PubMed

Divergent cellular phenotypes of human and mouse cells lacking the Werner syndrome RecQ helicase.

Dhillon KK, Sidorova JM, Albertson TM, Anderson JB, Ladiges WC, Rabinovitch PS, Preston BD, Monnat RJ Jr.

DNA Repair (Amst). 2009 Nov 4. [Epub ahead of print]PMID: 19896421 [PubMed - as supplied by publisher]Related articles

Attenuation of age-related metabolic dysfunction in mice with a targeted disruption of the Cbeta subunit of protein kinase A.

Enns LC, Morton JF, Mangalindan RS, McKnight GS, Schwartz MW, Kaeberlein MR, Kennedy BK, Rabinovitch PS, Ladiges WC.

J Gerontol A Biol Sci Med Sci. 2009 Dec;64(12):1221-31. Epub 2009 Sep 23.PMID: 19776218 [PubMed - in process]Related articlesFree article

Disruption of protein kinase A in mice enhances healthy aging.

Enns LC, Morton JF, Treuting PR, Emond MJ, Wolf NS, McKnight GS, Rabinovitch PS, Ladiges WC.

PLoS One. 2009 Jun 18;4(6):e5963.PMID: 19536287 [PubMed - indexed for MEDLINE]Related articlesFree article

Overexpression of catalase targeted to mitochondria attenuates murine cardiac aging.

Dai DF, Santana LF, Vermulst M, Tomazela DM, Emond MJ, MacCoss MJ, Gollahon K, Martin GM, Loeb LA, Ladiges WC, Rabinovitch PS.

Circulation. 2009 Jun 2;119(21):2789-97. Epub 2009 May 18.PMID: 19451351 [PubMed - indexed for MEDLINE]Related articles

Reduction of age-associated pathology in old mice by overexpression of catalase in mitochondria.

Treuting PM, Linford NJ, Knoblaugh SE, Emond MJ, Morton JF, Martin GM, Rabinovitch PS, Ladiges WC.

J Gerontol A Biol Sci Med Sci. 2008 Aug;63(8):813-22.PMID: 18772469 [PubMed - indexed for MEDLINE]Related articles

Clinical relevance of transgenic mouse models for aging research.

Enns LC, Wiley JC, Ladiges WC.

Crit Rev Eukaryot Gene Expr. 2008;18(1):81-91. Review.PMID: 18197787 [PubMed - indexed for MEDLINE]Related articles

Fe65 stimulates proteolytic liberation of the beta-amyloid precursor protein intracellular domain.

Wiley JC, Smith EA, Hudson MP, Ladiges WC, Bothwell M.

J Biol Chem. 2007 Nov 16;282(46):33313-25. Epub 2007 Sep 11.PMID: 17855370 [PubMed - indexed for MEDLINE]Related articlesFree article

Mutation at the polymerase active site of mouse DNA polymerase delta increases genomic instability and accelerates tumorigenesis.

Venkatesan RN, Treuting PM, Fuller ED, Goldsby RE, Norwood TH, Gooley TA, Ladiges WC, Preston BD, Loeb LA.

Mol Cell Biol. 2007 Nov;27(21):7669-82. Epub 2007 Sep 4.PMID: 17785453 [PubMed - indexed for MEDLINE]Related articlesFree article

Glutamate cysteine ligase modifier subunit deficiency and gender as determinants of acetaminophen-induced hepatotoxicity in mice.

McConnachie LA, Mohar I, Hudson FN, Ware CB, Ladiges WC, Fernandez C, Chatterton-Kirchmeier S, White CC, Pierce RH, Kavanagh TJ.

Toxicol Sci. 2007 Oct;99(2):628-36. Epub 2007 Jun 21.PMID: 17584759 [PubMed - indexed for MEDLINE]Related articlesFree article

Mitochondrial point mutations do not limit the natural lifespan of mice.

Vermulst M, Bielas JH, Kujoth GC, Ladiges WC, Rabinovitch PS, Prolla TA, Loeb LA.

Nat Genet. 2007 Apr;39(4):540-3. Epub 2007 Mar 4.PMID: 17334366 [PubMed - indexed for MEDLINE]Related articles

Acetaminophen-induced liver injury is attenuated in male glutamate-cysteine ligase transgenic mice.

