PubMed

Vascular effects of TZDs: new implications.

Blaschke F, Spanheimer R, Khan M, Law RE.

Vascul Pharmacol. 2006 Jul;45(1):3-18. Epub 2006 Jun 5. Review.PMID: 16740417 [PubMed - indexed for MEDLINE]Related articles

Activation of peroxisome proliferator-activated receptor gamma suppresses telomerase activity in vascular smooth muscle cells.

Ogawa D, Nomiyama T, Nakamachi T, Heywood EB, Stone JF, Berger JP, Law RE, Bruemmer D.

Circ Res. 2006 Apr 14;98(7):e50-9. Epub 2006 Mar 23.PMID: 16556873 [PubMed - indexed for MEDLINE]Related articlesFree article

Liver x receptors: potential novel targets in cardiovascular diseases.

Bruemmer D, Law RE.

Curr Drug Targets Cardiovasc Haematol Disord. 2005 Dec;5(6):533-40. Review.PMID: 16503873 [PubMed - indexed for MEDLINE]Related articles

Obesity, peroxisome proliferator-activated receptor, and atherosclerosis in type 2 diabetes.

Blaschke F, Takata Y, Caglayan E, Law RE, Hsueh WA.

Arterioscler Thromb Vasc Biol. 2006 Jan;26(1):28-40. Epub 2005 Oct 20. Review.PMID: 16239592 [PubMed - indexed for MEDLINE]Related articlesFree article

Transcriptional repression of ATP-binding cassette transporter A1 gene in macrophages: a novel atherosclerotic effect of angiotensin II.

Takata Y, Chu V, Collins AR, Lyon CJ, Wang W, Blaschke F, Bruemmer D, Caglayan E, Daley W, Higaki J, Fishbein MC, Tangirala RK, Law RE, Hsueh WA.

Circ Res. 2005 Oct 28;97(9):e88-96. Epub 2005 Oct 13.PMID: 16224068 [PubMed - indexed for MEDLINE]Related articlesFree article

Liver x receptor agonists inhibit cytokine-induced osteopontin expression in macrophages through interference with activator protein-1 signaling pathways.

Ogawa D, Stone JF, Takata Y, Blaschke F, Chu VH, Towler DA, Law RE, Hsueh WA, Bruemmer D.

Circ Res. 2005 Apr 15;96(7):e59-67. Epub 2005 Mar 24.PMID: 15790955 [PubMed - indexed for MEDLINE]Related articlesFree article

New targets for PPARgamma in the vessel wall: implications for restenosis.

Bruemmer D, Blaschke F, Law RE.

Int J Obes (Lond). 2005 Mar;29 Suppl 1:S26-30. Review.PMID: 15711579 [PubMed - indexed for MEDLINE]Related articles

PPARgamma-mediated insulin sensitization: the importance of fat versus muscle.

Kintscher U, Law RE.

Am J Physiol Endocrinol Metab. 2005 Feb;288(2):E287-91. Review.PMID: 15637349 [PubMed - indexed for MEDLINE]Related articlesFree article

Liver X receptor agonists suppress vascular smooth muscle cell proliferation and inhibit neointima formation in balloon-injured rat carotid arteries.

Blaschke F, Leppanen O, Takata Y, Caglayan E, Liu J, Fishbein MC, Kappert K, Nakayama KI, Collins AR, Fleck E, Hsueh WA, Law RE, Bruemmer D.

Circ Res. 2004 Dec 10;95(12):e110-23. Epub 2004 Nov 11.PMID: 15539633 [PubMed - indexed for MEDLINE]Related articlesFree article

Will the potential of peroxisome proliferator-activated receptor agonists be realized in the clinical setting?

Blaschke F, Bruemmer D, Law RE.

Clin Cardiol. 2004 Jul;27(7 Suppl 4):IV3-10. Review.PMID: 15470905 [PubMed - indexed for MEDLINE]Related articles

C-reactive protein induces apoptosis in human coronary vascular smooth muscle cells.

