PubMed

Solution structure of ectodomains of the insulin receptor family: the ectodomain of the type 1 insulin-like growth factor receptor displays asymmetry of ligand binding accompanied by limited conformational change.

Whitten AE, Smith BJ, Menting JG, Margetts MB, McKern NM, Lovrecz GO, Adams TE, Richards K, Bentley JD, Trewhella J, Ward CW, Lawrence MC.

J Mol Biol. 2009 Dec 18;394(5):878-92. Epub 2009 Oct 14.PMID: 19835884 [PubMed - in process]Related articles

A thermodynamic study of ligand binding to the first three domains of the human insulin receptor: relationship between the receptor alpha-chain C-terminal peptide and the site 1 insulin mimetic peptides.

Menting JG, Ward CW, Margetts MB, Lawrence MC.

Biochemistry. 2009 Jun 16;48(23):5492-500.PMID: 19459609 [PubMed - indexed for MEDLINE]Related articles

Ligand-induced activation of the insulin receptor: a multi-step process involving structural changes in both the ligand and the receptor.

Ward CW, Lawrence MC.

Bioessays. 2009 Apr;31(4):422-34. Review.PMID: 19274663 [PubMed - indexed for MEDLINE]Related articles

Chromatin-bound mitogen-activated protein kinases transmit dynamic signals in transcription complexes in beta-cells.

Lawrence MC, McGlynn K, Shao C, Duan L, Naziruddin B, Levy MF, Cobb MH.

Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13315-20. Epub 2008 Aug 28.PMID: 18755896 [PubMed - indexed for MEDLINE]Related articlesFree article

The roles of MAPKs in disease.

Lawrence MC, Jivan A, Shao C, Duan L, Goad D, Zaganjor E, Osborne J, McGlynn K, Stippec S, Earnest S, Chen W, Cobb MH.

Cell Res. 2008 Apr;18(4):436-42. Review.PMID: 18347614 [PubMed - indexed for MEDLINE]Related articlesFree article

N-linked glycans of the human insulin receptor and their distribution over the crystal structure.

Sparrow LG, Lawrence MC, Gorman JJ, Strike PM, Robinson CP, McKern NM, Ward CW.

Proteins. 2008 Apr;71(1):426-39.PMID: 17957771 [PubMed - indexed for MEDLINE]Related articles

Insulin receptor structure and its implications for the IGF-1 receptor.

Lawrence MC, McKern NM, Ward CW.

Curr Opin Struct Biol. 2007 Dec;17(6):699-705. Epub 2007 Sep 11. Review.PMID: 17851071 [PubMed - indexed for MEDLINE]Related articles

Differential regulation of CHOP-10/GADD153 gene expression by MAPK signaling in pancreatic beta-cells.

Lawrence MC, McGlynn K, Naziruddin B, Levy MF, Cobb MH.

Proc Natl Acad Sci U S A. 2007 Jul 10;104(28):11518-25. Epub 2007 Jul 5.PMID: 17615236 [PubMed - indexed for MEDLINE]Related articlesFree article

A designed ankyrin repeat protein evolved to picomolar affinity to Her2.

Zahnd C, Wyler E, Schwenk JM, Steiner D, Lawrence MC, McKern NM, Pecorari F, Ward CW, Joos TO, Plückthun A.

J Mol Biol. 2007 Jun 15;369(4):1015-28. Epub 2007 Mar 20.PMID: 17466328 [PubMed - indexed for MEDLINE]Related articles

The insulin and EGF receptor structures: new insights into ligand-induced receptor activation.

Ward CW, Lawrence MC, Streltsov VA, Adams TE, McKern NM.

Trends Biochem Sci. 2007 Mar;32(3):129-37. Epub 2007 Feb 5. Review.PMID: 17280834 [PubMed - indexed for MEDLINE]Related articles

Structure of the insulin receptor ectodomain reveals a folded-over conformation.

McKern NM, Lawrence MC, Streltsov VA, Lou MZ, Adams TE, Lovrecz GO, Elleman TC, Richards KM, Bentley JD, Pilling PA, Hoyne PA, Cartledge KA, Pham TM, Lewis JL, Sankovich SE, Stoichevska V, Da Silva E, Robinson CP, Frenkel MJ, Sparrow LG, Fernley RT, Epa VC, Ward CW.

Nature. 2006 Sep 14;443(7108):218-21. Epub 2006 Sep 6.PMID: 16957736 [PubMed - indexed for MEDLINE]Related articles

Inhibition of glucose-stimulated activation of extracellular signal-regulated protein kinases 1 and 2 by epinephrine in pancreatic beta-cells.