Botta D, Shi S, White CC, Dabrowski MJ, Keener CL, Srinouanprachanh SL, Farin FM, Ware CB, Ladiges WC, Pierce RH, Fausto N, Kavanagh TJ.

J Biol Chem. 2006 Sep 29;281(39):28865-75. Epub 2006 Jul 13.PMID: 16840778 [PubMed - indexed for MEDLINE]Related articlesFree article

Mouse models of XRCC1 DNA repair polymorphisms and cancer.

Ladiges WC.

Oncogene. 2006 Mar 13;25(11):1612-9. Review.PMID: 16550161 [PubMed - indexed for MEDLINE]Related articles

Approaches to determine clinical significance of genetic variants.

MacAuley A, Ladiges WC.

Mutat Res. 2005 Jun 3;573(1-2):205-20. Review.PMID: 15829249 [PubMed - indexed for MEDLINE]Related articles

Pancreatic beta-cell failure and diabetes in mice with a deletion mutation of the endoplasmic reticulum molecular chaperone gene P58IPK.

Ladiges WC, Knoblaugh SE, Morton JF, Korth MJ, Sopher BL, Baskin CR, MacAuley A, Goodman AG, LeBoeuf RC, Katze MG.

Diabetes. 2005 Apr;54(4):1074-81.PMID: 15793246 [PubMed - indexed for MEDLINE]Related articlesFree article

Polymorphic variation in hOGG1 and risk of cancer: a review of the functional and epidemiologic literature.

Weiss JM, Goode EL, Ladiges WC, Ulrich CM.

Mol Carcinog. 2005 Mar;42(3):127-41. Review.PMID: 15584022 [PubMed - indexed for MEDLINE]Related articles

Utility of a C57BL/6 ES line versus 129 ES lines for targeted mutations in mice.

Ware CB, Siverts LA, Nelson AM, Morton JF, Ladiges WC.

Transgenic Res. 2003 Dec;12(6):743-6.PMID: 14713204 [PubMed - indexed for MEDLINE]Related articles

Detection of transgene product in mouse peripheral blood lymphocytes: a minimally invasive microassay.

Chou ST, Ladiges WC.

Comp Med. 2002 Dec;52(6):543-7.PMID: 12540168 [PubMed - indexed for MEDLINE]Related articles

Generation of genetically altered mouse models for aging studies.

Treuting PM, Hopkins HC, Ware CA, Rabinovitch PR, Ladiges WC.

Exp Mol Pathol. 2002 Feb;72(1):49-55.PMID: 11784122 [PubMed - indexed for MEDLINE]Related articles

Levels of DNA damage are unaltered in mice overexpressing human catalase in nuclei.

Schriner SE, Ogburn CE, Smith AC, Newcomb TG, Ladiges WC, Dollé ME, Vijg J, Fukuchi K, Martin GM.

Free Radic Biol Med. 2000 Oct 1;29(7):664-73.PMID: 11033419 [PubMed - indexed for MEDLINE]Related articles

Cellular Werner phenotypes in mice expressing a putative dominant-negative human WRN gene.

Wang L, Ogburn CE, Ware CB, Ladiges WC, Youssoufian H, Martin GM, Oshima J.

Genetics. 2000 Jan;154(1):357-62.PMID: 10628995 [PubMed - indexed for MEDLINE]Related articlesFree article

Evaluation of FVB/N mice as recipients for transgenic embryos.

Perret-Gentil MI, Murray L, Bird DJ, Ladiges WC.

Lab Anim Sci. 1999 Aug;49(4):427-8. No abstract available. PMID: 10480651 [PubMed - indexed for MEDLINE]Related articles

FVB/N (H2(q)) mouse is resistant to arthritis induction and exhibits a genomic deletion of T-cell receptor V beta gene segments.

Osman GE, Hannibal MC, Anderson JP, Lasky SR, Ladiges WC, Hood L.

Immunogenetics. 1999 Sep;49(10):851-9.PMID: 10436178 [PubMed - indexed for MEDLINE]Related articles

T-cell receptor vbeta deletion and valpha polymorphism are responsible for the resistance of SWR mouse to arthritis induction.

Osman GE, Hannibal MC, Anderson JP, Cheunsuk S, Lasky SR, Liggitt HD, Ladiges WC, Hood LE.

