PubMed

Dynamics of human regulatory T cells in lung lavages of lung transplant recipients.

Neujahr DC, Cardona AC, Ulukpo O, Rigby M, Pelaez A, Ramirez A, Gal AA, Force SD, Lawrence EC, Kirk AD, Larsen CP.

Transplantation. 2009 Aug 27;88(4):521-7.PMID: 19696635 [PubMed - indexed for MEDLINE]Related articlesFree article

Cellular localization of epidermal-type and brain-type fatty acid-binding proteins in adult hippocampus and their response to cerebral ischemia.

Ma D, Zhang M, Mori Y, Yao C, Larsen CP, Yamashima T, Zhou L.

Hippocampus. 2009 Jul 21. [Epub ahead of print]PMID: 19623607 [PubMed - as supplied by publisher]Related articles

Anti-CD40 monoclonal antibody synergizes with CTLA4-Ig in promoting long-term graft survival in murine models of transplantation.

Gilson CR, Milas Z, Gangappa S, Hollenbaugh D, Pearson TC, Ford ML, Larsen CP.

J Immunol. 2009 Aug 1;183(3):1625-35. Epub 2009 Jul 10.PMID: 19592649 [PubMed - indexed for MEDLINE]Related articles

Alefacept promotes co-stimulation blockade based allograft survival in nonhuman primates.

Weaver TA, Charafeddine AH, Agarwal A, Turner AP, Russell M, Leopardi FV, Kampen RL, Stempora L, Song M, Larsen CP, Kirk AD.

Nat Med. 2009 Jul;15(7):746-9. Epub 2009 Jul 5.PMID: 19584865 [PubMed - indexed for MEDLINE]Related articles

mTOR regulates memory CD8 T-cell differentiation.

Araki K, Turner AP, Shaffer VO, Gangappa S, Keller SA, Bachmann MF, Larsen CP, Ahmed R.

Nature. 2009 Jul 2;460(7251):108-12. Epub 2009 Jun 21.PMID: 19543266 [PubMed - indexed for MEDLINE]Related articles

Donor-reactive T-cell stimulation history and precursor frequency: barriers to tolerance induction.

Ford ML, Kirk AD, Larsen CP.

Transplantation. 2009 May 15;87(9 Suppl):S69-74. Review.PMID: 19424013 [PubMed - indexed for MEDLINE]Related articles

Translating costimulation blockade to the clinic: lessons learned from three pathways.

Ford ML, Larsen CP.

Immunol Rev. 2009 May;229(1):294-306. Review.PMID: 19426229 [PubMed - indexed for MEDLINE]Related articles

IFN-gamma dictates allograft fate via opposing effects on the graft and on recipient CD8 T cell responses.

Coley SM, Ford ML, Hanna SC, Wagener ME, Kirk AD, Larsen CP.

J Immunol. 2009 Jan 1;182(1):225-33.PMID: 19109153 [PubMed - indexed for MEDLINE]Related articles

Acute kidney failure in the third trimester of pregnancy.

Larsen CP, Ejiofor MC, Walker PD.

Am J Kidney Dis. 2009 Jan;53(1):175-9. Epub 2008 Nov 12. No abstract available. PMID: 19008026 [PubMed - indexed for MEDLINE]Related articles

PD-1-dependent mechanisms maintain peripheral tolerance of donor-reactive CD8+ T cells to transplanted tissue.

Koehn BH, Ford ML, Ferrer IR, Borom K, Gangappa S, Kirk AD, Larsen CP.

J Immunol. 2008 Oct 15;181(8):5313-22.PMID: 18832687 [PubMed - indexed for MEDLINE]Related articlesFree article

Expanded nonhuman primate tregs exhibit a unique gene expression signature and potently downregulate alloimmune responses.

Anderson A, Martens CL, Hendrix R, Stempora LL, Miller WP, Hamby K, Russell M, Strobert E, Blazar BR, Pearson TC, Larsen CP, Kean LS.

Am J Transplant. 2008 Nov;8(11):2252-64. Epub 2008 Sep 17.PMID: 18801023 [PubMed - indexed for MEDLINE]Related articles

CD28/CD154 blockade prevents autoimmune diabetes by inducing nondeletional tolerance after effector t-cell inhibition and regulatory T-cell expansion.

Rigby MR, Trexler AM, Pearson TC, Larsen CP.

Diabetes. 2008 Oct;57(10):2672-83. Epub 2008 May 20.PMID: 18492787 [PubMed - indexed for MEDLINE]Related articlesFree article

A critical precursor frequency of donor-reactive CD4+ T cell help is required for CD8+ T cell-mediated CD28/CD154-independent rejection.