Gibson TB, Lawrence MC, Gibson CJ, Vanderbilt CA, McGlynn K, Arnette D, Chen W, Collins J, Naziruddin B, Levy MF, Ehrlich BE, Cobb MH.

Diabetes. 2006 Apr;55(4):1066-73.PMID: 16567530 [PubMed - indexed for MEDLINE]Related articlesFree article

ERK1/2-dependent activation of transcription factors required for acute and chronic effects of glucose on the insulin gene promoter.

Lawrence MC, McGlynn K, Park BH, Cobb MH.

J Biol Chem. 2005 Jul 22;280(29):26751-9. Epub 2005 May 16.PMID: 15899886 [PubMed - indexed for MEDLINE]Related articlesFree article

The three-dimensional structure of the bifunctional 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase/dihydropteroate synthase of Saccharomyces cerevisiae.

Lawrence MC, Iliades P, Fernley RT, Berglez J, Pilling PA, Macreadie IG.

J Mol Biol. 2005 May 6;348(3):655-70.PMID: 15826662 [PubMed - indexed for MEDLINE]Related articles

The X-ray structure of a hemipteran ecdysone receptor ligand-binding domain: comparison with a lepidopteran ecdysone receptor ligand-binding domain and implications for insecticide design.

Carmichael JA, Lawrence MC, Graham LD, Pilling PA, Epa VC, Noyce L, Lovrecz G, Winkler DA, Pawlak-Skrzecz A, Eaton RE, Hannan GN, Hill RJ.

J Biol Chem. 2005 Jun 10;280(23):22258-69. Epub 2005 Apr 4.PMID: 15809296 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibition of parainfluenza virus type 3 and Newcastle disease virus hemagglutinin-neuraminidase receptor binding: effect of receptor avidity and steric hindrance at the inhibitor binding sites.

Porotto M, Murrell M, Greengard O, Lawrence MC, McKimm-Breschkin JL, Moscona A.

J Virol. 2004 Dec;78(24):13911-9.PMID: 15564499 [PubMed - indexed for MEDLINE]Related articlesFree article

Structure of the haemagglutinin-neuraminidase from human parainfluenza virus type III.

Lawrence MC, Borg NA, Streltsov VA, Pilling PA, Epa VC, Varghese JN, McKimm-Breschkin JL, Colman PM.

J Mol Biol. 2004 Jan 30;335(5):1343-57.PMID: 14729348 [PubMed - indexed for MEDLINE]Related articles

Regulation of ERK1 and ERK2 by glucose and peptide hormones in pancreatic beta cells.

Arnette D, Gibson TB, Lawrence MC, January B, Khoo S, McGlynn K, Vanderbilt CA, Cobb MH.

J Biol Chem. 2003 Aug 29;278(35):32517-25. Epub 2003 Jun 2.PMID: 12783880 [PubMed - indexed for MEDLINE]Related articlesFree article

The structural biology of type I viral membrane fusion.

Colman PM, Lawrence MC.

Nat Rev Mol Cell Biol. 2003 Apr;4(4):309-19. Review.PMID: 12671653 [PubMed - indexed for MEDLINE]Related articles

Binding of hydrophobic D-galactopyranosides to the lactose permease of Escherichia coli.

Sahin-Tóth M, Gunawan P, Lawrence MC, Toyokuni T, Kaback HR.

Biochemistry. 2002 Oct 29;41(43):13039-45.PMID: 12390031 [PubMed - indexed for MEDLINE]Related articles

Modelling the structure of the fusion protein from human respiratory syncytial virus.

Smith BJ, Lawrence MC, Colman PM.

Protein Eng. 2002 May;15(5):365-71.PMID: 12034856 [PubMed - indexed for MEDLINE]Related articlesFree article

Cloning, expression, and crystallization of the fusion protein of Newcastle disease virus.

Chen L, Colman PM, Cosgrove LJ, Lawrence MC, Lawrence LJ, Tulloch PA, Gorman JJ.

Virology. 2001 Nov 25;290(2):290-9.PMID: 11883193 [PubMed - indexed for MEDLINE]Related articles

NFAT regulates insulin gene promoter activity in response to synergistic pathways induced by glucose and glucagon-like peptide-1.

Lawrence MC, Bhatt HS, Easom RA.

Diabetes. 2002 Mar;51(3):691-8.PMID: 11872668 [PubMed - indexed for MEDLINE]Related articlesFree article

Substrate-Assisted Catalysis in Sialic Acid Aldolase.

Smith BJ, Lawrence MC, Barbosa JA.