Blaschke F, Bruemmer D, Yin F, Takata Y, Wang W, Fishbein MC, Okura T, Higaki J, Graf K, Fleck E, Hsueh WA, Law RE.

Circulation. 2004 Aug 3;110(5):579-87. Epub 2004 Jul 26.PMID: 15277326 [PubMed - indexed for MEDLINE]Related articlesFree article

Egr-1 is a major vascular pathogenic transcription factor in atherosclerosis and restenosis.

Blaschke F, Bruemmer D, Law RE.

Rev Endocr Metab Disord. 2004 Aug;5(3):249-54. Review. No abstract available. PMID: 15211096 [PubMed - indexed for MEDLINE]Related articles

Osteopontin modulates angiotensin II-induced fibrosis in the intact murine heart.

Collins AR, Schnee J, Wang W, Kim S, Fishbein MC, Bruemmer D, Law RE, Nicholas S, Ross RS, Hsueh WA.

J Am Coll Cardiol. 2004 May 5;43(9):1698-705.PMID: 15120833 [PubMed - indexed for MEDLINE]Related articles

Signaling pathways involved in induction of GADD45 gene expression and apoptosis by troglitazone in human MCF-7 breast carcinoma cells.

Yin F, Bruemmer D, Blaschke F, Hsueh WA, Law RE, Herle AJ.

Oncogene. 2004 Jun 3;23(26):4614-23.PMID: 15064713 [PubMed - indexed for MEDLINE]Related articles

Angiotensin II, PPAR-gamma and atherosclerosis.

Kintscher U, Lyon CJ, Law RE.

Front Biosci. 2004 Jan 1;9:359-69. Review.PMID: 14766373 [PubMed - indexed for MEDLINE]Related articles

Thiazolidinedione regulation of smooth muscle cell proliferation.

Bruemmer D, Law RE.

Am J Med. 2003 Dec 8;115 Suppl 8A:87S-92S. Review.PMID: 14678872 [PubMed - indexed for MEDLINE]Related articles

Angiotensin II-accelerated atherosclerosis and aneurysm formation is attenuated in osteopontin-deficient mice.

Bruemmer D, Collins AR, Noh G, Wang W, Territo M, Arias-Magallona S, Fishbein MC, Blaschke F, Kintscher U, Graf K, Law RE, Hsueh WA.

J Clin Invest. 2003 Nov;112(9):1318-31.PMID: 14597759 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of minichromosome maintenance proteins in vascular smooth muscle cells is ERK/MAPK dependent.

Bruemmer D, Yin F, Liu J, Kiyono T, Fleck E, Van Herle AJ, Law RE.

Exp Cell Res. 2003 Oct 15;290(1):28-37.PMID: 14516785 [PubMed - indexed for MEDLINE]Related articles

Regulation of the growth arrest and DNA damage-inducible gene 45 (GADD45) by peroxisome proliferator-activated receptor gamma in vascular smooth muscle cells.

Bruemmer D, Yin F, Liu J, Berger JP, Sakai T, Blaschke F, Fleck E, Van Herle AJ, Forman BM, Law RE.

Circ Res. 2003 Aug 22;93(4):e38-47. Epub 2003 Jul 24.PMID: 12881480 [PubMed - indexed for MEDLINE]Related articlesFree article

PGE(2) is generated by specific COX-2 activity and increases VEGF production in COX-2-expressing human pancreatic cancer cells.

Eibl G, Bruemmer D, Okada Y, Duffy JP, Law RE, Reber HA, Hines OJ.

Biochem Biophys Res Commun. 2003 Jul 11;306(4):887-97.PMID: 12821125 [PubMed - indexed for MEDLINE]Related articles

p38 MAP kinase negatively regulates angiotensin II-mediated effects on cell cycle molecules in human coronary smooth muscle cells.

Kintscher U, Bruemmer D, Blaschke F, Unger T, Law RE.

