PubMed

Thyroid hormone activation in vascular smooth muscle cells is negatively regulated by glucocorticoid.

Toyoda N, Yasuzawa-Amano S, Nomura E, Yamauchi A, Nishimura K, Ukita C, Morimoto S, Kosaki A, Iwasaka T, Harney JW, Larsen PR, Nishikawa M.

Thyroid. 2009 Jul;19(7):755-63.PMID: 19508118 [PubMed - indexed for MEDLINE]Related articles

Type 2 iodothyronine deiodinase in human skeletal muscle: new insights into its physiological role and regulation.

Larsen PR.

J Clin Endocrinol Metab. 2009 Jun;94(6):1893-5. No abstract available. PMID: 19494166 [PubMed - indexed for MEDLINE]Related articles

Serum bile acids are higher in humans with prior gastric bypass: potential contribution to improved glucose and lipid metabolism.

Patti ME, Houten SM, Bianco AC, Bernier R, Larsen PR, Holst JJ, Badman MK, Maratos-Flier E, Mun EC, Pihlajamaki J, Auwerx J, Goldfine AB.

Obesity (Silver Spring). 2009 Sep;17(9):1671-7. Epub 2009 Apr 9.PMID: 19360006 [PubMed - indexed for MEDLINE]Related articles

Thyroid hormone analogs and metabolites: new applications for an old hormone?

Larsen PR.

Nat Clin Pract Endocrinol Metab. 2009 Jan;5(1):1. No abstract available. PMID: 19079269 [PubMed - indexed for MEDLINE]Related articles

Endocrinology and oncology: closer ties will be mutually beneficial.

Larsen PR.

Nat Clin Pract Endocrinol Metab. 2008 Nov;4(11):585. No abstract available. PMID: 18946487 [PubMed - indexed for MEDLINE]Related articles

Dr Joseph Edward Rall.

Wolff J, Larsen PR.

Nat Clin Pract Endocrinol Metab. 2008 Jul;4(7):359. No abstract available. PMID: 18568042 [PubMed - indexed for MEDLINE]Related articles

Insights from the 78(th) Annual Meeting of the American Thyroid Association.

Larsen PR.

Nat Clin Pract Endocrinol Metab. 2008 Apr;4(4):179. No abstract available. PMID: 18356825 [PubMed - indexed for MEDLINE]Related articles

The thyroid hormone-inactivating deiodinase functions as a homodimer.

Sagar GD, Gereben B, Callebaut I, Mornon JP, Zeöld A, Curcio-Morelli C, Harney JW, Luongo C, Mulcahey MA, Larsen PR, Huang SA, Bianco AC.

Mol Endocrinol. 2008 Jun;22(6):1382-93. Epub 2008 Mar 20.PMID: 18356288 [PubMed - indexed for MEDLINE]Related articlesFree article

Lack of association between the type 2 deiodinase A/G polymorphism and hypertensive traits: the Framingham Heart Study.

Maia AL, Hwang SJ, Levy D, Larson MG, Larsen PR, Fox CS.

Hypertension. 2008 Apr;51(4):e22-3. Epub 2008 Feb 19. No abstract available. PMID: 18285610 [PubMed - indexed for MEDLINE]Related articlesFree article

Cardiovascular and metabolic issues in patients with thyroid dysfunction will be highlighted at the Fifth Anniversary of ATA Spring Meetings in March 2008.

Larsen PR, Baxter JD.

Thyroid. 2008 Feb;18(2):101. No abstract available. PMID: 18279010 [PubMed - indexed for MEDLINE]Related articles

Hypoxia-inducible factor induces local thyroid hormone inactivation during hypoxic-ischemic disease in rats.

Simonides WS, Mulcahey MA, Redout EM, Muller A, Zuidwijk MJ, Visser TJ, Wassen FW, Crescenzi A, da-Silva WS, Harney J, Engel FB, Obregon MJ, Larsen PR, Bianco AC, Huang SA.

