PubMed

Increased local expression of coagulation factor X contributes to the fibrotic response in human and murine lung injury.

Scotton CJ, Krupiczojc MA, Königshoff M, Mercer PF, Lee YC, Kaminski N, Morser J, Post JM, Maher TM, Nicholson AG, Moffatt JD, Laurent GJ, Derian CK, Eickelberg O, Chambers RC.

J Clin Invest. 2009 Sep;119(9):2550-63. doi: 10.1172/JCI33288. Epub 2009 Aug 3.PMID: 19652365 [PubMed - indexed for MEDLINE]Related articlesFree article

Mitochondria matter: new concepts of dynamics and roles in pathophysiology.

Kargul J, Laurent GJ.

Int J Biochem Cell Biol. 2009 Oct;41(10):1747. Epub 2009 Jun 21. No abstract available. PMID: 19545643 [PubMed - indexed for MEDLINE]Related articles

Absence of proteinase-activated receptor-1 signaling in mice confers protection from fMLP-induced goblet cell metaplasia.

Atzori L, Lucattelli M, Scotton CJ, Laurent GJ, Bartalesi B, De Cunto G, Lunghi B, Chambers RC, Lungarella G.

Am J Respir Cell Mol Biol. 2009 Dec;41(6):680-7. Epub 2009 Mar 23.PMID: 19307611 [PubMed - in process]Related articles

Epigenetics and human disease.

Kargul J, Laurent GJ.

Int J Biochem Cell Biol. 2009 Jan;41(1):1. Epub 2008 Oct 2. No abstract available. PMID: 18935971 [PubMed - indexed for MEDLINE]Related articles

Escape from the matrix: multiple mechanisms for fibroblast activation in pulmonary fibrosis.

Laurent GJ, McAnulty RJ, Hill M, Chambers R.

Proc Am Thorac Soc. 2008 Apr 15;5(3):311-5.PMID: 18403325 [PubMed - indexed for MEDLINE]Related articlesFree article

Proteases and antiproteases in immune defense, tissue homeostasis and development.

Kargul J, Laurent GJ.

Int J Biochem Cell Biol. 2008;40(6-7):1065. Epub 2008 Mar 2. No abstract available. PMID: 18395485 [PubMed - indexed for MEDLINE]Related articles

Idiopathic pulmonary fibrosis: multiple causes and multiple mechanisms?

Maher TM, Wells AU, Laurent GJ.

Eur Respir J. 2007 Nov;30(5):835-9. Review.PMID: 17978154 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of matrix turnover: fibroblasts, forces, factors and fibrosis.

Laurent GJ, Chambers RC, Hill MR, McAnulty RJ.

Biochem Soc Trans. 2007 Aug;35(Pt 4):647-51. Review.PMID: 17635112 [PubMed - indexed for MEDLINE]Related articles

Mice lacking neutrophil elastase are resistant to bleomycin-induced pulmonary fibrosis.

Chua F, Dunsmore SE, Clingen PH, Mutsaers SE, Shapiro SD, Segal AW, Roes J, Laurent GJ.

Am J Pathol. 2007 Jan;170(1):65-74.PMID: 17200183 [PubMed - indexed for MEDLINE]Related articlesFree article

Functional prostaglandin-endoperoxide synthase 2 polymorphism predicts poor outcome in sarcoidosis.

Hill MR, Papafili A, Booth H, Lawson P, Hubner M, Beynon H, Read C, Lindahl G, Marshall RP, McAnulty RJ, Laurent GJ.

Am J Respir Crit Care Med. 2006 Oct 15;174(8):915-22. Epub 2006 Jul 13.PMID: 16840740 [PubMed - indexed for MEDLINE]Related articlesFree article

Neutrophil elastase: mediator of extracellular matrix destruction and accumulation.

Chua F, Laurent GJ.

Proc Am Thorac Soc. 2006 Jul;3(5):424-7. Review.PMID: 16799086 [PubMed - indexed for MEDLINE]Related articlesFree article

Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury.

Jenkins RG, Su X, Su G, Scotton CJ, Camerer E, Laurent GJ, Davis GE, Chambers RC, Matthay MA, Sheppard D.

J Clin Invest. 2006 Jun;116(6):1606-14. Epub 2006 May 18.PMID: 16710477 [PubMed - indexed for MEDLINE]Related articlesFree article

Diabetes: new challenges for the control of disease globalisation.

Kargul J, Laurent GJ.