Biochem Biophys Res Commun. 2003 Jun 6;305(3):552-6.PMID: 12763029 [PubMed - indexed for MEDLINE]Related articles

Minireview: adiposity, inflammation, and atherogenesis.

Lyon CJ, Law RE, Hsueh WA.

Endocrinology. 2003 Jun;144(6):2195-200. Review.PMID: 12746274 [PubMed - indexed for MEDLINE]Related articlesFree article

Inhibitory activity of clinical thiazolidinedione peroxisome proliferator activating receptor-gamma ligands toward internal mammary artery, radial artery, and saphenous vein smooth muscle cell proliferation.

de Dios ST, Bruemmer D, Dilley RJ, Ivey ME, Jennings GL, Law RE, Little PJ.

Circulation. 2003 May 27;107(20):2548-50. Epub 2003 May 12.PMID: 12742988 [PubMed - indexed for MEDLINE]Related articlesFree article

A non-thiazolidinedione partial peroxisome proliferator-activated receptor gamma ligand inhibits vascular smooth muscle cell growth.

Bruemmer D, Berger JP, Liu J, Kintscher U, Wakino S, Fleck E, Moller DE, Law RE.

Eur J Pharmacol. 2003 Apr 18;466(3):225-34.PMID: 12694805 [PubMed - indexed for MEDLINE]Related articles

Peroxisome proliferator-activated receptor gamma inhibits expression of minichromosome maintenance proteins in vascular smooth muscle cells.

Bruemmer D, Yin F, Liu J, Berger JP, Kiyono T, Chen J, Fleck E, Van Herle AJ, Forman BM, Law RE.

Mol Endocrinol. 2003 Jun;17(6):1005-18. Epub 2003 Apr 3.PMID: 12677008 [PubMed - indexed for MEDLINE]Related articlesFree article

Rapamycin inhibits E2F-dependent expression of minichromosome maintenance proteins in vascular smooth muscle cells.

Bruemmer D, Yin F, Liu J, Kiyono T, Fleck E, Van Herle AJ, Law RE.

Biochem Biophys Res Commun. 2003 Mar 28;303(1):251-8.PMID: 12646195 [PubMed - indexed for MEDLINE]Related articles

Atorvastatin inhibits expression of minichromosome maintenance proteins in vascular smooth muscle cells.

Bruemmer D, Yin F, Liu J, Kiyono T, Fleck E, Van Herle A, Graf K, Law RE.

Eur J Pharmacol. 2003 Feb 21;462(1-3):15-23.PMID: 12591091 [PubMed - indexed for MEDLINE]Related articles

PPARalpha inhibits TGF-beta-induced beta5 integrin transcription in vascular smooth muscle cells by interacting with Smad4.

Kintscher U, Lyon C, Wakino S, Bruemmer D, Feng X, Goetze S, Graf K, Moustakas A, Staels B, Fleck E, Hsueh WA, Law RE.

Circ Res. 2002 Nov 29;91(11):e35-44.PMID: 12456495 [PubMed - indexed for MEDLINE]Related articlesFree article

Leptin induces endothelial cell migration through Akt, which is inhibited by PPARgamma-ligands.

Goetze S, Bungenstock A, Czupalla C, Eilers F, Stawowy P, Kintscher U, Spencer-Hänsch C, Graf K, Nürnberg B, Law RE, Fleck E, Gräfe M.

Hypertension. 2002 Nov;40(5):748-54.PMID: 12411472 [PubMed - indexed for MEDLINE]Related articlesFree article

TGF-beta(1) induces peroxisome proliferator-activated receptor gamma1 and gamma2 expression in human THP-1 monocytes.

Kintscher U, Wakino S, Bruemmer D, Goetze S, Graf K, Hsueh WA, Law RE.

Biochem Biophys Res Commun. 2002 Oct 4;297(4):794-9.PMID: 12359222 [PubMed - indexed for MEDLINE]Related articles

Tamoxifen-induced growth arrest and apoptosis in pituitary tumor cells in vitro via a protein kinase C-independent pathway.

