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    Results: 25

    1.

    Reduced endoplasmic reticulum (ER)-to-Golgi protein trafficking contributes to ER stress in lipotoxic mouse beta cells by promoting protein overload.

    Preston AM, Gurisik E, Bartley C, Laybutt DR, Biden TJ.

    Diabetologia. 2009 Aug 29. [Epub ahead of print]PMID: 19727664 [PubMed - as supplied by publisher]Related articles

    2.

    p38 MAPK is a major regulator of MafA protein stability under oxidative stress.

    Kondo T, El Khattabi I, Nishimura W, Laybutt DR, Geraldes P, Shah S, King G, Bonner-Weir S, Weir G, Sharma A.

    Mol Endocrinol. 2009 Aug;23(8):1281-90. Epub 2009 Apr 30.PMID: 19407223 [PubMed - in process]Related articles

    3.

    Alterations in microRNA expression contribute to fatty acid-induced pancreatic beta-cell dysfunction.

    Lovis P, Roggli E, Laybutt DR, Gattesco S, Yang JY, Widmann C, Abderrahmani A, Regazzi R.

    Diabetes. 2008 Oct;57(10):2728-36. Epub 2008 Jul 15.PMID: 18633110 [PubMed - indexed for MEDLINE]Related articlesFree article

    4.

    Cytokine-induced beta-cell death is independent of endoplasmic reticulum stress signaling.

    Akerfeldt MC, Howes J, Chan JY, Stevens VA, Boubenna N, McGuire HM, King C, Biden TJ, Laybutt DR.

    Diabetes. 2008 Nov;57(11):3034-44. Epub 2008 Jun 30.PMID: 18591394 [PubMed - indexed for MEDLINE]Related articlesFree article

    5.

    Fructose-1,6-bisphosphatase overexpression in pancreatic beta-cells results in reduced insulin secretion: a new mechanism for fat-induced impairment of beta-cell function.

    Kebede M, Favaloro J, Gunton JE, Laybutt DR, Shaw M, Wong N, Fam BC, Aston-Mourney K, Rantzau C, Zulli A, Proietto J, Andrikopoulos S.

    Diabetes. 2008 Jul;57(7):1887-95. Epub 2008 Mar 28.PMID: 18375435 [PubMed - indexed for MEDLINE]Related articlesFree article

    6.

    Inhibition of PKCepsilon improves glucose-stimulated insulin secretion and reduces insulin clearance.

    Schmitz-Peiffer C, Laybutt DR, Burchfield JG, Gurisik E, Narasimhan S, Mitchell CJ, Pedersen DJ, Braun U, Cooney GJ, Leitges M, Biden TJ.

    Cell Metab. 2007 Oct;6(4):320-8.PMID: 17908560 [PubMed - indexed for MEDLINE]Related articles

    7.

    Influence of diabetes on the loss of beta cell differentiation after islet transplantation in rats.

    Laybutt DR, Hawkins YC, Lock J, Lebet J, Sharma A, Bonner-Weir S, Weir GC.

    Diabetologia. 2007 Oct;50(10):2117-25. Epub 2007 Jul 20.PMID: 17641871 [PubMed - indexed for MEDLINE]Related articles

    8.

    Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: possible contribution to impaired incretin effects in diabetes.

    Xu G, Kaneto H, Laybutt DR, Duvivier-Kali VF, Trivedi N, Suzuma K, King GL, Weir GC, Bonner-Weir S.

    Diabetes. 2007 Jun;56(6):1551-8. Epub 2007 Mar 14.PMID: 17360984 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes.

    Laybutt DR, Preston AM, Akerfeldt MC, Kench JG, Busch AK, Biankin AV, Biden TJ.

    Diabetologia. 2007 Apr;50(4):752-63. Epub 2007 Feb 1.PMID: 17268797 [PubMed - indexed for MEDLINE]Related articles

    10.

    The influence of genetic background on the induction of oxidative stress and impaired insulin secretion in mouse islets.

    Zraika S, Aston-Mourney K, Laybutt DR, Kebede M, Dunlop ME, Proietto J, Andrikopoulos S.

    Diabetologia. 2006 Jun;49(6):1254-63. Epub 2006 Mar 29.PMID: 16570159 [PubMed - indexed for MEDLINE]Related articles

    11.

    Increased fatty acid desaturation and enhanced expression of stearoyl coenzyme A desaturase protects pancreatic beta-cells from lipoapoptosis.

    Busch AK, Gurisik E, Cordery DV, Sudlow M, Denyer GS, Laybutt DR, Hughes WE, Biden TJ.

    Diabetes. 2005 Oct;54(10):2917-24.PMID: 16186393 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    Chronic hyperglycemia, independent of plasma lipid levels, is sufficient for the loss of beta-cell differentiation and secretory function in the db/db mouse model of diabetes.

    Kjørholt C, Akerfeldt MC, Biden TJ, Laybutt DR.

    Diabetes. 2005 Sep;54(9):2755-63.PMID: 16123366 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Critical reduction in beta-cell mass results in two distinct outcomes over time. Adaptation with impaired glucose tolerance or decompensated diabetes.