Immunogenetics. 1999 Aug;49(9):764-72.PMID: 10398803 [PubMed - indexed for MEDLINE]Related articles

Transgenic mice over-expressing the C-99 fragment of betaPP with an alpha-secretase site mutation develop a myopathy similar to human inclusion body myositis.

Jin LW, Hearn MG, Ogburn CE, Dang N, Nochlin D, Ladiges WC, Martin GM.

Am J Pathol. 1998 Dec;153(6):1679-86.PMID: 9846957 [PubMed - indexed for MEDLINE]Related articlesFree article

Expression of a type II collagen-specific TCR transgene accelerates the onset of arthritis in mice.

Osman GE, Cheunsuk S, Allen SE, Chi E, Liggitt HD, Hood LE, Ladiges WC.

Int Immunol. 1998 Nov;10(11):1613-22.PMID: 9846690 [PubMed - indexed for MEDLINE]Related articlesFree article

SWR: an inbred strain suitable for generating transgenic mice.

Osman GE, Jacobson DP, Li SW, Hood LE, Liggitt HD, Ladiges WC.

Lab Anim Sci. 1997 Apr;47(2):167-71.PMID: 9150496 [PubMed - indexed for MEDLINE]Related articles

Alternatives to the use of conventional research animals in neoplasia research.

Ladiges WC.

J Am Vet Med Assoc. 1992 Mar 1;200(5):674-6. Review. No abstract available. PMID: 1568910 [PubMed - indexed for MEDLINE]Related articles

Late failure of autologous marrow grafts in lethally irradiated dogs given anti-class II monoclonal antibody.

Greinix HT, Ladiges WC, Graham TC, Maslan S, Raff RF, Sandmaier BM, Appelbaum FR, Schuening FG, Deeg HJ, Storb R.

Blood. 1991 Oct 15;78(8):2131-8.PMID: 1912590 [PubMed - indexed for MEDLINE]Related articlesFree article

Soft tissue mineralization in rabbits fed a diet containing excess vitamin D.

Zimmerman TE, Giddens WE Jr, DiGiacomo RF, Ladiges WC.

Lab Anim Sci. 1990 Mar;40(2):212-5. No abstract available. PMID: 2157109 [PubMed - indexed for MEDLINE]Related articles

Failure of anti-MHC antibodies to prevent GVHD in DLA mismatched unrelated canine marrow recipients.

Ladiges WC, Storb R, Raff RF, Appelbaum FR, Sandmaier B, Schuening F, Graham T.

Bone Marrow Transplant. 1990 Jan;5(1):43-6.PMID: 2297589 [PubMed - indexed for MEDLINE]Related articles

Canine models of bone marrow transplantation.

Ladiges WC, Storb R, Thomas ED.

Lab Anim Sci. 1990 Jan;40(1):11-5. Review.PMID: 2153851 [PubMed - indexed for MEDLINE]Related articles

Comparative reactivity of anti-Ia monoclonal antibodies in man and laboratory animals.

Ladiges WC, Severns E, Pesando JM.

Hybridoma. 1988 Oct;7(5):465-70.PMID: 2974014 [PubMed - indexed for MEDLINE]Related articles

Phenotypic characterization of canine lymphoma, using monoclonal antibodies and a microlymphocytotoxicity assay.

Ladiges WC, Keast M, Appelbaum F, Storb R.

Am J Vet Res. 1988 Jun;49(6):870-2.PMID: 3400923 [PubMed - indexed for MEDLINE]Related articles

Selective inhibition of the canine mixed lymphocyte response by HLA-DR and DP-reactive monoclonal antibodies.

Ladiges WC, Pesando JM, Severns E, Longton G, Deeg HJ, Storb R.

Transplantation. 1988 Feb;45(2):484-8.PMID: 2964111 [PubMed - indexed for MEDLINE]Related articles

Murine monoclonal antibodies cross-reactive with feline peripheral blood mononuclear cells.

Shelton GH, Ladiges WC.

Vet Immunol Immunopathol. 1987 Nov;16(3-4):271-6.PMID: 2829413 [PubMed - indexed for MEDLINE]Related articles

Monoclonal antibodies to canine differentiation antigens.

Deeg HJ, Ladiges WC, Aprile J, Schuening F, Raff RF, Storb R.