Simard M, Zhang W, Hinton DR, Chen TC, Weiss MH, Su YZ, Gopalakrishna R, Law RE, Couldwell WT.

Cancer Lett. 2002 Nov 28;185(2):131-8.PMID: 12169386 [PubMed - indexed for MEDLINE]Related articles

PPAR activators inhibit endothelial cell migration by targeting Akt.

Goetze S, Eilers F, Bungenstock A, Kintscher U, Stawowy P, Blaschke F, Graf K, Law RE, Fleck E, Gräfe M.

Biochem Biophys Res Commun. 2002 May 24;293(5):1431-7.PMID: 12054675 [PubMed - indexed for MEDLINE]Related articles

Rat and human aortic smooth muscle cells display differing migration and matrix metalloproteinase activities in response to dexamethasone.

Pross C, Farooq MM, Lane JS, Angle N, Tomono CK, Xavier AE, Freischlag JA, Collins AE, Law RE, Gelabert HA.

J Vasc Surg. 2002 Jun;35(6):1253-9.PMID: 12042738 [PubMed - indexed for MEDLINE]Related articles

Synthetic LXR ligand inhibits the development of atherosclerosis in mice.

Joseph SB, McKilligin E, Pei L, Watson MA, Collins AR, Laffitte BA, Chen M, Noh G, Goodman J, Hagger GN, Tran J, Tippin TK, Wang X, Lusis AJ, Hsueh WA, Law RE, Collins JL, Willson TM, Tontonoz P.

Proc Natl Acad Sci U S A. 2002 May 28;99(11):7604-9.PMID: 12032330 [PubMed - indexed for MEDLINE]Related articlesFree article

Vascular protective effects by activation of nuclear receptor PPARgamma.

Wakino S, Law RE, Hsueh WA.

J Diabetes Complications. 2002 Jan-Feb;16(1):46-9. Review.PMID: 11872366 [PubMed - indexed for MEDLINE]Related articles

Dexamethasone inhibits vascular smooth muscle cell migration via modulation of matrix metalloproteinase activity.

Pross C, Farooq MM, Angle N, Lane JS, Cerveira JJ, Xavier AE, Freischlag JA, Law RE, Gelabert HA.

J Surg Res. 2002 Feb;102(2):57-62.PMID: 11795999 [PubMed - indexed for MEDLINE]Related articles

PPARgamma and atherosclerosis: effects on cell growth and movement.

Hsueh WA, Law RE.

Arterioscler Thromb Vasc Biol. 2001 Dec;21(12):1891-5. Review.PMID: 11742860 [PubMed - indexed for MEDLINE]Related articlesFree article

Peroxisome proliferator-activated receptor-gamma ligands inhibit nuclear but not cytosolic extracellular signal-regulated kinase/mitogen-activated protein kinase-regulated steps in vascular smooth muscle cell migration.

Goetze S, Kintscher U, Kim S, Meehan WP, Kaneshiro K, Collins AR, Fleck E, Hsueh WA, Law RE.

J Cardiovasc Pharmacol. 2001 Dec;38(6):909-21.PMID: 11707695 [PubMed - indexed for MEDLINE]Related articles

TNFalpha induces expression of transcription factors c-fos, Egr-1, and Ets-1 in vascular lesions through extracellular signal-regulated kinases 1/2.

Goetze S, Kintscher U, Kaneshiro K, Meehan WP, Collins A, Fleck E, Hsueh WA, Law RE.

Atherosclerosis. 2001 Nov;159(1):93-101.PMID: 11689211 [PubMed - indexed for MEDLINE]Related articles

Peroxisome proliferator-activated receptor gamma ligands inhibit mitogenic induction of p21(Cip1) by modulating the protein kinase Cdelta pathway in vascular smooth muscle cells.

Wakino S, Kintscher U, Liu Z, Kim S, Yin F, Ohba M, Kuroki T, Schönthal AH, Hsueh WA, Law RE.