J Clin Invest. 2008 Mar;118(3):975-83.PMID: 18259611 [PubMed - indexed for MEDLINE]Related articlesFree article

Long-term assessment of a multidisciplinary approach to thyroid nodule diagnostic evaluation.

Yassa L, Cibas ES, Benson CB, Frates MC, Doubilet PM, Gawande AA, Moore FD Jr, Kim BW, Nosé V, Marqusee E, Larsen PR, Alexander EK.

Cancer. 2007 Dec 25;111(6):508-16.PMID: 17999413 [PubMed - indexed for MEDLINE]Related articlesFree article

Activation of thyroid hormone is transcriptionally regulated by epidermal growth factor in human placenta-derived JEG3 cells.

Canettieri G, Franchi A, Guardia MD, Morantte I, Santaguida MG, Harney JW, Larsen PR, Centanni M.

Endocrinology. 2008 Feb;149(2):695-702. Epub 2007 Nov 8.PMID: 17991726 [PubMed - indexed for MEDLINE]Related articlesFree article

Sonic hedgehog-induced type 3 deiodinase blocks thyroid hormone action enhancing proliferation of normal and malignant keratinocytes.

Dentice M, Luongo C, Huang S, Ambrosio R, Elefante A, Mirebeau-Prunier D, Zavacki AM, Fenzi G, Grachtchouk M, Hutchin M, Dlugosz AA, Bianco AC, Missero C, Larsen PR, Salvatore D.

Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14466-71. Epub 2007 Aug 24.PMID: 17720805 [PubMed - indexed for MEDLINE]Related articlesFree article

Thyroid physiology becomes more complicated.

Larsen PR.

Nat Clin Pract Endocrinol Metab. 2007 Jul;3(7):495. No abstract available. PMID: 17581620 [PubMed - indexed for MEDLINE]Related articles

The type 2 deiodinase (DIO2) A/G polymorphism is not associated with glycemic traits: the Framingham Heart Study.

Maia AL, Dupuis J, Manning A, Liu C, Meigs JB, Cupples LA, Larsen PR, Fox CS.

Thyroid. 2007 Mar;17(3):199-202.PMID: 17381351 [PubMed - indexed for MEDLINE]Related articles

Insights from the 77th annual meeting of the American Thyroid Association.

Larsen PR.

Nat Clin Pract Endocrinol Metab. 2007 Mar;3(3):197. No abstract available. PMID: 17315028 [PubMed - indexed for MEDLINE]Related articles

Management of thyroid nodules detected at US: Society of Radiologists in Ultrasound consensus conference statement.

Frates MC, Benson CB, Charboneau JW, Cibas ES, Clark OH, Coleman BG, Cronan JJ, Doubilet PM, Evans DB, Goellner JR, Hay ID, Hertzberg BS, Intenzo CM, Jeffrey RB, Langer JE, Larsen PR, Mandel SJ, Middleton WD, Reading CC, Sherman SI, Tessler FN.

Ultrasound Q. 2006 Dec;22(4):231-8; discussion 239-40.PMID: 17146329 [PubMed]Related articles

Mice with impaired extrathyroidal thyroxine to 3,5,3'-triiodothyronine conversion maintain normal serum 3,5,3'-triiodothyronine concentrations.

Christoffolete MA, Arrojo e Drigo R, Gazoni F, Tente SM, Goncalves V, Amorim BS, Larsen PR, Bianco AC, Zavacki AM.

Endocrinology. 2007 Mar;148(3):954-60. Epub 2006 Nov 30.PMID: 17138654 [PubMed - indexed for MEDLINE]Related articlesFree article

Hypothyroidism after sunitinib treatment for patients with gastrointestinal stromal tumors.

Desai J, Yassa L, Marqusee E, George S, Frates MC, Chen MH, Morgan JA, Dychter SS, Larsen PR, Demetri GD, Alexander EK.