Int J Biochem Cell Biol. 2006;38(5-6):685-6. Epub 2006 Jan 18. No abstract available. PMID: 16473036 [PubMed - indexed for MEDLINE]Related articles

Aberrant expression of BARD1 in breast and ovarian cancers with poor prognosis.

Wu JY, Vlastos AT, Pelte MF, Caligo MA, Bianco A, Krause KH, Laurent GJ, Irminger-Finger I.

Int J Cancer. 2006 Mar 1;118(5):1215-26.PMID: 16152612 [PubMed - indexed for MEDLINE]Related articles

No bit PARt for PAR-1.

Laurent GJ.

Am J Respir Cell Mol Biol. 2005 Sep;33(3):213-5. No abstract available. PMID: 16107573 [PubMed - indexed for MEDLINE]Related articlesFree article

Pulmonary fibrosis: searching for model answers.

Chua F, Gauldie J, Laurent GJ.

Am J Respir Cell Mol Biol. 2005 Jul;33(1):9-13. Review.PMID: 15964990 [PubMed - indexed for MEDLINE]Related articlesFree article

Absence of proteinase-activated receptor-1 signaling affords protection from bleomycin-induced lung inflammation and fibrosis.

Howell DC, Johns RH, Lasky JA, Shan B, Scotton CJ, Laurent GJ, Chambers RC.

Am J Pathol. 2005 May;166(5):1353-65.PMID: 15855637 [PubMed - indexed for MEDLINE]Related articlesFree article

Quantification of collagen and proteoglycan deposition in a murine model of airway remodelling.

Reinhardt AK, Bottoms SE, Laurent GJ, McAnulty RJ.

Respir Res. 2005 Apr 8;6:30.PMID: 15819978 [PubMed - indexed for MEDLINE]Related articlesFree article

Pediatric lung disease: from proteinases to pulmonary fibrosis.

Chua F, Sly PD, Laurent GJ.

Pediatr Pulmonol. 2005 May;39(5):392-401. Review.PMID: 15786437 [PubMed - indexed for MEDLINE]Related articles

Procollagen type I gene expression and cell proliferation are increased in lipodermatosclerosis.

Degiorgio-Miller AM, Treharne LJ, McAnulty RJ, Coleridge Smith PD, Laurent GJ, Herrick SE.

Br J Dermatol. 2005 Feb;152(2):242-9.PMID: 15727634 [PubMed - indexed for MEDLINE]Related articles

Factor Xa stimulates fibroblast procollagen production, proliferation, and calcium signaling via PAR1 activation.

Blanc-Brude OP, Archer F, Leoni P, Derian C, Bolsover S, Laurent GJ, Chambers RC.

Exp Cell Res. 2005 Mar 10;304(1):16-27. Epub 2004 Dec 1.PMID: 15707570 [PubMed - indexed for MEDLINE]Related articles

Getting grant applications funded: lessons from the past and advice for the future.

Laurent GJ.

Thorax. 2004 Dec;59(12):1010-1. No abstract available. PMID: 15563696 [PubMed - indexed for MEDLINE]Related articlesFree article

Severity of lung injury in cyclooxygenase-2-deficient mice is dependent on reduced prostaglandin E(2) production.

Hodges RJ, Jenkins RG, Wheeler-Jones CP, Copeman DM, Bottoms SE, Bellingan GJ, Nanthakumar CB, Laurent GJ, Hart SL, Foster ML, McAnulty RJ.

Am J Pathol. 2004 Nov;165(5):1663-76.PMID: 15509536 [PubMed - indexed for MEDLINE]Related articlesFree article

A case of scientific fraud.

Laurent GJ, Radola BJ, Breen CG.

Int J Biochem Cell Biol. 2004 Nov;36(11):2097. No abstract available. PMID: 15313454 [PubMed - indexed for MEDLINE]Related articles

Promoter variants in tissue inhibitor of metalloproteinase-3 (TIMP-3) protect against susceptibility in pigeon breeders' disease.

Hill MR, Briggs L, Montaño MM, Estrada A, Laurent GJ, Selman M, Pardo A.

Thorax. 2004 Jul;59(7):586-90.PMID: 15223866 [PubMed - indexed for MEDLINE]Related articlesFree article

Editorial: A case of scientific fraud.

Laurent GJ, Radola BJ.

Electrophoresis. 2004 Jun;25(12):following table of contents. No abstract available. PMID: 15213996 [PubMed - indexed for MEDLINE]Related articles

Special Issue on HIV.

Laurent GJ.

Int J Biochem Cell Biol. 2004 Sep;36(9):1665. No abstract available. PMID: 15183335 [PubMed - indexed for MEDLINE]Related articles

Shooting for PARs in lung diseases.

