PubMed

Peroxisome Proliferator-Activated Receptor-{alpha} Control of Lipid and Glucose Metabolism in Human White Adipocytes.

Ribet C, Montastier E, Valle C, Bezaire V, Mazzucotelli A, Mairal A, Viguerie N, Langin D.

Endocrinology. 2009 Nov 3. [Epub ahead of print]PMID: 19887568 [PubMed - as supplied by publisher]Related articles

Obesity-related Polymorphisms and Their Associations With the Ability to Regulate Fat Oxidation in Obese Europeans: The NUGENOB Study.

Corpeleijn E, Petersen L, Holst C, Saris WH, Astrup A, Langin D, Macdonald I, Martinez JA, Oppert JM, Polak J, Pedersen O, Froguel P, Arner P, Sørensen TI, Blaak EE.

Obesity (Silver Spring). 2009 Oct 29. [Epub ahead of print]PMID: 19876004 [PubMed - as supplied by publisher]Related articles

Recruitment of brown fat and conversion of white into brown adipocytes: Strategies to fight the metabolic complications of obesity?

Langin D.

Biochim Biophys Acta. 2009 Sep 24. [Epub ahead of print]PMID: 19782764 [PubMed - as supplied by publisher]Related articles

Effect of hyperinsulinemia and very-low-calorie diet on interstitial cytokine levels in subcutaneous adipose tissue of obese women.

Siklova-Vitkova M Phd, Polak J, Klimcakova E, Vrzalova J, Hejnova J, Kovacikova M, Kovacova Z, Bajzova M, Rossmeislova L, Hnevkovska Z, Langin D, Stich V Phd.

Am J Physiol Endocrinol Metab. 2009 Sep 1. [Epub ahead of print]PMID: 19724021 [PubMed - as supplied by publisher]Related articles

Regulation of adipose tissue lipolysis revisited.

Bézaire V, Langin D.

Proc Nutr Soc. 2009 Nov;68(4):350-60. Epub 2009 Aug 24.PMID: 19698205 [PubMed - in process]Related articles

Chronic TNFalpha and cAMP pre-treatment of human adipocytes alter HSL, ATGL and perilipin to regulate basal and stimulated lipolysis.

Bézaire V, Mairal A, Anesia R, Lefort C, Langin D.

FEBS Lett. 2009 Sep 17;583(18):3045-9. Epub 2009 Aug 18.PMID: 19695247 [PubMed - indexed for MEDLINE]Related articles

Macronutrient-specific effect of FTO rs9939609 in response to a 10-week randomized hypo-energetic diet among obese Europeans.

Grau K, Hansen T, Holst C, Astrup A, Saris WH, Arner P, Rössner S, Macdonald I, Polak J, Oppert JM, Langin D, Martinez JA, Pedersen O, Sørensen TI.

Int J Obes (Lond). 2009 Nov;33(11):1227-34. Epub 2009 Aug 18.PMID: 19687793 [PubMed - in process]Related articles

Influence of gender, obesity, and muscle lipase activity on intramyocellular lipids in sedentary individuals.

Moro C, Galgani JE, Luu L, Pasarica M, Mairal A, Bajpeyi S, Schmitz G, Langin D, Liebisch G, Smith SR.

J Clin Endocrinol Metab. 2009 Sep;94(9):3440-7. Epub 2009 Jun 16.PMID: 19531593 [PubMed - indexed for MEDLINE]Related articles

Transcription of the human uncoupling protein 3 gene is governed by a complex interplay between the promoter and intronic sequences.

Girousse A, Tavernier G, Tiraby C, Lichtenstein L, Iacovoni JS, Mairal A, Villarroya F, Langin D.

Diabetologia. 2009 Aug;52(8):1638-46. Epub 2009 May 26.PMID: 19468707 [PubMed - indexed for MEDLINE]Related articles

Lipolysis and lipid mobilization in human adipose tissue.

Lafontan M, Langin D.

Prog Lipid Res. 2009 Sep;48(5):275-97. Epub 2009 May 21.PMID: 19464318 [PubMed - in process]Related articles

Contribution of adipose triglyceride lipase and hormone-sensitive lipase to lipolysis in hMADS adipocytes.

Bezaire V, Mairal A, Ribet C, Lefort C, Girousse A, Jocken J, Laurencikiene J, Anesia R, Rodriguez AM, Ryden M, Stenson BM, Dani C, Ailhaud G, Arner P, Langin D.