    Laybutt DR, Glandt M, Xu G, Ahn YB, Trivedi N, Bonner-Weir S, Weir GC.

    J Biol Chem. 2003 Jan 31;278(5):2997-3005. Epub 2002 Nov 15.PMID: 12438314 [PubMed - indexed for MEDLINE]Related articlesFree article

    14.

    Overexpression of c-Myc in beta-cells of transgenic mice causes proliferation and apoptosis, downregulation of insulin gene expression, and diabetes.

    Laybutt DR, Weir GC, Kaneto H, Lebet J, Palmiter RD, Sharma A, Bonner-Weir S.

    Diabetes. 2002 Jun;51(6):1793-804.PMID: 12031967 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    Increased expression of antioxidant and antiapoptotic genes in islets that may contribute to beta-cell survival during chronic hyperglycemia.

    Laybutt DR, Kaneto H, Hasenkamp W, Grey S, Jonas JC, Sgroi DC, Groff A, Ferran C, Bonner-Weir S, Sharma A, Weir GC.

    Diabetes. 2002 Feb;51(2):413-23.PMID: 11812749 [PubMed - indexed for MEDLINE]Related articlesFree article

    16.

    Induction of c-Myc expression suppresses insulin gene transcription by inhibiting NeuroD/BETA2-mediated transcriptional activation.

    Kaneto H, Sharma A, Suzuma K, Laybutt DR, Xu G, Bonner-Weir S, Weir GC.

    J Biol Chem. 2002 Apr 12;277(15):12998-3006. Epub 2002 Jan 17.PMID: 11799123 [PubMed - indexed for MEDLINE]Related articlesFree article

    17.

    Genetic regulation of metabolic pathways in beta-cells disrupted by hyperglycemia.

    Laybutt DR, Sharma A, Sgroi DC, Gaudet J, Bonner-Weir S, Weir GC.

    J Biol Chem. 2002 Mar 29;277(13):10912-21. Epub 2002 Jan 8.PMID: 11782487 [PubMed - indexed for MEDLINE]Related articlesFree article

    18.

    High glucose stimulates early response gene c-Myc expression in rat pancreatic beta cells.

    Jonas JC, Laybutt DR, Steil GM, Trivedi N, Pertusa JG, Van de Casteele M, Weir GC, Henquin JC.

    J Biol Chem. 2001 Sep 21;276(38):35375-81. Epub 2001 Jul 16.PMID: 11457846 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Beta-cell adaptation and decompensation during the progression of diabetes.

    Weir GC, Laybutt DR, Kaneto H, Bonner-Weir S, Sharma A.

    Diabetes. 2001 Feb;50 Suppl 1:S154-9. Review.PMID: 11272180 [PubMed - indexed for MEDLINE]Related articles

    20.

    Muscle lipid accumulation and protein kinase C activation in the insulin-resistant chronically glucose-infused rat.

    Laybutt DR, Schmitz-Peiffer C, Saha AK, Ruderman NB, Biden TJ, Kraegen EW.

    Am J Physiol. 1999 Dec;277(6 Pt 1):E1070-6.PMID: 10600797 [PubMed - indexed for MEDLINE]Related articlesFree article

    21.

    Cytosolic citrate and malonyl-CoA regulation in rat muscle in vivo.

    Saha AK, Laybutt DR, Dean D, Vavvas D, Sebokova E, Ellis B, Klimes I, Kraegen EW, Shafrir E, Ruderman NB.

    Am J Physiol. 1999 Jun;276(6 Pt 1):E1030-7.PMID: 10362615 [PubMed - indexed for MEDLINE]Related articlesFree article

    22.

    Malonyl CoA as a metabolic switch and a regulator of insulin sensitivity.

    Ruderman NB, Saha AK, Vavvas D, Kurowski T, Laybutt DR, Schmitz-Peiffer C, Biden T, Kraegen EW.

    Adv Exp Med Biol. 1998;441:263-70. Review.PMID: 9781332 [PubMed - indexed for MEDLINE]Related articles

    23.

    Selective chronic regulation of GLUT1 and GLUT4 content by insulin, glucose, and lipid in rat cardiac muscle in vivo.

    Laybutt DR, Thompson AL, Cooney GJ, Kraegen EW.

    Am J Physiol. 1997 Sep;273(3 Pt 2):H1309-16.PMID: 9321820 [PubMed - indexed for MEDLINE]Related articles

    24.

    Specific adaptations in muscle and adipose tissue in response to chronic systemic glucose oversupply in rats.

    Laybutt DR, Chisholm DJ, Kraegen EW.

    Am J Physiol. 1997 Jul;273(1 Pt 1):E1-9.PMID: 9252473 [PubMed - indexed for MEDLINE]Related articles

    25.

    A new antidiabetic agent, BRL 49653, reduces lipid availability and improves insulin action and glucoregulation in the rat.

    Oakes ND, Kennedy CJ, Jenkins AB, Laybutt DR, Chisholm DJ, Kraegen EW.

    Diabetes. 1994 Oct;43(10):1203-10.PMID: 7926289 [PubMed - indexed for MEDLINE]Related articles

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