J Org Chem. 1999 Feb 5;64(3):945-949.PMID: 11674166 [PubMed - as supplied by publisher]Related articles

The C-4 hydroxyl group of galactopyranosides is the major determinant for ligand recognition by the lactose permease of Escherichia coli.

Sahin-Tóth M, Lawrence MC, Nishio T, Kaback HR.

Biochemistry. 2001 Oct 30;40(43):13015-9.PMID: 11669639 [PubMed - indexed for MEDLINE]Related articles

Regulation of insulin gene transcription by a Ca(2+)-responsive pathway involving calcineurin and nuclear factor of activated T cells.

Lawrence MC, Bhatt HS, Watterson JM, Easom RA.

Mol Endocrinol. 2001 Oct;15(10):1758-67.PMID: 11579208 [PubMed - indexed for MEDLINE]Related articlesFree article

The structure of the fusion glycoprotein of Newcastle disease virus suggests a novel paradigm for the molecular mechanism of membrane fusion.

Chen L, Gorman JJ, McKimm-Breschkin J, Lawrence LJ, Tulloch PA, Smith BJ, Colman PM, Lawrence MC.

Structure. 2001 Mar 7;9(3):255-66.PMID: 11286892 [PubMed - indexed for MEDLINE]Related articles

Active site modulation in the N-acetylneuraminate lyase sub-family as revealed by the structure of the inhibitor-complexed Haemophilus influenzae enzyme.

Barbosa JA, Smith BJ, DeGori R, Ooi HC, Marcuccio SM, Campi EM, Jackson WR, Brossmer R, Sommer M, Lawrence MC.

J Mol Biol. 2000 Oct 27;303(3):405-21.PMID: 11031117 [PubMed - indexed for MEDLINE]Related articles

The sucrose permease of Escherichia coli: functional significance of cysteine residues and properties of a cysteine-less transporter.

Sahin-Tóth M, Frillingos S, Lawrence MC, Kaback HR.

Biochemistry. 2000 May 23;39(20):6164-9.PMID: 10821690 [PubMed - indexed for MEDLINE]Related articles

Expression, purification and preliminary X-ray crystallographic analysis of PsaA, a putative metal-transporter protein of Streptococcus pneumoniae.

Pilling PA, Lawrence MC, Berry AM, Ogunniyi AD, Lock RA, Paton JC.

Acta Crystallogr D Biol Crystallogr. 1998 Nov 1;54(Pt 6 Pt 2):1464-6.PMID: 10089539 [PubMed - indexed for MEDLINE]Related articles

The crystal structure of pneumococcal surface antigen PsaA reveals a metal-binding site and a novel structure for a putative ABC-type binding protein.

Lawrence MC, Pilling PA, Epa VC, Berry AM, Ogunniyi AD, Paton JC.

Structure. 1998 Dec 15;6(12):1553-61.PMID: 9862808 [PubMed - indexed for MEDLINE]Related articles

Structure and mechanism of a sub-family of enzymes related to N-acetylneuraminate lyase.

Lawrence MC, Barbosa JA, Smith BJ, Hall NE, Pilling PA, Ooi HC, Marcuccio SM.

J Mol Biol. 1997 Feb 21;266(2):381-99.PMID: 9047371 [PubMed - indexed for MEDLINE]Related articles

Properties of permease dimer, a fusion protein containing two lactose permease molecules from Escherichia coli.

Sahin-Tóth M, Lawrence MC, Kaback HR.

Proc Natl Acad Sci U S A. 1994 Jun 7;91(12):5421-5.PMID: 8202501 [PubMed - indexed for MEDLINE]Related articlesFree article

Structure of phaseolin at 2.2 A resolution. Implications for a common vicilin/legumin structure and the genetic engineering of seed storage proteins.

Lawrence MC, Izard T, Beuchat M, Blagrove RJ, Colman PM.

J Mol Biol. 1994 May 20;238(5):748-76.PMID: 8182747 [PubMed - indexed for MEDLINE]Related articles

The three-dimensional structure of N-acetylneuraminate lyase from Escherichia coli.

Izard T, Lawrence MC, Malby RL, Lilley GG, Colman PM.

Structure. 1994 May 15;2(5):361-9.PMID: 8081752 [PubMed - indexed for MEDLINE]Related articles

Recombinant anti-sialidase single-chain variable fragment antibody. Characterization, formation of dimer and higher-molecular-mass multimers and the solution of the crystal structure of the single-chain variable fragment/sialidase complex.