J Biol Chem. 2009 Jul 3;284(27):18282-91. Epub 2009 May 11.PMID: 19433586 [PubMed - indexed for MEDLINE]Related articles

Adrenaline but not noradrenaline is a determinant of exercise-induced lipid mobilization in human subcutaneous adipose tissue.

de Glisezinski I, Larrouy D, Bajzova M, Koppo K, Polak J, Berlan M, Bulow J, Langin D, Marques MA, Crampes F, Lafontan M, Stich V.

J Physiol. 2009 Jul 1;587(Pt 13):3393-404. Epub 2009 May 5.PMID: 19417097 [PubMed - indexed for MEDLINE]Related articles

Macrophages and adipocytes in human obesity: adipose tissue gene expression and insulin sensitivity during calorie restriction and weight stabilization.

Capel F, Klimcáková E, Viguerie N, Roussel B, Vítková M, Kováciková M, Polák J, Kovácová Z, Galitzky J, Maoret JJ, Hanácek J, Pers TH, Bouloumié A, Stich V, Langin D.

Diabetes. 2009 Jul;58(7):1558-67. Epub 2009 Apr 28.PMID: 19401422 [PubMed - indexed for MEDLINE]Related articlesFree article

CXC ligand 5 is an adipose-tissue derived factor that links obesity to insulin resistance.

Chavey C, Lazennec G, Lagarrigue S, Clapé C, Iankova I, Teyssier J, Annicotte JS, Schmidt J, Mataki C, Yamamoto H, Sanches R, Guma A, Stich V, Vitkova M, Jardin-Watelet B, Renard E, Strieter R, Tuthill A, Hotamisligil GS, Vidal-Puig A, Zorzano A, Langin D, Fajas L.

Cell Metab. 2009 Apr;9(4):339-49.PMID: 19356715 [PubMed - indexed for MEDLINE]Related articles

Secretion of adiponectin multimeric complexes from adipose tissue explants is not modified by very low calorie diet.

Kovacova Z, Vitkova M, Kovacikova M, Klimcakova E, Bajzova M, Hnevkovska Z, Rossmeislova L, Stich V, Langin D, Polak J.

Eur J Endocrinol. 2009 Apr;160(4):585-92. Epub 2009 Jan 20.PMID: 19155318 [PubMed - indexed for MEDLINE]Related articles

ApoB100-LDL acts as a metabolic signal from liver to peripheral fat causing inhibition of lipolysis in adipocytes.

Skogsberg J, Dicker A, Rydén M, Aström G, Nilsson R, Bhuiyan H, Vitols S, Mairal A, Langin D, Alberts P, Walum E, Tegnér J, Hamsten A, Arner P, Björkegren J.

PLoS One. 2008;3(11):e3771. Epub 2008 Nov 20.PMID: 19020660 [PubMed - indexed for MEDLINE]Related articlesFree article

Evidence for an important role of CIDEA in human cancer cachexia.

Laurencikiene J, Stenson BM, Arvidsson Nordström E, Agustsson T, Langin D, Isaksson B, Permert J, Rydén M, Arner P.

Cancer Res. 2008 Nov 15;68(22):9247-54.PMID: 19010897 [PubMed - indexed for MEDLINE]Related articlesFree article

Contribution of energy restriction and macronutrient composition to changes in adipose tissue gene expression during dietary weight-loss programs in obese women.

Capel F, Viguerie N, Vega N, Dejean S, Arner P, Klimcakova E, Martinez JA, Saris WH, Holst C, Taylor M, Oppert JM, Sørensen TI, Clément K, Vidal H, Langin D.

J Clin Endocrinol Metab. 2008 Nov;93(11):4315-22. Epub 2008 Sep 9.PMID: 18782868 [PubMed - indexed for MEDLINE]Related articlesFree article

Gene expression profiling of human skeletal muscle in response to stabilized weight loss.

Larrouy D, Barbe P, Valle C, Déjean S, Pelloux V, Thalamas C, Bastard JP, Le Bouil A, Diquet B, Clément K, Langin D, Viguerie N.

Am J Clin Nutr. 2008 Jul;88(1):125-32.PMID: 18614732 [PubMed - indexed for MEDLINE]Related articlesFree article

Visfatin expression in subcutaneous adipose tissue of pre-menopausal women: relation to hormones and weight reduction.

Kovacikova M, Vitkova M, Klimcakova E, Polak J, Hejnova J, Bajzova M, Kovacova Z, Viguerie N, Langin D, Stich V.