Moffatt JD, Page CP, Laurent GJ.

Curr Opin Pharmacol. 2004 Jun;4(3):221-9. Review.PMID: 15140412 [PubMed - indexed for MEDLINE]Related articles

Comparison of the morphological and biochemical changes in normal human lung fibroblasts and fibroblasts derived from lungs of patients with idiopathic pulmonary fibrosis during FasL-induced apoptosis.

Moodley YP, Caterina P, Scaffidi AK, Misso NL, Papadimitriou JM, McAnulty RJ, Laurent GJ, Thompson PJ, Knight DA.

J Pathol. 2004 Apr;202(4):486-95.PMID: 15095276 [PubMed - indexed for MEDLINE]Related articles

Attenuation of bleomycin induced pulmonary fibrosis in mice using the heme oxygenase inhibitor Zn-deuteroporphyrin IX-2,4-bisethylene glycol.

Atzori L, Chua F, Dunsmore SE, Willis D, Barbarisi M, McAnulty RJ, Laurent GJ.

Thorax. 2004 Mar;59(3):217-23.PMID: 14985557 [PubMed - indexed for MEDLINE]Related articlesFree article

Differential roles of extracellular signal-regulated kinase 1/2 and p38MAPK in mechanical load-induced procollagen alpha1(I) gene expression in cardiac fibroblasts.

Papakrivopoulou J, Lindahl GE, Bishop JE, Laurent GJ.

Cardiovasc Res. 2004 Mar 1;61(4):736-44.PMID: 14985070 [PubMed - indexed for MEDLINE]Related articlesFree article

Pulmonary gene therapy. Realistic hope for the future, or false dawn in the promised land?

Jenkins RG, McAnulty RJ, Hart SL, Laurent GJ.

Monaldi Arch Chest Dis. 2003 Jan-Mar;59(1):17-24. Review.PMID: 14533278 [PubMed - indexed for MEDLINE]Related articles

Short course dexamethasone treatment following injury inhibits bleomycin induced fibrosis in rats.

Dik WA, McAnulty RJ, Versnel MA, Naber BA, Zimmermann LJ, Laurent GJ, Mutsaers SE.

Thorax. 2003 Sep;58(9):765-71.PMID: 12947134 [PubMed - indexed for MEDLINE]Related articlesFree article

Fibroblasts isolated from normal lungs and those with idiopathic pulmonary fibrosis differ in interleukin-6/gp130-mediated cell signaling and proliferation.

Moodley YP, Scaffidi AK, Misso NL, Keerthisingam C, McAnulty RJ, Laurent GJ, Mutsaers SE, Thompson PJ, Knight DA.

Am J Pathol. 2003 Jul;163(1):345-54.PMID: 12819039 [PubMed - indexed for MEDLINE]Related articlesFree article

Formation of LID vector complexes in water alters physicochemical properties and enhances pulmonary gene expression in vivo.

Jenkins RG, Meng QH, Hodges RJ, Lee LK, Bottoms SE, Laurent GJ, Willis D, Ayazi Shamlou P, McAnulty RJ, Hart SL.

Gene Ther. 2003 Jun;10(12):1026-34.PMID: 12776160 [PubMed - indexed for MEDLINE]Related articles

Angiotensin II and the fibroproliferative response to acute lung injury.

Marshall RP, Gohlke P, Chambers RC, Howell DC, Bottoms SE, Unger T, McAnulty RJ, Laurent GJ.

Am J Physiol Lung Cell Mol Physiol. 2004 Jan;286(1):L156-64. Epub 2003 May 16.PMID: 12754187 [PubMed - indexed for MEDLINE]Related articlesFree article

Inverse effects of interleukin-6 on apoptosis of fibroblasts from pulmonary fibrosis and normal lungs.

Moodley YP, Misso NL, Scaffidi AK, Fogel-Petrovic M, McAnulty RJ, Laurent GJ, Thompson PJ, Knight DA.

Am J Respir Cell Mol Biol. 2003 Oct;29(4):490-8. Epub 2003 Apr 24.PMID: 12714376 [PubMed - indexed for MEDLINE]Related articlesFree article

Quantitative assessment of subepithelial collagen deposition in the airways of mice following ovalbumin sensitization and intratracheal challenge.

Reinhardt AK, Bottoms SE, Laurent GJ, McAnulty RJ.

Chest. 2003 Mar;123(3 Suppl):428S. Review. No abstract available. PMID: 12629017 [PubMed - indexed for MEDLINE]Related articlesFree article

Global expression profiling of fibroblast responses to transforming growth factor-beta1 reveals the induction of inhibitor of differentiation-1 and provides evidence of smooth muscle cell phenotypic switching.