Kortt AA, Malby RL, Caldwell JB, Gruen LC, Ivancic N, Lawrence MC, Howlett GJ, Webster RG, Hudson PJ, Colman PM.

Eur J Biochem. 1994 Apr 1;221(1):151-7.PMID: 8168505 [PubMed - indexed for MEDLINE]Related articlesFree article

Shape complementarity at protein/protein interfaces.

Lawrence MC, Colman PM.

J Mol Biol. 1993 Dec 20;234(4):946-50.PMID: 8263940 [PubMed - indexed for MEDLINE]Related articles

Transthyretin gene expression in choroid plexus first evolved in reptiles.

Achen MG, Duan W, Pettersson TM, Harms PJ, Richardson SJ, Lawrence MC, Wettenhall RE, Aldred AR, Schreiber G.

Am J Physiol. 1993 Nov;265(5 Pt 2):R982-9.PMID: 8238627 [PubMed - indexed for MEDLINE]Related articles

Sequence and structure alignment of paramyxovirus hemagglutinin-neuraminidase with influenza virus neuraminidase.

Colman PM, Hoyne PA, Lawrence MC.

J Virol. 1993 Jun;67(6):2972-80.PMID: 8497041 [PubMed - indexed for MEDLINE]Related articlesFree article

CLIX: a search algorithm for finding novel ligands capable of binding proteins of known three-dimensional structure.

Lawrence MC, Davis PC.

Proteins. 1992 Jan;12(1):31-41.PMID: 1313175 [PubMed - indexed for MEDLINE]Related articles

The application of the molecular replacement method to the de novo determination of protein structure.

Lawrence MC.

Q Rev Biophys. 1991 Nov;24(4):399-424. Review. No abstract available. PMID: 1784712 [PubMed - indexed for MEDLINE]Related articles

Isolation, characterization, cDNA cloning and gene expression of an avian transthyretin. Implications for the evolution of structure and function of transthyretin in vertebrates.

Duan W, Achen MG, Richardson SJ, Lawrence MC, Wettenhall RE, Jaworowski A, Schreiber G.

Eur J Biochem. 1991 Sep 15;200(3):679-87.PMID: 1833190 [PubMed - indexed for MEDLINE]Related articlesFree article

The three-dimensional structure of the seed storage protein phaseolin at 3 A resolution.

Lawrence MC, Suzuki E, Varghese JN, Davis PC, Van Donkelaar A, Tulloch PA, Colman PM.

EMBO J. 1990 Jan;9(1):9-15.PMID: 2295315 [PubMed - indexed for MEDLINE]Related articlesFree article

The application of the maximum entropy method to electron microscopic tomography.

Lawrence MC, Jaffer MA, Sewell BT.

Ultramicroscopy. 1989 Nov;31(3):285-301.PMID: 2617723 [PubMed - indexed for MEDLINE]Related articles

Modelling the surface lattice of alpha-keratin filaments.

Lawrence MC.

Int J Biol Macromol. 1989 Oct;11(5):285-9.PMID: 2484966 [PubMed - indexed for MEDLINE]Related articles

A method for monitoring the collapse of plastic sections as a function of electron dose.

Luther PK, Lawrence MC, Crowther RA.

Ultramicroscopy. 1988;24(1):7-18.PMID: 3344552 [PubMed - indexed for MEDLINE]Related articles

Dose-related effects of isoflurane on superior mesenteric vasoconstriction induced by endotoxemia in the rat.

Biber B, Schaefer CF, Smolik MJ, Lawrence MC, Lerner MR, Brackett DJ, Wilson MF, Fagraeus L.

Acta Anaesthesiol Scand. 1987 Jul;31(5):430-7.PMID: 3307267 [PubMed - indexed for MEDLINE]Related articles

Crystallographic structure of allosterically inhibited phosphofructokinase at 7 A resolution.

Evans PR, Farrants GW, Lawrence MC.

J Mol Biol. 1986 Oct 20;191(4):713-20.PMID: 2949086 [PubMed - indexed for MEDLINE]Related articles

The nature of heme-aniline interactions during hemin-mediated oxygen activation and insertion reactions.

Adams PA, Adams C, Berman MC, Lawrence MC.

J Inorg Biochem. 1984 Apr;20(4):291-7.PMID: 6716103 [PubMed - indexed for MEDLINE]Related articles

ELISA for Schistosoma mansoni infection: durability of blood spots on filter paper.

Long EG, Lawrence MC, Augustine T.

Trans R Soc Trop Med Hyg. 1981;75(5):740-1. No abstract available. PMID: 7330929 [PubMed - indexed for MEDLINE]Related articles