Eur J Clin Invest. 2008 Jul;38(7):516-22.PMID: 18578692 [PubMed - indexed for MEDLINE]Related articles

The transcriptional co-activator PGC-1alpha up regulates apelin in human and mouse adipocytes.

Mazzucotelli A, Ribet C, Castan-Laurell I, Daviaud D, Guigné C, Langin D, Valet P.

Regul Pept. 2008 Oct 9;150(1-3):33-7. Epub 2008 Apr 13.PMID: 18501443 [PubMed - indexed for MEDLINE]Related articles

Total adiponectin and adiponectin multimeric complexes in relation to weight loss-induced improvements in insulin sensitivity in obese women: the NUGENOB study.

Polak J, Kovacova Z, Holst C, Verdich C, Astrup A, Blaak E, Patel K, Oppert JM, Langin D, Martinez JA, Sørensen TI, Stich V.

Eur J Endocrinol. 2008 Apr;158(4):533-41.PMID: 18362301 [PubMed - indexed for MEDLINE]Related articlesFree article

Effects of TCF7L2 polymorphisms on obesity in European populations.

Cauchi S, Choquet H, Gutiérrez-Aguilar R, Capel F, Grau K, Proença C, Dina C, Duval A, Balkau B, Marre M, Potoczna N, Langin D, Horber F, Sørensen TI, Charpentier G, Meyre D, Froguel P.

Obesity (Silver Spring). 2008 Feb;16(2):476-82.PMID: 18239663 [PubMed - indexed for MEDLINE]Related articles

Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity.

Henegar C, Tordjman J, Achard V, Lacasa D, Cremer I, Guerre-Millo M, Poitou C, Basdevant A, Stich V, Viguerie N, Langin D, Bedossa P, Zucker JD, Clement K.

Genome Biol. 2008 Jan 21;9(1):R14. [Epub ahead of print]PMID: 18208606 [PubMed - as supplied by publisher]Related articlesFree article

Fatty acid-induced mitochondrial uncoupling in adipocytes is not a promising target for treatment of insulin resistance unless adipocyte oxidative capacity is increased.

Frayn KN, Langin D, Karpe F.

Diabetologia. 2008 Mar;51(3):394-7. Epub 2007 Dec 21.PMID: 18097647 [PubMed - indexed for MEDLINE]Related articles

Adipose gene expression prior to weight loss can differentiate and weakly predict dietary responders.

Mutch DM, Temanni MR, Henegar C, Combes F, Pelloux V, Holst C, Sørensen TI, Astrup A, Martinez JA, Saris WH, Viguerie N, Langin D, Zucker JD, Clément K.

PLoS One. 2007 Dec 19;2(12):e1344.PMID: 18094752 [PubMed - indexed for MEDLINE]Related articlesFree article

Retinol-binding protein 4 expression in visceral and subcutaneous fat in human obesity.

Bajzová M, Kováciková M, Vítková M, Klimcáková E, Polák J, Kovácová Z, Viguerie N, Vedral T, Mikulásek L, Srámková P, Srp A, Hejnová J, Langin D, Stich V.

Physiol Res. 2008;57(6):927-34. Epub 2007 Nov 30.PMID: 18052678 [PubMed - indexed for MEDLINE]Related articlesFree article

Regulation of inflammation-related genes in human adipose tissue.

Clement K, Langin D.

J Intern Med. 2007 Oct;262(4):422-30. Review.PMID: 17875178 [PubMed - indexed for MEDLINE]Related articles

Resistance to high-fat-diet-induced obesity and sexual dimorphism in the metabolic responses of transgenic mice with moderate uncoupling protein 3 overexpression in glycolytic skeletal muscles.

Tiraby C, Tavernier G, Capel F, Mairal A, Crampes F, Rami J, Pujol C, Boutin JA, Langin D.

Diabetologia. 2007 Oct;50(10):2190-9. Epub 2007 Aug 4.PMID: 17676309 [PubMed - indexed for MEDLINE]Related articles

The transcriptional coactivator peroxisome proliferator activated receptor (PPAR)gamma coactivator-1 alpha and the nuclear receptor PPAR alpha control the expression of glycerol kinase and metabolism genes independently of PPAR gamma activation in human white adipocytes.

Mazzucotelli A, Viguerie N, Tiraby C, Annicotte JS, Mairal A, Klimcakova E, Lepin E, Delmar P, Dejean S, Tavernier G, Lefort C, Hidalgo J, Pineau T, Fajas L, Clément K, Langin D.