Chambers RC, Leoni P, Kaminski N, Laurent GJ, Heller RA.

Am J Pathol. 2003 Feb;162(2):533-46.PMID: 12547711 [PubMed - indexed for MEDLINE]Related articlesFree article

Adhesion molecule-dependent mechanisms regulate the rate of macrophage clearance during the resolution of peritoneal inflammation.

Bellingan GJ, Xu P, Cooksley H, Cauldwell H, Shock A, Bottoms S, Haslett C, Mutsaers SE, Laurent GJ.

J Exp Med. 2002 Dec 2;196(11):1515-21.PMID: 12461086 [PubMed - indexed for MEDLINE]Related articlesFree article

Common promoter variant in cyclooxygenase-2 represses gene expression: evidence of role in acute-phase inflammatory response.

Papafili A, Hill MR, Brull DJ, McAnulty RJ, Marshall RP, Humphries SE, Laurent GJ.

Arterioscler Thromb Vasc Biol. 2002 Oct 1;22(10):1631-6.PMID: 12377741 [PubMed - indexed for MEDLINE]Related articlesFree article

Angiotensin converting enzyme insertion/deletion polymorphism is associated with susceptibility and outcome in acute respiratory distress syndrome.

Marshall RP, Webb S, Bellingan GJ, Montgomery HE, Chaudhari B, McAnulty RJ, Humphries SE, Hill MR, Laurent GJ.

Am J Respir Crit Care Med. 2002 Sep 1;166(5):646-50.PMID: 12204859 [PubMed - indexed for MEDLINE]Related articlesFree article

The rapamycin analogue SDZ RAD attenuates bleomycin-induced pulmonary fibrosis in rats.

Simler NR, Howell DC, Marshall RP, Goldsack NR, Hasleton PS, Laurent GJ, Chambers RC, Egan JJ.

Eur Respir J. 2002 Jun;19(6):1124-7.PMID: 12108867 [PubMed - indexed for MEDLINE]Related articlesFree article

Oncostatin M stimulates proliferation, induces collagen production and inhibits apoptosis of human lung fibroblasts.

Scaffidi AK, Mutsaers SE, Moodley YP, McAnulty RJ, Laurent GJ, Thompson PJ, Knight DA.

Br J Pharmacol. 2002 Jul;136(5):793-801.PMID: 12086989 [PubMed - indexed for MEDLINE]Related articlesFree article

Role of thrombin and its major cellular receptor, protease-activated receptor-1, in pulmonary fibrosis.

Howell DC, Laurent GJ, Chambers RC.

Biochem Soc Trans. 2002 Apr;30(2):211-6. Review.PMID: 12023853 [PubMed - indexed for MEDLINE]Related articles

Coagulation cascade proteases and tissue fibrosis.

Chambers RC, Laurent GJ.

Biochem Soc Trans. 2002 Apr;30(2):194-200. Review.PMID: 12023850 [PubMed - indexed for MEDLINE]Related articles

Role of plasminogen activators in peritoneal adhesion formation.

Sulaiman H, Dawson L, Laurent GJ, Bellingan GJ, Herrick SE.

Biochem Soc Trans. 2002 Apr;30(2):126-31. Review.PMID: 12023839 [PubMed - indexed for MEDLINE]Related articles

Evidence for incorporation of free-floating mesothelial cells as a mechanism of serosal healing.

Foley-Comer AJ, Herrick SE, Al-Mishlab T, Prêle CM, Laurent GJ, Mutsaers SE.

J Cell Sci. 2002 Apr 1;115(Pt 7):1383-9.PMID: 11896186 [PubMed - indexed for MEDLINE]Related articlesFree article

Cyclooxygenase-2 overexpression, using an integrin-targeted gene delivery system (the LID vector), inhibits fibroblast proliferation in vitro and leads to increased prostaglandin E(2) in the lung.

Jenkins G, Hart SL, Hodges RJ, Meng QH, Kinnon C, Laurent GJ, McAnulty RJ.

Chest. 2002 Mar;121(3 Suppl):102S-104S. No abstract available. PMID: 11893724 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic polymorphisms associated with susceptibility and outcome in ARDS.

Marshall RP, Webb S, Hill MR, Humphries SE, Laurent GJ.

Chest. 2002 Mar;121(3 Suppl):68S-69S. No abstract available. PMID: 11893690 [PubMed - indexed for MEDLINE]Related articlesFree article