Ann Intern Med. 2006 Nov 7;145(9):660-4.PMID: 17088579 [PubMed - indexed for MEDLINE]Related articlesFree article

Good news from MEDLINE--and how you can help us stay one step ahead.

Larsen PR, Newman I.

Nat Clin Pract Endocrinol Metab. 2006 Sep;2(9):471. No abstract available. PMID: 16957754 [PubMed - indexed for MEDLINE]Related articles

New guidelines for patients with thyroid nodules and differentiated thyroid cancer.

Larsen PR.

Nat Clin Pract Endocrinol Metab. 2006 Jun;2(6):297. No abstract available. PMID: 16932301 [PubMed - indexed for MEDLINE]Related articles

Detecting and treating hypothyroidism during pregnancy.

Larsen PR.

Nat Clin Pract Endocrinol Metab. 2006 Feb;2(2):59. No abstract available. PMID: 16932254 [PubMed - indexed for MEDLINE]Related articles

Insights from the ENDO 2005 meeting.

Larsen PR.

Nat Clin Pract Endocrinol Metab. 2005 Dec;1(2):59. No abstract available. PMID: 16929367 [PubMed - indexed for MEDLINE]Related articles

Prevalence and distribution of carcinoma in patients with solitary and multiple thyroid nodules on sonography.

Frates MC, Benson CB, Doubilet PM, Kunreuther E, Contreras M, Cibas ES, Orcutt J, Moore FD Jr, Larsen PR, Marqusee E, Alexander EK.

J Clin Endocrinol Metab. 2006 Sep;91(9):3411-7. Epub 2006 Jul 11.PMID: 16835280 [PubMed - indexed for MEDLINE]Related articlesFree article

Atypical expression of type 2 iodothyronine deiodinase in thyrotrophs explains the thyroxine-mediated pituitary thyrotropin feedback mechanism.

Christoffolete MA, Ribeiro R, Singru P, Fekete C, da Silva WS, Gordon DF, Huang SA, Crescenzi A, Harney JW, Ridgway EC, Larsen PR, Lechan RM, Bianco AC.

Endocrinology. 2006 Apr;147(4):1735-43. Epub 2006 Jan 5.PMID: 16396983 [PubMed - indexed for MEDLINE]Related articlesFree article

Management of thyroid nodules detected at US: Society of Radiologists in Ultrasound consensus conference statement.

Frates MC, Benson CB, Charboneau JW, Cibas ES, Clark OH, Coleman BG, Cronan JJ, Doubilet PM, Evans DB, Goellner JR, Hay ID, Hertzberg BS, Intenzo CM, Jeffrey RB, Langer JE, Larsen PR, Mandel SJ, Middleton WD, Reading CC, Sherman SI, Tessler FN; Society of Radiologists in Ultrasound.

Radiology. 2005 Dec;237(3):794-800.PMID: 16304103 [PubMed - indexed for MEDLINE]Related articlesFree article

Cellular and structural biology of the deiodinases.

Bianco AC, Larsen PR.

Thyroid. 2005 Aug;15(8):777-86. Review.PMID: 16131321 [PubMed - indexed for MEDLINE]Related articles

Type 2 iodothyronine deiodinase is the major source of plasma T3 in euthyroid humans.

Maia AL, Kim BW, Huang SA, Harney JW, Larsen PR.

J Clin Invest. 2005 Sep;115(9):2524-33. Epub 2005 Aug 25.PMID: 16127464 [PubMed - indexed for MEDLINE]Related articlesFree article

Transforming growth factor-beta promotes inactivation of extracellular thyroid hormones via transcriptional stimulation of type 3 iodothyronine deiodinase.

Huang SA, Mulcahey MA, Crescenzi A, Chung M, Kim BW, Barnes C, Kuijt W, Turano H, Harney J, Larsen PR.

Mol Endocrinol. 2005 Dec;19(12):3126-36. Epub 2005 Jul 21.PMID: 16037131 [PubMed - indexed for MEDLINE]Related articlesFree article

The type 2 deiodinase A/G (Thr92Ala) polymorphism is associated with decreased enzyme velocity and increased insulin resistance in patients with type 2 diabetes mellitus.