Diabetes. 2007 Oct;56(10):2467-75. Epub 2007 Jul 23.PMID: 17646210 [PubMed - indexed for MEDLINE]Related articlesFree article

Transcriptional control of brown fat determination by PRDM16.

Seale P, Kajimura S, Yang W, Chin S, Rohas LM, Uldry M, Tavernier G, Langin D, Spiegelman BM.

Cell Metab. 2007 Jul;6(1):38-54.PMID: 17618855 [PubMed - indexed for MEDLINE]Related articlesFree article

An intervention study of the effects of calcium intake on faecal fat excretion, energy metabolism and adipose tissue mRNA expression of lipid-metabolism related proteins.

Boon N, Hul GB, Stegen JH, Sluijsmans WE, Valle C, Langin D, Viguerie N, Saris WH.

Int J Obes (Lond). 2007 Nov;31(11):1704-12. Epub 2007 Jun 19.PMID: 17579637 [PubMed - indexed for MEDLINE]Related articles

Profiling of adipokines secreted from human subcutaneous adipose tissue in response to PPAR agonists.

Klimcakova E, Moro C, Mazzucotelli A, Lolmède K, Viguerie N, Galitzky J, Stich V, Langin D.

Biochem Biophys Res Commun. 2007 Jul 6;358(3):897-902. Epub 2007 May 11.PMID: 17511960 [PubMed - indexed for MEDLINE]Related articles

The role of neutral lipases in human adipose tissue lipolysis.

Arner P, Langin D.

Curr Opin Lipidol. 2007 Jun;18(3):246-50. Review.PMID: 17495596 [PubMed - indexed for MEDLINE]Related articles

Plasma levels and adipose tissue messenger ribonucleic acid expression of retinol-binding protein 4 are reduced during calorie restriction in obese subjects but are not related to diet-induced changes in insulin sensitivity.

Vitkova M, Klimcakova E, Kovacikova M, Valle C, Moro C, Polak J, Hanacek J, Capel F, Viguerie N, Richterova B, Bajzova M, Hejnova J, Stich V, Langin D.

J Clin Endocrinol Metab. 2007 Jun;92(6):2330-5. Epub 2007 Apr 3.PMID: 17405846 [PubMed - indexed for MEDLINE]Related articlesFree article

The atrial natriuretic peptide- and catecholamine-induced lipolysis and expression of related genes in adipose tissue in hypothyroid and hyperthyroid patients.

Polak J, Moro C, Klimcakova E, Kovacikova M, Bajzova M, Vitkova M, Kovacova Z, Sotornik R, Berlan M, Viguerie N, Langin D, Stich V.

Am J Physiol Endocrinol Metab. 2007 Jul;293(1):E246-51. Epub 2007 Mar 27.PMID: 17389707 [PubMed - indexed for MEDLINE]Related articlesFree article

Impaired fat-induced thermogenesis in obese subjects: the NUGENOB study.

Blaak EE, Hul G, Verdich C, Stich V, Martinez JA, Petersen M, Feskens EF, Patel K, Oppert JM, Barbe P, Toubro S, Polak J, Anderson I, Astrup A, Macdonald I, Langin D, Sørensen T, Saris WH; NUGENOB Consortium.

Obesity (Silver Spring). 2007 Mar;15(3):653-63.PMID: 17372316 [PubMed - indexed for MEDLINE]Related articles

Adipose triglyceride lipase and hormone-sensitive lipase protein expression is decreased in the obese insulin-resistant state.

Jocken JW, Langin D, Smit E, Saris WH, Valle C, Hul GB, Holm C, Arner P, Blaak EE.

J Clin Endocrinol Metab. 2007 Jun;92(6):2292-9. Epub 2007 Mar 13.PMID: 17356053 [PubMed - indexed for MEDLINE]Related articlesFree article

Comparative studies of the role of hormone-sensitive lipase and adipose triglyceride lipase in human fat cell lipolysis.

Rydén M, Jocken J, van Harmelen V, Dicker A, Hoffstedt J, Wirén M, Blomqvist L, Mairal A, Langin D, Blaak E, Arner P.

Am J Physiol Endocrinol Metab. 2007 Jun;292(6):E1847-55. Epub 2007 Feb 27.PMID: 17327373 [PubMed - indexed for MEDLINE]Related articlesFree article

Atrial natriuretic peptide inhibits the production of adipokines and cytokines linked to inflammation and insulin resistance in human subcutaneous adipose tissue.