Ford ML, Wagener ME, Hanna SS, Pearson TC, Kirk AD, Larsen CP.

J Immunol. 2008 Jun 1;180(11):7203-11.PMID: 18490719 [PubMed - indexed for MEDLINE]Related articlesFree article

Immunosuppressive protocols for pig-to-human islet transplantation: lessons from pre-clinical non-human primate models.

Gangappa S, Larsen CP.

Xenotransplantation. 2008 Mar;15(2):107-11. No abstract available. PMID: 18447881 [PubMed - indexed for MEDLINE]Related articles

Measuring symptom experience of side-effects of immunosuppressive drugs: the Modified Transplant Symptom Occurrence and Distress Scale.

Dobbels F, Moons P, Abraham I, Larsen CP, Dupont L, De Geest S.

Transpl Int. 2008 Aug;21(8):764-73. Epub 2008 May 29.PMID: 18435683 [PubMed - indexed for MEDLINE]Related articles

MRSA-associated bacterial myocarditis causing ruptured ventricle and tamponade.

LeLeiko RM, Bower DJ, Larsen CP.

Cardiology. 2008;111(3):188-90. Epub 2008 Apr 25.PMID: 18434723 [PubMed - indexed for MEDLINE]Related articles

Kidney biopsy findings in a patient with fever, bilateral pulmonary infiltrates, and acute renal failure.

Larsen CP, Moreira RK, Hennigar RA, Bijol V.

Am J Kidney Dis. 2008 Mar;51(3):524-9. No abstract available. PMID: 18295069 [PubMed - indexed for MEDLINE]Related articles

Expansion of effector memory TCR Vbeta4+ CD8+ T cells is associated with latent infection-mediated resistance to transplantation tolerance.

Stapler D, Lee ED, Selvaraj SA, Evans AG, Kean LS, Speck SH, Larsen CP, Gangappa S.

J Immunol. 2008 Mar 1;180(5):3190-200.PMID: 18292543 [PubMed - indexed for MEDLINE]Related articlesFree article

Glial cell line-derived neurotrophic factor increases beta-cell mass and improves glucose tolerance.

Mwangi S, Anitha M, Mallikarjun C, Ding X, Hara M, Parsadanian A, Larsen CP, Thule P, Sitaraman SV, Anania F, Srinivasan S.

Gastroenterology. 2008 Mar;134(3):727-37. Epub 2008 Feb 1.PMID: 18241861 [PubMed - indexed for MEDLINE]Related articles

Immune responsiveness and protective immunity after transplantation.

Gangappa S, Kokko KE, Carlson LM, Gourley T, Newell KA, Pearson TC, Ahmed R, Larsen CP.

Transpl Int. 2008 Apr;21(4):293-303. Epub 2008 Jan 21. Review.PMID: 18225995 [PubMed - indexed for MEDLINE]Related articles

Belatacept and basiliximab diminish human antiporcine xenoreactivity and synergize to inhibit alloimmunity.

Emamaullee JA, Merani S, Larsen CP, Shapiro AM.

Transplantation. 2008 Jan 15;85(1):118-24.PMID: 18192921 [PubMed - indexed for MEDLINE]Related articles

Viral targeting of fibroblastic reticular cells contributes to immunosuppression and persistence during chronic infection.

Mueller SN, Matloubian M, Clemens DM, Sharpe AH, Freeman GJ, Gangappa S, Larsen CP, Ahmed R.

Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15430-5. Epub 2007 Sep 18.PMID: 17878315 [PubMed - indexed for MEDLINE]Related articlesFree article

Engraftment of adult porcine islet xenografts in diabetic nonhuman primates through targeting of costimulation pathways.

Cardona K, Milas Z, Strobert E, Cano J, Jiang W, Safley SA, Gangappa S, Hering BJ, Weber CJ, Pearson TC, Larsen CP.

Am J Transplant. 2007 Oct;7(10):2260-8.PMID: 17845561 [PubMed - indexed for MEDLINE]Related articles

Fully MHC-disparate mixed hemopoietic chimeras show specific defects in the control of chronic viral infections.

Koehn BH, Williams MA, Borom K, Gangappa S, Pearson TC, Ahmed R, Larsen CP.

J Immunol. 2007 Aug 15;179(4):2616-26.PMID: 17675525 [PubMed - indexed for MEDLINE]Related articlesFree article

Infusion of stably immature monocyte-derived dendritic cells plus CTLA4Ig modulates alloimmune reactivity in rhesus macaques.

Zahorchak AF, Kean LS, Tokita D, Turnquist HR, Abe M, Finke J, Hamby K, Rigby MR, Larsen CP, Thomson AW.