Canani LH, Capp C, Dora JM, Meyer EL, Wagner MS, Harney JW, Larsen PR, Gross JL, Bianco AC, Maia AL.

J Clin Endocrinol Metab. 2005 Jun;90(6):3472-8. Epub 2005 Mar 29.PMID: 15797963 [PubMed - indexed for MEDLINE]Related articlesFree article

CARs and drugs: a risky combination.

Zavacki AM, Larsen PR.

Endocrinology. 2005 Mar;146(3):992-4. No abstract available. PMID: 15713940 [PubMed - indexed for MEDLINE]Related articlesFree article

Thyroid hormone and adrenergic signaling in the heart.

Kim B, Carvalho-Bianco SD, Larsen PR.

Arq Bras Endocrinol Metabol. 2004 Feb;48(1):171-5. Epub 2004 Jun 1. Review.PMID: 15611830 [PubMed - indexed for MEDLINE]Related articlesFree article

Type 1 iodothyronine deiodinase is a sensitive marker of peripheral thyroid status in the mouse.

Zavacki AM, Ying H, Christoffolete MA, Aerts G, So E, Harney JW, Cheng SY, Larsen PR, Bianco AC.

Endocrinology. 2005 Mar;146(3):1568-75. Epub 2004 Dec 9.PMID: 15591136 [PubMed - indexed for MEDLINE]Related articlesFree article

A novel cell type-specific mechanism for thyroid hormone-dependent negative regulation of the human type 1 deiodinase gene.

Kim SW, Hong SJ, Kim KM, Ho SC, So EC, Harney JW, Larsen PR.

Mol Endocrinol. 2004 Dec;18(12):2924-36. Epub 2004 Aug 26.PMID: 15331760 [PubMed - indexed for MEDLINE]Related articlesFree article

Timing and magnitude of increases in levothyroxine requirements during pregnancy in women with hypothyroidism.

Alexander EK, Marqusee E, Lawrence J, Jarolim P, Fischer GA, Larsen PR.

N Engl J Med. 2004 Jul 15;351(3):241-9.PMID: 15254282 [PubMed - indexed for MEDLINE]Related articlesFree article

Chronic cardiac-specific thyrotoxicosis increases myocardial beta-adrenergic responsiveness.

Carvalho-Bianco SD, Kim BW, Zhang JX, Harney JW, Ribeiro RS, Gereben B, Bianco AC, Mende U, Larsen PR.

Mol Endocrinol. 2004 Jul;18(7):1840-9. Epub 2004 May 6.PMID: 15131256 [PubMed - indexed for MEDLINE]Related articlesFree article

Lipopolysaccharide induces type 2 iodothyronine deiodinase in the mediobasal hypothalamus: implications for the nonthyroidal illness syndrome.

Fekete C, Gereben B, Doleschall M, Harney JW, Dora JM, Bianco AC, Sarkar S, Liposits Z, Rand W, Emerson C, Kacskovics I, Larsen PR, Lechan RM.

Endocrinology. 2004 Apr;145(4):1649-55. Epub 2003 Dec 18.PMID: 14684601 [PubMed - indexed for MEDLINE]Related articlesFree article

Endoplasmic reticulum-associated degradation of the human type 2 iodothyronine deiodinase (D2) is mediated via an association between mammalian UBC7 and the carboxyl region of D2.

Kim BW, Zavacki AM, Curcio-Morelli C, Dentice M, Harney JW, Larsen PR, Bianco AC.

Mol Endocrinol. 2003 Dec;17(12):2603-12. Epub 2003 Aug 21.PMID: 12933904 [PubMed - indexed for MEDLINE]Related articlesFree article

The iodothyronine selenodeiodinases are thioredoxin-fold family proteins containing a glycoside hydrolase clan GH-A-like structure.

