed - indexed for MEDLINE]Related articles

Signaling via the insulin-like growth factor-I receptor: does it differ from insulin receptor signaling?

Blakesley VA, Scrimgeour A, Esposito D, Le Roith D.

Cytokine Growth Factor Rev. 1996 Aug;7(2):153-9. Review.PMID: 8899293 [PubMed - indexed for MEDLINE]Related articles

Hypoglycemia in pregnancy secondary to a non-islet cell tumor of the pleura and ectopic insulin-like growth factor II hormone production.

Schweichler M, Hennessey JV, Cole P, Perdue JF, Le Roith D.

Obstet Gynecol. 1995 May;85(5 Pt 2):810-3.PMID: 7724120 [PubMed - indexed for MEDLINE]Related articles

Insulin receptors and insulin action in dissociated brain cells.

Masters BA, Shemer J, Judkins JH, Clarke DW, Le Roith D, Raizada MK.

Brain Res. 1987 Aug 11;417(2):247-56.PMID: 3308002 [PubMed - indexed for MEDLINE]Related articles

Anxiety and hirsutism.

Rabinowitz S, Cohen R, Le Roith D.

Psychol Rep. 1983 Dec;53(3 Pt 1):827-30. No abstract available. PMID: 6657838 [PubMed - indexed for MEDLINE]Related articles

Two distinct insulins in the guinea pig: the broad relevance of these findings to evolution of peptide hormones.

Rosenzweig JL, Le Roith D, Lesniak MA, MacIntyre I, Sawyer WH, Roth J.

Fed Proc. 1983 Jun;42(9):2608-14.PMID: 6343124 [PubMed - indexed for MEDLINE]Related articles

Are messenger molecules in microbes the ancestors of the vertebrate hormones and tissue factors?

Le Roith D, Shiloach J, Berelowitz M, Frohman LA, Liotta AS, Krieger DT, Roth J.

Fed Proc. 1983 Jun;42(9):2602-7.PMID: 6133783 [PubMed - indexed for MEDLINE]Related articles

Insulin in brain and other extrapancreatic tissues of vertebrates and nonvertebrates.

Le Roith D, Hendricks SA, Lesniak MA, Rishi S, Becker KL, Havrankova J, Rosenzweig JL, Brownstein MJ, Roth J.

Adv Metab Disord. 1983;10:303-40. Review. No abstract available. PMID: 6364717 [PubMed - indexed for MEDLINE]Related articles

Is there an earlier phylogenetic precursor that is common to both the nervous and endocrine systems?

Le Roith D, Shiloach J, Roth J.

Peptides. 1982 May-Jun;3(3):211-5. No abstract available. PMID: 6126861 [PubMed - indexed for MEDLINE]Related articles

The effect of abdominal pressure on plasma antidiuretic hormone levels in the dog.

Le Roith D, Bark H, Nyska M, Glick SM.

J Surg Res. 1982 Jan;32(1):65-9. No abstract available. PMID: 6172664 [PubMed - indexed for MEDLINE]Related articles

Congenital hyperparathyroidism and rickets: secondary to maternal hypoparathyroidism and vitamin D deficiency.

Gradus D, Le Roith D, Karplus M, Zmora E, Grief M, Bar-Ziv J.

Isr J Med Sci. 1981 Aug;17(8):705-8.PMID: 7197265 [PubMed - indexed for MEDLINE]Related articles

Increased high-molecular-weight thyrotropin with impaired biologic activity in a euthyroid man.

Spitz IM, Le Roith D, Hirsch H, Carayon P, Pekonen F, Liel Y, Sobel R, Chorer Z, Weintraub B.

N Engl J Med. 1981 Jan 29;304(5):278-82. No abstract available. PMID: 6255331 [PubMed - indexed for MEDLINE]Related articles