Transplantation. 2007 Jul 27;84(2):196-206.PMID: 17667811 [PubMed - indexed for MEDLINE]Related articles

NK cells rapidly reject allogeneic bone marrow in the spleen through a perforin- and Ly49D-dependent, but NKG2D-independent mechanism.

Hamby K, Trexler A, Pearson TC, Larsen CP, Rigby MR, Kean LS.

Am J Transplant. 2007 Aug;7(8):1884-96.PMID: 17617852 [PubMed - indexed for MEDLINE]Related articles

Transplantation tolerance.

Newell KA, Larsen CP.

Semin Nephrol. 2007 Jul;27(4):487-97. Review.PMID: 17616279 [PubMed - indexed for MEDLINE]Related articles

Antigenic disparity impacts outcome of agonism but not blockade of costimulatory pathways in experimental transplant models.

Ford ML, Wagener ME, Gangappa S, Pearson TC, Larsen CP.

Am J Transplant. 2007 Jun;7(6):1471-81.PMID: 17511677 [PubMed - indexed for MEDLINE]Related articles

Role of CD28 in fatal autoimmune disorder in scurfy mice.

Singh N, Chandler PR, Seki Y, Baban B, Takezaki M, Kahler DJ, Munn DH, Larsen CP, Mellor AL, Iwashima M.

Blood. 2007 Aug 15;110(4):1199-206. Epub 2007 Apr 26.PMID: 17463170 [PubMed - indexed for MEDLINE]Related articlesFree article

Antigen-specific precursor frequency impacts T cell proliferation, differentiation, and requirement for costimulation.

Ford ML, Koehn BH, Wagener ME, Jiang W, Gangappa S, Pearson TC, Larsen CP.

J Exp Med. 2007 Feb 19;204(2):299-309. Epub 2007 Jan 29.PMID: 17261633 [PubMed - indexed for MEDLINE]Related articlesFree article

Induction of chimerism in rhesus macaques through stem cell transplant and costimulation blockade-based immunosuppression.

Kean LS, Adams AB, Strobert E, Hendrix R, Gangappa S, Jones TR, Shirasugi N, Rigby MR, Hamby K, Jiang J, Bello H, Anderson D, Cardona K, Durham MM, Pearson TC, Larsen CP.

Am J Transplant. 2007 Feb;7(2):320-35.PMID: 17241112 [PubMed - indexed for MEDLINE]Related articles

Alloimmunity: no toll exemption.

Gangappa S, Larsen CP, Pearson TC.

Am J Transplant. 2007 Jan;7(1):3-4. No abstract available. Erratum in: Am J Transplant. 2007 Jun;7(6):1681. PMID: 17227552 [PubMed - indexed for MEDLINE]Related articles

Apoptotic donor leukocytes limit mixed-chimerism induced by CD40-CD154 blockade in allogeneic bone marrow transplantation.

Li JM, Gorechlad J, Larsen CP, Waller EK.

Biol Blood Marrow Transplant. 2006 Dec;12(12):1239-49.PMID: 17162205 [PubMed - indexed for MEDLINE]Related articles

Continuous recruitment of naive T cells contributes to heterogeneity of antiviral CD8 T cells during persistent infection.

Vezys V, Masopust D, Kemball CC, Barber DL, O'Mara LA, Larsen CP, Pearson TC, Ahmed R, Lukacher AE.

J Exp Med. 2006 Oct 2;203(10):2263-9. Epub 2006 Sep 11.PMID: 16966427 [PubMed - indexed for MEDLINE]Related articlesFree article

Toward transplantation tolerance: a large step on a long road.

Newell KA, Larsen CP.

Am J Transplant. 2006 Sep;6(9):1989-90. Epub 2006 Jul 26. No abstract available. PMID: 16869804 [PubMed - indexed for MEDLINE]Related articles

Infection in renal transplantation: a case of acute Q fever.

Larsen CP, Bell JM, Ketel BL, Walker PD.

Am J Kidney Dis. 2006 Aug;48(2):321-6.PMID: 16860200 [PubMed - indexed for MEDLINE]Related articles

Tolerance assays: measuring the unknown.

Newell KA, Larsen CP.

Transplantation. 2006 Jun 15;81(11):1503-9. Review.PMID: 16770237 [PubMed - indexed for MEDLINE]Related articles

A mouse model for polyomavirus-associated nephropathy of kidney transplants.

Han Lee ED, Kemball CC, Wang J, Dong Y, Stapler DC Jr, Hamby KM, Gangappa S, Newell KA, Pearson TC, Lukacher AE, Larsen CP.