Callebaut I, Curcio-Morelli C, Mornon JP, Gereben B, Buettner C, Huang S, Castro B, Fonseca TL, Harney JW, Larsen PR, Bianco AC.

J Biol Chem. 2003 Sep 19;278(38):36887-96. Epub 2003 Jul 7.PMID: 12847093 [PubMed - indexed for MEDLINE]Related articlesFree article

Genetic and biological subgroups of low-stage follicular thyroid cancer.

French CA, Alexander EK, Cibas ES, Nose V, Laguette J, Faquin W, Garber J, Moore F Jr, Fletcher JA, Larsen PR, Kroll TG.

Am J Pathol. 2003 Apr;162(4):1053-60.PMID: 12651598 [PubMed - indexed for MEDLINE]Related articlesFree article

Type 3 iodothyronine deiodinase is highly expressed in the human uteroplacental unit and in fetal epithelium.

Huang SA, Dorfman DM, Genest DR, Salvatore D, Larsen PR.

J Clin Endocrinol Metab. 2003 Mar;88(3):1384-8.PMID: 12629133 [PubMed - indexed for MEDLINE]Related articlesFree article

In vivo dimerization of types 1, 2, and 3 iodothyronine selenodeiodinases.

Curcio-Morelli C, Gereben B, Zavacki AM, Kim BW, Huang S, Harney JW, Larsen PR, Bianco AC.

Endocrinology. 2003 Mar;144(3):937-46.PMID: 12586771 [PubMed - indexed for MEDLINE]Related articlesFree article

Natural history of benign solid and cystic thyroid nodules.

Alexander EK, Hurwitz S, Heering JP, Benson CB, Frates MC, Doubilet PM, Cibas ES, Larsen PR, Marqusee E.

Ann Intern Med. 2003 Feb 18;138(4):315-8.PMID: 12585829 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of type 2 iodothyronine deiodinase in follicular carcinoma as a cause of low circulating free thyroxine levels.

Kim BW, Daniels GH, Harrison BJ, Price A, Harney JW, Larsen PR, Weetman AP.

J Clin Endocrinol Metab. 2003 Feb;88(2):594-8.PMID: 12574186 [PubMed - indexed for MEDLINE]Related articlesFree article

Human type 3 iodothyronine selenodeiodinase is located in the plasma membrane and undergoes rapid internalization to endosomes.

Baqui M, Botero D, Gereben B, Curcio C, Harney JW, Salvatore D, Sorimachi K, Larsen PR, Bianco AC.

J Biol Chem. 2003 Jan 10;278(2):1206-11. Epub 2002 Nov 4.PMID: 12419801 [PubMed - indexed for MEDLINE]Related articlesFree article

A 21-year-old woman with consumptive hypothyroidism due to a vascular tumor expressing type 3 iodothyronine deiodinase.

Huang SA, Fish SA, Dorfman DM, Salvatore D, Kozakewich HP, Mandel SJ, Larsen PR.

J Clin Endocrinol Metab. 2002 Oct;87(10):4457-61.PMID: 12364418 [PubMed - indexed for MEDLINE]Related articlesFree article

The mRNA structure has potent regulatory effects on type 2 iodothyronine deiodinase expression.

Gereben B, Kollár A, Harney JW, Larsen PR.

Mol Endocrinol. 2002 Jul;16(7):1667-79.PMID: 12089359 [PubMed - indexed for MEDLINE]Related articlesFree article

High dose of (131)I therapy for the treatment of hyperthyroidism caused by Graves' disease.

Alexander EK, Larsen PR.

J Clin Endocrinol Metab. 2002 Mar;87(3):1073-7.PMID: 11889166 [PubMed - indexed for MEDLINE]Related articlesFree article

Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases.

Bianco AC, Salvatore D, Gereben B, Berry MJ, Larsen PR.

Endocr Rev. 2002 Feb;23(1):38-89. Review.PMID: 11844744 [PubMed - indexed for MEDLINE]Related articlesFree article