Moro C, Klimcakova E, Lolmède K, Berlan M, Lafontan M, Stich V, Bouloumié A, Galitzky J, Arner P, Langin D.

Diabetologia. 2007 May;50(5):1038-47. Epub 2007 Feb 23.PMID: 17318625 [PubMed - indexed for MEDLINE]Related articles

NF-kappaB is important for TNF-alpha-induced lipolysis in human adipocytes.

Laurencikiene J, van Harmelen V, Arvidsson Nordström E, Dicker A, Blomqvist L, Näslund E, Langin D, Arner P, Rydén M.

J Lipid Res. 2007 May;48(5):1069-77. Epub 2007 Feb 1.PMID: 17272828 [PubMed - indexed for MEDLINE]Related articlesFree article

[Fatty acid mobilization and their use in adipose tissue]

Mazzucotelli A, Langin D.

J Soc Biol. 2006;200(1):83-91. Review. French. PMID: 17144166 [PubMed - indexed for MEDLINE]Related articles

Genotype-by-nutrient interactions assessed in European obese women. A case-only study.

Santos JL, Boutin P, Verdich C, Holst C, Larsen LH, Toubro S, Dina C, Saris WH, Blaak EE, Hoffstedt J, Taylor MA, Polak J, Clement K, Langin D, Astrup A, Froguel P, Pedersen O, Sorensen TI, Martinez JA; NUGENOB* consortium.

Eur J Nutr. 2006 Dec;45(8):454-62. Epub 2006 Nov 1.PMID: 17080261 [PubMed - indexed for MEDLINE]Related articles

The effects of increasing serum calcitriol on energy and fat metabolism and gene expression.

Boon N, Hul GB, Sicard A, Kole E, Van Den Berg ER, Viguerie N, Langin D, Saris WH.

Obesity (Silver Spring). 2006 Oct;14(10):1739-46.PMID: 17062803 [PubMed - indexed for MEDLINE]Related articles

Effect of aerobic training on plasma levels and subcutaneous abdominal adipose tissue gene expression of adiponectin, leptin, interleukin 6, and tumor necrosis factor alpha in obese women.

Polak J, Klimcakova E, Moro C, Viguerie N, Berlan M, Hejnova J, Richterova B, Kraus I, Langin D, Stich V.

Metabolism. 2006 Oct;55(10):1375-81.PMID: 16979409 [PubMed - indexed for MEDLINE]Related articles

Dynamic strength training improves insulin sensitivity without altering plasma levels and gene expression of adipokines in subcutaneous adipose tissue in obese men.

Klimcakova E, Polak J, Moro C, Hejnova J, Majercik M, Viguerie N, Berlan M, Langin D, Stich V.

J Clin Endocrinol Metab. 2006 Dec;91(12):5107-12. Epub 2006 Sep 12.PMID: 16968804 [PubMed - indexed for MEDLINE]Related articlesFree article

Importance of TNFalpha and neutral lipases in human adipose tissue lipolysis.

Langin D, Arner P.

Trends Endocrinol Metab. 2006 Oct;17(8):314-20. Epub 2006 Aug 30. Review.PMID: 16938460 [PubMed - indexed for MEDLINE]Related articles

Genetic polymorphisms and weight loss in obesity: a randomised trial of hypo-energetic high- versus low-fat diets.

Sørensen TI, Boutin P, Taylor MA, Larsen LH, Verdich C, Petersen L, Holst C, Echwald SM, Dina C, Toubro S, Petersen M, Polak J, Clément K, Martínez JA, Langin D, Oppert JM, Stich V, Macdonald I, Arner P, Saris WH, Pedersen O, Astrup A, Froguel P; NUGENOB Consortium.

PLoS Clin Trials. 2006 Jun;1(2):e12. Epub 2006 Jun 30.PMID: 16871334 [PubMed]Related articlesFree article

Control of fatty acid and glycerol release in adipose tissue lipolysis.

Langin D.

C R Biol. 2006 Aug;329(8):598-607; discussion 653-5. Epub 2006 Apr 27. Review.PMID: 16860278 [PubMed - indexed for MEDLINE]Related articles

Human adipose triglyceride lipase (PNPLA2) is not regulated by obesity and exhibits low in vitro triglyceride hydrolase activity.

Mairal A, Langin D, Arner P, Hoffstedt J.

Diabetologia. 2006 Jul;49(7):1629-36. Epub 2006 May 10.PMID: 16752181 [PubMed - indexed for MEDLINE]Related articles