Am J Transplant. 2006 May;6(5 Pt 1):913-22.PMID: 16611327 [PubMed - indexed for MEDLINE]Related articles

Transplant tolerance in non-human primates: progress, current challenges and unmet needs.

Kean LS, Gangappa S, Pearson TC, Larsen CP.

Am J Transplant. 2006 May;6(5 Pt 1):884-93. Review.PMID: 16611324 [PubMed - indexed for MEDLINE]Related articles

A new look at blockade of T-cell costimulation: a therapeutic strategy for long-term maintenance immunosuppression.

Larsen CP, Knechtle SJ, Adams A, Pearson T, Kirk AD.

Am J Transplant. 2006 May;6(5 Pt 1):876-83. Review.PMID: 16611323 [PubMed - indexed for MEDLINE]Related articles

Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathways.

Cardona K, Korbutt GS, Milas Z, Lyon J, Cano J, Jiang W, Bello-Laborn H, Hacquoil B, Strobert E, Gangappa S, Weber CJ, Pearson TC, Rajotte RV, Larsen CP.

Nat Med. 2006 Mar;12(3):304-6. Epub 2006 Feb 26.PMID: 16501570 [PubMed - indexed for MEDLINE]Related articles

Patients, pathogens, and protective immunity: the relevance of virus-induced alloreactivity in transplantation.

Koehn B, Gangappa S, Miller JD, Ahmed R, Larsen CP.

J Immunol. 2006 Mar 1;176(5):2691-6. Review.PMID: 16493023 [PubMed - indexed for MEDLINE]Related articlesFree article

Immunosuppressive and trafficking properties of donor splenic and bone marrow dendritic cells.

Emmanouilidis N, Guo Z, Dong Y, Newton-West M, Adams AB, Lee ED, Wang J, Pearson TC, Larsen CP, Newell KA.

Transplantation. 2006 Feb 15;81(3):455-62.PMID: 16477234 [PubMed - indexed for MEDLINE]Related articles

NK cells mediate costimulation blockade-resistant rejection of allogeneic stem cells during nonmyeloablative transplantation.

Kean LS, Hamby K, Koehn B, Lee E, Coley S, Stempora L, Adams AB, Heiss E, Pearson TC, Larsen CP.

Am J Transplant. 2006 Feb;6(2):292-304.PMID: 16426313 [PubMed - indexed for MEDLINE]Related articles

Costimulation requirements for antiviral CD8+ T cells differ for acute and persistent phases of polyoma virus infection.

Kemball CC, Lee ED, Szomolanyi-Tsuda E, Pearson TC, Larsen CP, Lukacher AE.

J Immunol. 2006 Feb 1;176(3):1814-24.PMID: 16424212 [PubMed - indexed for MEDLINE]Related articlesFree article

Transplant tolerance: converging on a moving target.

Newell KA, Larsen CP, Kirk AD.

Transplantation. 2006 Jan 15;81(1):1-6. Review.PMID: 16421467 [PubMed - indexed for MEDLINE]Related articles

Late priming and variability of epitope-specific CD8+ T cell responses during a persistent virus infection.

Kemball CC, Lee ED, Vezys V, Pearson TC, Larsen CP, Lukacher AE.

J Immunol. 2005 Jun 15;174(12):7950-60.PMID: 15944301 [PubMed - indexed for MEDLINE]Related articlesFree article

Six years' experience of using the BacT/ALERT system to screen all platelet concentrates, and additional testing of outdated platelet concentrates to estimate the frequency of false-negative results.

Larsen CP, Ezligini F, Hermansen NO, Kjeldsen-Kragh J.

Vox Sang. 2005 Feb;88(2):93-7.PMID: 15720606 [PubMed - indexed for MEDLINE]Related articles

Rational development of LEA29Y (belatacept), a high-affinity variant of CTLA4-Ig with potent immunosuppressive properties.

Larsen CP, Pearson TC, Adams AB, Tso P, Shirasugi N, Strobertm E, Anderson D, Cowan S, Price K, Naemura J, Emswiler J, Greene J, Turk LA, Bajorath J, Townsend R, Hagerty D, Linsley PS, Peach RJ.

Am J Transplant. 2005 Mar;5(3):443-53.PMID: 15707398 [PubMed - indexed for MEDLINE]Related articles

Impaired recall of CD8 memory T cells in immunologically privileged tissue.

Dai Z, Nasr IW, Reel M, Deng S, Diggs L, Larsen CP, Rothstein DM, Lakkis FG.

J Immunol. 2005 Feb 1;174(3):1165-70.PMID: 15661869 [PubMed - indexed for MEDLINE]Related articlesFree article