Methods Find Exp Clin Pharmacol. 1987 Nov;9(11):749-53. Review.PMID: 2452332 [PubMed - indexed for MEDLINE]Related articles

A DLA-associated polymorphic cell surface determinant defined by the murine monoclonal antibody W3G10.

Ladiges WC, Raff RF, Storb R.

Anim Genet. 1987;18(2):149-58.PMID: 2444142 [PubMed - indexed for MEDLINE]Related articles

Postmortem findings in four litters of dogs with familial canine dermatomyositis.

Hargis AM, Prieur DJ, Haupt KH, Collier LL, Evermann JF, Ladiges WC.

Am J Pathol. 1986 Jun;123(3):480-96.PMID: 3717301 [PubMed - indexed for MEDLINE]Related articlesFree article

An extension of Green and Woodrow's sibling method for detecting MHC-disease associations.

Farewell VT, Ladiges WC.

Tissue Antigens. 1986 Jan;27(1):53-5.PMID: 3952724 [PubMed - indexed for MEDLINE]Related articles

Recognition of target cell determinants associated with DLA-D-locus-encoded antigens by canine cytotoxic lymphocytes.

Raff RF, Storb R, Ladiges WC, Deeg HJ.

Transplantation. 1985 Sep;40(3):323-8.PMID: 2412323 [PubMed - indexed for MEDLINE]Related articles

Immunogenetic aspects of a canine breeding colony.

Ladiges WC, Deeg HJ, Raff RF, Storb R.

Lab Anim Sci. 1985 Feb;35(1):58-62.PMID: 2580117 [PubMed - indexed for MEDLINE]Related articles

Monoclonal antibodies to canine cell surface antigens: a comparison of screening assays.

Ladiges WC, Durkopp N, Urban C, Wulff JC, Storb R.

Hybridoma. 1984 Winter;3(4):387-90.PMID: 6396199 [PubMed - indexed for MEDLINE]Related articles

The canine major histocompatibility complex. Supertypic specificities defined by the primed lymphocyte test (PLT).

Ladiges WC, Raff RF, Brown S, Deeg HJ, Storb R.

Immunogenetics. 1984;19(4):359-65. No abstract available. PMID: 6201443 [PubMed - indexed for MEDLINE]Related articles

Polymorphism of the sixth component of complement (C6) in the dog.

Anderson JE, Ladiges WC, Giblett ER, Weiden P, Storb R.

Biochem Genet. 1983 Feb;21(1-2):155-60.PMID: 6838487 [PubMed - indexed for MEDLINE]Related articles

Prevalence of Toxoplasma gondii antibodies and oocysts in pound-source cats.

Ladiges WC, DiGiacomo RF, Yamaguchi RA.

J Am Vet Med Assoc. 1982 Jun 1;180(11):1334-5.PMID: 7096176 [PubMed - indexed for MEDLINE]Related articles

Prevalence and sequelae of feline leukemia virus infection in laboratory cats.

Ladiges WC, DiGiacomo RF, Wardrop KJ, Hardy WD Jr.

J Am Vet Med Assoc. 1981 Dec 1;179(11):1206-7.PMID: 6276347 [PubMed - indexed for MEDLINE]Related articles

Iron dextran-induced anaphylaxis in a goat (Capra hircus).

Ladiges WC, Garlinghouse LE Jr.

Lab Anim Sci. 1981 Aug;31(4):421-2. No abstract available. PMID: 7311471 [PubMed - indexed for MEDLINE]Related articles

Treatment of feline leukemia and reversal of FeLV by ex vivo removal of IgG: a preliminary report.

Jones FR, Yoshida LH, Ladiges WC, Kenny MA.

Cancer. 1980 Aug 15;46(4):675-84.PMID: 6249487 [PubMed - indexed for MEDLINE]Related articles

Heterotransplantation of feline malignant tumors in nude thymusless mice.

Ladiges WC, Van Hoosier GL Jr.

Am J Vet Res. 1980 May;41(5):840-2.PMID: 7406308 [PubMed - indexed for MEDLINE]Related articles

A summary of responses to cancer therapy in cats.

Ladiges WC.

Mod Vet Pract. 1980 Mar;61(3):227-9. No abstract available. PMID: 6245346 [PubMed - indexed for MEDLINE]Related articles