J Biol Chem. 2001 Dec 14;276(50):47650-7. Epub 2001 Oct 11.PMID: 11598137 [PubMed - indexed for MEDLINE]Related articlesFree article

TNFalpha inhibits insulin's antiapoptotic signaling in vascular smooth muscle cells.

Goetze S, Blaschke F, Stawowy P, Bruemmer D, Spencer C, Graf K, Gräfe M, Law RE, Fleck E.

Biochem Biophys Res Commun. 2001 Sep 28;287(3):662-70.PMID: 11563846 [PubMed - indexed for MEDLINE]Related articles

Troglitazone inhibits growth of MCF-7 breast carcinoma cells by targeting G1 cell cycle regulators.

Yin F, Wakino S, Liu Z, Kim S, Hsueh WA, Collins AR, Van Herle AJ, Law RE.

Biochem Biophys Res Commun. 2001 Sep 7;286(5):916-22.PMID: 11527386 [PubMed - indexed for MEDLINE]Related articles

Retinoids inhibit proliferation of human coronary smooth muscle cells by modulating cell cycle regulators.

Wakino S, Kintscher U, Kim S, Jackson S, Yin F, Nagpal S, Chandraratna RA, Hsueh WA, Law RE.

Arterioscler Thromb Vasc Biol. 2001 May;21(5):746-51.PMID: 11348869 [PubMed - indexed for MEDLINE]Related articlesFree article

Response of experimental retinal neovascularization to thiazolidinediones.

Murata T, Hata Y, Ishibashi T, Kim S, Hsueh WA, Law RE, Hinton DR.

Arch Ophthalmol. 2001 May;119(5):709-17.PMID: 11346398 [PubMed - indexed for MEDLINE]Related articles

Doxazosin inhibits monocyte chemotactic protein 1-directed migration of human monocytes.

Kintscher U, Kon D, Wakino S, Goetze S, Graf K, Fleck E, Hsueh WA, Law RE.

J Cardiovasc Pharmacol. 2001 May;37(5):532-9.PMID: 11336104 [PubMed - indexed for MEDLINE]Related articles

Apigenin inhibits growth and induces G2/M arrest by modulating cyclin-CDK regulators and ERK MAP kinase activation in breast carcinoma cells.

Yin F, Giuliano AE, Law RE, Van Herle AJ.

Anticancer Res. 2001 Jan-Feb;21(1A):413-20.PMID: 11299771 [PubMed - indexed for MEDLINE]Related articles

Troglitazone inhibits formation of early atherosclerotic lesions in diabetic and nondiabetic low density lipoprotein receptor-deficient mice.

Collins AR, Meehan WP, Kintscher U, Jackson S, Wakino S, Noh G, Palinski W, Hsueh WA, Law RE.

Arterioscler Thromb Vasc Biol. 2001 Mar;21(3):365-71.PMID: 11231915 [PubMed - indexed for MEDLINE]Related articlesFree article

Angiotensin II induces migration and Pyk2/paxillin phosphorylation of human monocytes.

Kintscher U, Wakino S, Kim S, Fleck E, Hsueh WA, Law RE.

Hypertension. 2001 Feb;37(2 Part 2):587-93.PMID: 11230339 [PubMed - indexed for MEDLINE]Related articlesFree article

Integrins alphavbeta3 and alphavbeta5 mediate VSMC migration and are elevated during neointima formation in the rat aorta.

Kappert K, Blaschke F, Meehan WP, Kawano H, Grill M, Fleck E, Hsueh WA, Law RE, Graf K.

Basic Res Cardiol. 2001 Feb;96(1):42-9.PMID: 11215531 [PubMed - indexed for MEDLINE]Related articles

Control of vascular cell proliferation and migration by PPAR-gamma: a new approach to the macrovascular complications of diabetes.

Hsueh WA, Jackson S, Law RE.

Diabetes Care. 2001 Feb;24(2):392-7. Review.PMID: 11213897 [PubMed - indexed for MEDLINE]Related articlesFree article